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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Pancreas Acinar Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-026 1836-75-5 Nitrofen Rats Osborne Mendel Female Dosed-Feed Pancreas Acinar Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-196 87-29-6 Cinnamyl anthranilate Rats F344/N Male Dosed-Feed Pancreas Acinar Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Male Gavage Pancreas Acinar Cell Positive Positive ADENOMA 1/47 3/47 7/49 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Rats F344/N Male Dosed-Feed Pancreas Acinar Cell Clear Evidence Clear Evidence ADENOMA 0/49 4/50 6/50 Neoplastic Lesions
Yes TR-342 62-73-7 Dichlorvos Rats F344/N Male Gavage Pancreas Acinar Cell Some Evidence Some Evidence ADENOMA 25/50 30/49 33/50 Neoplastic Lesions
Yes TR-332 149-30-4 2-Mercaptobenzothiazole Rats F344/N Male Gavage Pancreas Acinar Cell Some Evidence Some Evidence ADENOMA 2/50 13/50 6/50 Neoplastic Lesions
Yes TR-334 121-88-0 2-Amino-5-nitrophenol Rats F344/N Male Gavage Pancreas Acinar Cell Some Evidence Some Evidence ADENOMA 1/50 10/50 3/49 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Pancreas Acinar Cell Clear Evidence Clear Evidence ADENOMA 5/50 21/50 36/49 29/52 Neoplastic Lesions
Yes TR-458 85-68-7 Butyl benzyl phthalate Rats F344/N Male Dosed-Feed Pancreas Acinar Cell Some Evidence Some Evidence ADENOMA 3/50 2/49 3/50 10/50 OR CARCINOMA 0/50 0/49 0/50 1/50 COMBINED 3/50 2/49 3/50 11/50 Neoplastic Lesions
Yes TR-530 TEFBINARYMIX Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) Rats Harlan Sprague-Dawley Female Gavage Pancreas Acinar Cell Clear Evidence Clear Evidence ADENOMA 0/53 1/53 1/52 3/52 1/50 ADENOMA OR CARCINOMA 0/53 1/53 1/52 4 /52 2/50 Neoplastic Lesions
Yes TR-526 TEFDIOXINMIX Toxic equivalency factor evaluation (Dioxin mixture) Rats Harlan Sprague-Dawley Female Gavage Pancreas Acinar Cell Clear Evidence Equivocal Evidence ADENOMA OR CARCINOMA 0/52 1/53 2/53 2/53 0/51 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Pancreas Acinar Cell Clear Evidence Equivocal Evidence ADENOMA 1/51 2/53 4/51 3/53 3/59 May Have Been Related
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Pancreas Acinar Cell Clear Evidence Equivocal Evidence ADENOMA OR CARCINOMA 0/51 0/54 0/52 0/53 0/52 3/51 1/49 May Have Been Related
Yes TR-525 57117-31-4 Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) Rats Harlan Sprague-Dawley Female Gavage Pancreas Acinar Cell Some Evidence Equivocal Evidence ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49 May Have Been Related
Yes TR-559 31508-00-6 Toxic equivalency factor evaluation (PCB 118) Rats Harlan Sprague-Dawley Female Gavage Pancreas Acinar Cell Clear Evidence Equivocal Evidence Adenoma 0/52 0/52 0/52 2/52 3/52 1/47 0/49 adenoma or carcinoma 0/50 0/52 0/52 2/52 3/52 2/47 0/49 May Have Been Related
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Male Dosed-Feed Pancreas Acinar Cell Clear Evidence Clear Evidence Perinatal + Postweaning: acinar cell adenoma (7/50, 18/50, 30/50, 30/50); acinar cell adenocarcinoma (0/50, 2/50, 1/50, 3/50), acinar cell adenoma or adenocarcinoma (7/50, 20/50, 30/50, 30/50) Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Male Dosed-Feed Pancreas Acinar Cell Clear Evidence Clear Evidence Postweaning: acinar cell adenoma (3/50, 28/50, 26/50, 32/50); acinar cell adenocarcinoma (0/50, 3/50, 1/50, 3/50), acinar cell adenoma or adenocarcinoma (3/50, 29/50, 26/50, 32/50) Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Female Dosed-Feed Pancreas Acinar Cell Some Evidence Some Evidence Perinatal + Postweaning: acinar cell adenoma (0/50, 0/50, 3/50); acinar cell adenocarcinoma (0/50, 0/50, 2/50); acinar cell adenoma or adenocarcinoma (0/50, 0/50, 5/50) Neoplastic Lesions
Yes TR-598 335-67-1 Perfluorooctanoic acid (PFOA) Rats Harlan Sprague-Dawley Female Dosed-Feed Pancreas Acinar Cell Some Evidence Some Evidence Postweaning: acinar cell adenoma (0/50, 0/50, 1/49); acinar cell adenocarcinoma (0/50, 0/50, 1/49); acinar cell adenoma or adenocarcinoma (0/50, 0/50, 2/49) Neoplastic Lesions