No
|
TR-423
|
119-84-6 |
3,4-Dihydrocoumarin |
Mice |
B6C3F1 |
Male |
Gavage |
Unspecified
|
No Evidence |
|
Not applicable
|
Not applicable
|
Yes
|
TR-423
|
119-84-6 |
3,4-Dihydrocoumarin |
Rats |
F344/N |
Male |
Gavage |
Kidney Transitional Cell
|
Some Evidence |
Equivocal Evidence |
CARCINOMA 0/50 0/48 0/47 2/50
|
May Have Been Related
|
No
|
TR-423
|
119-84-6 |
3,4-Dihydrocoumarin |
Rats |
F344/N |
Male |
Gavage |
Kidney Tubular Cell
|
Some Evidence |
Some Evidence |
ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50
|
Neoplastic Lesions
|
No
|
TR-423
|
119-84-6 |
3,4-Dihydrocoumarin |
Mice |
B6C3F1 |
Female |
Gavage |
Liver
|
Some Evidence |
Some Evidence |
ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52
|
Neoplastic Lesions
|
Yes
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Some Evidence |
Some Evidence |
PAPILLOMA 0/50 0/50 2/50 0/50 1/50
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Female |
Dosed-Feed |
Kidney Tubular Cell
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Some Evidence |
Some Evidence |
ADENOMA 1/50 3/50 9/50 5/50 3/50
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Male |
Dosed-Feed |
Liver
|
Some Evidence |
Equivocal Evidence |
ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50
|
May Have Been Related
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 2/50 6/50 4/50 3/50
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Thyroid Gland Follicular Cell
|
Clear Evidence |
Equivocal Evidence |
ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48
|
May Have Been Related
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Thyroid Gland Follicular Cell
|
Clear Evidence |
Equivocal Evidence |
ADENOMA 0/50 0/50 2/49 2/46
|
May Have Been Related
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Clear Evidence |
Clear Evidence |
TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49
|
Neoplastic Lesions
|
No
|
TR-494
|
84-65-1 |
Anthraquinone |
Rats |
F344/N |
Male |
Dosed-Feed |
Urinary Bladder
|
Some Evidence |
Some Evidence |
TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49
|
Neoplastic Lesions
|
Yes
|
TR-335
|
6373-74-6 |
C.I. Acid Orange 3 |
Rats |
F344/N |
Female |
Gavage |
Kidney Transitional Cell
|
Clear Evidence |
Clear Evidence |
CARCINOMA 0/50 0/50 6/50
|
Neoplastic Lesions
|
No
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Mice |
B6C3F1 |
Male |
Gavage |
Unspecified
|
Inadequate Study |
|
Not applicable
|
Not applicable
|
No
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Mice |
B6C3F1 |
Female |
Gavage |
Unspecified
|
No Evidence |
|
Not applicable
|
Not applicable
|
No
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Rats |
F344/N |
Female |
Gavage |
Unspecified
|
No Evidence |
|
Not applicable
|
Not applicable
|
No
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Rats |
F344/N |
Male |
Gavage |
Hematopoietic System
|
Some Evidence |
Equivocal Evidence |
LEUKEMIA 10/50 11/50 17/50
|
May Have Been Related
|
Yes
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Rats |
F344/N |
Male |
Gavage |
Kidney Transitional Cell
|
Some Evidence |
Some Evidence |
PAPILLOMA 0/50 7/50 3/49
|
Neoplastic Lesions
|
No
|
TR-323
|
756-79-6 |
Dimethyl methylphosphonate |
Rats |
F344/N |
Male |
Gavage |
Kidney Tubular Cell
|
Some Evidence |
Some Evidence |
ADENOCARCINOMA 0/50 2/50 3/49
|
Neoplastic Lesions
|
No
|
TR-313
|
2385-85-5 |
Mirex |
Rats |
F344/N |
Male |
Dosed-Feed |
Adrenal Gland Medulla
|
Clear Evidence |
Clear Evidence |
PHEOCHROMOCYTOMA 8/51 7/52 13/52 11/52 18/51 19/51
|
Neoplastic Lesions
|
No
|
TR-313
|
2385-85-5 |
Mirex |
Rats |
F344/N |
Female |
Dosed-Feed |
Hematopoietic System
|
Clear Evidence |
Clear Evidence |
LEUKEMIA 6/52 9/52 14/52
|
Neoplastic Lesions
|
Yes
|
TR-313
|
2385-85-5 |
Mirex |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Clear Evidence |
Clear Evidence |
PAPILLOMA 0/51 0/51 0/52 0/52 1/51 3/52
|
Neoplastic Lesions
|
No
|
TR-313
|
2385-85-5 |
Mirex |
Rats |
F344/N |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
NEOPLASTIC NODULE 2/52 23/52 30/52
|
Neoplastic Lesions
|
No
|
TR-313
|
2385-85-5 |
Mirex |
Rats |
F344/N |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
NEOPLASTIC NODULE 3/52 5/52 5/52 14/52 15/52 26/52
|
Neoplastic Lesions
|
No
|
TR-006
|
139-13-9 |
Nitrilotriacetic acid (NTA) |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Kidney Tubular Cell
|
Positive |
Positive |
ADENOCARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
139-13-9 |
Nitrilotriacetic acid (NTA) |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Positive |
Positive |
ADENOCARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
139-13-9 |
Nitrilotriacetic acid (NTA) |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Positive |
Positive |
ADENOMA OR ADENOCARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
139-13-9 |
Nitrilotriacetic acid (NTA) |
Rats |
F344/N |
Male |
Dosed-Feed |
Ureter
|
Positive |
Positive |
(ADENOMA OR PAPILLOMA)
|
Neoplastic Lesions
|
No
|
TR-006
|
139-13-9 |
Nitrilotriacetic acid (NTA) |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Unspecified
|
Negative |
|
Not applicable
|
Not applicable
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Unspecified
|
Negative |
|
Not applicable
|
Not applicable
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Equivocal Evidence |
Equivocal |
PAPILLOMA
|
Neoplastic Lesions
|
Yes
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Positive |
Positive |
CARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Equivocal Evidence |
Equivocal |
ADENOCARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Female |
Dosed-Feed |
Kidney Tubular Cell
|
Positive |
Positive |
ADENOMA OR ADENOCARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Positive |
Positive |
ADENOCARCINOMA OR CARCINOMA
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Female |
Dosed-Feed |
Ureter
|
Positive |
Positive |
(TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Male |
Dosed-Feed |
Ureter
|
Positive |
Positive |
(TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Equivocal Evidence |
Equivocal |
(TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-006
|
18662-53-8 |
Nitrilotriacetic acid trisodium monohydrate |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
Yes
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Positive |
Positive |
CARCINOMA
|
Neoplastic Lesions
|
No
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Rats |
F344/N |
Male |
Dosed-Feed |
Thyroid Gland Follicular Cell
|
Positive |
Positive |
ADENOMA OR CARCINOMA
|
Neoplastic Lesions
|
No
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-089
|
134-29-2 |
o-Anisidine hydrochloride |
Rats |
F344/N |
Male |
Dosed-Feed |
Urinary Bladder
|
Positive |
Positive |
(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Female |
Dosed-Feed |
Forestomach
|
Clear Evidence |
Equivocal Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50
|
May Have Been Related
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Forestomach
|
Clear Evidence |
Equivocal Evidence |
SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50
|
May Have Been Related
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Female |
Dosed-Feed |
Hematopoietic System
|
Clear Evidence |
Clear Evidence |
MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Hematopoietic System
|
Clear Evidence |
Clear Evidence |
MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Female |
Dosed-Feed |
Intestines (Large)
|
Clear Evidence |
Clear Evidence |
(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Intestines (Large)
|
Clear Evidence |
Clear Evidence |
(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60
|
Neoplastic Lesions
|
Yes
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Female |
Dosed-Feed |
Kidney Transitional Cell
|
Clear Evidence |
Clear Evidence |
(STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60
|
Neoplastic Lesions
|
Yes
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Transitional Cell
|
Clear Evidence |
Clear Evidence |
PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Kidney Tubular Cell
|
Clear Evidence |
Equivocal Evidence |
ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49
|
May Have Been Related
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Liver
|
Some Evidence |
Some Evidence |
ADENOMA 14/50 2/50 36/50 18/50
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Female |
Dosed-Feed |
Urinary Bladder
|
Clear Evidence |
Clear Evidence |
(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60
|
Neoplastic Lesions
|
No
|
TR-416
|
91-23-6 |
o-Nitroanisole |
Rats |
F344/N |
Male |
Dosed-Feed |
Urinary Bladder
|
Clear Evidence |
Clear Evidence |
(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60
|
Neoplastic Lesions
|
No
|
TR-367
|
50-33-9 |
Phenylbutazone |
Mice |
B6C3F1 |
Female |
Gavage |
Unspecified
|
No Evidence |
|
Not applicable
|
Not applicable
|
Yes
|
TR-367
|
50-33-9 |
Phenylbutazone |
Rats |
F344/N |
Female |
Gavage |
Kidney Transitional Cell
|
Some Evidence |
Some Evidence |
CARCINOMA 0/50 0/50 2/50
|
Neoplastic Lesions
|
No
|
TR-367
|
50-33-9 |
Phenylbutazone |
Rats |
F344/N |
Female |
Gavage |
Kidney Tubular Cell
|
Some Evidence |
Equivocal Evidence |
ADENOMA (STEP SECTIONS) 0/50 3/50 1/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 1/50
|
May Have Been Related
|
No
|
TR-367
|
50-33-9 |
Phenylbutazone |
Rats |
F344/N |
Male |
Gavage |
Kidney Tubular Cell
|
Equivocal Evidence |
Equivocal Evidence |
ADENOMA 0/50 0/49 3/50 OR CARCINOMA 0/50 1/49 0/50 COMBINED 0/50 1/49 3/50
|
Neoplastic Lesions
|
No
|
TR-367
|
50-33-9 |
Phenylbutazone |
Mice |
B6C3F1 |
Male |
Gavage |
Liver
|
Some Evidence |
Some Evidence |
ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50
|
Neoplastic Lesions
|
Yes
|
TR-457
|
599-79-1 |
Salicylazosulfapyridine |
Rats |
F344/N |
Female |
Gavage |
Kidney Transitional Cell
|
Some Evidence |
Some Evidence |
PAPILLOMA 0/50 0/50 0/50 2/50
|
Neoplastic Lesions
|
No
|
TR-457
|
599-79-1 |
Salicylazosulfapyridine |
Mice |
B6C3F1 |
Female |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49
|
Neoplastic Lesions
|
No
|
TR-457
|
599-79-1 |
Salicylazosulfapyridine |
Mice |
B6C3F1 |
Male |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50
|
Neoplastic Lesions
|
No
|
TR-457
|
599-79-1 |
Salicylazosulfapyridine |
Rats |
F344/N |
Female |
Gavage |
Urinary Bladder
|
Some Evidence |
Some Evidence |
TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50
|
Neoplastic Lesions
|
No
|
TR-457
|
599-79-1 |
Salicylazosulfapyridine |
Rats |
F344/N |
Male |
Gavage |
Urinary Bladder
|
Some Evidence |
Some Evidence |
(CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50
|
Neoplastic Lesions
|