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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Oral Cavity
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats F344/N Female Inhalation Oral Cavity Positive Positive SQUAMOUS CELL PAPILLOMA 0/50 3/50 11/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 5/50 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats F344/N Male Inhalation Oral Cavity Positive Positive SQUAMOUS CELL PAPILLOMA 0/50 1/50 8/49; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Rats F344/N Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Rats F344/N Male Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50 May Have Been Related
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Rats F344/N Male Dosed-Feed Oral Cavity Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 5/51; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 1/51; BASOSQUAMOUS TUMOR BENIGN 0/50 0/50 0/50 1/51 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Male Gavage Oral Cavity Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60 Neoplastic Lesions
Yes TR-530 TEFBINARYMIX Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Female Dosed-Feed Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50 Neoplastic Lesions
Yes TR-509 142-83-6 2,4-Hexadienal Mice B6C3F1 Male Gavage Oral Cavity Clear Evidence Equivocal Evidence (TONGUE) SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 2/50 May Have Been Related
Yes TR-531 TEFPCBMIX Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Clear Evidence Clear Evidence GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 1/51 2/53 4/53 0/53 1/66 1/50 Neoplastic Lesions
Yes TR-463 8003-22-3 D&C Yellow No. 11 Rats F344/N Female Dosed-Feed Oral Cavity Some Evidence Equivocal Evidence SQUAMOUS CELL CARCINOMA 0/50 0/51 0/50 1/51 May Have Been Related
Yes TR-463 8003-22-3 D&C Yellow No. 11 Rats F344/N Male Dosed-Feed Oral Cavity Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 1/50 1/51 2/51 4/54 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/51 1/54 COMBINED 1/50 2/51 3/51 5/54 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Male Inhalation Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60 Neoplastic Lesions
Yes TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Clear Evidence Clear Evidence GINGIVAL SQUAMOUS CELL CARINOMA (ORAL MUCOSA) 0/53 1/55 1/53 1/53 2/53 2/53 7/53 2/50 Neoplastic Lesions
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Clear Evidence Clear Evidence GINGIVAL SQAMOUS CELL CARCINOMA (ORAL MUCOSA) 1/53 2/54 1/53 0/53 4/53 10/53 5/50 Neoplastic Lesions
Yes TR-525 57117-31-4 Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Some Evidence Some Evidence (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Female Gavage Oral Cavity Clear Evidence Clear Evidence Mucosa: Gingival squamous cell carcinoma 0/50 0/50 4/50 6/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Male Gavage Oral Cavity Clear Evidence Clear Evidence Mucosa: Gingival squamous cell carcinoma 1/50 5/50 4/50 5/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48 Neoplastic Lesions
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Male Dosed-Water Oral Cavity Clear Evidence Equivocal Evidence (oral mucosa and tongue): squamous cell papilloma or squamous cell carcinoma 1/50 0/50 3/50 3/50 May Have Been Related
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Rats F344/N Female Dosed-Water Oral Cavity Some Evidence Some Evidence Squamous cell papilloma 1/50 0/50 4/50 0/50 Neoplastic Lesions
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Male Gavage Oral Cavity Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50 Neoplastic Lesions
Yes TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Rats F344/N Female Dosed-Water Oral Cavity Clear Evidence Clear Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 2/50, 11/50); squamous cell papilloma or carcinoma (1/50, 1/50, 0/50, 2/50, 11/50) Neoplastic Lesions
Yes TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Rats F344/N Male Dosed-Water Oral Cavity Clear Evidence Clear Evidence squamous cell carcinoma (0/50, 1/50, 0/49, 0/50, 6/49); squamous cell papilloma or carcinoma (0/50, 1/50, 0/49, 0/50, 7/49) Neoplastic Lesions