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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Nasal Cavity
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-080 123-91-1 1,4-Dioxane Rats Osborne Mendel Female Dosed-Water Nasal Cavity Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-080 123-91-1 1,4-Dioxane Rats Osborne Mendel Male Dosed-Water Nasal Cavity Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Rats F344/N Female Dosed-Feed Nasal Cavity Positive Positive (NEUROBLASTOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Rats F344/N Male Dosed-Feed Nasal Cavity Positive Positive (NEUROBLASTOMA) Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Female Inhalation Nasal Cavity Positive Positive BENIGN AND MALIGNANT TUMORS 0/50 11/50 38/50 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Male Inhalation Nasal Cavity Positive Positive BENIGN AND MALIGNANT TUMORS 0/45 1/42 21/48 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats F344/N Female Inhalation Nasal Cavity Positive Positive BENIGN AND MALIGNANT TUMORS 1/50 21/50 32/50 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats F344/N Male Inhalation Nasal Cavity Positive Positive BENIGN AND MALIGNANT TUMORS 0/50 32/50 39/49 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Inhalation Nasal Cavity Positive Positive CARCINOMA 0/50 0/50 6/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Female Inhalation Nasal Cavity Positive Positive ADENOMA 0/50 11/50 3/50; ADENOCARCINOMA 0/50 20/50 29/50; CARCINOMA 0/50 0/50 25/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Male Inhalation Nasal Cavity Positive Positive ADENOMA 0/50 11/50 0/50; ADENOCARCINOMA 0/50 20/50 28/50; CARCINOMA 0/50 0/50 21/50 Neoplastic Lesions
Yes TR-278 87-62-7 2,6-Xylidine Rats CD Female Dosed-Feed Nasal Cavity Positive Positive ADENOMA 0/56 0/56 1/56 6/56; CARCINOMA 0/56 0/56 1/56 24/56 Neoplastic Lesions
Yes TR-278 87-62-7 2,6-Xylidine Rats CD Male Dosed-Feed Nasal Cavity Positive Positive ADENOMA 0/56 0/56 2/56 10/56; CARCINOMA 0/56 0/56 0/56 26/56 Neoplastic Lesions
Yes TR-267 75-56-9 1,2-Propylene oxide Rats F344/N Female Inhalation Nasal Cavity Some Evidence Some Evidence ADENOMA 0/50 0/50 3/50 Neoplastic Lesions
Yes TR-267 75-56-9 1,2-Propylene oxide Rats F344/N Male Inhalation Nasal Cavity Some Evidence Some Evidence ADENOMA 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Nasal Cavity Clear Evidence Clear Evidence ADENOMA 0/50 44/50 49/50 Neoplastic Lesions
Yes TR-376 106-92-3 Allyl glycidyl ether Mice B6C3F1 Male Inhalation Nasal Cavity Some Evidence Some Evidence ADENOMA 0/50 0/50 3/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Female Gavage Nasal Cavity Clear Evidence Clear Evidence ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Nasal Cavity Clear Evidence Clear Evidence ADENOMA 0/50 48/50 48/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Male Gavage Nasal Cavity Clear Evidence Clear Evidence ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32 Neoplastic Lesions
Yes TR-340 5634-39-9 Iodinated glycerol Rats F344/N Male Gavage Nasal Cavity Some Evidence Equivocal Evidence ADENOMA 0/48 0/47 2/49 May Have Been Related
Yes TR-542 98-82-8 Cumene Rats F344/N Female Inhalation Nasal Cavity Some Evidence Some Evidence respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50) Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Rats F344/N Male Inhalation Nasal Cavity Clear Evidence Clear Evidence respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50) Neoplastic Lesions
Yes TR-482 98-00-0 Furfuryl alcohol Rats F344/N Male Inhalation Nasal Cavity Some Evidence Some Evidence ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50 Neoplastic Lesions
Yes TR-483 87-86-5 Pentachlorophenol, purified Rats F344/N Male Dosed-Feed Nasal Cavity Some Evidence Some Evidence CARCINOMA 1/50 3/50 1/50 0/50 5/50 (STOP STUDY) Neoplastic Lesions
Yes TR-500 91-20-3 Naphthalene Rats F344/N Female Inhalation Nasal Cavity Clear Evidence Clear Evidence (RESPIRATORY EPITHELIUM) ADENOMA 0/49 0/49 4/49 2/49 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 2/49 3/49 12/49 Neoplastic Lesions
Yes TR-500 91-20-3 Naphthalene Rats F344/N Male Inhalation Nasal Cavity Clear Evidence Clear Evidence (RESPIRATORY EPITHELIUM) ADENOMA 0/49 6/49 8/48 15/48 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 0/49 4/48 3/48 Neoplastic Lesions
Yes TR-552 107-19-7 Propargyl alcohol Mice B6C3F1/N Male Inhalation Nasal Cavity Some Evidence Some Evidence adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50) Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats F344/N Female Gavage Nasal Cavity Clear Evidence Clear Evidence transitional epithelium, adenoma 0/50, 1/49, 0/50, 2/49 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats F344/N Male Gavage Nasal Cavity Clear Evidence Clear Evidence transitional epithelium, adenoma 0/50, 3/49, 2/50, 11/49; transitional epithelium, adenoma or carcinoma 0/50, 3/49, 2/50, 13/49 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Rats F344/N Female Gavage Nasal Cavity Some Evidence Equivocal Evidence respiratory epithelium, adenoma 0/49, 0/49, 2/50, 0/46 May Have Been Related
Yes TR-582 75-35-4 Vinylidene Chloride Rats F344/N Male Inhalation Nasal Cavity Clear Evidence Clear Evidence respiratory epithelium, adenoma 0/49 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-593 431-03-8 2,3-Butanedione Rats Wistar Han Female Inhalation Nasal Cavity Some Evidence Some Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) Neoplastic Lesions
Yes TR-593 431-03-8 2,3-Butanedione Rats Wistar Han Male Inhalation Nasal Cavity Some Evidence Some Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 3/50); squamous cell papilloma or carcinoma (0/50, 0/50, 0/50, 4/50) Neoplastic Lesions
Yes TR-552 107-19-7 Propargyl alcohol Rats F344/N Male Inhalation Nasal Cavity Some Evidence Some Evidence adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49) Neoplastic Lesions
Yes TR-329 106-88-7 1,2-Epoxybutane Rats F344/N Male Inhalation Nasal Cavity Clear Evidence Clear Evidence ADENOMA 0/50 0/50 7/50 Neoplastic Lesions
Yes TR-552 107-19-7 Propargyl alcohol Mice B6C3F1/N Female Inhalation Nasal Cavity Some Evidence Some Evidence adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50) Neoplastic Lesions