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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Lung
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Male Intraperitoneal Injection Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-034 1582-09-8 Trifluralin Mice B6C3F1 Female Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Female Intraperitoneal Injection Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice B6C3F1 Female Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice B6C3F1 Male Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Male Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Female Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Male Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Female Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Male Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Female Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice B6C3F1 Male Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-115 95-06-7 Sulfallate Mice B6C3F1 Male Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Female Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Male Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Mice B6C3F1 Female Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-160 137-17-7 2,4,5-Trimethylaniline Rats F344/N Female Dosed-Feed Lung Positive Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-194 7446-34-6 Selenium sulfide Mice B6C3F1 Female Gavage Lung Positive Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Female Inhalation Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 3/49 10/47; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 2/49 4/47 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Male Inhalation Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 1/40 6/45; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 2/40 1/45 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Inhalation Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Male Inhalation Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Female Inhalation Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice B6C3F1 Female Gavage Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/50 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice B6C3F1 Male Gavage Lung Positive Positive ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 13/50 11/50 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50 Neoplastic Lesions
Yes TR-271 2784-94-3 HC Blue 1 Rats F344/N Female Dosed-Feed Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50 Neoplastic Lesions
Yes TR-287 868-85-9 Dimethyl hydrogen phosphite Rats F344/N Male Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 5/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 20/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Male Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Rats F344/N Male Dosed-Feed Lung Clear Evidence Equivocal Evidence ADENOMA 0/50 3/50 5/50 May Have Been Related
Yes TR-306 75-09-2 Methylene chloride Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 23/48 28/48; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 13/48 29/48 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 19/50 24/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 10/50 28/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Female Topical Application Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50 May Have Been Related
Yes TR-421 14807-96-6 Talc Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 0/48 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 5/50 COMBINED 1/50 0/48 13/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Male Topical Application Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78 Neoplastic Lesions
Yes TR-359 298-81-7 8-Methoxypsoralen Rats F344/N Male Gavage Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 9/50 9/49 May Have Been Related
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50 May Have Been Related
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice B6C3F1 Female Topical Application Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Male Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Male Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Female Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49 Neoplastic Lesions
Yes TR-410 91-20-3 Naphthalene Mice B6C3F1 Female Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/68 2/64 28/134 Neoplastic Lesions
Yes TR-422 91-64-5 Coumarin Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/51 5/49 7/49 20/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 0/49 0/49 7/51 COMBINED 2/51 5/49 7/49 27/51 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50 Neoplastic Lesions
Yes TR-363 74-96-4 Bromoethane (ethyl bromide) Rats F344/N Male Inhalation Lung Some Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/48 0/49 1/48 1/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/48 0/49 3/48 0/48 COMBINED 0/48 0/49 4/48 1/48 May Have Been Related
Yes TR-422 91-64-5 Coumarin Mice B6C3F1 Male Gavage Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 14/50 8/50 14/50 24/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 2/50 1/51 COMBINED 14/50 9/50 15/50 25/51 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Male Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Mice B6C3F1 Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Male Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49 Neoplastic Lesions
Yes TR-462 1313-27-5 Molybdenum trioxide Mice B6C3F1 Female Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/49 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 0/49 6/50 COMBINED 3/50 6/50 8/49 15/49 Neoplastic Lesions
Yes TR-462 1313-27-5 Molybdenum trioxide Mice B6C3F1 Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 14/50 10/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 16/50 14/49 10/50 COMBINED 11/50 27/50 21/49 18/50 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Lung Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Lung Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46 Neoplastic Lesions
Yes TR-535 822-36-6 4-Methylimidazole Mice B6C3F1 Female Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 8/50 16/50 8/50 ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 0/50 2/50 7/50 COMBINED 3/50 8/50 17/50 14/50 Neoplastic Lesions
Yes TR-535 822-36-6 4-Methylimidazole Mice B6C3F1 Male Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 4/50 4/50 8/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA (COMBINED) 9/50 13/50 16/50 22/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Lung Clear Evidence Equivocal Evidence Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50 May Have Been Related
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice B6C3F1 Female Dosed-Water Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/50 3/50 6/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/50 5/50 5/50 7/50 May Have Been Related
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice B6C3F1 Male Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Male Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice B6C3F1/N Female Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50) Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47 Neoplastic Lesions
Yes TR-526 TEFDIOXINMIX Toxic equivalency factor evaluation (Dioxin mixture) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/53 2/53 20/53 Neoplastic Lesions
Yes TR-531 TEFPCBMIX Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/51 0/53 20/53 49/53 41/66 12/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice B6C3F1/N Male Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50) Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50 Neoplastic Lesions
Yes TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats F344/N Female Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/53 0/53 1/53 4/54 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 0/53 5/53 1/54 COMBINED 1/53 0/53 6/53 5/54 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53 Neoplastic Lesions
Yes TR-466 100-41-4 Ethylbenzene Mice B6C3F1 Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50 Neoplastic Lesions
Yes TR-492 1303-00-0 Gallium arsenide Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 2/50 7/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 2/50 3/50 COMBINED 0/50 0/50 4/50 9/50 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Female Gavage Lung Clear Evidence Equivocal Evidence ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50 May Have Been Related
Yes TR-507 1314-62-1 Vanadium pentoxide Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 17/50 23/50 19/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 23/50 18/50 22/50 COMBINED 1/50 32/50 35/50 32/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Mice B6C3F1 Female Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50 Neoplastic Lesions
Yes TR-440 10028-15-6 Ozone Mice B6C3F1 Female Inhalation Lung Some Evidence Some Evidence (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 5/50 5/49 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 5/49 8/50 COMBINED 6/50 7/50 9/49 16/50 Neoplastic Lesions
Yes TR-507 1314-62-1 Vanadium pentoxide Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 13/50 16/50 26/50 15/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 12/50 29/50 30/50 35/50 COMBINED 22/50 42/50 43/50 43/50 Neoplastic Lesions
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/54 0/53 0/52 0/53 9/52 0/50 Neoplastic Lesions
Yes TR-440 10028-15-6 Ozone Mice B6C3F1 Female Inhalation Lung Some Evidence Some Evidence (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/49 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 5/49 2/50 COMBINED 6/50 8/49 12/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50 Neoplastic Lesions
Yes TR-522 30516-87-1 AZT transplacental carcinogenesis study Mice Swiss CD-1 Male In Utero Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 5/50 11/50 6/50 11/37 8/32 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 14/50 20/50 13/50 18/37 18/32 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats F344/N Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/54 1/53 3/53 2/52 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/54 0/53 3/53 2/52 OR SQUAMOUS CELL CARCINOMA 1/54 0/53 0/53 0/52 COMBINED 1/54 1/53 6/53 4/52 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 6/50 9/50 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 4/50 9/50 COMBINED 4/50 7/50 13/50 18/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 12/50 13/50 18/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/50 5/50 7/50 11/50 COMBINED 11/50 14/50 19/50 28/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats F344/N Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/49 10/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 6/50 6/50 COMBINED 0/50 3/49 16/50 16/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats F344/N Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 1/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 3/48 1/50 COMBINED 1/50 4/50 4/48 7/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-507 1314-62-1 Vanadium pentoxide Rats F344/N Male Inhalation Lung Some Evidence Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 8/49 5/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/49 1/48 3/50 COMBINED 4/50 10/49 6/48 9/50 Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Mice B6C3F1 Female Gavage Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50 Neoplastic Lesions
Yes TR-485 434-07-1 Oxymetholone Rats F344/N Female Gavage Lung Clear Evidence Clear Evidence ADEMONA 0/50 0/50 6/50 1/49 COMBINED 0/50 0/50 7/50 1/49 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Lung Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48 Neoplastic Lesions
Yes TR-530 TEFBINARYMIX Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52 Neoplastic Lesions
Yes TR-525 57117-31-4 Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) Rats Harlan Sprague-Dawley Female Gavage Lung Some Evidence Equivocal Evidence CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50 May Have Been Related
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Lung Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Male Gavage Lung Clear Evidence Clear Evidence Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice B6C3F1/N Female Gavage Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 2/50, 4/50, 8/50, 12/50; alveolar/bronchiolar adenoma or carcinoma 2/50, 5/50, 9/50, 13/50 Neoplastic Lesions
Yes TR-559 31508-00-6 Toxic equivalency factor evaluation (PCB 118) Rats Harlan Sprague-Dawley Female Gavage Lung Clear Evidence Clear Evidence Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50 Neoplastic Lesions
Yes TR-580 108-99-6 beta-Picoline Mice B6C3F1/N Female Dosed-Water Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 5/50 6/50 4/49 11/50 carcinoma 7/50 8/50 10/49 13/50 alveolar/bronchiolar adenoma or carcinoma 11/50 13/50 13/49 21/50 Neoplastic Lesions
Yes TR-580 108-99-6 beta-Picoline Rats F344/N Female Dosed-Water Lung Some Evidence Some Evidence alveolar/bronchiolar adenoma 0/50 3/50 2/50 5/50 alveolar/bronchiolar adenoma or carcinoma 0/50 4/50 2/50 5/50 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Mice B6C3F1/N Female Inhalation Lung Clear Evidence Equivocal Evidence alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50 May Have Been Related
Yes TR-581 7440-48-4 Cobalt Mice B6C3F1/N Male Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Male Dosed-Water Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Male Dosed-Water Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Female Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Male Inhalation Lung Clear Evidence Equivocal Evidence cystic keratinizing epithelioma 0/50 1/50 0/50 1/50 May Have Been Related
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Male Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50 Neoplastic Lesions
Yes TR-582 75-35-4 Vinylidene Chloride Mice B6C3F1/N Female Inhalation Lung Clear Evidence Equivocal Evidence alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49 May Have Been Related
Yes TR-590 1309-64-4 Antimony Trioxide Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50) Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Mice B6C3F1/N Female Inhalation Lung Clear Evidence Clear Evidence Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50 Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Wistar Han Female Inhalation Lung Some Evidence Equivocal Evidence cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) May Have Been Related
Yes TR-590 1309-64-4 Antimony Trioxide Rats Wistar Han Female Inhalation Lung Some Evidence Some Evidence alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Wistar Han Male Inhalation Lung Some Evidence Some Evidence alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50) Neoplastic Lesions
Yes TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar carcinoma 5/50 3/50 6/50 14/50 alveolar/bronchiolar adenoma or carcinoma 9/50 8/50 8/50 20/50 Neoplastic Lesions
Yes TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice B6C3F1 Male Inhalation Lung Clear Evidence Clear Evidence alveolar/bronchiolar adenoma or carcinoma 14/50 14/50 11/49 23/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Mice B6C3F1 Female Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50 Neoplastic Lesions
Yes TR-329 106-88-7 1,2-Epoxybutane Rats F344/N Male Inhalation Lung Clear Evidence Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49 Neoplastic Lesions
Yes TR-586 CIMSTAR3800 Metal Working Fluids: CIMSTAR 3800 Mice B6C3F1/N Female Inhalation Lung Some Evidence Some Evidence alveolar/bronchiolar carcinoma 4/50 1/50 4/50 8/50 alveolar/bronchiolar adenoma or carcinoma 4/50 5/50 6/50 12/50 Neoplastic Lesions
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Harlan Sprague-Dawley Male Inhalation Lung Some Evidence Equivocal Evidence alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50) May Have Been Related
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice B6C3F1/N Male Gavage Lung Clear Evidence Clear Evidence Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice B6C3F1/N Female Gavage Lung Clear Evidence Clear Evidence Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50 Neoplastic Lesions