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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Preputial Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50	May Have Been Related
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
Yes	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 1/50 8/50 4/50	May Have Been Related
Yes	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	CARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
Yes	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50	Neoplastic Lesions
Yes	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44	Neoplastic Lesions
Yes	TR-368	389-08-2	Nalidixic acid	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/49 10/49 10/47, PAPILLOMA 1/49 0/49 0/47, OR CARCINOMA 0/49 10/49 12/47 COMBINED 3/49 19/49 20/47	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
Yes	TR-334	121-88-0	2-Amino-5-nitrophenol	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Equivocal Evidence	ADENOMA 3/50 2/50 1/50 OR CARCINOMA 0/50 0/50 4/50 COMBINED 3/50 2/50 5/50	May Have Been Related
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
Yes	TR-570	76231-76-0	alpha/beta Thujone mixture	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 6/49 12/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 5/50 21/50 36/49 29/52	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/50 2/48 1/49	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 4/42 10/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 5/40 0/44	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 1/50 10/49 10/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 0/50 23/50 29/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ACINAR CELL CARCINOMA 0/50 2/49 6/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/49 6/45 12/48	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 11/48 18/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 16/49 7/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50	May Have Been Related
No	TR-334	121-88-0	2-Amino-5-nitrophenol	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-334	121-88-0	2-Amino-5-nitrophenol	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-334	121-88-0	2-Amino-5-nitrophenol	Rats	F344/N	Female	Gavage	Clitoral Gland	No Evidence	Equivocal Evidence	ADENOMA 2/50 1/50 7/50 OR CARCINOMA 1/50 2/50 0/50 COMBINED 3/50 3/50 7/50	May Have Been Related
No	TR-334	121-88-0	2-Amino-5-nitrophenol	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Some Evidence	Some Evidence	ADENOMA 1/50 10/50 3/49	Neoplastic Lesions
Yes	TR-334	121-88-0	2-Amino-5-nitrophenol	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Equivocal Evidence	ADENOMA 3/50 2/50 1/50 OR CARCINOMA 0/50 0/50 4/50 COMBINED 3/50 2/50 5/50	May Have Been Related
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Female	Gavage	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 1/50 5/50 6/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 7/50 16/50 3/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Mice	B6C3F1	Female	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 7/49 4/50 OR CARCINOMA 1/50 5/49 0/50 COMBINED 4/50 12/49 4/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Some Evidence	Some Evidence	ADENOMA 2/50 13/50 6/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Female	Gavage	Pituitary Gland	Some Evidence	Some Evidence	ADENOMA 15/49 24/50 25/50	Neoplastic Lesions
Yes	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland C-Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 2/44 3/75 1/60	May Have Been Related
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/60 2/45 14/75 20/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
No	TR-570	76231-76-0	alpha/beta Thujone mixture	Mice	B6C3F1/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-570	76231-76-0	alpha/beta Thujone mixture	Mice	B6C3F1/N	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-570	76231-76-0	alpha/beta Thujone mixture	Rats	F344/N	Male	Gavage	Adrenal Gland Medulla	Some Evidence	Equivocal Evidence	Benign pheochromocytoma 6/50 850 12/49	May Have Been Related
Yes	TR-570	76231-76-0	alpha/beta Thujone mixture	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 1/35 1/65 2/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/35 1/65 3/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 2/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
No	TR-304	115-28-6	Chlorendic acid	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-304	115-28-6	Chlorendic acid	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50	Neoplastic Lesions
No	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50	Neoplastic Lesions
No	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/50 21/50 23/50	Neoplastic Lesions
No	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/50 5/50	May Have Been Related
No	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 4/50 6/50	Neoplastic Lesions
Yes	TR-304	115-28-6	Chlorendic acid	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 1/50 8/50 4/50	May Have Been Related
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Female	Gavage	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/49 3/50 1/49	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Male	Gavage	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/50 4/50 1/49 COMBINED 0/50 6/50 4/49	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 40/47 36/43	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/48 3/47 8/44; SQUAMOUS CELL CARCINOMA 0/48 42/47 35/44	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 1/49 COMBINED 1/50 9/50 2/49	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/49 7/50 0/50; SQUAMOUS CELL CARCINOMA 0/49 7/50 0/50	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Female	Gavage	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Male	Gavage	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50	Neoplastic Lesions
No	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
Yes	TR-316	513-37-1	Dimethylvinyl chloride (DMVC)	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-291	78-59-1	Isophorone	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	LYMPHOMA 8/48 18/50 5/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 6/48 7/50 13/50 OR CARCINOMA 14/48 13/50 22/50 COMBINED 18/48 18/50 29/50	Neoplastic Lesions
Yes	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	CARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Subcutaneous Tissue	Equivocal Evidence	Equivocal Evidence	FIBROMA 0/48 2/50 3/50; FIBROSARCOMA 3/48 4/50 10/50; NEUROFIBROSARCOMA 1/48 0/50 0/50; SARCOMA 0/48 0/50 1/50	Neoplastic Lesions
No	TR-368	389-08-2	Nalidixic acid	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-368	389-08-2	Nalidixic acid	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 4/46 10/46 11/47, PAPILLOMA 0/46 1/46 0/47, OR CARCINOMA 1/46 4/46 5/47 COMBINED 5/46 15/46 16/47	Neoplastic Lesions
Yes	TR-368	389-08-2	Nalidixic acid	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/49 10/49 10/47, PAPILLOMA 1/49 0/49 0/47, OR CARCINOMA 0/49 10/49 12/47 COMBINED 3/49 19/49 20/47	Neoplastic Lesions
No	TR-368	389-08-2	Nalidixic acid	Mice	B6C3F1	Male	Dosed-Feed	Subcutaneous Tissue	Equivocal Evidence	Equivocal Evidence	FIBROMA 1/50 3/50 3/50 OR FIBROSARCOMA 4/50 6/50 11/50 COMBINED 5/50 9/50 14/50	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Preputial Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions