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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Kidney Transitional Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats F344/N Male Dosed-Feed Kidney Transitional Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Rats F344/N Male Dosed-Feed Kidney Transitional Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-423 119-84-6 3,4-Dihydrocoumarin Rats F344/N Male Gavage Kidney Transitional Cell Some Evidence Equivocal Evidence CARCINOMA 0/50 0/48 0/47 2/50 May Have Been Related
Yes TR-367 50-33-9 Phenylbutazone Rats F344/N Female Gavage Kidney Transitional Cell Some Evidence Some Evidence CARCINOMA 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Female Dosed-Feed Kidney Transitional Cell Clear Evidence Clear Evidence (STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Kidney Transitional Cell Clear Evidence Clear Evidence PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60 Neoplastic Lesions
Yes TR-335 6373-74-6 C.I. Acid Orange 3 Rats F344/N Female Gavage Kidney Transitional Cell Clear Evidence Clear Evidence CARCINOMA 0/50 0/50 6/50 Neoplastic Lesions
Yes TR-323 756-79-6 Dimethyl methylphosphonate Rats F344/N Male Gavage Kidney Transitional Cell Some Evidence Some Evidence PAPILLOMA 0/50 7/50 3/49 Neoplastic Lesions
Yes TR-313 2385-85-5 Mirex Rats F344/N Male Dosed-Feed Kidney Transitional Cell Clear Evidence Clear Evidence PAPILLOMA 0/51 0/51 0/52 0/52 1/51 3/52 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Male Dosed-Feed Kidney Transitional Cell Some Evidence Some Evidence PAPILLOMA 0/50 0/50 2/50 0/50 1/50 Neoplastic Lesions
Yes TR-457 599-79-1 Salicylazosulfapyridine Rats F344/N Female Gavage Kidney Transitional Cell Some Evidence Some Evidence PAPILLOMA 0/50 0/50 0/50 2/50 Neoplastic Lesions