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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Preputial Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Mice B6C3F1 Male Intraperitoneal Injection Preputial Gland Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Male Dosed-Feed Preputial Gland Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Preputial Gland Clear Evidence Equivocal Evidence SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50 May Have Been Related
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Male Gavage Preputial Gland Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35 Neoplastic Lesions
Yes TR-304 115-28-6 Chlorendic acid Rats F344/N Male Dosed-Feed Preputial Gland Clear Evidence Equivocal Evidence CARCINOMA 1/50 8/50 4/50 May Have Been Related
Yes TR-291 78-59-1 Isophorone Rats F344/N Male Gavage Preputial Gland Some Evidence Some Evidence CARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
Yes TR-332 149-30-4 2-Mercaptobenzothiazole Rats F344/N Male Gavage Preputial Gland Some Evidence Some Evidence ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Mice B6C3F1 Male Gavage Preputial Gland Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44 Neoplastic Lesions
Yes TR-368 389-08-2 Nalidixic acid Rats F344/N Male Dosed-Feed Preputial Gland Clear Evidence Clear Evidence ADENOMA 2/49 10/49 10/47, PAPILLOMA 1/49 0/49 0/47, OR CARCINOMA 0/49 10/49 12/47 COMBINED 3/49 19/49 20/47 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Preputial Gland Clear Evidence Clear Evidence ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50 Neoplastic Lesions
Yes TR-334 121-88-0 2-Amino-5-nitrophenol Rats F344/N Male Gavage Preputial Gland Some Evidence Equivocal Evidence ADENOMA 3/50 2/50 1/50 OR CARCINOMA 0/50 0/50 4/50 COMBINED 3/50 2/50 5/50 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Preputial Gland Clear Evidence Clear Evidence ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Preputial Gland Clear Evidence Clear Evidence ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Preputial Gland Clear Evidence Clear Evidence ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Preputial Gland Clear Evidence Clear Evidence CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50 Neoplastic Lesions
Yes TR-570 76231-76-0 alpha/beta Thujone mixture Rats F344/N Male Gavage Preputial Gland Some Evidence Some Evidence Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50 Neoplastic Lesions