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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Liver
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-008 57-74-9 Chlordane (analytical grade) Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-008 57-74-9 Chlordane (analytical grade) Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-009 76-44-8 Heptachlor Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-009 76-44-8 Heptachlor Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-013 127-18-4 Tetrachloroethylene Mice B6C3F1 Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-013 127-18-4 Tetrachloroethylene Mice B6C3F1 Male Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-000 (143-50-0) 143-50-0 Chlordecone Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
Yes TR-000 (143-50-0) 143-50-0 Chlordecone Mice B6C3F1 Male Dosed-Feed Liver Positive Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
Yes TR-000 (143-50-0) 143-50-0 Chlordecone Rats Osborne Mendel Female Dosed-Feed Liver Positive Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
Yes TR-000 (143-50-0) 143-50-0 Chlordecone Rats Osborne Mendel Male Dosed-Feed Liver Positive Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
Yes TR-000 (67-66-3) 67-66-3 Chloroform Mice B6C3F1 Female Gavage Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-000 (67-66-3) 67-66-3 Chloroform Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-002 79-01-6 Trichloroethylene Mice B6C3F1 Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-002 79-01-6 Trichloroethylene Mice B6C3F1 Male Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-021 309-00-2 Aldrin Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-025 133-90-4 Chloramben Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-026 1836-75-5 Nitrofen Mice B6C3F1 Female Dosed-Feed Liver Positive Positive HEPATOCELLULAR CARCINOMA Neoplastic Lesions
Yes TR-026 1836-75-5 Nitrofen Mice B6C3F1 Male Dosed-Feed Liver Positive Positive HEPATOCELLULAR CARCINOMA Neoplastic Lesions
Yes TR-027 79-34-5 1,1,2,2-Tetrachloroethane Mice B6C3F1 Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-027 79-34-5 1,1,2,2-Tetrachloroethane Mice B6C3F1 Male Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-033 961-11-5 Tetrachlorvinphos Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE) Neoplastic Lesions
Yes TR-033 961-11-5 Tetrachlorvinphos Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-034 1582-09-8 Trifluralin Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-037 8001-35-2 Toxaphene Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-037 8001-35-2 Toxaphene Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-039 303-34-4 Lasiocarpine Rats F344/N Female Dosed-Feed Liver Positive Positive Angiosarcoma, carcinoma, adenoma Neoplastic Lesions
Yes TR-039 303-34-4 Lasiocarpine Rats F344/N Male Dosed-Feed Liver Positive Positive Angiosarcoma, carcinoma, adenoma Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Mice B6C3F1 Male Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Male Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-068 67-72-1 Hexachloroethane Mice B6C3F1 Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-068 67-72-1 Hexachloroethane Mice B6C3F1 Male Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-074 79-00-5 1,1,2-Trichloroethane Mice B6C3F1 Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-074 79-00-5 1,1,2-Trichloroethane Mice B6C3F1 Male Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-075 510-15-6 Chlorobenzilate Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-075 510-15-6 Chlorobenzilate Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Rats Osborne Mendel Female Gavage Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-090 115-32-2 Dicofol Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-092 122-66-7 Hydrazobenzene Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-092 122-66-7 Hydrazobenzene Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE) Neoplastic Lesions
Yes TR-092 122-66-7 Hydrazobenzene Rats F344/N Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-080 123-91-1 1,4-Dioxane Mice B6C3F1 Female Dosed-Water Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-080 123-91-1 1,4-Dioxane Mice B6C3F1 Male Dosed-Water Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-080 123-91-1 1,4-Dioxane Rats Osborne Mendel Female Dosed-Water Liver Positive Positive (ADENOMA) Neoplastic Lesions
Yes TR-085 5131-60-2 4-Chloro-m-phenylenediamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-099 136-40-3 Phenazopyridine hydrochloride Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Female Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Male Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-107 99-55-8 5-Nitro-o-toluidine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-107 99-55-8 5-Nitro-o-toluidine Mice B6C3F1 Male Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-111 82-28-0 1-Amino-2-methylanthraquinone Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
Yes TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-117 94-52-0 6-Nitrobenzimidazole Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-117 94-52-0 6-Nitrobenzimidazole Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-133 1777-84-0 3-Nitro-p-acetophenetide Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
Yes TR-124 120-62-7 Piperonyl sulfoxide Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-127 99-59-2 5-Nitro-o-anisidine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-144 117-79-3 2-Aminoanthraquinone Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-144 117-79-3 2-Aminoanthraquinone Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-144 117-79-3 2-Aminoanthraquinone Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
Yes TR-146 139-94-6 Nithiazide Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-131 72-55-9 p,p'-Dichlorodiphenyl dichloroethylene Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-131 72-55-9 p,p'-Dichlorodiphenyl dichloroethylene Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-155 88-06-2 2,4,6-Trichlorophenol Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-155 88-06-2 2,4,6-Trichlorophenol Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-160 137-17-7 2,4,5-Trimethylaniline Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-160 137-17-7 2,4,5-Trimethylaniline Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-160 137-17-7 2,4,5-Trimethylaniline Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-181 90-94-8 Michler's ketone Rats F344/N Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-181 90-94-8 Michler's ketone Rats F344/N Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-184 1836-75-5 Nitrofen Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-184 1836-75-5 Nitrofen Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-187 95-79-4 5-Chloro-o-toluidine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-187 95-79-4 5-Chloro-o-toluidine Mice B6C3F1 Male Dosed-Feed Liver Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-190 156-10-5 p-Nitrosodiphenylamine Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-190 156-10-5 p-Nitrosodiphenylamine Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
Yes TR-194 7446-34-6 Selenium sulfide Mice B6C3F1 Female Gavage Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-169 5307-14-2 2-Nitro-p-phenylenediamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA) Neoplastic Lesions
Yes TR-194 7446-34-6 Selenium sulfide Rats F344/N Female Gavage Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-194 7446-34-6 Selenium sulfide Rats F344/N Male Gavage Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-196 87-29-6 Cinnamyl anthranilate Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-196 87-29-6 Cinnamyl anthranilate Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Mice B6C3F1 Female Gavage Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Mice B6C3F1 Male Gavage Liver Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Rats Osborne Mendel Female Gavage Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-181 90-94-8 Michler's ketone Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Mice B6C3F1 Female Dosed-Feed Liver Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Mice B6C3F1 Male Dosed-Feed Liver Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Rats F344/N Female Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Rats F344/N Male Dosed-Feed Liver Positive Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
Yes TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice B6C3F1 Female Gavage Liver Positive Positive CARCINOMA 1/73 2/50 2/48 6/47 Neoplastic Lesions
Yes TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA 8/73 9/49 8/49 17/50 Neoplastic Lesions
Yes TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Rats Osborne Mendel Female Gavage Liver Positive Positive NEOPLASTIC NODULE 5/75 1/49 3/50 12/49 Neoplastic Lesions
Yes TR-217 117-81-7 Di(2-ethylhexyl) Phthalate Rats F344/N Female Dosed-Feed Liver Positive Positive CARCINOMA 0/50 2/49 8/50 Neoplastic Lesions
Yes TR-217 117-81-7 Di(2-ethylhexyl) Phthalate Rats F344/N Male Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49 Neoplastic Lesions
Yes TR-219 609-20-1 2,6-Dichloro-p-phenylenediamine Mice B6C3F1 Female Dosed-Feed Liver Positive Positive ADENOMA 4/50 4/50 9/50 OR CARCINOMA 2/50 2/50 7/50 Neoplastic Lesions
Yes TR-219 609-20-1 2,6-Dichloro-p-phenylenediamine Mice B6C3F1 Male Dosed-Feed Liver Positive Positive ADENOMA 4/50 7/50 15/50 Neoplastic Lesions
Yes TR-225 5160-02-1 D&C Red No. 9 Rats F344/N Male Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 0/50 6/50 7/49 Neoplastic Lesions
Yes TR-226 842-07-9 C.I. Solvent Yellow 14 Rats F344/N Female Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 2/50 3/49 10/48 Neoplastic Lesions
Yes TR-226 842-07-9 C.I. Solvent Yellow 14 Rats F344/N Male Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 5/50 10/50 30/50 Neoplastic Lesions
Yes TR-232 76-01-7 Pentachloroethane Mice B6C3F1 Female Gavage Liver Positive Positive ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45 Neoplastic Lesions
Yes TR-232 76-01-7 Pentachloroethane Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA 4/48 26/44 7/45 Neoplastic Lesions
Yes TR-212 103-23-1 Di(2-ethylhexyl)adipate Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA 1/50 14/50 12/49 Neoplastic Lesions
Yes TR-212 103-23-1 Di(2-ethylhexyl)adipate Mice B6C3F1 Male Dosed-Feed Liver Positive Positive ADENOMA 6/50 8/49 15/49 Neoplastic Lesions
Yes TR-216 2432-99-7 11-Aminoundecanoic acid Rats F344/N Male Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 1/50 9/50 8/50 Neoplastic Lesions
Yes TR-217 117-81-7 Di(2-ethylhexyl) Phthalate Mice B6C3F1 Female Dosed-Feed Liver Positive Positive CARCINOMA 0/50 7/50 17/50 Neoplastic Lesions
Yes TR-217 117-81-7 Di(2-ethylhexyl) Phthalate Mice B6C3F1 Male Dosed-Feed Liver Positive Positive CARCINOMA 9/50 14/48 19/50 Neoplastic Lesions
Yes TR-250 140-11-4 Benzyl acetate Mice B6C3F1 Male Gavage Liver Some Evidence Some Evidence ADENOMA 0/50 5/49 13/50 Neoplastic Lesions
Yes TR-235 17924-92-4 Zearalenone Mice B6C3F1 Female Dosed-Feed Liver Positive Positive ADENOMA 0/50 2/49 7/49 Neoplastic Lesions
Yes TR-237 630-20-6 1,1,1,2-Tetrachloroethane Mice B6C3F1 Female Gavage Liver Positive Positive ADENOMA 4/49 8/46 24/48 OR CARCINOMA 1/49 5/46 6/48 COMBINED 5/49 13/46 30/48 Neoplastic Lesions
Yes TR-237 630-20-6 1,1,1,2-Tetrachloroethane Mice B6C3F1 Male Gavage Liver Positive Positive ADENOMA 6/48 14/46 21/50 Neoplastic Lesions
Yes TR-222 2832-40-8 C.I. Disperse Yellow 3 Mice B6C3F1 Female Dosed-Feed Liver Positive Positive ADENOMA 0/50 6/50 12/50 Neoplastic Lesions
Yes TR-222 2832-40-8 C.I. Disperse Yellow 3 Rats F344/N Male Dosed-Feed Liver Positive Positive NEOPLASTIC NODULE 1/49 15/50 10/50 Neoplastic Lesions
Yes TR-243 79-01-6 Trichloroethylene Mice B6C3F1 Female Gavage Liver Positive Positive ADENOMA 2/48 8/49; CARCINOMA 2/48 13/49 Neoplastic Lesions
Yes TR-243 79-01-6 Trichloroethylene Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA 8/48 30/50 Neoplastic Lesions
Yes TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice B6C3F1 Female Gavage Liver Positive Positive CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8 Neoplastic Lesions
Yes TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22 Neoplastic Lesions
Yes TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats F344/N Female Gavage Liver Positive Positive NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20 Neoplastic Lesions
Yes TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats F344/N Male Gavage Liver Positive Positive NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Female Dosed-Water Liver Positive Positive ADENOMA 3/50 9/50 12/50 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Male Dosed-Water Liver Positive Positive CARCINOMA 10/49 33/50 29/50 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats F344/N Male Dosed-Water Liver Positive Positive NEOPLASTIC NODULE 1/50 12/50 25/50 Neoplastic Lesions
Yes TR-250 140-11-4 Benzyl acetate Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 0/50 0/50 6/50 Neoplastic Lesions
Yes TR-263 78-87-5 1,2-Dichloropropane (propylene dichloride) Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 1/50 5/50 5/50 Neoplastic Lesions
Yes TR-263 78-87-5 1,2-Dichloropropane (propylene dichloride) Mice B6C3F1 Male Gavage Liver Some Evidence Some Evidence ADENOMA 7/50 10/50 17/50 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice B6C3F1 Male Gavage Liver Positive Positive CARCINOMA 5/50 13/50 17/50 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 1/52 6/52 7/52 Neoplastic Lesions
Yes TR-271 2784-94-3 HC Blue 1 Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence CARCINOMA 1/50 24/48 47/49 Neoplastic Lesions
Yes TR-271 2784-94-3 HC Blue 1 Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence CARCINOMA 11/50 20/50 30/50 Neoplastic Lesions
Yes TR-274 78-42-2 tris(2-Ethylhexyl)phosphate Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence CARCINOMA 0/48 4/50 7/50 Neoplastic Lesions
Yes TR-278 87-62-7 2,6-Xylidine Rats CD Female Dosed-Feed Liver Positive Equivocal Evidence NEOPLASTIC NODULE 0/56 1/56 2/56 4/56 May Have Been Related
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Mice B6C3F1 Female Gavage Liver Positive Positive ADENOMA 2/50 3/50 12/50 Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Female Gavage Liver Positive Positive NEOPLASTIC NODULE 3/50 8/50 8/48 Neoplastic Lesions
Yes TR-282 124-48-1 Chlorodibromomethane Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 2/50 4/49 11/50 OR CARCINOMA 4/50 6/49 8/50 COMBINED 6/50 10/49 19/50 Neoplastic Lesions
Yes TR-266 150-68-5 Monuron Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence CARCINOMA 3/49 19/50 37/49 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence CARCINOMA 10/50 20/50 27/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence CARCINOMA 0/50 2/50 8/50 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 2/50 6/48 22/48 OR CARCINOMA 1/50 11/48 32/48 COMBINED 3/50 16/48 40/48 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 10/50 14/49 14/49 OR CARCINOMA 13/50 15/49 26/49 COMBINED 22/50 24/49 33/49 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48 Neoplastic Lesions
Yes TR-309 1163-19-5 Decabromodiphenyl Oxide Rats F344/N Female Dosed-Feed Liver Some Evidence Some Evidence NEOPLASTIC NODULE 1/50 3/49 9/50 Neoplastic Lesions
Yes TR-309 1163-19-5 Decabromodiphenyl Oxide Rats F344/N Male Dosed-Feed Liver Some Evidence Some Evidence NEOPLASTIC NODULE 1/50 7/50 15/49 Neoplastic Lesions
Yes TR-423 119-84-6 3,4-Dihydrocoumarin Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Male Topical Application Liver Clear Evidence Clear Evidence ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Mice B6C3F1 Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 14/50 2/50 36/50 18/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Liver Clear Evidence Clear Evidence NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50 Neoplastic Lesions
Yes TR-367 50-33-9 Phenylbutazone Mice B6C3F1 Male Gavage Liver Some Evidence Some Evidence ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50 Neoplastic Lesions
Yes TR-351 20265-96-7 p-Chloroaniline hydrochloride Mice B6C3F1 Male Gavage Liver Some Evidence Some Evidence ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50 Neoplastic Lesions
Yes TR-311 127-18-4 Tetrachloroethylene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence CARCINOMA 1/48 13/50 36/50 Neoplastic Lesions
Yes TR-311 127-18-4 Tetrachloroethylene Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50 Neoplastic Lesions
Yes TR-395 57-66-9 Probenecid Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 3/48 2/49 14/49, CARCINOMA 2/48 2/49 3/49, COMBINED 5/48 3/49 16/49 Neoplastic Lesions
Yes TR-420 396-01-0 Triamterene Mice B6C3F1 Female Dosed-Feed Liver Some Evidence Some Evidence (FIRST STUDY) ADENOMA 10/50 22/50 23/50 36/60 OR CARCINOMA 4/50 4/50 3/50 8/60 COMBINED 13/50 26/50 25/50 37/60; (SECOND STUDY) ADENOMA 7/50 28/51 OR CARCINOMA 5/50 11/51 COMBINED 10/50 31/51 Neoplastic Lesions
Yes TR-420 396-01-0 Triamterene Mice B6C3F1 Male Dosed-Feed Liver Some Evidence Some Evidence (FIRST STUDY) ADENOMA 17/50 22/50 19/50 20/60 OR CARCINOMA 5/50 7/50 3/50 13/60 COMBINED 20/50 26/50 19/50 29/60; (SECOND STUDY) ADENOMA 21/50 36/50 OR CARCINOMA 9/50 11/50 COMBINED 25/50 38/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Liver Clear Evidence Clear Evidence NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 3/50 4/50 17/49 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50 Neoplastic Lesions
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Rats F344/N Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 0/50 0/50 1/50 10/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50 Neoplastic Lesions
Yes TR-346 75-00-3 Chloroethane Mice B6C3F1 Female Inhalation Liver Clear Evidence Equivocal Evidence ADENOMA 0/49 1/48 OR CARCINOMA 3/49 7/48 COMBINED 3/49 8/48 May Have Been Related
Yes TR-402 110-00-9 Furan Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49 Neoplastic Lesions
Yes TR-382 98-01-1 Furfural Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence ADENOMA 1/50 3/50 5/50 8/50 Neoplastic Lesions
Yes TR-382 98-01-1 Furfural Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50 Neoplastic Lesions
Yes TR-382 98-01-1 Furfural Rats F344/N Male Gavage Liver Some Evidence Some Evidence CHOLANGIOCARCINOMA 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50 Neoplastic Lesions
Yes TR-313 2385-85-5 Mirex Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 2/52 23/52 30/52 Neoplastic Lesions
Yes TR-313 2385-85-5 Mirex Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 3/52 5/52 5/52 14/52 15/52 26/52 Neoplastic Lesions
Yes TR-422 91-64-5 Coumarin Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 8/50 26/49 29/51 12/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50 Neoplastic Lesions
Yes TR-404 57-41-0 5,5-Diphenylhydantoin (phenytoin) Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 5/48 13/49 22/50, HEPATOBLASTOMA OR CARCINOMA 0/48 1/49 12/50, COMBINED 5/48 14/49 30/50 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48 Neoplastic Lesions
Yes TR-366 123-31-9 Hydroquinone Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, technical Mice B6C3F1 Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50 Neoplastic Lesions
Yes TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 4/50 39/50 46/48; CARCINOMA 1/50 22/50 35/48 Neoplastic Lesions
Yes TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 9/50 48/49 42/50; CARCINOMA 8/50 30/49 36/50 Neoplastic Lesions
Yes TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 0/50 10/50 38/50 OR CARCINOMA 0/50 2/50 4/50 COMBINED 0/50 12/50 39/50 Neoplastic Lesions
Yes TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 1/50 10/49 38/50 OR CARCINOMA 0/50 2/49 19/50 COMBINED 1/50 12/49 41/50 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, technical Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50 Neoplastic Lesions
Yes TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Medaka (Oryzias latipes) Male Aquatic Liver Positive Positive ADENOMA 1/47 0/59 0/56 6/59 ADENOMA OR CARCINOMA 1/47 0/59 0/56 8/59 Neoplastic Lesions
Yes TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Guppy (Poecilia reticulata) Male Aquatic Liver Positive Positive ADENOMA 0/28 3/22 3/21 6/24 ADENOMA OR CARCINOMA 0/28 3/22 3/21 9/24 Neoplastic Lesions
Yes TR-526 TEFDIOXINMIX Toxic equivalency factor evaluation (Dioxin mixture) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 0/53 1/53 1/53 1/53 11/51 OR CHOLANGIOCARCINOMA 0/53 0/53 2/53 7/53 9/51 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Liver Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Liver Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48 Neoplastic Lesions
Yes TR-476 125-33-7 Primidone (primaclone) Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 15/50 42/50 45/49 47/50, CARCINOMA 3/50 11/50 19/49 38/50 OR HEPATOBLASTOMA 1/50 4/50 4/49 4/50 COMBINED 16/50 42/50 46/49 50/50 Neoplastic Lesions
Yes TR-476 125-33-7 Primidone (primaclone) Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 22/50 41/50 39/50 32/50, CARCINOMA 12/50 31/50 35/50 38/50 OR HEPATOBLASTOMA 0/50 17/50 26/50 7/50 COMBINED 31/50 49/50 49/50 46/50 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50 Neoplastic Lesions
Yes TR-515 57018-52-7 Propylene glycol mono-t-butyl ether Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49 Neoplastic Lesions
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice B6C3F1 Female Dosed-Water Liver Clear Evidence Clear Evidence ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Female Dosed-Feed Liver Clear Evidence Equivocal Evidence ADENOMA 1/60 0/59 1/60 6/60 May Have Been Related
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice B6C3F1 Male Dosed-Water Liver Clear Evidence Clear Evidence ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60 Neoplastic Lesions
Yes TR-541 75-12-7 Formamide Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence hemangiosarcoma (1/50, 5/50, 7/50, 8/50) Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice B6C3F1/N Female Inhalation Liver Clear Evidence Clear Evidence adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50) Neoplastic Lesions
Yes TR-518 102-71-6 Triethanolamine Mice B6C3F1/N Female Topical Application Liver Some Evidence Some Evidence ADENOMA 9/50 18/50 20/50 33/50 COMBINED 12/50 23/50 24/50 34/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Liver Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 0/50 2/50 6/50 4/50 3/50 Neoplastic Lesions
Yes TR-531 TEFPCBMIX Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Equivocal Evidence HEPATOCHOLANGIOMA 0/53 0/51 0/53 1/53 1/53 1/65 1/50 CHOLANGIOMA 0/53 0/51 0/53 1/53 0/53 0/65 0/50 May Have Been Related
Yes TR-531 TEFPCBMIX Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence CHOLANGIOCARCINOMA 0/53 0/51 5/53 19/53 28/53 12/65 19/50 ADENOMA 2/53 1/51 0/53 4/53 17/53 5/65 1/50 CARCINOMA 0/53 0/51 0/53 0/53 1/53 0/65 0/50 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48 Neoplastic Lesions
Yes TR-527 129-73-7 Leucomalachite green Mice MV Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA OR CARCINOMA 3/47 6/48 6/47 11/47 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Male Dosed-Feed Liver Some Evidence Equivocal Evidence ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50 May Have Been Related
Yes TR-515 57018-52-7 Propylene glycol mono-t-butyl ether Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Mice B6C3F1/N Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 3/50 4/49 6/49 10/50 Neoplastic Lesions
Yes TR-463 8003-22-3 D&C Yellow No. 11 Rats F344/N Female Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 0/50 2/51 5/50 4/51 OR CARCINOMA 0/50 0/51 0/50 1/51 COMBINED 0/50 2/51 5/50 5/51 Neoplastic Lesions
Yes TR-463 8003-22-3 D&C Yellow No. 11 Rats F344/N Male Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 1/50 2/51 1/51 7/54 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50 Neoplastic Lesions
Yes TR-478 111-42-2 Diethanolamine Mice B6C3F1 Female Topical Application Liver Clear Evidence Clear Evidence ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50 Neoplastic Lesions
Yes TR-478 111-42-2 Diethanolamine Mice B6C3F1 Male Topical Application Liver Clear Evidence Clear Evidence ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50 Neoplastic Lesions
Yes TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice B6C3F1 Female Topical Application Liver Clear Evidence Clear Evidence adenoma 32/50, 44/50, 43/50; hepatocellular carcinoma 3/50, 21/50, 32/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 33/50, 46/50, 48/50 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Mice B6C3F1/N Male Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50 Neoplastic Lesions
Yes TR-538 108-10-1 Methyl isobutyl ketone Mice B6C3F1 Female Inhalation Liver Some Evidence Some Evidence ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50 Neoplastic Lesions
Yes TR-538 108-10-1 Methyl isobutyl ketone Mice B6C3F1 Male Inhalation Liver Some Evidence Some Evidence ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50 Neoplastic Lesions
Yes TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice B6C3F1 Male Topical Application Liver Clear Evidence Clear Evidence adenoma 22/50, 35/50, 45/50; hepatoblastoma 1/50, 1/50, 10/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 29/50, 39/50, 49/50 Neoplastic Lesions
Yes TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice B6C3F1 Female Gavage Liver Some Evidence Some Evidence HEMANGIOSARCOMA 1/50 1/49 1/50 4/49; ADENOMA 7/50 5/49 4/50 15/49; HEPATOCELLULAR ADENOMA OR CARCINOMA 10/50 8/49 9/50 18/49 Neoplastic Lesions
Yes TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice B6C3F1 Male Gavage Liver Some Evidence Equivocal Evidence ADENOMA OR CARCINOMA 23/50 23/50 26/50 31/50 May Have Been Related
Yes TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice B6C3F1 Male Gavage Liver Some Evidence Some Evidence HEMANGIOSARCOMA 2/50 0/50 4/50 9/50 Neoplastic Lesions
Yes TR-543 98-83-9 alpha-Methylstyrene Mice B6C3F1/N Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50 Neoplastic Lesions
Yes TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Equivocal Evidence CHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 1/51 1/53 0/50 May Have Been Related
Yes TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50 Neoplastic Lesions
Yes TR-496 116355-83-0 Fumonisin B1 Mice MV Female Dosed-Feed Liver Clear Evidence Clear Evidence Adenoma 5/47 3/48 1/48 16/47 31/45 or Carcinoma 0/47 0/48 0/48 10/47 9/45 Combined 5/47 3/48 1/48 19/47 39/45 Neoplastic Lesions
Yes TR-533 119-61-9 Benzophenone Mice B6C3F1/N Female Dosed-Feed Liver Some Evidence Equivocal Evidence ADENOMA 5/50 4/50 10/50 8/50 May Have Been Related
Yes TR-533 119-61-9 Benzophenone Mice B6C3F1/N Male Dosed-Feed Liver Some Evidence Some Evidence ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50 Neoplastic Lesions
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Equivocal Evidence HEPATOCHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 2/53 0/50 OR CHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 0/53 1/50 May Have Been Related
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Medaka (Oryzias latipes) Female Aquatic Liver Positive Positive CHOLANGIOCARCINOMA 0/95 29/93 53/94 41/67 ADENOMA 1/95 1/93 5/94 8/67 CARCINOMA 1/95 1/93 2/94 5/67 ADENOMA OR CARCINOMA 2/95 2/93 7/94 13/67 HEPATOCHOLANGIOCARCINOMA 0/95 0/93 4/94 7/67 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Rats F344/N Female Dosed-Feed Liver Clear Evidence Equivocal Evidence ADENOMA 1/50 0/49 2/50 4/50 May Have Been Related
Yes TR-516 693-98-1 2-Methylimidazole Rats F344/N Male Dosed-Feed Liver Some Evidence Equivocal Evidence ADENOMA OR CARCINOMA 0/50 1/50 3/50 3/50 May Have Been Related
Yes TR-466 100-41-4 Ethylbenzene Mice B6C3F1 Female Inhalation Liver Some Evidence Some Evidence ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50 Neoplastic Lesions
Yes TR-470 110-86-1 Pyridine Mice B6C3F1 Female Dosed-Water Liver Clear Evidence Clear Evidence ADENOMA 37/49 39/50 43/50 34/50, CARCINOMA 13/49 23/50 33/50 41/50, HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50 Neoplastic Lesions
Yes TR-470 110-86-1 Pyridine Mice B6C3F1 Male Dosed-Water Liver Clear Evidence Clear Evidence ADENOMA 29/50 40/50 34/49 39/50, CARCINOMA 15/50 35/50 41/49 40/50, HEPATOBLASTOMA 2/50 18/50 22/49 15/50; COMBINED 38/50, 47/50, 46/49, 47/50 Neoplastic Lesions
Yes TR-480 120-40-1 Lauric acid diethanolamine condensate Mice B6C3F1 Female Topical Application Liver Some Evidence Some Evidence ADENOMA 23/50 32/49 29/50 ADENOMA OR CARCINOMA COMBINED 28/50 40/49 36/50 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Liver Clear Evidence Clear Evidence HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44 Neoplastic Lesions
Yes TR-439 298-59-9 Methylphenidate hydrochloride Mice B6C3F1 Female Dosed-Feed Liver Some Evidence Some Evidence HEPATOCELLULAR ADENOMA 6/49 10/48 10/49 28/50 CARCINOMA 5/49 3/48 2/49 6/50 COMBINED 9/49 11/48 11/49 30/50 Neoplastic Lesions
Yes TR-439 298-59-9 Methylphenidate hydrochloride Mice B6C3F1 Male Dosed-Feed Liver Some Evidence Some Evidence HEPATOCELLULAR ADENOMA 18/50 18/50 16/50 29/50 CARCINOMA 10/50 9/50 17/50 11/50 COMBINED 24/50 23/50 26/50 34/50; HEPATOBLASTOMA 0/50 1/50 1/50 5/50 Neoplastic Lesions
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 0/53 0/54 0/53 0/53 1/53 13/53 2/50 OR CHOLANGIOCARCINOMA 0/53 0/54 0/53 1/53 4/53 25/53 2/50 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Medaka (Oryzias latipes) Female Aquatic Liver Positive Positive CHOLANGIOCARCINOMA 1/57 15/44 31/49 21/31 ADENOMA 4/57 2/44 2/49 1/31 CARCINOMA 0/57 2/44 1/49 4/31 ADENOMA OR CARCINOMA 4/57 4/44 2/49 5/31 HEPATOCHOLANGIOCARCINOMA 0/57 0/44 0/49 1/31 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Medaka (Oryzias latipes) Male Aquatic Liver Positive Positive CHOLANGIOMA 0/42 0/47 3/33 1/46 CHOLANGIOCARCINOMA 0/42 19/47 16/33 26/46 ADENOMA 0/42 1/47 0/33 0/46 ADENOMA OR CARCINOMA 0/42 2/47 0/33 1/46 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Medaka (Oryzias latipes) Male Aquatic Liver Positive Positive CHOLANGIOMA 0/95 6/94 2/65 1/78 CHOLANGIOCARCINOMA 0/95 32/94 43/65 45/78 ADENOMA OR CARCINOMA 0/95 2/94 1/65 6/78 HEPATOCHOLANGIOCARCINOMA 0/95 0/94 2/65 6/78 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Guppy (Poecilia reticulata) Female Aquatic Liver Positive Positive CHOLANGIOMA 0/64 3/64 4/47 2/33 CHOLANGIOCARCINOMA 0/64 0/64 0/47 6/33 ADENOMA OR CARCINOMA 5/64 4/64 4/47 8/33 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Guppy (Poecilia reticulata) Female Aquatic Liver Positive Positive CHOLANGIOMA 2/31 2/31 0/31 2/27 CHOLANGIOCARCINOMA 0/31 0/31 0/31 5/27 ADENOMA OR CARCINOMA 2/31 1/31 2/31 3/27 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Guppy (Poecilia reticulata) Male Aquatic Liver Positive Positive CHOLANGIOCARCINOMA 0/32 0/19 0/26 1/19 ADENOMA 3/32 4/19 5/26 7/19 CARCINOMA 0/32 0/19 1/26 4/19 ADENOMA OR CARCINOMA COMBINED 3/32 4/19 5/26 10/19 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 2/50 21/50 23/50 Neoplastic Lesions
Yes TR-443 604-75-1 Oxazepam Mice B6C3F1 Female Dosed-Feed Liver Clear Evidence Clear Evidence (SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50 Neoplastic Lesions
Yes TR-457 599-79-1 Salicylazosulfapyridine Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49 Neoplastic Lesions
Yes TR-457 599-79-1 Salicylazosulfapyridine Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50 Neoplastic Lesions
Yes TR-484 111-76-2 2-Butoxyethanol (ethylene glycol monobutyl ether) Mice B6C3F1 Male Inhalation Liver Some Evidence Equivocal Evidence HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49 May Have Been Related
Yes TR-443 604-75-1 Oxazepam Mice B6C3F1 Male Dosed-Feed Liver Clear Evidence Clear Evidence (SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50 Neoplastic Lesions
Yes TR-443 604-75-1 Oxazepam Mice Swiss Webster Female Dosed-Feed Liver Clear Evidence Clear Evidence (SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50 Neoplastic Lesions
Yes TR-443 604-75-1 Oxazepam Mice Swiss Webster Male Dosed-Feed Liver Clear Evidence Clear Evidence (SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50 Neoplastic Lesions
Yes TR-475 109-99-9 Tetrahydrofuran Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence ADENOMA 12/50 17/50 18/50 31/48 OR CARCINOMA 6/50 10/50 10/50 16/48 COMBINED 17/50 24/50 26/50 41/48 Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50 Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50 Neoplastic Lesions
Yes TR-485 434-07-1 Oxymetholone Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 1/50 1/50 1/50 8/49 COMBINED 1/50 1/50 1/50 10/49 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Liver Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Liver Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48 Neoplastic Lesions
Yes TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Guppy (Poecilia reticulata) Male Aquatic Liver Positive Positive ADENOMA 3/61 4/50 4/41 8/38 ADENOMA OR CARCINOMA 4/61 6/50 6/41 10/38 Neoplastic Lesions
Yes TR-530 TEFBINARYMIX Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51 Neoplastic Lesions
Yes TR-503 302-17-0 Chloral hydrate Mice MV Male Gavage Liver Some Evidence Some Evidence ADEMONA OR CARCINOMA 16/48 25/48 23/47 22/48 (AD LIBITUM-FED GROUPS) Neoplastic Lesions
Yes TR-503 302-17-0 Chloral hydrate Mice MV Male Gavage Liver Some Evidence Some Evidence CARCINOMA 2/48 5/58 4/48 8/48 (DIETARY-CONTROLLED GROUPS) Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50 Neoplastic Lesions
Yes TR-525 57117-31-4 Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) Rats Harlan Sprague-Dawley Female Gavage Liver Some Evidence Some Evidence ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50 Neoplastic Lesions
Yes TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Guppy (Poecilia reticulata) Male Aquatic Liver Positive Positive CHOLANGIOCARCINOMA 0/61 0/47 0/67 3/27 ADENOMA 3/61 8/47 17/67 9/27 CARCINOMA 0/61 1/47 0/67 7/27 ADENOMA OR CARCINOMA COMBINED 3/61 9/47 17/67 15/27 Neoplastic Lesions
Yes TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Medaka (Oryzias latipes) Male Aquatic Liver Positive Positive ADENOMA 1/27 0/21 1/31 3/29 ADENOMA OR CARCINOMA 1/27 0/21 1/31 4/29 Neoplastic Lesions
Yes TR-595 CELLPRADCDMA Cell Phone Radiation: CDMA Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Liver Clear Evidence Equivocal Evidence hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88) May Have Been Related
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence Cholangiocarcinoma 1/50 1/50 1/49 3/49 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Male Gavage Liver Clear Evidence Clear Evidence Cholangiocarcinoma 0/50 4/50 4/50 6/50 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice B6C3F1/N Female Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma 17/50, 19/50, 37/50, 44/50; hepatocellular carcinoma 6/50, 13/50, 18/50, 31/50; hepatoblastoma 0/50, 1/50, 0/50, 4/50 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma, multiple 17/50, 19/50, 27/50, 26/50; hepatocellular carcinoma 22/50, 25/50, 30/50, 36/50; hepatoblastoma 1/50, 5/50, 10/50, 8/50 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence hepatocellular carcinoma 0/50, 0/50, 0/50, 4/49; hepatocellular adenoma or carcinoma 0/50, 1/50, 1/50, 7/49 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence hepatocellular carcinoma 0/50, 0/50, 1/50, 6/50; hepatocellular adenoma or carcinoma 0/50, 0/50, 2/50, 6/50 Neoplastic Lesions
Yes TR-559 31508-00-6 Toxic equivalency factor evaluation (PCB 118) Rats Harlan Sprague-Dawley Female Gavage Liver Clear Evidence Clear Evidence Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49 Neoplastic Lesions
Yes TR-580 108-99-6 beta-Picoline Mice B6C3F1/N Female Dosed-Water Liver Clear Evidence Clear Evidence hepatocellular carcinoma 11/49 20/50 26/50 23/50 hepatoblastoma 1/49 3/50 4/50 4/50 Neoplastic Lesions
Yes TR-560 63-05-8 Androstenedione Mice B6C3F1/N Female Gavage Liver Clear Evidence Clear Evidence Adenoma 14/50 16/50 18/50 28/50 carcinoma 5/50 13/50 15/50 15/50 adenoma or carcinoma 17/50 23/50 27/50 32/50 Neoplastic Lesions
Yes TR-560 63-05-8 Androstenedione Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence Hepatocellular adenoma, multiple 16/50 27/50 23/50 34/50 hepatocellular adenoma (includes multiples) 32/50 38/50 29/50 43/50 hepatocellular carcinoma multiple 7/50 12/50 10/50 17/50 hepatocellular adenoma or hepatocellular carcinoma (combined includes multiples) 41/50 47/50 42/50 48/50 hepatoblastoma 3/50 8/50 7/50 8/50 hepatocellular adenoma, carcinoma, or hepatoblastoma (combined) 41/50 47/50 43/50 48/50 Neoplastic Lesions
Yes TR-576 15625-89-5 Trimethylolpropane triacrylate Mice B6C3F1 Female Topical Application Liver Some Evidence Some Evidence hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50 Neoplastic Lesions
Yes TR-561 119-64-2 Tetralin Rats F344/N Female Inhalation Liver Some Evidence Some Evidence Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-589 32534-81-9 Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma 5/50 7/49 32/50 46/49 hepatocellular carcinoma 4/50 2/49 6/50 27/49 hepatocellular adenoma or carcinoma 8/50 8/49 33/50 47/49 Neoplastic Lesions
Yes TR-589 32534-81-9 Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma 23/50 35/50 49/50 40/50 hepatocellular carcinoma 18/50 15/50 30/50 45/50 hepatocellular adenoma or carcinoma 31/50 40/50 49/50 47/50 hepatoblastoma 1/50 1/50 16/50 5/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 31/50 40/50 49/50 47/50 Neoplastic Lesions
Yes TR-589 32534-81-9 Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] Rats Wistar Han Female Gavage Liver Clear Evidence Clear Evidence cholangiocarcinoma 0/50 0/49 0/50 2/47 hepatocholangioma 0/50 0/49 0/50 8/47 hepatocellular adenoma 3/50 2/49 8/50 16/47 hepatocellular carcinoma 0/50 0/49 1/50 6/47 hepatocellular adenoma or carcinoma 3/50 2/49 8/50 17/47) hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/50 2/49 8/50 21/47 Neoplastic Lesions
Yes TR-562 GOLDENSEALRT Goldenseal root powder Mice B6C3F1/N Male Dosed-Feed Liver Some Evidence Some Evidence Hepatoblastoma 1/50 2/50 1/5 6/50 multiple adenoma 3/50 5/50 11/50 18/50 Neoplastic Lesions
Yes TR-562 GOLDENSEALRT Goldenseal root powder Rats F344/N Female Dosed-Feed Liver Clear Evidence Clear Evidence Adenoma: 0/50 0/50 1/50 8/50 Neoplastic Lesions
Yes TR-589 32534-81-9 Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] Rats Wistar Han Male Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma or carcinoma 3/49 2/50 4/50 9/50; hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/49 2/50 4/50 11/50 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Mice B6C3F1/N Female Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma 17/50, 37/50, 41/50, 48/50; hepatocellular carcinoma 9/50, 10/50, 15/50, 44/50; hepatoblastoma 1/50, 1/50, 8/50, 11/50 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence hepatocellular carcinoma 22/50, 31/50, 41/50, 47/50; hepatoblastoma 3/50, 28/50, 36/50, 38/50 Neoplastic Lesions
Yes TR-562 GOLDENSEALRT Goldenseal root powder Rats F344/N Male Dosed-Feed Liver Clear Evidence Clear Evidence Adenoma: 1/50 1/50 2/50 10/50 adenoma or carcinoma 1/50 1/50 2/50 11/50 Neoplastic Lesions
Yes TR-563 89-82-7 Pulegone Mice B6C3F1/N Female Gavage Liver Clear Evidence Clear Evidence Hepatocellular: Adenoma 13/49 15/50 13/50 27/50 adenoma, carcinoma or hepatoblastoma 17/49 15/50 15/50 33/50 Neoplastic Lesions
Yes TR-563 89-82-7 Pulegone Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence Hepatocellular: Adenoma 22/50 31/50 35/50 28/50 adenoma, carcinoma, or hepatoblastoma 29/50 37/50 42/50 36/50 Neoplastic Lesions
Yes TR-582 75-35-4 Vinylidene Chloride Mice B6C3F1/N Female Inhalation Liver Clear Evidence Clear Evidence hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Rats F344/N Male Gavage Liver Some Evidence Equivocal Evidence hepatocellular adenoma 0/50, 3/50, 3/50, 0/50 May Have Been Related
Yes TR-582 75-35-4 Vinylidene Chloride Mice B6C3F1/N Male Inhalation Liver Clear Evidence Equivocal Evidence hepatocholangiocarcionoma 1/50 2/50 2/50 3/50 May Have Been Related
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Mice B6C3F1/N Female Dosed-Water Liver Clear Evidence Clear Evidence hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50 Neoplastic Lesions
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Mice B6C3F1/N Male Dosed-Water Liver Clear Evidence Equivocal Evidence Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50 May Have Been Related
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Mice B6C3F1/N Male Dosed-Water Liver Clear Evidence Clear Evidence hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51 Neoplastic Lesions
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice B6C3F1 Female Inhalation Liver Clear Evidence Clear Evidence hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50) Neoplastic Lesions
Yes TR-554 67-47-0 5-(Hydroxymethyl)-2-furfural Mice B6C3F1/N Female Gavage Liver Some Evidence Some Evidence Adenoma 14/50 26/49 26/50 6/50 Neoplastic Lesions
Yes TR-557 123-35-3 beta-Myrcene Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence Adenoma 26/50 41/50 43/50 carcinoma 14/50 20/50 28/50 adenoma or carcinoma 33/50 44/50 48/50 hepatoblastoma 4/50 6/50 11/50 adenoma, carcinoma, or hepatoblastoma 34/50 45/50 48/50 Neoplastic Lesions
Yes TR-328 598-55-0 Methyl carbamate Rats F344/N Female Gavage Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-328 598-55-0 Methyl carbamate Rats F344/N Male Gavage Liver Clear Evidence Clear Evidence NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49 Neoplastic Lesions
Yes TR-584 700-06-1 Indole-3-carbinol Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence hepatocellular adenoma 26/50 32/50 31/49 41/50 hepatocellular carcinoma 12/50 11/50 29/49 14/50 hepatoblastoma 3/50 4/50 4/49 14/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/50 36/50 44/49 45/50 Neoplastic Lesions
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice B6C3F1 Male Inhalation Liver Clear Evidence Clear Evidence hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50) Neoplastic Lesions
Yes TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Mice B6C3F1 Female Gavage Liver Clear Evidence Clear Evidence ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50 Neoplastic Lesions
Yes TR-571 9000-38-8 Kava kava extract Mice B6C3F1/N Female Gavage Liver Clear Evidence Clear Evidence Hepatocellular carcinoma 3/50 13/50 8/50 8/50 hepatocellular adenoma or carcinoma 10/50 21/50 20/50 13/50 Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Female Dosed-Feed Liver Some Evidence Equivocal Evidence Perinatal + Postweaning: hepatocellular carcinoma (1/50, 0/50, 4/50) May Have Been Related
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Female Dosed-Feed Liver Some Evidence Equivocal Evidence Postweaning: hepatocellular carcinoma (1/50, 1/50, 3/49) May Have Been Related
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Mice B6C3F1/N Female Dosed-Water Liver Clear Evidence Clear Evidence Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50 Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Mice B6C3F1/N Male Dosed-Water Liver Clear Evidence Clear Evidence Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50 Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Female Dosed-Water Liver Clear Evidence Equivocal Evidence Adenoma 0/50 0/50 0/50 3/50 May Have Been Related
Yes TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Mice B6C3F1 Male Gavage Liver Clear Evidence Clear Evidence ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50 Neoplastic Lesions
Yes TR-551 97-54-1 Isoeugenol Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence Adenoma 24/50 35/50 37/50 33/50 carcinoma 8/50 18/50 19/50 18/50 adenoma or carcinoma 28/50 43/50 43/50 43/50 Neoplastic Lesions
Yes TR-587 79-94-7 Tetrabromobisphenol A Mice B6C3F1/N Male Gavage Liver Some Evidence Some Evidence hepatoblastoma 2/50 11/50 8/50 Neoplastic Lesions
Yes TR-571 9000-38-8 Kava kava extract Mice B6C3F1/N Male Gavage Liver Clear Evidence Clear Evidence Hepatoblastoma 0/50 4/50 9/50 12/50 Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Male Dosed-Feed Liver Clear Evidence Clear Evidence Perinatal + Postweaning: hepatocellular adenoma (0/50, 1/50, 5/50, 10/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 4/50); hepatocellular adenoma or carcinoma (0/50, 1/50, 5/50, 12/50) Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Male Dosed-Feed Liver Clear Evidence Clear Evidence Postweaning: hepatocellular adenoma (0/50, 0/50, 7/50, 11/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50); hepatocellular adenoma or carcinoma (0/50, 0/50, 7/50,11/50) Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Male Dosed-Water Liver Clear Evidence Equivocal Evidence Adenoma 2/50 0/50 3/50 4/50 May Have Been Related
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Liver Clear Evidence Clear Evidence adenoma 0/48 0/48 1/48 1/48 3/48 Neoplastic Lesions