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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Mesothelium (Abdominal Cavity/Tunica Vaginalis)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-049 7008-42-6 Acronycine Rats Sprague Dawley Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive MESOTHELIOMA; SARCOMA Neoplastic Lesions
Yes TR-049 7008-42-6 Acronycine Rats Sprague Dawley Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive MESOTHELIOMA; SARCOMA Neoplastic Lesions
Yes TR-072 63-92-3 Phenoxybenzamine hydrochloride Mice B6C3F1 Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive SARCOMA Neoplastic Lesions
Yes TR-072 63-92-3 Phenoxybenzamine hydrochloride Mice B6C3F1 Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive SARCOMA Neoplastic Lesions
Yes TR-072 63-92-3 Phenoxybenzamine hydrochloride Rats Sprague Dawley Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive SARCOMA Neoplastic Lesions
Yes TR-072 63-92-3 Phenoxybenzamine hydrochloride Rats Sprague Dawley Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive SARCOMA Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive MESOTHELIOMA Neoplastic Lesions
Yes TR-207 21739-91-3 Cytembena Rats F344/N Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive MESOTHELIOMA 0/50 37/50 36/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Male Inhalation Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive Positive MESOTHELIOMA 0/50 7/50 25/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MESOTHELIOMA 0/60 0/45 3/75 4/60 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MESOTHELIOMA 3/50 34/50 39/50 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MESOTHELIOMA 2/60 1/45 7/75 6/60 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence SARCOMA 0/50 4/50 8/50 3/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Male Gavage Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50 Neoplastic Lesions
Yes TR-483 87-86-5 Pentachlorophenol, purified Rats F344/N Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Some Evidence Some Evidence MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY) Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60 Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Male Inhalation Mesothelium (Abdominal Cavity/Tunica Vaginalis) Some Evidence Equivocal Evidence Malignant: 0/50 2/50 2/50 4/50 May Have Been Related
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Clear Evidence Malignant Mesothelioma 1/50 5/50 10/50 6/50 Neoplastic Lesions