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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Mammary Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Female Intraperitoneal Injection Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Male Intraperitoneal Injection Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-028 96-12-8 1,2-Dibromo-3-chloropropane Rats Osborne Mendel Female Gavage Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-032 3778-73-2 Isophosphamide Rats Sprague Dawley Female Intraperitoneal Injection Mammary Gland Positive Positive (FIBROADENOMA) Neoplastic Lesions
Yes TR-049 7008-42-6 Acronycine Rats Sprague Dawley Female Intraperitoneal Injection Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-054 121-14-2 2,4-Dinitrotoluene Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (FIBROADENOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice B6C3F1 Female Gavage Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Rats Osborne Mendel Female Gavage Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Rats Sprague Dawley Female Gavage Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-092 122-66-7 Hydrazobenzene Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-115 95-06-7 Sulfallate Mice B6C3F1 Female Dosed-Feed Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-115 95-06-7 Sulfallate Rats Osborne Mendel Female Dosed-Feed Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-146 139-94-6 Nithiazide Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (FIBROADENOMA OR CYSTADENOMA) Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (ADENOMA OR FIBROADENOMA) Neoplastic Lesions
Yes TR-193 50-55-5 Reserpine Mice B6C3F1 Female Dosed-Feed Mammary Gland Positive Positive (FIBROADENOMA, ADENOCARCINOMA, ADENOSQUAMOUS CARCINOMA) Neoplastic Lesions
Yes TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats F344/N Female Dosed-Feed Mammary Gland Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-207 21739-91-3 Cytembena Rats F344/N Female Intraperitoneal Injection Mammary Gland Positive Positive FIBROADENOMA 13/49 22/50 36/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Inhalation Mammary Gland Positive Positive ADENOCARCINOMA 2/50 14/50 8/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Female Inhalation Mammary Gland Positive Positive FIBROADENOMA 4/50 29/50 24/50 Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Female Gavage Mammary Gland Positive Positive FIBROADENOMA 15/50 21/50 18/50 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Mammary Gland Clear Evidence Clear Evidence ACINAR CELL CARCINOMA 0/50 2/49 6/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Female Gavage Mammary Gland Clear Evidence Clear Evidence CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Female Dosed-Feed Mammary Gland Clear Evidence Equivocal Evidence ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50 May Have Been Related
Yes TR-306 75-09-2 Methylene chloride Rats F344/N Female Inhalation Mammary Gland Clear Evidence Clear Evidence ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 5/50 11/50 13/50 22/50 COMBINED 5/50 11/50 13/50 23/50 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Rats F344/N Male Inhalation Mammary Gland Some Evidence Some Evidence ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 0/50 0/50 2/50 4/50 COMBINED 0/50 0/50 2/50 5/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Mammary Gland Clear Evidence Clear Evidence ADENOCARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
Yes TR-358 303-47-9 Ochratoxin A Rats F344/N Female Gavage Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 17/50 23/51 22/50 28/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Mammary Gland Clear Evidence Clear Evidence ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Mammary Gland Clear Evidence Equivocal Evidence ADENOCARCINOMA 0/50 3/35 6/65 3/50 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence ADENOCARCINOMA 0/60 1/45 3/75 6/60 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50 Neoplastic Lesions
Yes TR-337 59-87-0 Nitrofurazone Rats F344/N Female Dosed-Feed Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 8/49 36/50 36/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Mammary Gland Clear Evidence Clear Evidence ADENOCARCINOMA 1/50 6/49 12/52 21/52 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence ADENOCARCINOMA 1/60 2/45 14/75 20/60 Neoplastic Lesions
Yes TR-356 54-31-9 Furosemide Mice B6C3F1 Female Dosed-Feed Mammary Gland Some Evidence Some Evidence ADENOCARCINOMA 0/50 2/50 5/48 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 3/50 8/50 7/50 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Female Inhalation Mammary Gland Clear Evidence Clear Evidence ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Female Gavage Mammary Gland Clear Evidence Clear Evidence ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Rats F344/N Female Inhalation Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 19/50 21/50 33/50 36/50 OR CARCINOMA 2/50 7/50 1/50 11/50 COMBINED 9/50 25/50 34/50 39/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Female Dosed-Feed Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 25/50 45/51 46/53 45/52 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Female Inhalation Mammary Gland Clear Evidence Equivocal Evidence CARCINOMA 0/50 8/50 3/50 2/50 May Have Been Related
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 24/49 32/50 36/50 36/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Mammary Gland Clear Evidence Clear Evidence CARCINOMA 3/50 4/50 7/50 12/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Female Dosed-Feed Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 23/60 47/60 52/60 56/60 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Male Gavage Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 5/50 5/50 15/50 13/50 6/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Mammary Gland Clear Evidence Equivocal Evidence CARCINOMA 0/52 0/50 1/51 2/50 May Have Been Related
Yes TR-486 78-79-5 Isoprene Rats F344/N Female Inhalation Mammary Gland Some Evidence Some Evidence FIBROADENOMA 19/50 35/50 32/50 32/50 MULTIPLE FIBROADENOMA 7/50 12/50 19/50 17/50 Neoplastic Lesions
Yes TR-486 78-79-5 Isoprene Rats F344/N Male Inhalation Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 2/50 4/50 6/50 21/50 FIBROADENOMA OR CARCINOMA COMBINED 2/50 5/50 7/50 21/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Male Dosed-Feed Mammary Gland Clear Evidence Clear Evidence FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence fibroadenoma 16/48 26/48 35/48 33/48 36/48 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence fibroadenoma 16/48 18/48 24/46 22/47 31/48 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45 Neoplastic Lesions
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence fibroadenoma 28/50 47/50 47/50 39/50 carcinoma 0/50 1/50 3/50 8/50 fibroadenoma, adenoma, or carcinoma 28/50 47/50 48/50 42/50 Neoplastic Lesions
Yes TR-545 446-72-0 Endocrine disruptor (Genistein) Rats Sprague Dawley Female Dosed-Feed Mammary Gland Some Evidence Equivocal Evidence ADENOMA OR ADENOCARCINOMA 7/53 8/49 11/50 13/50 May Have Been Related
Yes TR-545 446-72-0 Endocrine disruptor (Genistein) Rats Sprague Dawley Female Dosed-Feed Mammary Gland Some Evidence Some Evidence ADENOMA OR ADENOCARCINOMA 9/54 4/50 8/50 16/49 Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Female Dosed-Water Mammary Gland Clear Evidence Clear Evidence Fibroadenoma, multiple 22/50 24/50 43/50 38/50 Neoplastic Lesions