Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Female	Gavage	Pancreas Islet Cell	Positive	Positive	ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47	Neoplastic Lesions
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50	May Have Been Related
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 9/50 1/49	May Have Been Related
Yes	TR-540	7220-79-3	Methylene blue trihydrate	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Some Evidence	Some Evidence	ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50	Neoplastic Lesions
Yes	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (13/90, 27/89, 19/86, 16/85)	May Have Been Related
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
Yes	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Female	Gavage	Pancreas Islet Cell	Clear Evidence	Clear Evidence	Adenoma 0/49 2/50 4/49 4/48	Neoplastic Lesions
Yes	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Male	Gavage	Pancreas Islet Cell	Clear Evidence	Clear Evidence	Adenoma (includes multiples) 2/50 2/50 2/50 5/49	Neoplastic Lesions
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	carcinoma 1/50 0/50 0/50 3/50	May Have Been Related
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma or carcinoma 2/50 2/50 10/48 9/49	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Pancreas Islet Cell	Some Evidence	Equivocal Evidence	Adenoma 0/50 5/50 4/50 5/50	May Have Been Related
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	Adenoma 3/50 4/50 9/50 3/50	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 1/50 2/50 5/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Intestines (Large)	Some Evidence	Some Evidence	Adenoma 0/50 0/50 2/50 1/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Equivocal Evidence	Malignant: 0/50 2/50 2/50 4/50	May Have Been Related
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Pancreas Islet Cell	Some Evidence	Equivocal Evidence	Adenoma 0/50 5/50 4/50 5/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Skin	Some Evidence	Some Evidence	Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Mice	B6C3F1	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Mice	B6C3F1	Female	Gavage	Liver	Positive	Positive	ADENOMA 2/50 3/50 12/50	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Female	Gavage	Liver	Positive	Positive	NEOPLASTIC NODULE 3/50 8/50 8/48	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Female	Gavage	Mammary Gland	Positive	Positive	FIBROADENOMA 15/50 21/50 18/50	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Positive	Positive	ADENOMA 1/47 3/47 7/49	Neoplastic Lesions
Yes	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Female	Gavage	Pancreas Islet Cell	Positive	Positive	ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Female	Gavage	Subcutaneous Tissue	Positive	Positive	FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Rats	F344/N	Male	Gavage	Subcutaneous Tissue	Positive	Positive	FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50	Neoplastic Lesions
No	TR-251	26471-62-5	2,4- & 2,6-Toluene diisocyanate	Mice	B6C3F1	Female	Gavage	Vascular System (Unspecified)	Positive	Positive	HEMANGIOMA 0/50 1/50 2/50 OR HEMANGIOSARCOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 5/50	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-560	63-05-8	Androstenedione	Rats	F344/N	Female	Gavage	All Organs	Equivocal Evidence	Equivocal Evidence	Mononuclear cell leukemia 5/50 11/50 18/50 15/50 (choose all organs until programmer intervention)	May Have Been Related
No	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	Adenoma 14/50 16/50 18/50 28/50 carcinoma 5/50 13/50 15/50 15/50 adenoma or carcinoma 17/50 23/50 27/50 32/50	Neoplastic Lesions
No	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	Hepatocellular adenoma, multiple 16/50 27/50 23/50 34/50 hepatocellular adenoma (includes multiples) 32/50 38/50 29/50 43/50 hepatocellular carcinoma multiple 7/50 12/50 10/50 17/50 hepatocellular adenoma or hepatocellular carcinoma (combined includes multiples) 41/50 47/50 42/50 48/50 hepatoblastoma 3/50 8/50 7/50 8/50 hepatocellular adenoma, carcinoma, or hepatoblastoma (combined) 41/50 47/50 43/50 48/50	Neoplastic Lesions
No	TR-560	63-05-8	Androstenedione	Rats	F344/N	Male	Gavage	Lung	Equivocal Evidence	Equivocal Evidence	Alveolar/bronchiolar adenoma 0/50 0/50 5/50 2/50 alveolar/bronchiolar adenoma or carcinoma (combined) 0/50 0/50 5/50 3/50	May Have Been Related
Yes	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Female	Gavage	Pancreas Islet Cell	Clear Evidence	Clear Evidence	Adenoma 0/49 2/50 4/49 4/48	Neoplastic Lesions
Yes	TR-560	63-05-8	Androstenedione	Mice	B6C3F1/N	Male	Gavage	Pancreas Islet Cell	Clear Evidence	Clear Evidence	Adenoma (includes multiples) 2/50 2/50 2/50 5/49	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Lung	Equivocal Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50	Neoplastic Lesions
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50	May Have Been Related
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Adrenal Gland Medulla	Equivocal Evidence	Equivocal Evidence	benign, malignant, or complex pheochromocytoma (1/86, 9/89, 5/87, 4/88)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Brain	Equivocal Evidence	Equivocal Evidence	glioma malignant (0/90, 3/90, 0/90, 0/90)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Clear Evidence	glioma malignant (0/90, 0/90, 0/90, 3/90)	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Heart	Equivocal Evidence	Equivocal Evidence	schwannoma malignant (0/90, 2/90, 0/90, 2/90)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 3/90, 6/90)	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Liver	Clear Evidence	Equivocal Evidence	hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pituitary Gland	Clear Evidence	Equivocal Evidence	pars distalis, adenoma (17/89, 25/90, 34/90, 13/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87)	Neoplastic Lesions
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Equivocal Evidence	meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Clear Evidence	glioma malignant (0/90, 3/90, 3/90, 2/90)	Neoplastic Lesions
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Heart	Equivocal Evidence	Equivocal Evidence	schwannoma malignant (0/90, 0/90, 2/90, 0/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 1/90, 5/90)	Neoplastic Lesions
Yes	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (13/90, 27/89, 19/86, 16/85)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pituitary Gland	Clear Evidence	Equivocal Evidence	pars distalis, adenoma (17/89, 28/90, 26/90, 26/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Prostate Gland	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (2/90, 2/90, 7/90, 3/90)	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign pheochromocytoma 6/50 12/50 22/50 36/50 malignant pheochromocytoma 0/50 2/50 3/50 11/50 benign or malignant pheochromocytoma 6/50 13/50 23/50 40/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign pheochromocytoma 15/50 23/50 37/50 34/50 malignant pheochromocytoma 2/50 2/50 9/50 16/50 benign or malignant pheochromocytoma 17/50 23/50 38/50 41/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 16/50 29/50 28/50 27/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Kidney	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (standard evaluation) 0/50 1/50 0/50 4/50 (standard and extended evaluations combined) 3/50 1/50 1/50 7/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Lung	Clear Evidence	Equivocal Evidence	cystic keratinizing epithelioma 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Mice	B6C3F1/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50	Neoplastic Lesions
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	carcinoma 1/50 0/50 0/50 3/50	May Have Been Related
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma or carcinoma 2/50 2/50 10/48 9/49	Neoplastic Lesions
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 9/50 1/49	May Have Been Related
No	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50	Neoplastic Lesions
No	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50	Neoplastic Lesions
No	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50	May Have Been Related
No	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50	May Have Been Related
No	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Male	Gavage	Intestines (Small)	Some Evidence	Some Evidence	CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50	Neoplastic Lesions
Yes	TR-540	7220-79-3	Methylene blue trihydrate	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Some Evidence	Some Evidence	ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 0/50 3/50 7/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 2/50 0/50 4/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 0/50 0/50 0/50 3/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 2/50 0/50 3/50 4/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	Fibroadenoma, multiple 22/50 24/50 43/50 38/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	Malignant Mesothelioma 1/50 5/50 10/50 6/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	Adenoma 3/50 4/50 9/50 3/50	May Have Been Related