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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Kidney Tubular Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-000 (67-66-3) 67-66-3 Chloroform Rats Osborne Mendel Male Gavage Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA COMBINED Neoplastic Lesions
Yes TR-006 139-13-9 Nitrilotriacetic acid (NTA) Mice B6C3F1 Female Dosed-Feed Kidney Tubular Cell Positive Positive ADENOCARCINOMA Neoplastic Lesions
Yes TR-006 139-13-9 Nitrilotriacetic acid (NTA) Mice B6C3F1 Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOCARCINOMA Neoplastic Lesions
Yes TR-006 139-13-9 Nitrilotriacetic acid (NTA) Rats F344/N Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats F344/N Female Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats F344/N Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOCARCINOMA OR CARCINOMA Neoplastic Lesions
Yes TR-041 1897-45-6 Chlorothalonil Rats Osborne Mendel Female Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-041 1897-45-6 Chlorothalonil Rats Osborne Mendel Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Rats F344/N Female Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Rats F344/N Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA, ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats F344/N Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-196 87-29-6 Cinnamyl anthranilate Rats F344/N Male Dosed-Feed Kidney Tubular Cell Positive Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
Yes TR-266 150-68-5 Monuron Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49 Neoplastic Lesions
Yes TR-291 78-59-1 Isophorone Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50 Neoplastic Lesions
Yes TR-358 303-47-9 Ochratoxin A Rats F344/N Female Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50 Neoplastic Lesions
Yes TR-341 67-20-9 Nitrofurantoin Rats F344/N Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50 Neoplastic Lesions
Yes TR-423 119-84-6 3,4-Dihydrocoumarin Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Kidney Tubular Cell Clear Evidence Equivocal Evidence ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80 May Have Been Related
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50 Neoplastic Lesions
Yes TR-358 303-47-9 Ochratoxin A Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50 Neoplastic Lesions
Yes TR-359 298-81-7 8-Methoxypsoralen Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49 Neoplastic Lesions
Yes TR-366 123-31-9 Hydroquinone Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence Adenoma 0/55 4/55 8/55 Neoplastic Lesions
Yes TR-311 127-18-4 Tetrachloroethylene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50 Neoplastic Lesions
Yes TR-367 50-33-9 Phenylbutazone Rats F344/N Female Gavage Kidney Tubular Cell Some Evidence Equivocal Evidence ADENOMA (STEP SECTIONS) 0/50 3/50 1/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 1/50 May Have Been Related
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-361 67-72-1 Hexachloroethane Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-361 67-72-1 Hexachloroethane Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 7/50 Neoplastic Lesions
Yes TR-369 98-85-1 alpha-Methylbenzyl alcohol Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Equivocal Evidence ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49 May Have Been Related
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Mice B6C3F1 Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 0/50 0/50 6/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 20/49 21/52 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Mice B6C3F1 Male Dosed-Feed Kidney Tubular Cell Clear Evidence Equivocal Evidence ADENOMA 0/50 2/50 1/50 1/50 OR CARCINOMA 0/50 1/50 0/50 0/50 COMBINED 0/50 3/50 1/50 1/50 May Have Been Related
Yes TR-323 756-79-6 Dimethyl methylphosphonate Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOCARCINOMA 0/50 2/50 3/49 Neoplastic Lesions
Yes TR-401 137-09-7 2,4-Diaminophenol dihydrochloride Mice B6C3F1 Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 0/48 3/50 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Rats F344/N Female Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOCARCINOMA 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-382 98-01-1 Furfural Mice B6C3F1 Male Gavage Kidney Tubular Cell Clear Evidence Equivocal Evidence ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50 May Have Been Related
Yes TR-409 117-39-5 Quercetin Rats F344/N Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 2/50 7/50 8/50 (SINGLE SECTIONS) ADENOCARCINOMA 0/50 0/50 0/50 1/50 (SINGLE AND STEP SECTIONS) OVERALL ADENOMA OR ADENOCARCINOMA 1/50 2/50 7/50 9/50 Neoplastic Lesions
Yes TR-339 99-57-0 2-Amino-4-nitrophenol Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 1/48 3/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-422 91-64-5 Coumarin Rats F344/N Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 1/49 2/50 2/51 1/50, STEP SECTIONS 0/49 4/50 5/51 4/50 Neoplastic Lesions
Yes TR-347 5989-27-5 D-Limonene Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Mice B6C3F1 Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Rats F344/N Female Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Female Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48 Neoplastic Lesions
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Female Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 5/50 Neoplastic Lesions
Yes TR-424 120-32-1 o-Benzyl-p-chlorophenol Mice B6C3F1 Male Gavage Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50 Neoplastic Lesions
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/50 5/50 24/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Male Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 0/51 3/50 2/49 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50 Neoplastic Lesions
Yes TR-475 109-99-9 Tetrahydrofuran Rats F344/N Male Inhalation Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 1/50 1/50 4/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 1/50 1/50 4/50 5/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-466 100-41-4 Ethylbenzene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50 Neoplastic Lesions
Yes TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOCARCINOMA 1/50 3/50 7/50 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Female Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence ADENOMA 1/50 3/50 9/50 5/50 3/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Equivocal Evidence ADENOMA 0/51 0/53 1/51 3/55 1/59 May Have Been Related
Yes TR-463 8003-22-3 D&C Yellow No. 11 Rats F344/N Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/51 0/51 2/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 0/51 1/51 2/54; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/51 4/51 4/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 2/51 5/51 4/54 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Female Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50 Neoplastic Lesions
Yes TR-478 111-42-2 Diethanolamine Mice B6C3F1 Male Topical Application Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50) Neoplastic Lesions
Yes TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice B6C3F1 Male Topical Application Kidney Tubular Cell Clear Evidence Clear Evidence adenoma 1/50, 1/50, 7/50; renal tubule adenoma or carcinoma 1/50, 1/50, 9/50 Neoplastic Lesions
Yes TR-538 108-10-1 Methyl isobutyl ketone Rats F344/N Male Inhalation Kidney Tubular Cell Some Evidence Some Evidence ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50) Neoplastic Lesions
Yes TR-519 64742-88-7 Stoddard solvent (type lIC) Rats F344/N Male Inhalation Kidney Tubular Cell Some Evidence Equivocal Evidence (STANDARD AND EXTENDED EVALUATION COMBINED) ADENOMA 3/50 2/50 3/50 7/50 May Have Been Related
Yes TR-496 116355-83-0 Fumonisin B1 Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence Adenoma 0/48 0/40 0/48 2/48 5/48 or Carcinoma 0/48 0/40 0/48 7/48 10/48 Combined 0/48 0/40 0/48 9/48 15/48 Neoplastic Lesions
Yes TR-533 119-61-9 Benzophenone Rats F344/N Male Dosed-Feed Kidney Tubular Cell Some Evidence Some Evidence ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50 Neoplastic Lesions
Yes TR-465 77-09-8 Phenolphthalein Rats F344/N Male Dosed-Feed Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50 Neoplastic Lesions
Yes TR-470 110-86-1 Pyridine Rats F344/N Male Dosed-Water Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49 Neoplastic Lesions
Yes TR-482 98-00-0 Furfuryl alcohol Mice B6C3F1 Male Inhalation Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50 Neoplastic Lesions
Yes TR-466 100-41-4 Ethylbenzene Rats F344/N Female Inhalation Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49 Neoplastic Lesions
Yes TR-470 110-86-1 Pyridine Rats Wistar Male Dosed-Water Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49 Neoplastic Lesions
Yes TR-436 75-65-0 tert-Butyl alcohol Rats F344/N Male Dosed-Water Kidney Tubular Cell Some Evidence Some Evidence (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50 Neoplastic Lesions
Yes TR-513 91-17-8 Decalin Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20 Neoplastic Lesions
Yes TR-456 147-47-7 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) Rats F344/N Male Topical Application Kidney Tubular Cell Some Evidence Some Evidence ADENOMA (SINGLE SECTIONS) 1/50 7/50 10/50 7/50 (STEP SECTIONS) 6/50 5/50 6/50 8/50 (COMBINED) 7/50 11/50 14/50 14/50; CARCINOMA (SINGLE SECTIONS) 0/50 1/50 0/50 0/50 (STEP SECTIONS) 0/50 1/50 0/50 0/50 (COMBINED) 0/50 1/50 0/50 0/50; ADENOMA OR CARCINOMA COMBINED (SINGLE SECTIONS) 1/50 8/50 10/50 7/50 (STEP SECTIONS) 6/50 6/50 6/50 8/50 (COMBINED) 7/50 12/50 14/50 14/50 Neoplastic Lesions
Yes TR-486 78-79-5 Isoprene Rats F344/N Male Inhalation Kidney Tubular Cell Clear Evidence Clear Evidence (SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50 Neoplastic Lesions
Yes TR-543 98-83-9 alpha-Methylstyrene Rats F344/N Male Inhalation Kidney Tubular Cell Some Evidence Some Evidence ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50 Neoplastic Lesions
Yes TR-557 123-35-3 beta-Myrcene Rats F344/N Male Gavage Kidney Tubular Cell Clear Evidence Clear Evidence Adenoma (standard evaluation) 0/50 4/50 8/50 (standard and extended evaluations) 0/50 12/50 13/50 adenoma or carcinoma (standard evaluation) 0/50 7/50 9/50 (standard and extended evaluations) 0/50 14/50 13/50 Neoplastic Lesions