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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Ovary
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-118 602-87-9 5-Nitroacenaphthene Mice B6C3F1 Female Dosed-Feed Ovary Positive Positive (TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA) Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Ovary Clear Evidence Clear Evidence GRANULOSA CELL TUMOR 0/49 6/45 12/48 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Female Gavage Ovary Clear Evidence Clear Evidence BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Ovary Clear Evidence Clear Evidence BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice B6C3F1 Female Topical Application Ovary Clear Evidence Clear Evidence BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Female Gavage Ovary Clear Evidence Clear Evidence GRANULOSA CELL TUMOR 0/50 5/45 5/47 Neoplastic Lesions
Yes TR-337 59-87-0 Nitrofurazone Mice B6C3F1 Female Dosed-Feed Ovary Clear Evidence Clear Evidence GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50 Neoplastic Lesions
Yes TR-341 67-20-9 Nitrofurantoin Mice B6C3F1 Female Dosed-Feed Ovary Clear Evidence Clear Evidence TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Ovary Clear Evidence Clear Evidence BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39 Neoplastic Lesions
Yes TR-465 77-09-8 Phenolphthalein Mice B6C3F1 Female Dosed-Feed Ovary Clear Evidence Clear Evidence BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Female Gavage Ovary Clear Evidence Equivocal Evidence BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50 May Have Been Related
Yes TR-303 100-40-3 4-Vinylcyclohexene Mice B6C3F1 Female Gavage Ovary Clear Evidence Clear Evidence GRANULOSA CELL TUMOR 1/49 9/48 11/47 OR CARCINOMA 0/49 1/48 2/47 COMBINED 1/49 10/48 13/47 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Ovary Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Ovary Clear Evidence Clear Evidence benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Ovary Clear Evidence Equivocal Evidence granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44 May Have Been Related