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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Pancreas Islet Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Female Gavage Pancreas Islet Cell Positive Positive ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47 Neoplastic Lesions
Yes TR-299 2475-45-8 C.I. Disperse Blue 1 Rats F344/N Male Dosed-Feed Pancreas Islet Cell Clear Evidence Equivocal Evidence ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50 May Have Been Related
Yes TR-331 24382-04-5 Malonaldehyde, sodium salt Rats F344/N Male Gavage Pancreas Islet Cell Clear Evidence Equivocal Evidence ADENOMA 0/49 9/50 1/49 May Have Been Related
Yes TR-540 7220-79-3 Methylene blue trihydrate Rats F344/N Male Gavage Pancreas Islet Cell Some Evidence Some Evidence ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50 Neoplastic Lesions
Yes TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Pancreas Islet Cell Clear Evidence Equivocal Evidence adenoma or carcinoma (13/90, 27/89, 19/86, 16/85) May Have Been Related
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Male Dosed-Water Pancreas Islet Cell Clear Evidence Clear Evidence adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48 Neoplastic Lesions
Yes TR-560 63-05-8 Androstenedione Mice B6C3F1/N Female Gavage Pancreas Islet Cell Clear Evidence Clear Evidence Adenoma 0/49 2/50 4/49 4/48 Neoplastic Lesions
Yes TR-560 63-05-8 Androstenedione Mice B6C3F1/N Male Gavage Pancreas Islet Cell Clear Evidence Clear Evidence Adenoma (includes multiples) 2/50 2/50 2/50 5/49 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Female Inhalation Pancreas Islet Cell Clear Evidence Equivocal Evidence carcinoma 1/50 0/50 0/50 3/50 May Have Been Related
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Male Inhalation Pancreas Islet Cell Clear Evidence Clear Evidence adenoma or carcinoma 2/50 2/50 10/48 9/49 Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Male Inhalation Pancreas Islet Cell Some Evidence Equivocal Evidence Adenoma 0/50 5/50 4/50 5/50 May Have Been Related
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Male Dosed-Water Pancreas Islet Cell Clear Evidence Equivocal Evidence Adenoma 3/50 4/50 9/50 3/50 May Have Been Related