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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA; SARCOMA	Neoplastic Lesions
Yes	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA; SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA	Neoplastic Lesions
Yes	TR-207	21739-91-3	Cytembena	Rats	F344/N	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA 0/50 37/50 36/50	Neoplastic Lesions
Yes	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA 0/50 7/50 25/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50	Neoplastic Lesions
Yes	TR-483	87-86-5	Pentachlorophenol, purified	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Some Evidence	MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY)	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Equivocal Evidence	Malignant: 0/50 2/50 2/50 4/50	May Have Been Related
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	Malignant Mesothelioma 1/50 5/50 10/50 6/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 1/50 2/50 5/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Intestines (Large)	Some Evidence	Some Evidence	Adenoma 0/50 0/50 2/50 1/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Equivocal Evidence	Malignant: 0/50 2/50 2/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Pancreas Islet Cell	Some Evidence	Equivocal Evidence	Adenoma 0/50 5/50 4/50 5/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Skin	Some Evidence	Some Evidence	Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Female	Inhalation	Lung	Positive	Positive	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Male	Inhalation	Lung	Positive	Positive	ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Female	Inhalation	Lung	Positive	Positive	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Positive	Positive	ADENOCARCINOMA 2/50 14/50 8/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Female	Inhalation	Mammary Gland	Positive	Positive	FIBROADENOMA 4/50 29/50 24/50	Neoplastic Lesions
Yes	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA 0/50 7/50 25/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Female	Inhalation	Nasal Cavity	Positive	Positive	CARCINOMA 0/50 0/50 6/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Female	Inhalation	Nasal Cavity	Positive	Positive	ADENOMA 0/50 11/50 3/50; ADENOCARCINOMA 0/50 20/50 29/50; CARCINOMA 0/50 0/50 25/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Male	Inhalation	Nasal Cavity	Positive	Positive	ADENOMA 0/50 11/50 0/50; ADENOCARCINOMA 0/50 20/50 28/50; CARCINOMA 0/50 0/50 21/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Positive	Positive	FIBROSARCOMA 0/50 5/50 11/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA 0/50 11/50 23/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Female	Inhalation	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-210	106-93-4	1,2-Dibromoethane	Rats	F344/N	Male	Inhalation	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA 0/50 1/50 15/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 44/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 48/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Vascular System (Spleen)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 2/44 3/75 1/60	May Have Been Related
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/60 2/45 14/75 20/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
No	TR-049	7008-42-6	Acronycine	Mice	B6C3F1	Female	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-049	7008-42-6	Acronycine	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Bone	Positive	Positive	(OSTEOSARCOMA)	Neoplastic Lesions
No	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA; SARCOMA	Neoplastic Lesions
Yes	TR-049	7008-42-6	Acronycine	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA; SARCOMA	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-207	21739-91-3	Cytembena	Mice	B6C3F1	Female	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
No	TR-207	21739-91-3	Cytembena	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
No	TR-207	21739-91-3	Cytembena	Rats	F344/N	Female	Intraperitoneal Injection	Mammary Gland	Positive	Positive	FIBROADENOMA 13/49 22/50 36/50	Neoplastic Lesions
Yes	TR-207	21739-91-3	Cytembena	Rats	F344/N	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA 0/50 37/50 36/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 1/50 3/50	May Have Been Related
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	MALIGNANT NEUROENDOCRINE TUMOR 0/49 0/48 0/49 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 0/50 0/50 13/50 9/50 5/50 OR MALIGNANT NEUROENDOCRINE TUMOR 0/50 1/50 12/50 26/50 36/50 COMBINED 0/50 1/50 25/50 34/50 41/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 1/50 0/50 0/50 3/50 2/50 OR MALIGNANT NEURENDOCRINE TUMOR 0/50 0/50 0/50 4/50 2/50 COMBINED 1/50 0/50 0/50 7/50 4/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 5/50 5/50 15/50 13/50 6/50	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/60 2/60 3/60 50/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 4/60 17/60 55/60 60/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 1/60 4/60 3/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 12/60 9/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 1/60 6/60	May Have Been Related
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 23/60 47/60 52/60 56/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOMA OR FIBROADENOMA)	Neoplastic Lesions
Yes	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Spleen	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Spleen	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Positive	Positive	(FIBROMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-483	87-86-5	Pentachlorophenol, purified	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-483	87-86-5	Pentachlorophenol, purified	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Some Evidence	MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY)	Neoplastic Lesions
No	TR-483	87-86-5	Pentachlorophenol, purified	Rats	F344/N	Male	Dosed-Feed	Nasal Cavity	Some Evidence	Some Evidence	CARCINOMA 1/50 3/50 1/50 0/50 5/50 (STOP STUDY)	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
Yes	TR-072	63-92-3	Phenoxybenzamine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	SARCOMA	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 0/50 3/50 7/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 2/50 0/50 4/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 0/50 0/50 0/50 3/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 2/50 0/50 3/50 4/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	Fibroadenoma, multiple 22/50 24/50 43/50 38/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	Malignant Mesothelioma 1/50 5/50 10/50 6/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	Adenoma 3/50 4/50 9/50 3/50	May Have Been Related