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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Positive	Positive	(TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA)	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/49 6/45 12/48	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50	Neoplastic Lesions
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/50 5/45 5/47	Neoplastic Lesions
Yes	TR-337	59-87-0	Nitrofurazone	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50	Neoplastic Lesions
Yes	TR-341	67-20-9	Nitrofurantoin	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50	Neoplastic Lesions
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Equivocal Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50	May Have Been Related
Yes	TR-303	100-40-3	4-Vinylcyclohexene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 1/49 9/48 11/47 OR CARCINOMA 0/49 1/48 2/47 COMBINED 1/49 10/48 13/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/50 2/48 1/49	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 4/42 10/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 5/40 0/44	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 1/50 10/49 10/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 0/50 23/50 29/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ACINAR CELL CARCINOMA 0/50 2/49 6/49	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/49 6/45 12/48	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 11/48 18/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 16/49 7/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50	May Have Been Related
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50	May Have Been Related
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50	Neoplastic Lesions
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50	Neoplastic Lesions
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50	Neoplastic Lesions
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50	Neoplastic Lesions
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50	Neoplastic Lesions
No	TR-303	100-40-3	4-Vinylcyclohexene	Mice	B6C3F1	Male	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-303	100-40-3	4-Vinylcyclohexene	Rats	F344/N	Female	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-303	100-40-3	4-Vinylcyclohexene	Rats	F344/N	Male	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-303	100-40-3	4-Vinylcyclohexene	Mice	B6C3F1	Female	Gavage	Adrenal Gland Cortex	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/49 4/48	May Have Been Related
Yes	TR-303	100-40-3	4-Vinylcyclohexene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 1/49 9/48 11/47 OR CARCINOMA 0/49 1/48 2/47 COMBINED 1/49 10/48 13/47	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Male	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Positive	Positive	(TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50	May Have Been Related
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Equivocal Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50	May Have Been Related
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
No	TR-510	64-17-5	Ethanol	Mice	MV	Female	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-510	64-17-5	Ethanol	Mice	MV	Male	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-352	924-42-5	N-Methylolacrylamide	Rats	F344/N	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/47 8/45 20/48	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/48 14/49 29/50	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 3/50 4/50 17/49	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50	Neoplastic Lesions
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/50 5/45 5/47	Neoplastic Lesions
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Bone	Some Evidence	Equivocal Evidence	OSTEOSARCOMA 0/50 1/50 2/50	May Have Been Related
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50	Neoplastic Lesions
Yes	TR-341	67-20-9	Nitrofurantoin	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50	Neoplastic Lesions
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Some Evidence	Equivocal Evidence	FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50	May Have Been Related
No	TR-337	59-87-0	Nitrofurazone	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-337	59-87-0	Nitrofurazone	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 8/49 36/50 36/50	Neoplastic Lesions
No	TR-337	59-87-0	Nitrofurazone	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Equivocal Evidence	Equivocal Evidence	MESOTHELIOMA 0/50 7/50 2/50	Neoplastic Lesions
Yes	TR-337	59-87-0	Nitrofurazone	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50	Neoplastic Lesions
No	TR-337	59-87-0	Nitrofurazone	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Equivocal Evidence	Equivocal Evidence	ADENOMA 8/50 8/50 2/50 OR CARCINOMA 1/50 8/50 5/50 COMBINED 9/50 16/50 7/50	Neoplastic Lesions
No	TR-337	59-87-0	Nitrofurazone	Rats	F344/N	Male	Dosed-Feed	Skin	Equivocal Evidence	Equivocal Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 4/50; TRICHOEPITHELIOMA 0/50 0/50 1/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Female	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 1/47 5/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 0/46 2/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/45 1/47 4/46	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 0/48 2/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46	Neoplastic Lesions