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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:
- Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
- Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
- Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
| Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Pancreas Islet Cell | Positive | Positive | ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47 | Neoplastic Lesions |
| Yes | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Rats | F344/N | Male | Dosed-Feed | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50 | May Have Been Related |
| Yes | TR-331 | 24382-04-5 | Malonaldehyde, sodium salt | Rats | F344/N | Male | Gavage | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | ADENOMA 0/49 9/50 1/49 | May Have Been Related |
| Yes | TR-540 | 7220-79-3 | Methylene blue trihydrate | Rats | F344/N | Male | Gavage | Pancreas Islet Cell | Some Evidence | Some Evidence | ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50 | Neoplastic Lesions |
| Yes | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | adenoma or carcinoma (13/90, 27/89, 19/86, 16/85) | May Have Been Related |
| Yes | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Pancreas Islet Cell | Clear Evidence | Clear Evidence | adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48 | Neoplastic Lesions |
| Yes | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Female | Gavage | Pancreas Islet Cell | Clear Evidence | Clear Evidence | Adenoma 0/49 2/50 4/49 4/48 | Neoplastic Lesions |
| Yes | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Male | Gavage | Pancreas Islet Cell | Clear Evidence | Clear Evidence | Adenoma (includes multiples) 2/50 2/50 2/50 5/49 | Neoplastic Lesions |
| Yes | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Female | Inhalation | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | carcinoma 1/50 0/50 0/50 3/50 | May Have Been Related |
| Yes | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Pancreas Islet Cell | Clear Evidence | Clear Evidence | adenoma or carcinoma 2/50 2/50 10/48 9/49 | Neoplastic Lesions |
| Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Pancreas Islet Cell | Some Evidence | Equivocal Evidence | Adenoma 0/50 5/50 4/50 5/50 | May Have Been Related |
| Yes | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | Adenoma 3/50 4/50 9/50 3/50 | May Have Been Related |
| Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Female | Inhalation | Intestines (Large) | Clear Evidence | Clear Evidence | Adenoma 0/50 1/50 2/50 5/50 | Neoplastic Lesions |
| No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Intestines (Large) | Some Evidence | Some Evidence | Adenoma 0/50 0/50 2/50 1/50 | Neoplastic Lesions |
| No | TR-564 | 106-94-5 | 1-Bromopropane | Mice | B6C3F1/N | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50 | Neoplastic Lesions |
| No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Some Evidence | Equivocal Evidence | Malignant: 0/50 2/50 2/50 4/50 | May Have Been Related |
| Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Pancreas Islet Cell | Some Evidence | Equivocal Evidence | Adenoma 0/50 5/50 4/50 5/50 | May Have Been Related |
| No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Female | Inhalation | Skin | Clear Evidence | Equivocal Evidence | Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50 | May Have Been Related |
| No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Skin | Some Evidence | Some Evidence | Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Mice | B6C3F1 | Male | Gavage | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Mice | B6C3F1 | Female | Gavage | Liver | Positive | Positive | ADENOMA 2/50 3/50 12/50 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Liver | Positive | Positive | NEOPLASTIC NODULE 3/50 8/50 8/48 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Mammary Gland | Positive | Positive | FIBROADENOMA 15/50 21/50 18/50 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Male | Gavage | Pancreas Acinar Cell | Positive | Positive | ADENOMA 1/47 3/47 7/49 | Neoplastic Lesions |
| Yes | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Pancreas Islet Cell | Positive | Positive | ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Female | Gavage | Subcutaneous Tissue | Positive | Positive | FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Rats | F344/N | Male | Gavage | Subcutaneous Tissue | Positive | Positive | FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50 | Neoplastic Lesions |
| No | TR-251 | 26471-62-5 | 2,4- & 2,6-Toluene diisocyanate | Mice | B6C3F1 | Female | Gavage | Vascular System (Unspecified) | Positive | Positive | HEMANGIOMA 0/50 1/50 2/50 OR HEMANGIOSARCOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 5/50 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | carcinoma 1/4 6/48 12/47 3/48 8/47 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis | Clear Evidence | Clear Evidence | malignant mesothelioma 2/48 2/48 1/48 5/48 8/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis or Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 2/48 2/48 1/48 5/48 8/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 4/46 0/46 2/48 5/45 8/42 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 0/45 8/44 20/48 32/47 31/43 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | malignant Schwannoma 2/48 1/48 0/48 2/48 4/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | malignant Schwannoma 1/48 2/48 3/48 4/48 6/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | adenoma 0/48 0/48 1/48 1/48 3/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | fibroadenoma 16/48 18/48 24/46 22/47 31/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42 | Neoplastic Lesions |
| Yes | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Pancreas Islet Cell | Clear Evidence | Clear Evidence | adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 1/48 2/48 1/48 1/48 5/48 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47 | Neoplastic Lesions |
| No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48 | Neoplastic Lesions |
| No | TR-560 | 63-05-8 | Androstenedione | Rats | F344/N | Female | Gavage | All Organs | Equivocal Evidence | Equivocal Evidence | Mononuclear cell leukemia 5/50 11/50 18/50 15/50 (choose all organs until programmer intervention) | May Have Been Related |
| No | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Adenoma 14/50 16/50 18/50 28/50 carcinoma 5/50 13/50 15/50 15/50 adenoma or carcinoma 17/50 23/50 27/50 32/50 | Neoplastic Lesions |
| No | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Hepatocellular adenoma, multiple 16/50 27/50 23/50 34/50 hepatocellular adenoma (includes multiples) 32/50 38/50 29/50 43/50 hepatocellular carcinoma multiple 7/50 12/50 10/50 17/50 hepatocellular adenoma or hepatocellular carcinoma (combined includes multiples) 41/50 47/50 42/50 48/50 hepatoblastoma 3/50 8/50 7/50 8/50 hepatocellular adenoma, carcinoma, or hepatoblastoma (combined) 41/50 47/50 43/50 48/50 | Neoplastic Lesions |
| No | TR-560 | 63-05-8 | Androstenedione | Rats | F344/N | Male | Gavage | Lung | Equivocal Evidence | Equivocal Evidence | Alveolar/bronchiolar adenoma 0/50 0/50 5/50 2/50 alveolar/bronchiolar adenoma or carcinoma (combined) 0/50 0/50 5/50 3/50 | May Have Been Related |
| Yes | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Female | Gavage | Pancreas Islet Cell | Clear Evidence | Clear Evidence | Adenoma 0/49 2/50 4/49 4/48 | Neoplastic Lesions |
| Yes | TR-560 | 63-05-8 | Androstenedione | Mice | B6C3F1/N | Male | Gavage | Pancreas Islet Cell | Clear Evidence | Clear Evidence | Adenoma (includes multiples) 2/50 2/50 2/50 5/49 | Neoplastic Lesions |
| No | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | No Evidence | Not applicable | Not applicable | |
| No | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Equivocal Evidence | Equivocal Evidence | ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50 | Neoplastic Lesions |
| No | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Mice | B6C3F1 | Male | Dosed-Feed | Lung | Equivocal Evidence | Equivocal Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50 | Neoplastic Lesions |
| Yes | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Rats | F344/N | Male | Dosed-Feed | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50 | May Have Been Related |
| No | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Rats | F344/N | Female | Dosed-Feed | Urinary Bladder | Clear Evidence | Clear Evidence | TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48 | Neoplastic Lesions |
| No | TR-299 | 2475-45-8 | C.I. Disperse Blue 1 | Rats | F344/N | Male | Dosed-Feed | Urinary Bladder | Clear Evidence | Clear Evidence | TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49 | Neoplastic Lesions |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Female | Whole Body Exposure | Adrenal Gland Medulla | Equivocal Evidence | Equivocal Evidence | benign, malignant, or complex pheochromocytoma (1/86, 9/89, 5/87, 4/88) | May Have Been Related |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Female | Whole Body Exposure | Brain | Equivocal Evidence | Equivocal Evidence | glioma malignant (0/90, 3/90, 0/90, 0/90) | May Have Been Related |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Brain | Clear Evidence | Clear Evidence | glioma malignant (0/90, 0/90, 0/90, 3/90) | Neoplastic Lesions |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Female | Whole Body Exposure | Heart | Equivocal Evidence | Equivocal Evidence | schwannoma malignant (0/90, 2/90, 0/90, 2/90) | May Have Been Related |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Heart | Clear Evidence | Clear Evidence | schwannoma malignant (0/90, 2/90, 3/90, 6/90) | Neoplastic Lesions |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Liver | Clear Evidence | Equivocal Evidence | hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88) | May Have Been Related |
| No | TR-595 | CELLPRADCDMA | Cell Phone Radiation: CDMA | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Pituitary Gland | Clear Evidence | Equivocal Evidence | pars distalis, adenoma (17/89, 25/90, 34/90, 13/90) | May Have Been Related |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87) | Neoplastic Lesions |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Brain | Clear Evidence | Equivocal Evidence | meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90) | May Have Been Related |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Brain | Clear Evidence | Clear Evidence | glioma malignant (0/90, 3/90, 3/90, 2/90) | Neoplastic Lesions |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Female | Whole Body Exposure | Heart | Equivocal Evidence | Equivocal Evidence | schwannoma malignant (0/90, 0/90, 2/90, 0/90) | May Have Been Related |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Heart | Clear Evidence | Clear Evidence | schwannoma malignant (0/90, 2/90, 1/90, 5/90) | Neoplastic Lesions |
| Yes | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | adenoma or carcinoma (13/90, 27/89, 19/86, 16/85) | May Have Been Related |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Pituitary Gland | Clear Evidence | Equivocal Evidence | pars distalis, adenoma (17/89, 28/90, 26/90, 26/90) | May Have Been Related |
| No | TR-595 | CELLPRADGSM | Cell Phone Radiation: GSM | Rats | Hsd:Sprague Dawley SD | Male | Whole Body Exposure | Prostate Gland | Clear Evidence | Equivocal Evidence | adenoma or carcinoma (2/90, 2/90, 7/90, 3/90) | May Have Been Related |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Female | Inhalation | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | benign pheochromocytoma 6/50 12/50 22/50 36/50 malignant pheochromocytoma 0/50 2/50 3/50 11/50 benign or malignant pheochromocytoma 6/50 13/50 23/50 40/50 | Neoplastic Lesions |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | benign pheochromocytoma 15/50 23/50 37/50 34/50 malignant pheochromocytoma 2/50 2/50 9/50 16/50 benign or malignant pheochromocytoma 17/50 23/50 38/50 41/50 | Neoplastic Lesions |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Female | Inhalation | All Organs | Clear Evidence | Clear Evidence | Mononuclear Cell Leukemia 16/50 29/50 28/50 27/50 | Neoplastic Lesions |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Kidney | Clear Evidence | Equivocal Evidence | adenoma or carcinoma (standard evaluation) 0/50 1/50 0/50 4/50 (standard and extended evaluations combined) 3/50 1/50 1/50 7/50 | May Have Been Related |
| No | TR-581 | 7440-48-4 | Cobalt | Mice | B6C3F1/N | Female | Inhalation | Lung | Clear Evidence | Equivocal Evidence | alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50 | May Have Been Related |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Lung | Clear Evidence | Equivocal Evidence | cystic keratinizing epithelioma 0/50 1/50 0/50 1/50 | May Have Been Related |
| No | TR-581 | 7440-48-4 | Cobalt | Mice | B6C3F1/N | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50 | Neoplastic Lesions |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50 | Neoplastic Lesions |
| No | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50 | Neoplastic Lesions |
| Yes | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Female | Inhalation | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | carcinoma 1/50 0/50 0/50 3/50 | May Have Been Related |
| Yes | TR-581 | 7440-48-4 | Cobalt | Rats | F344/NTac | Male | Inhalation | Pancreas Islet Cell | Clear Evidence | Clear Evidence | adenoma or carcinoma 2/50 2/50 10/48 9/49 | Neoplastic Lesions |
| Yes | TR-331 | 24382-04-5 | Malonaldehyde, sodium salt | Rats | F344/N | Male | Gavage | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | ADENOMA 0/49 9/50 1/49 | May Have Been Related |
| No | TR-331 | 24382-04-5 | Malonaldehyde, sodium salt | Rats | F344/N | Female | Gavage | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50 | Neoplastic Lesions |
| No | TR-331 | 24382-04-5 | Malonaldehyde, sodium salt | Rats | F344/N | Male | Gavage | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50 | Neoplastic Lesions |
| No | TR-540 | 7220-79-3 | Methylene blue trihydrate | Mice | B6C3F1 | Female | Gavage | Hematopoietic System | Equivocal Evidence | Equivocal Evidence | MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50 | May Have Been Related |
| No | TR-540 | 7220-79-3 | Methylene blue trihydrate | Mice | B6C3F1 | Male | Gavage | Hematopoietic System | Some Evidence | Equivocal Evidence | MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50 | May Have Been Related |
| No | TR-540 | 7220-79-3 | Methylene blue trihydrate | Mice | B6C3F1 | Male | Gavage | Intestines (Small) | Some Evidence | Some Evidence | CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50 | Neoplastic Lesions |
| Yes | TR-540 | 7220-79-3 | Methylene blue trihydrate | Rats | F344/N | Male | Gavage | Pancreas Islet Cell | Some Evidence | Some Evidence | ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Female | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | Adenoma 0/50 0/50 3/50 7/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | Adenoma 0/50 2/50 0/50 4/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Adenoma 0/50 0/50 0/50 3/50 | May Have Been Related |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Adenoma 2/50 0/50 3/50 4/50 | May Have Been Related |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Mice | B6C3F1/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | Fibroadenoma, multiple 22/50 24/50 43/50 38/50 | Neoplastic Lesions |
| No | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | Malignant Mesothelioma 1/50 5/50 10/50 6/50 | Neoplastic Lesions |
| Yes | TR-549 | 5589-96-8 | Water disinfection byproducts (Bromochloroacetic acid) | Rats | F344/N | Male | Dosed-Water | Pancreas Islet Cell | Clear Evidence | Equivocal Evidence | Adenoma 3/50 4/50 9/50 3/50 | May Have Been Related |