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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:
- Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
- Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
- Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
| Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TR-008 | 57-74-9 | Chlordane (analytical grade) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-008 | 57-74-9 | Chlordane (analytical grade) | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-009 | 76-44-8 | Heptachlor | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-009 | 76-44-8 | Heptachlor | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-013 | 127-18-4 | Tetrachloroethylene | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-013 | 127-18-4 | Tetrachloroethylene | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-000 (143-50-0) | 143-50-0 | Chlordecone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA; HYPERPLASIA | Neoplastic Lesions | |
| TR-000 (143-50-0) | 143-50-0 | Chlordecone | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA; HYPERPLASIA | Neoplastic Lesions | |
| TR-000 (143-50-0) | 143-50-0 | Chlordecone | Rats | Osborne Mendel | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA; HYPERPLASIA | Neoplastic Lesions | |
| TR-000 (143-50-0) | 143-50-0 | Chlordecone | Rats | Osborne Mendel | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA; HYPERPLASIA | Neoplastic Lesions | |
| TR-000 (67-66-3) | 67-66-3 | Chloroform | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-000 (67-66-3) | 67-66-3 | Chloroform | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-002 | 79-01-6 | Trichloroethylene | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-002 | 79-01-6 | Trichloroethylene | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-021 | 309-00-2 | Aldrin | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-025 | 133-90-4 | Chloramben | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-026 | 1836-75-5 | Nitrofen | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | HEPATOCELLULAR CARCINOMA | Neoplastic Lesions | |
| TR-026 | 1836-75-5 | Nitrofen | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | HEPATOCELLULAR CARCINOMA | Neoplastic Lesions | |
| TR-027 | 79-34-5 | 1,1,2,2-Tetrachloroethane | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-027 | 79-34-5 | 1,1,2,2-Tetrachloroethane | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-029 | 129-15-7 | 2-Methyl-1-nitroanthraquinone | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE OR CARCINOMA) | Neoplastic Lesions | |
| TR-029 | 129-15-7 | 2-Methyl-1-nitroanthraquinone | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-033 | 961-11-5 | Tetrachlorvinphos | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE) | Neoplastic Lesions | |
| TR-033 | 961-11-5 | Tetrachlorvinphos | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-034 | 1582-09-8 | Trifluralin | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-037 | 8001-35-2 | Toxaphene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-037 | 8001-35-2 | Toxaphene | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-039 | 303-34-4 | Lasiocarpine | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | Angiosarcoma, carcinoma, adenoma | Neoplastic Lesions | |
| TR-039 | 303-34-4 | Lasiocarpine | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | Angiosarcoma, carcinoma, adenoma | Neoplastic Lesions | |
| TR-047 | 139-65-1 | 4,4'-Thiodianiline | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-047 | 139-65-1 | 4,4'-Thiodianiline | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-047 | 139-65-1 | 4,4'-Thiodianiline | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-063 | 95-83-0 | 4-Chloro-o-phenylenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-063 | 95-83-0 | 4-Chloro-o-phenylenediamine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-068 | 67-72-1 | Hexachloroethane | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-068 | 67-72-1 | Hexachloroethane | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-074 | 79-00-5 | 1,1,2-Trichloroethane | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-074 | 79-00-5 | 1,1,2-Trichloroethane | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-075 | 510-15-6 | Chlorobenzilate | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-075 | 510-15-6 | Chlorobenzilate | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-076 | 126-72-7 | tris(2,3-Dibromopropyl) phosphate | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-086 | 106-93-4 | 1,2-Dibromoethane | Rats | Osborne Mendel | Female | Gavage | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-090 | 115-32-2 | Dicofol | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-092 | 122-66-7 | Hydrazobenzene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-092 | 122-66-7 | Hydrazobenzene | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE) | Neoplastic Lesions | |
| TR-092 | 122-66-7 | Hydrazobenzene | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-080 | 123-91-1 | 1,4-Dioxane | Mice | B6C3F1 | Female | Dosed-Water | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-080 | 123-91-1 | 1,4-Dioxane | Mice | B6C3F1 | Male | Dosed-Water | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-080 | 123-91-1 | 1,4-Dioxane | Rats | Osborne Mendel | Female | Dosed-Water | Liver | Positive | Positive | (ADENOMA) | Neoplastic Lesions | |
| TR-085 | 5131-60-2 | 4-Chloro-m-phenylenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-099 | 136-40-3 | Phenazopyridine hydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-100 | 135-20-6 | Cupferron | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-100 | 135-20-6 | Cupferron | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-100 | 135-20-6 | Cupferron | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-107 | 99-55-8 | 5-Nitro-o-toluidine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-107 | 99-55-8 | 5-Nitro-o-toluidine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-111 | 82-28-0 | 1-Amino-2-methylanthraquinone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE OR CARCINOMA) | Neoplastic Lesions | |
| TR-111 | 82-28-0 | 1-Amino-2-methylanthraquinone | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-111 | 82-28-0 | 1-Amino-2-methylanthraquinone | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-117 | 94-52-0 | 6-Nitrobenzimidazole | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-117 | 94-52-0 | 6-Nitrobenzimidazole | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-118 | 602-87-9 | 5-Nitroacenaphthene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-133 | 1777-84-0 | 3-Nitro-p-acetophenetide | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-142 | 120-71-8 | p-Cresidine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-142 | 120-71-8 | p-Cresidine | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE OR CARCINOMA) | Neoplastic Lesions | |
| TR-124 | 120-62-7 | Piperonyl sulfoxide | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-144 | 117-79-3 | 2-Aminoanthraquinone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-144 | 117-79-3 | 2-Aminoanthraquinone | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-144 | 117-79-3 | 2-Aminoanthraquinone | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE OR CARCINOMA) | Neoplastic Lesions | |
| TR-146 | 139-94-6 | Nithiazide | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-131 | 72-55-9 | p,p'-Dichlorodiphenyl dichloroethylene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-131 | 72-55-9 | p,p'-Dichlorodiphenyl dichloroethylene | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-153 | 636-21-5 | o-Toluidine hydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-155 | 88-06-2 | 2,4,6-Trichlorophenol | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-155 | 88-06-2 | 2,4,6-Trichlorophenol | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-160 | 137-17-7 | 2,4,5-Trimethylaniline | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-160 | 137-17-7 | 2,4,5-Trimethylaniline | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-160 | 137-17-7 | 2,4,5-Trimethylaniline | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-181 | 90-94-8 | Michler's ketone | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-181 | 90-94-8 | Michler's ketone | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-184 | 1836-75-5 | Nitrofen | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-184 | 1836-75-5 | Nitrofen | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-186 | 101-61-1 | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-187 | 95-79-4 | 5-Chloro-o-toluidine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-187 | 95-79-4 | 5-Chloro-o-toluidine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA | Neoplastic Lesions | |
| TR-190 | 156-10-5 | p-Nitrosodiphenylamine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-190 | 156-10-5 | p-Nitrosodiphenylamine | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE OR CARCINOMA) | Neoplastic Lesions | |
| TR-194 | 7446-34-6 | Selenium sulfide | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-162 | 95-80-7 | 2,4-Diaminotoluene (2,4-toluene diamine) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-162 | 95-80-7 | 2,4-Diaminotoluene (2,4-toluene diamine) | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-162 | 95-80-7 | 2,4-Diaminotoluene (2,4-toluene diamine) | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-169 | 5307-14-2 | 2-Nitro-p-phenylenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA) | Neoplastic Lesions | |
| TR-194 | 7446-34-6 | Selenium sulfide | Rats | F344/N | Female | Gavage | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-194 | 7446-34-6 | Selenium sulfide | Rats | F344/N | Male | Gavage | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-196 | 87-29-6 | Cinnamyl anthranilate | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-196 | 87-29-6 | Cinnamyl anthranilate | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-198 | 57653-85-7 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-198 | 57653-85-7 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions | |
| TR-198 | 57653-85-7 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin | Rats | Osborne Mendel | Female | Gavage | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-181 | 90-94-8 | Michler's ketone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-205 | 101-80-4 | 4,4'-Oxydianiline | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions | |
| TR-205 | 101-80-4 | 4,4'-Oxydianiline | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions | |
| TR-205 | 101-80-4 | 4,4'-Oxydianiline | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-205 | 101-80-4 | 4,4'-Oxydianiline | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE, CARCINOMA) | Neoplastic Lesions | |
| TR-209 | 1746-01-6 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | CARCINOMA 1/73 2/50 2/48 6/47 | Neoplastic Lesions | |
| TR-209 | 1746-01-6 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA 8/73 9/49 8/49 17/50 | Neoplastic Lesions | |
| TR-209 | 1746-01-6 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | Rats | Osborne Mendel | Female | Gavage | Liver | Positive | Positive | NEOPLASTIC NODULE 5/75 1/49 3/50 12/49 | Neoplastic Lesions | |
| TR-217 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA 0/50 2/49 8/50 | Neoplastic Lesions | |
| TR-217 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49 | Neoplastic Lesions | |
| TR-219 | 609-20-1 | 2,6-Dichloro-p-phenylenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | ADENOMA 4/50 4/50 9/50 OR CARCINOMA 2/50 2/50 7/50 | Neoplastic Lesions | |
| TR-219 | 609-20-1 | 2,6-Dichloro-p-phenylenediamine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | ADENOMA 4/50 7/50 15/50 | Neoplastic Lesions | |
| TR-225 | 5160-02-1 | D&C Red No. 9 | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 0/50 6/50 7/49 | Neoplastic Lesions | |
| TR-226 | 842-07-9 | C.I. Solvent Yellow 14 | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 2/50 3/49 10/48 | Neoplastic Lesions | |
| TR-226 | 842-07-9 | C.I. Solvent Yellow 14 | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 5/50 10/50 30/50 | Neoplastic Lesions | |
| TR-232 | 76-01-7 | Pentachloroethane | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45 | Neoplastic Lesions | |
| TR-232 | 76-01-7 | Pentachloroethane | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA 4/48 26/44 7/45 | Neoplastic Lesions | |
| TR-212 | 103-23-1 | Di(2-ethylhexyl)adipate | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA 1/50 14/50 12/49 | Neoplastic Lesions | |
| TR-212 | 103-23-1 | Di(2-ethylhexyl)adipate | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | ADENOMA 6/50 8/49 15/49 | Neoplastic Lesions | |
| TR-216 | 2432-99-7 | 11-Aminoundecanoic acid | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 1/50 9/50 8/50 | Neoplastic Lesions | |
| TR-217 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | CARCINOMA 0/50 7/50 17/50 | Neoplastic Lesions | |
| TR-217 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | CARCINOMA 9/50 14/48 19/50 | Neoplastic Lesions | |
| TR-250 | 140-11-4 | Benzyl acetate | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 0/50 5/49 13/50 | Neoplastic Lesions | |
| TR-235 | 17924-92-4 | Zearalenone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | ADENOMA 0/50 2/49 7/49 | Neoplastic Lesions | |
| TR-237 | 630-20-6 | 1,1,1,2-Tetrachloroethane | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | ADENOMA 4/49 8/46 24/48 OR CARCINOMA 1/49 5/46 6/48 COMBINED 5/49 13/46 30/48 | Neoplastic Lesions | |
| TR-237 | 630-20-6 | 1,1,1,2-Tetrachloroethane | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | ADENOMA 6/48 14/46 21/50 | Neoplastic Lesions | |
| TR-222 | 2832-40-8 | C.I. Disperse Yellow 3 | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | ADENOMA 0/50 6/50 12/50 | Neoplastic Lesions | |
| TR-222 | 2832-40-8 | C.I. Disperse Yellow 3 | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 1/49 15/50 10/50 | Neoplastic Lesions | |
| TR-243 | 79-01-6 | Trichloroethylene | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | ADENOMA 2/48 8/49; CARCINOMA 2/48 13/49 | Neoplastic Lesions | |
| TR-243 | 79-01-6 | Trichloroethylene | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA 8/48 30/50 | Neoplastic Lesions | |
| TR-244 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8 | Neoplastic Lesions | |
| TR-244 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22 | Neoplastic Lesions | |
| TR-244 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Rats | F344/N | Female | Gavage | Liver | Positive | Positive | NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20 | Neoplastic Lesions | |
| TR-244 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Rats | F344/N | Male | Gavage | Liver | Positive | Positive | NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31 | Neoplastic Lesions | |
| TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Female | Dosed-Water | Liver | Positive | Positive | ADENOMA 3/50 9/50 12/50 | Neoplastic Lesions | |
| TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Male | Dosed-Water | Liver | Positive | Positive | CARCINOMA 10/49 33/50 29/50 | Neoplastic Lesions | |
| TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Positive | Positive | NEOPLASTIC NODULE 1/50 12/50 25/50 | Neoplastic Lesions | |
| TR-250 | 140-11-4 | Benzyl acetate | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 0/50 0/50 6/50 | Neoplastic Lesions | |
| TR-263 | 78-87-5 | 1,2-Dichloropropane (propylene dichloride) | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 1/50 5/50 5/50 | Neoplastic Lesions | |
| TR-263 | 78-87-5 | 1,2-Dichloropropane (propylene dichloride) | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 7/50 10/50 17/50 | Neoplastic Lesions | |
| TR-239 | 108-60-1 | bis(2-Chloro-1-methylethyl) ether | Mice | B6C3F1 | Male | Gavage | Liver | Positive | Positive | CARCINOMA 5/50 13/50 17/50 | Neoplastic Lesions | |
| TR-269 | 542-75-6 | 1,3-Dichloropropene (Telone II) | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 1/52 6/52 7/52 | Neoplastic Lesions | |
| TR-271 | 2784-94-3 | HC Blue 1 | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 1/50 24/48 47/49 | Neoplastic Lesions | |
| TR-271 | 2784-94-3 | HC Blue 1 | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 11/50 20/50 30/50 | Neoplastic Lesions | |
| TR-274 | 78-42-2 | tris(2-Ethylhexyl)phosphate | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | CARCINOMA 0/48 4/50 7/50 | Neoplastic Lesions | |
| TR-278 | 87-62-7 | 2,6-Xylidine | Rats | CD | Female | Dosed-Feed | Liver | Positive | Equivocal Evidence | NEOPLASTIC NODULE 0/56 1/56 2/56 4/56 | May Have Been Related | |
| TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | ADENOMA 2/50 3/50 12/50 | Neoplastic Lesions | |
| TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Liver | Positive | Positive | NEOPLASTIC NODULE 3/50 8/50 8/48 | Neoplastic Lesions | |
| TR-282 | 124-48-1 | Chlorodibromomethane | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 2/50 4/49 11/50 OR CARCINOMA 4/50 6/49 8/50 COMBINED 6/50 10/49 19/50 | Neoplastic Lesions | |
| TR-266 | 150-68-5 | Monuron | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50 | Neoplastic Lesions | |
| TR-288 | 106-99-0 | 1,3-Butadiene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49 | Neoplastic Lesions | |
| TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 3/49 19/50 37/49 | Neoplastic Lesions | |
| TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 10/50 20/50 27/50 | Neoplastic Lesions | |
| TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 0/50 2/50 8/50 | Neoplastic Lesions | |
| TR-306 | 75-09-2 | Methylene chloride | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 2/50 6/48 22/48 OR CARCINOMA 1/50 11/48 32/48 COMBINED 3/50 16/48 40/48 | Neoplastic Lesions | |
| TR-306 | 75-09-2 | Methylene chloride | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 10/50 14/49 14/49 OR CARCINOMA 13/50 15/49 26/49 COMBINED 22/50 24/49 33/49 | Neoplastic Lesions | |
| TR-308 | 108171-26-2 | Chlorinated paraffins: C12, 60% chlorine | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50 | Neoplastic Lesions | |
| TR-308 | 108171-26-2 | Chlorinated paraffins: C12, 60% chlorine | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50 | Neoplastic Lesions | |
| TR-308 | 108171-26-2 | Chlorinated paraffins: C12, 60% chlorine | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50 | Neoplastic Lesions | |
| TR-308 | 108171-26-2 | Chlorinated paraffins: C12, 60% chlorine | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48 | Neoplastic Lesions | |
| TR-309 | 1163-19-5 | Decabromodiphenyl Oxide | Rats | F344/N | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | NEOPLASTIC NODULE 1/50 3/49 9/50 | Neoplastic Lesions | |
| TR-309 | 1163-19-5 | Decabromodiphenyl Oxide | Rats | F344/N | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | NEOPLASTIC NODULE 1/50 7/50 15/49 | Neoplastic Lesions | |
| TR-423 | 119-84-6 | 3,4-Dihydrocoumarin | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52 | Neoplastic Lesions | |
| TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50 | Neoplastic Lesions | |
| TR-416 | 91-23-6 | o-Nitroanisole | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 14/50 2/50 36/50 18/50 | Neoplastic Lesions | |
| TR-416 | 91-23-6 | o-Nitroanisole | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50 | Neoplastic Lesions | |
| TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50 | Neoplastic Lesions | |
| TR-434 | 106-99-0 | 1,3-Butadiene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80 | Neoplastic Lesions | |
| TR-434 | 106-99-0 | 1,3-Butadiene | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50 | Neoplastic Lesions | |
| TR-388 | 96-45-7 | Ethylene thiourea (ETU) | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50 | Neoplastic Lesions | |
| TR-367 | 50-33-9 | Phenylbutazone | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50 | Neoplastic Lesions | |
| TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50 | Neoplastic Lesions | |
| TR-311 | 127-18-4 | Tetrachloroethylene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | CARCINOMA 1/48 13/50 36/50 | Neoplastic Lesions | |
| TR-311 | 127-18-4 | Tetrachloroethylene | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50 | Neoplastic Lesions | |
| TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50 | Neoplastic Lesions | |
| TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50 | Neoplastic Lesions | |
| TR-395 | 57-66-9 | Probenecid | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 3/48 2/49 14/49, CARCINOMA 2/48 2/49 3/49, COMBINED 5/48 3/49 16/49 | Neoplastic Lesions | |
| TR-420 | 396-01-0 | Triamterene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | (FIRST STUDY) ADENOMA 10/50 22/50 23/50 36/60 OR CARCINOMA 4/50 4/50 3/50 8/60 COMBINED 13/50 26/50 25/50 37/60; (SECOND STUDY) ADENOMA 7/50 28/51 OR CARCINOMA 5/50 11/51 COMBINED 10/50 31/51 | Neoplastic Lesions | |
| TR-420 | 396-01-0 | Triamterene | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | (FIRST STUDY) ADENOMA 17/50 22/50 19/50 20/60 OR CARCINOMA 5/50 7/50 3/50 13/60 COMBINED 20/50 26/50 19/50 29/60; (SECOND STUDY) ADENOMA 21/50 36/50 OR CARCINOMA 9/50 11/50 COMBINED 25/50 38/50 | Neoplastic Lesions | |
| TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50 | Neoplastic Lesions | |
| TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50 | Neoplastic Lesions | |
| TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60 | Neoplastic Lesions | |
| TR-352 | 924-42-5 | N-Methylolacrylamide | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 3/50 4/50 17/49 | Neoplastic Lesions | |
| TR-384 | 96-18-4 | 1,2,3-Trichloropropane | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55 | Neoplastic Lesions | |
| TR-370 | 271-89-6 | Benzofuran | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47 | Neoplastic Lesions | |
| TR-370 | 271-89-6 | Benzofuran | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48 | Neoplastic Lesions | |
| TR-352 | 924-42-5 | N-Methylolacrylamide | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50 | Neoplastic Lesions | |
| TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 0/50 0/50 1/50 10/50 | Neoplastic Lesions | |
| TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50 | Neoplastic Lesions | |
| TR-430 | 28407-37-6 | C.I. Direct Blue 218 | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50 | Neoplastic Lesions | |
| TR-346 | 75-00-3 | Chloroethane | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Equivocal Evidence | ADENOMA 0/49 1/48 OR CARCINOMA 3/49 7/48 COMBINED 3/49 8/48 | May Have Been Related | |
| TR-402 | 110-00-9 | Furan | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50 | Neoplastic Lesions | |
| TR-402 | 110-00-9 | Furan | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50 | Neoplastic Lesions | |
| TR-384 | 96-18-4 | 1,2,3-Trichloropropane | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56 | Neoplastic Lesions | |
| TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60 | Neoplastic Lesions | |
| TR-430 | 28407-37-6 | C.I. Direct Blue 218 | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49 | Neoplastic Lesions | |
| TR-382 | 98-01-1 | Furfural | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 1/50 3/50 5/50 8/50 | Neoplastic Lesions | |
| TR-382 | 98-01-1 | Furfural | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50 | Neoplastic Lesions | |
| TR-382 | 98-01-1 | Furfural | Rats | F344/N | Male | Gavage | Liver | Some Evidence | Some Evidence | CHOLANGIOCARCINOMA 0/50 0/50 2/50 | Neoplastic Lesions | |
| TR-383 | 81-49-2 | 1-Amino-2,4-dibromoanthraquinone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50 | Neoplastic Lesions | |
| TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60 | Neoplastic Lesions | |
| TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50 | Neoplastic Lesions | |
| TR-313 | 2385-85-5 | Mirex | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 2/52 23/52 30/52 | Neoplastic Lesions | |
| TR-313 | 2385-85-5 | Mirex | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 3/52 5/52 5/52 14/52 15/52 26/52 | Neoplastic Lesions | |
| TR-422 | 91-64-5 | Coumarin | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 8/50 26/49 29/51 12/50 | Neoplastic Lesions | |
| TR-402 | 110-00-9 | Furan | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50 | Neoplastic Lesions | |
| TR-402 | 110-00-9 | Furan | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50 | Neoplastic Lesions | |
| TR-404 | 57-41-0 | 5,5-Diphenylhydantoin (phenytoin) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/48 13/49 22/50, HEPATOBLASTOMA OR CARCINOMA 0/48 1/49 12/50, COMBINED 5/48 14/49 30/50 | Neoplastic Lesions | |
| TR-321 | 75-27-4 | Bromodichloromethane | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50 | Neoplastic Lesions | |
| TR-383 | 81-49-2 | 1-Amino-2,4-dibromoanthraquinone | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50 | Neoplastic Lesions | |
| TR-383 | 81-49-2 | 1-Amino-2,4-dibromoanthraquinone | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48 | Neoplastic Lesions | |
| TR-366 | 123-31-9 | Hydroquinone | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55 | Neoplastic Lesions | |
| TR-349 | 87-86-5 | Pentachlorophenol, Dowicide EC-7 | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48 | Neoplastic Lesions | |
| TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60 | Neoplastic Lesions | |
| TR-349 | 87-86-5 | Pentachlorophenol, Dowicide EC-7 | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49 | Neoplastic Lesions | |
| TR-349 | 87-86-5 | Pentachlorophenol, technical | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50 | Neoplastic Lesions | |
| TR-383 | 81-49-2 | 1-Amino-2,4-dibromoanthraquinone | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50 | Neoplastic Lesions | |
| TR-398 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 4/50 39/50 46/48; CARCINOMA 1/50 22/50 35/48 | Neoplastic Lesions | |
| TR-398 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 9/50 48/49 42/50; CARCINOMA 8/50 30/49 36/50 | Neoplastic Lesions | |
| TR-398 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 10/50 38/50 OR CARCINOMA 0/50 2/50 4/50 COMBINED 0/50 12/50 39/50 | Neoplastic Lesions | |
| TR-398 | 67774-32-7 | Polybrominated biphenyl mixture (Firemaster FF-1) | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 10/49 38/50 OR CARCINOMA 0/50 2/49 19/50 COMBINED 1/50 12/49 41/50 | Neoplastic Lesions | |
| TR-349 | 87-86-5 | Pentachlorophenol, technical | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48 | Neoplastic Lesions | |
| TR-388 | 96-45-7 | Ethylene thiourea (ETU) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50 | Neoplastic Lesions | |
| TR-528 | 3296-90-0 | Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) | Fish | Medaka (Oryzias latipes) | Male | Aquatic | Liver | Positive | Positive | ADENOMA 1/47 0/59 0/56 6/59 ADENOMA OR CARCINOMA 1/47 0/59 0/56 8/59 | Neoplastic Lesions | |
| TR-528 | 3296-90-0 | Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) | Fish | Guppy (Poecilia reticulata) | Male | Aquatic | Liver | Positive | Positive | ADENOMA 0/28 3/22 3/21 6/24 ADENOMA OR CARCINOMA 0/28 3/22 3/21 9/24 | Neoplastic Lesions | |
| TR-526 | TEFDIOXINMIX | Toxic equivalency factor evaluation (Dioxin mixture) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/53 1/53 1/53 1/53 11/51 OR CHOLANGIOCARCINOMA 0/53 0/53 2/53 7/53 9/51 | Neoplastic Lesions | |
| TR-491 | 93-15-2 | Methyleugenol | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50 | Neoplastic Lesions | |
| TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48 | Neoplastic Lesions | |
| TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48 | Neoplastic Lesions | |
| TR-476 | 125-33-7 | Primidone (primaclone) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 15/50 42/50 45/49 47/50, CARCINOMA 3/50 11/50 19/49 38/50 OR HEPATOBLASTOMA 1/50 4/50 4/49 4/50 COMBINED 16/50 42/50 46/49 50/50 | Neoplastic Lesions | |
| TR-476 | 125-33-7 | Primidone (primaclone) | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 22/50 41/50 39/50 32/50, CARCINOMA 12/50 31/50 35/50 38/50 OR HEPATOBLASTOMA 0/50 17/50 26/50 7/50 COMBINED 31/50 49/50 49/50 46/50 | Neoplastic Lesions | |
| TR-491 | 93-15-2 | Methyleugenol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50 | Neoplastic Lesions | |
| TR-515 | 57018-52-7 | Propylene glycol mono-t-butyl ether | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49 | Neoplastic Lesions | |
| TR-537 | 631-64-1 | Water disinfection byproducts (Dibromoacetic acid) | Mice | B6C3F1 | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49 | Neoplastic Lesions | |
| TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60 | Neoplastic Lesions | |
| TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Equivocal Evidence | ADENOMA 1/60 0/59 1/60 6/60 | May Have Been Related | |
| TR-537 | 631-64-1 | Water disinfection byproducts (Dibromoacetic acid) | Mice | B6C3F1 | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50 | Neoplastic Lesions | |
| TR-467 | 126-99-8 | Chloroprene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50 | Neoplastic Lesions | |
| TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60 | Neoplastic Lesions | |
| TR-541 | 75-12-7 | Formamide | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hemangiosarcoma (1/50, 5/50, 7/50, 8/50) | Neoplastic Lesions | |
| TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50) | Neoplastic Lesions | |
| TR-518 | 102-71-6 | Triethanolamine | Mice | B6C3F1/N | Female | Topical Application | Liver | Some Evidence | Some Evidence | ADENOMA 9/50 18/50 20/50 33/50 COMBINED 12/50 23/50 24/50 34/50 | Neoplastic Lesions | |
| TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47 | Neoplastic Lesions | |
| TR-494 | 84-65-1 | Anthraquinone | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 2/50 6/50 4/50 3/50 | Neoplastic Lesions | |
| TR-531 | TEFPCBMIX | Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Equivocal Evidence | HEPATOCHOLANGIOMA 0/53 0/51 0/53 1/53 1/53 1/65 1/50 CHOLANGIOMA 0/53 0/51 0/53 1/53 0/53 0/65 0/50 | May Have Been Related | |
| TR-531 | TEFPCBMIX | Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | CHOLANGIOCARCINOMA 0/53 0/51 5/53 19/53 28/53 12/65 19/50 ADENOMA 2/53 1/51 0/53 4/53 17/53 5/65 1/50 CARCINOMA 0/53 0/51 0/53 0/53 1/53 0/65 0/50 | Neoplastic Lesions | |
| TR-450 | 116-14-3 | Tetrafluoroethylene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47 | Neoplastic Lesions | |
| TR-450 | 116-14-3 | Tetrafluoroethylene | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48 | Neoplastic Lesions | |
| TR-527 | 129-73-7 | Leucomalachite green | Mice | MV | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA OR CARCINOMA 3/47 6/48 6/47 11/47 | Neoplastic Lesions | |
| TR-494 | 84-65-1 | Anthraquinone | Rats | F344/N | Male | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50 | May Have Been Related | |
| TR-515 | 57018-52-7 | Propylene glycol mono-t-butyl ether | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50 | Neoplastic Lesions | |
| TR-516 | 693-98-1 | 2-Methylimidazole | Mice | B6C3F1/N | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 3/50 4/49 6/49 10/50 | Neoplastic Lesions | |
| TR-463 | 8003-22-3 | D&C Yellow No. 11 | Rats | F344/N | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 0/50 2/51 5/50 4/51 OR CARCINOMA 0/50 0/51 0/50 1/51 COMBINED 0/50 2/51 5/50 5/51 | Neoplastic Lesions | |
| TR-463 | 8003-22-3 | D&C Yellow No. 11 | Rats | F344/N | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 1/50 2/51 1/51 7/54 | Neoplastic Lesions | |
| TR-450 | 116-14-3 | Tetrafluoroethylene | Rats | F344/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50 | Neoplastic Lesions | |
| TR-478 | 111-42-2 | Diethanolamine | Mice | B6C3F1 | Female | Topical Application | Liver | Clear Evidence | Clear Evidence | ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50 | Neoplastic Lesions | |
| TR-478 | 111-42-2 | Diethanolamine | Mice | B6C3F1 | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50 | Neoplastic Lesions | |
| TR-479 | 68603-42-9 | Coconut oil acid diethanolamine condensate | Mice | B6C3F1 | Female | Topical Application | Liver | Clear Evidence | Clear Evidence | adenoma 32/50, 44/50, 43/50; hepatocellular carcinoma 3/50, 21/50, 32/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 33/50, 46/50, 48/50 | Neoplastic Lesions | |
| TR-516 | 693-98-1 | 2-Methylimidazole | Mice | B6C3F1/N | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50 | Neoplastic Lesions | |
| TR-538 | 108-10-1 | Methyl isobutyl ketone | Mice | B6C3F1 | Female | Inhalation | Liver | Some Evidence | Some Evidence | ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50 | Neoplastic Lesions | |
| TR-538 | 108-10-1 | Methyl isobutyl ketone | Mice | B6C3F1 | Male | Inhalation | Liver | Some Evidence | Some Evidence | ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50 | Neoplastic Lesions | |
| TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50 | Neoplastic Lesions | |
| TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50 | Neoplastic Lesions | |
| TR-479 | 68603-42-9 | Coconut oil acid diethanolamine condensate | Mice | B6C3F1 | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | adenoma 22/50, 35/50, 45/50; hepatoblastoma 1/50, 1/50, 10/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 29/50, 39/50, 49/50 | Neoplastic Lesions | |
| TR-512 | 37319-17-8 | Elmiron (sodium pentosanpolysulfate) | Mice | B6C3F1 | Female | Gavage | Liver | Some Evidence | Some Evidence | HEMANGIOSARCOMA 1/50 1/49 1/50 4/49; ADENOMA 7/50 5/49 4/50 15/49; HEPATOCELLULAR ADENOMA OR CARCINOMA 10/50 8/49 9/50 18/49 | Neoplastic Lesions | |
| TR-512 | 37319-17-8 | Elmiron (sodium pentosanpolysulfate) | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Equivocal Evidence | ADENOMA OR CARCINOMA 23/50 23/50 26/50 31/50 | May Have Been Related | |
| TR-512 | 37319-17-8 | Elmiron (sodium pentosanpolysulfate) | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | HEMANGIOSARCOMA 2/50 0/50 4/50 9/50 | Neoplastic Lesions | |
| TR-543 | 98-83-9 | alpha-Methylstyrene | Mice | B6C3F1/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50 | Neoplastic Lesions | |
| TR-520 | 57465-28-8 | Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Equivocal Evidence | CHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 1/51 1/53 0/50 | May Have Been Related | |
| TR-520 | 57465-28-8 | Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50 | Neoplastic Lesions | |
| TR-496 | 116355-83-0 | Fumonisin B1 | Mice | MV | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | Adenoma 5/47 3/48 1/48 16/47 31/45 or Carcinoma 0/47 0/48 0/48 10/47 9/45 Combined 5/47 3/48 1/48 19/47 39/45 | Neoplastic Lesions | |
| TR-533 | 119-61-9 | Benzophenone | Mice | B6C3F1/N | Female | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | ADENOMA 5/50 4/50 10/50 8/50 | May Have Been Related | |
| TR-533 | 119-61-9 | Benzophenone | Mice | B6C3F1/N | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50 | Neoplastic Lesions | |
| TR-521 | 1746-01-6 | Toxic equivalency factor evaluation (TCDD) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Equivocal Evidence | HEPATOCHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 2/53 0/50 OR CHOLANGIOMA 0/53 0/54 0/53 0/53 0/53 0/53 1/50 | May Have Been Related | |
| TR-450 | 116-14-3 | Tetrafluoroethylene | Rats | F344/N | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Medaka (Oryzias latipes) | Female | Aquatic | Liver | Positive | Positive | CHOLANGIOCARCINOMA 0/95 29/93 53/94 41/67 ADENOMA 1/95 1/93 5/94 8/67 CARCINOMA 1/95 1/93 2/94 5/67 ADENOMA OR CARCINOMA 2/95 2/93 7/94 13/67 HEPATOCHOLANGIOCARCINOMA 0/95 0/93 4/94 7/67 | Neoplastic Lesions | |
| TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50 | Neoplastic Lesions | |
| TR-516 | 693-98-1 | 2-Methylimidazole | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Equivocal Evidence | ADENOMA 1/50 0/49 2/50 4/50 | May Have Been Related | |
| TR-516 | 693-98-1 | 2-Methylimidazole | Rats | F344/N | Male | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | ADENOMA OR CARCINOMA 0/50 1/50 3/50 3/50 | May Have Been Related | |
| TR-466 | 100-41-4 | Ethylbenzene | Mice | B6C3F1 | Female | Inhalation | Liver | Some Evidence | Some Evidence | ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50 | Neoplastic Lesions | |
| TR-470 | 110-86-1 | Pyridine | Mice | B6C3F1 | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | ADENOMA 37/49 39/50 43/50 34/50, CARCINOMA 13/49 23/50 33/50 41/50, HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50 | Neoplastic Lesions | |
| TR-470 | 110-86-1 | Pyridine | Mice | B6C3F1 | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | ADENOMA 29/50 40/50 34/49 39/50, CARCINOMA 15/50 35/50 41/49 40/50, HEPATOBLASTOMA 2/50 18/50 22/49 15/50; COMBINED 38/50, 47/50, 46/49, 47/50 | Neoplastic Lesions | |
| TR-480 | 120-40-1 | Lauric acid diethanolamine condensate | Mice | B6C3F1 | Female | Topical Application | Liver | Some Evidence | Some Evidence | ADENOMA 23/50 32/49 29/50 ADENOMA OR CARCINOMA COMBINED 28/50 40/49 36/50 | Neoplastic Lesions | |
| TR-494 | 84-65-1 | Anthraquinone | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49 | Neoplastic Lesions | |
| TR-494 | 84-65-1 | Anthraquinone | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49 | Neoplastic Lesions | |
| TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44 | Neoplastic Lesions | |
| TR-439 | 298-59-9 | Methylphenidate hydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | HEPATOCELLULAR ADENOMA 6/49 10/48 10/49 28/50 CARCINOMA 5/49 3/48 2/49 6/50 COMBINED 9/49 11/48 11/49 30/50 | Neoplastic Lesions | |
| TR-439 | 298-59-9 | Methylphenidate hydrochloride | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | HEPATOCELLULAR ADENOMA 18/50 18/50 16/50 29/50 CARCINOMA 10/50 9/50 17/50 11/50 COMBINED 24/50 23/50 26/50 34/50; HEPATOBLASTOMA 0/50 1/50 1/50 5/50 | Neoplastic Lesions | |
| TR-521 | 1746-01-6 | Toxic equivalency factor evaluation (TCDD) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 0/53 0/54 0/53 0/53 1/53 13/53 2/50 OR CHOLANGIOCARCINOMA 0/53 0/54 0/53 1/53 4/53 25/53 2/50 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Medaka (Oryzias latipes) | Female | Aquatic | Liver | Positive | Positive | CHOLANGIOCARCINOMA 1/57 15/44 31/49 21/31 ADENOMA 4/57 2/44 2/49 1/31 CARCINOMA 0/57 2/44 1/49 4/31 ADENOMA OR CARCINOMA 4/57 4/44 2/49 5/31 HEPATOCHOLANGIOCARCINOMA 0/57 0/44 0/49 1/31 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Medaka (Oryzias latipes) | Male | Aquatic | Liver | Positive | Positive | CHOLANGIOMA 0/42 0/47 3/33 1/46 CHOLANGIOCARCINOMA 0/42 19/47 16/33 26/46 ADENOMA 0/42 1/47 0/33 0/46 ADENOMA OR CARCINOMA 0/42 2/47 0/33 1/46 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Medaka (Oryzias latipes) | Male | Aquatic | Liver | Positive | Positive | CHOLANGIOMA 0/95 6/94 2/65 1/78 CHOLANGIOCARCINOMA 0/95 32/94 43/65 45/78 ADENOMA OR CARCINOMA 0/95 2/94 1/65 6/78 HEPATOCHOLANGIOCARCINOMA 0/95 0/94 2/65 6/78 | Neoplastic Lesions | |
| TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Guppy (Poecilia reticulata) | Female | Aquatic | Liver | Positive | Positive | CHOLANGIOMA 0/64 3/64 4/47 2/33 CHOLANGIOCARCINOMA 0/64 0/64 0/47 6/33 ADENOMA OR CARCINOMA 5/64 4/64 4/47 8/33 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Guppy (Poecilia reticulata) | Female | Aquatic | Liver | Positive | Positive | CHOLANGIOMA 2/31 2/31 0/31 2/27 CHOLANGIOCARCINOMA 0/31 0/31 0/31 5/27 ADENOMA OR CARCINOMA 2/31 1/31 2/31 3/27 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Guppy (Poecilia reticulata) | Male | Aquatic | Liver | Positive | Positive | CHOLANGIOCARCINOMA 0/32 0/19 0/26 1/19 ADENOMA 3/32 4/19 5/26 7/19 CARCINOMA 0/32 0/19 1/26 4/19 ADENOMA OR CARCINOMA COMBINED 3/32 4/19 5/26 10/19 | Neoplastic Lesions | |
| TR-461 | 75-52-5 | Nitromethane | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50 | Neoplastic Lesions | |
| TR-304 | 115-28-6 | Chlorendic acid | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50 | Neoplastic Lesions | |
| TR-304 | 115-28-6 | Chlorendic acid | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50 | Neoplastic Lesions | |
| TR-304 | 115-28-6 | Chlorendic acid | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 2/50 21/50 23/50 | Neoplastic Lesions | |
| TR-443 | 604-75-1 | Oxazepam | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | (SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50 | Neoplastic Lesions | |
| TR-457 | 599-79-1 | Salicylazosulfapyridine | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49 | Neoplastic Lesions | |
| TR-457 | 599-79-1 | Salicylazosulfapyridine | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50 | Neoplastic Lesions | |
| TR-484 | 111-76-2 | 2-Butoxyethanol (ethylene glycol monobutyl ether) | Mice | B6C3F1 | Male | Inhalation | Liver | Some Evidence | Equivocal Evidence | HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49 | May Have Been Related | |
| TR-443 | 604-75-1 | Oxazepam | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | (SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50 | Neoplastic Lesions | |
| TR-443 | 604-75-1 | Oxazepam | Mice | Swiss Webster | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | (SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50 | Neoplastic Lesions | |
| TR-443 | 604-75-1 | Oxazepam | Mice | Swiss Webster | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | (SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50 | Neoplastic Lesions | |
| TR-475 | 109-99-9 | Tetrahydrofuran | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 12/50 17/50 18/50 31/48 OR CARCINOMA 6/50 10/50 10/50 16/48 COMBINED 17/50 24/50 26/50 41/48 | Neoplastic Lesions | |
| TR-508 | 23246-96-0 | Riddelliine | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50 | Neoplastic Lesions | |
| TR-508 | 23246-96-0 | Riddelliine | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50 | Neoplastic Lesions | |
| TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 1/50 1/50 8/49 COMBINED 1/50 1/50 1/50 10/49 | Neoplastic Lesions | |
| TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46 | Neoplastic Lesions | |
| TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48 | Neoplastic Lesions | |
| TR-528 | 3296-90-0 | Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) | Fish | Guppy (Poecilia reticulata) | Male | Aquatic | Liver | Positive | Positive | ADENOMA 3/61 4/50 4/41 8/38 ADENOMA OR CARCINOMA 4/61 6/50 6/41 10/38 | Neoplastic Lesions | |
| TR-530 | TEFBINARYMIX | Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51 | Neoplastic Lesions | |
| TR-503 | 302-17-0 | Chloral hydrate | Mice | MV | Male | Gavage | Liver | Some Evidence | Some Evidence | ADEMONA OR CARCINOMA 16/48 25/48 23/47 22/48 (AD LIBITUM-FED GROUPS) | Neoplastic Lesions | |
| TR-503 | 302-17-0 | Chloral hydrate | Mice | MV | Male | Gavage | Liver | Some Evidence | Some Evidence | CARCINOMA 2/48 5/58 4/48 8/48 (DIETARY-CONTROLLED GROUPS) | Neoplastic Lesions | |
| TR-508 | 23246-96-0 | Riddelliine | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50 | Neoplastic Lesions | |
| TR-525 | 57117-31-4 | Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50 | Neoplastic Lesions | |
| TR-528 | 96-18-4 | Fish project 1 (1,2,3-Trichloropropane) | Fish | Guppy (Poecilia reticulata) | Male | Aquatic | Liver | Positive | Positive | CHOLANGIOCARCINOMA 0/61 0/47 0/67 3/27 ADENOMA 3/61 8/47 17/67 9/27 CARCINOMA 0/61 1/47 0/67 7/27 ADENOMA OR CARCINOMA COMBINED 3/61 9/47 17/67 15/27 | Neoplastic Lesions | |
| TR-528 | 3296-90-0 | Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) | Fish | Medaka (Oryzias latipes) | Male | Aquatic | Liver | Positive | Positive | ADENOMA 1/27 0/21 1/31 3/29 ADENOMA OR CARCINOMA 1/27 0/21 1/31 4/29 | Neoplastic Lesions | |
| TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Liver | Clear Evidence | Equivocal Evidence | hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88) | May Have Been Related | |
| TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Cholangiocarcinoma 1/50 1/50 1/49 3/49 | Neoplastic Lesions | |
| TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Cholangiocarcinoma 0/50 4/50 4/50 6/50 | Neoplastic Lesions | |
| TR-579 | 99-97-8 | N,N-Dimethyl-p-toluidine | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 17/50, 19/50, 37/50, 44/50; hepatocellular carcinoma 6/50, 13/50, 18/50, 31/50; hepatoblastoma 0/50, 1/50, 0/50, 4/50 | Neoplastic Lesions | |
| TR-579 | 99-97-8 | N,N-Dimethyl-p-toluidine | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma, multiple 17/50, 19/50, 27/50, 26/50; hepatocellular carcinoma 22/50, 25/50, 30/50, 36/50; hepatoblastoma 1/50, 5/50, 10/50, 8/50 | Neoplastic Lesions | |
| TR-579 | 99-97-8 | N,N-Dimethyl-p-toluidine | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 0/50, 0/50, 0/50, 4/49; hepatocellular adenoma or carcinoma 0/50, 1/50, 1/50, 7/49 | Neoplastic Lesions | |
| TR-579 | 99-97-8 | N,N-Dimethyl-p-toluidine | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 0/50, 0/50, 1/50, 6/50; hepatocellular adenoma or carcinoma 0/50, 0/50, 2/50, 6/50 | Neoplastic Lesions | |
| TR-559 | 31508-00-6 | Toxic equivalency factor evaluation (PCB 118) | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49 | Neoplastic Lesions | |
| TR-580 | 108-99-6 | beta-Picoline | Mice | B6C3F1/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 11/49 20/50 26/50 23/50 hepatoblastoma 1/49 3/50 4/50 4/50 | Neoplastic Lesions | |
| TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Adenoma 14/50 16/50 18/50 28/50 carcinoma 5/50 13/50 15/50 15/50 adenoma or carcinoma 17/50 23/50 27/50 32/50 | Neoplastic Lesions | |
| TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatocellular adenoma, multiple 16/50 27/50 23/50 34/50 hepatocellular adenoma (includes multiples) 32/50 38/50 29/50 43/50 hepatocellular carcinoma multiple 7/50 12/50 10/50 17/50 hepatocellular adenoma or hepatocellular carcinoma (combined includes multiples) 41/50 47/50 42/50 48/50 hepatoblastoma 3/50 8/50 7/50 8/50 hepatocellular adenoma, carcinoma, or hepatoblastoma (combined) 41/50 47/50 43/50 48/50 | Neoplastic Lesions | |
| TR-576 | 15625-89-5 | Trimethylolpropane triacrylate | Mice | B6C3F1 | Female | Topical Application | Liver | Some Evidence | Some Evidence | hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50 | Neoplastic Lesions | |
| TR-561 | 119-64-2 | Tetralin | Rats | F344/N | Female | Inhalation | Liver | Some Evidence | Some Evidence | Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50 | Neoplastic Lesions | |
| TR-589 | 32534-81-9 | Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 5/50 7/49 32/50 46/49 hepatocellular carcinoma 4/50 2/49 6/50 27/49 hepatocellular adenoma or carcinoma 8/50 8/49 33/50 47/49 | Neoplastic Lesions | |
| TR-589 | 32534-81-9 | Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 23/50 35/50 49/50 40/50 hepatocellular carcinoma 18/50 15/50 30/50 45/50 hepatocellular adenoma or carcinoma 31/50 40/50 49/50 47/50 hepatoblastoma 1/50 1/50 16/50 5/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 31/50 40/50 49/50 47/50 | Neoplastic Lesions | |
| TR-589 | 32534-81-9 | Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] | Rats | Wistar Han | Female | Gavage | Liver | Clear Evidence | Clear Evidence | cholangiocarcinoma 0/50 0/49 0/50 2/47 hepatocholangioma 0/50 0/49 0/50 8/47 hepatocellular adenoma 3/50 2/49 8/50 16/47 hepatocellular carcinoma 0/50 0/49 1/50 6/47 hepatocellular adenoma or carcinoma 3/50 2/49 8/50 17/47) hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/50 2/49 8/50 21/47 | Neoplastic Lesions | |
| TR-562 | GOLDENSEALRT | Goldenseal root powder | Mice | B6C3F1/N | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | Hepatoblastoma 1/50 2/50 1/5 6/50 multiple adenoma 3/50 5/50 11/50 18/50 | Neoplastic Lesions | |
| TR-562 | GOLDENSEALRT | Goldenseal root powder | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | Adenoma: 0/50 0/50 1/50 8/50 | Neoplastic Lesions | |
| TR-589 | 32534-81-9 | Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] | Rats | Wistar Han | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma or carcinoma 3/49 2/50 4/50 9/50; hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/49 2/50 4/50 11/50 | Neoplastic Lesions | |
| TR-578 | 90045-36-6 | Ginkgo biloba extract | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 17/50, 37/50, 41/50, 48/50; hepatocellular carcinoma 9/50, 10/50, 15/50, 44/50; hepatoblastoma 1/50, 1/50, 8/50, 11/50 | Neoplastic Lesions | |
| TR-578 | 90045-36-6 | Ginkgo biloba extract | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 22/50, 31/50, 41/50, 47/50; hepatoblastoma 3/50, 28/50, 36/50, 38/50 | Neoplastic Lesions | |
| TR-562 | GOLDENSEALRT | Goldenseal root powder | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | Adenoma: 1/50 1/50 2/50 10/50 adenoma or carcinoma 1/50 1/50 2/50 11/50 | Neoplastic Lesions | |
| TR-563 | 89-82-7 | Pulegone | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatocellular: Adenoma 13/49 15/50 13/50 27/50 adenoma, carcinoma or hepatoblastoma 17/49 15/50 15/50 33/50 | Neoplastic Lesions | |
| TR-563 | 89-82-7 | Pulegone | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatocellular: Adenoma 22/50 31/50 35/50 28/50 adenoma, carcinoma, or hepatoblastoma 29/50 37/50 42/50 36/50 | Neoplastic Lesions | |
| TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50 | Neoplastic Lesions | |
| TR-578 | 90045-36-6 | Ginkgo biloba extract | Rats | F344/N | Male | Gavage | Liver | Some Evidence | Equivocal Evidence | hepatocellular adenoma 0/50, 3/50, 3/50, 0/50 | May Have Been Related | |
| TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Male | Inhalation | Liver | Clear Evidence | Equivocal Evidence | hepatocholangiocarcionoma 1/50 2/50 2/50 3/50 | May Have Been Related | |
| TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Mice | B6C3F1/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50 | Neoplastic Lesions | |
| TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50 | May Have Been Related | |
| TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51 | Neoplastic Lesions | |
| TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50) | Neoplastic Lesions | |
| TR-554 | 67-47-0 | 5-(Hydroxymethyl)-2-furfural | Mice | B6C3F1/N | Female | Gavage | Liver | Some Evidence | Some Evidence | Adenoma 14/50 26/49 26/50 6/50 | Neoplastic Lesions | |
| TR-557 | 123-35-3 | beta-Myrcene | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Adenoma 26/50 41/50 43/50 carcinoma 14/50 20/50 28/50 adenoma or carcinoma 33/50 44/50 48/50 hepatoblastoma 4/50 6/50 11/50 adenoma, carcinoma, or hepatoblastoma 34/50 45/50 48/50 | Neoplastic Lesions | |
| TR-328 | 598-55-0 | Methyl carbamate | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50 | Neoplastic Lesions | |
| TR-328 | 598-55-0 | Methyl carbamate | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49 | Neoplastic Lesions | |
| TR-584 | 700-06-1 | Indole-3-carbinol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 26/50 32/50 31/49 41/50 hepatocellular carcinoma 12/50 11/50 29/49 14/50 hepatoblastoma 3/50 4/50 4/49 14/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/50 36/50 44/49 45/50 | Neoplastic Lesions | |
| TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50) | Neoplastic Lesions | |
| TR-319 | 106-46-7 | 1,4-Dichlorobenzene (p-dichlorobenzene) | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50 | Neoplastic Lesions | |
| TR-571 | 9000-38-8 | Kava kava extract | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatocellular carcinoma 3/50 13/50 8/50 8/50 hepatocellular adenoma or carcinoma 10/50 21/50 20/50 13/50 | Neoplastic Lesions | |
| TR-598 | 335-67-1 | Perfluorooctanoic acid (PFOA) | Rats | Harlan Sprague-Dawley | Female | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | Perinatal + Postweaning: hepatocellular carcinoma (1/50, 0/50, 4/50) | May Have Been Related | |
| TR-598 | 335-67-1 | Perfluorooctanoic acid (PFOA) | Rats | Harlan Sprague-Dawley | Female | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | Postweaning: hepatocellular carcinoma (1/50, 1/50, 3/49) | May Have Been Related | |
| TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Mice | B6C3F1/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50 | Neoplastic Lesions | |
| TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50 | Neoplastic Lesions | |
| TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Adenoma 0/50 0/50 0/50 3/50 | May Have Been Related | |
| TR-319 | 106-46-7 | 1,4-Dichlorobenzene (p-dichlorobenzene) | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50 | Neoplastic Lesions | |
| TR-551 | 97-54-1 | Isoeugenol | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Adenoma 24/50 35/50 37/50 33/50 carcinoma 8/50 18/50 19/50 18/50 adenoma or carcinoma 28/50 43/50 43/50 43/50 | Neoplastic Lesions | |
| TR-587 | 79-94-7 | Tetrabromobisphenol A | Mice | B6C3F1/N | Male | Gavage | Liver | Some Evidence | Some Evidence | hepatoblastoma 2/50 11/50 8/50 | Neoplastic Lesions | |
| TR-571 | 9000-38-8 | Kava kava extract | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatoblastoma 0/50 4/50 9/50 12/50 | Neoplastic Lesions | |
| TR-598 | 335-67-1 | Perfluorooctanoic acid (PFOA) | Rats | Harlan Sprague-Dawley | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | Perinatal + Postweaning: hepatocellular adenoma (0/50, 1/50, 5/50, 10/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 4/50); hepatocellular adenoma or carcinoma (0/50, 1/50, 5/50, 12/50) | Neoplastic Lesions | |
| TR-598 | 335-67-1 | Perfluorooctanoic acid (PFOA) | Rats | Harlan Sprague-Dawley | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | Postweaning: hepatocellular adenoma (0/50, 0/50, 7/50, 11/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50); hepatocellular adenoma or carcinoma (0/50, 0/50, 7/50,11/50) | Neoplastic Lesions | |
| TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Adenoma 2/50 0/50 3/50 4/50 | May Have Been Related | |
| TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | adenoma 0/48 0/48 1/48 1/48 3/48 | Neoplastic Lesions | |
| TR-601 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | Harlan Sprague-Dawley | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (0/50, 1/49, 0/50, 3/50, 8/49); hepatocellular carcinoma (1/50, 0/49, 0/50, 0/50, 3/49); hepatocellular adenoma or carcinoma (combined) (1/50, 1/49, 0/50, 3/50, 11/49) | Neoplastic Lesions | |
| TR-601 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | Harlan Sprague-Dawley | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (1/49, 0/50, 5/50, 9/50, 5/48); hepatocellular carcinoma (0/49, 0/50, 0/50, 0/50, 8/48); hepatocellular adenoma or carcinoma (combined) (1/49, 0/50, 5/50, 9/50, 13/48) | Neoplastic Lesions | |
| TR-601 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | Harlan Sprague-Dawley | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (0/50, 2/50, 0/50, 1/50, 6/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 6/50); hepatocellular adenoma or carcinoma (combined) (0/50, 2/50, 0/50, 1/50, 12/50) | Neoplastic Lesions | |
| TR-601 | 117-81-7 | Di(2-ethylhexyl) Phthalate | Rats | Harlan Sprague-Dawley | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (0/50, 0/50, 1/50, 1/50, 13/49); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 2/49); hepatocellular adenoma or carcinoma (combined) (0/50, 0/50, 1/50, 1/50, 14/49) | Neoplastic Lesions | |
| TR-602 | 13674-84-5 | Tris(Chloropropyl) Phosphate (TCPP) | Rats | Harlan Sprague-Dawley | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | hepatocellular adenoma or carcinoma (combined) (1/50, 0/50, 1/50, 7/50, 6/49) | Neoplastic Lesions | |
| TR-602 | 13674-84-5 | Tris(Chloropropyl) Phosphate (TCPP) | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Some Evidence | Some Evidence | hepatocellular carcinoma (includes multiple) (5/50, 14/50, 17/50, 14/50) | Neoplastic Lesions | |
| TR-602 | 13674-84-5 | Tris(Chloropropyl) Phosphate (TCPP) | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (includes multiple) (11/50, 5/50, 13/50, 23/50); hepatocellular carcinoma (includes multiple) (1/50, 2/50, 5/50, 10/50); hepatocellular adenoma or carcinoma (combined) (12/50, 7/50, 16/50, 29/50) | Neoplastic Lesions | |
| TR-602 | 13674-84-5 | Tris(Chloropropyl) Phosphate (TCPP) | Rats | Harlan Sprague-Dawley | Female | Dosed-Feed | Liver | Some Evidence | Equivocal Evidence | hepatocellular adenoma (1/50, 3/50, 0/50, 3/50, 3/50) | May Have Been Related |