Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-054	121-14-2	2,4-Dinitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(FIBROMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-146	139-94-6	Nithiazide	Rats	F344/N	Female	Dosed-Feed	Skin	Positive	Positive	(FIBROADENOMA OR CYSTADENOMA)	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Skin	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50	May Have Been Related
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47)	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48)	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 0/46 2/48	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48)	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47	Neoplastic Lesions
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Skin	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50	May Have Been Related
Yes	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Female	Gavage	Skin	Clear Evidence	Clear Evidence	COMBINED 0/50 0/50 4/50 5/50	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
Yes	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	squamous cell carcinoma (0/50, 0/50, 0/50, 2/50)	May Have Been Related
Yes	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Male	Inhalation	Skin	Clear Evidence	Clear Evidence	fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50)	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50	May Have Been Related
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Skin	Some Evidence	Some Evidence	Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50	Neoplastic Lesions
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50	Neoplastic Lesions
Yes	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Rats	F344/N	Female	Dosed-Water	Skin	Some Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50	May Have Been Related
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50	Neoplastic Lesions
Yes	TR-584	700-06-1	Indole-3-carbinol	Rats	Harlan Sprague-Dawley	Female	Gavage	Skin	Some Evidence	Equivocal Evidence	fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50	May Have Been Related
Yes	TR-569	30516-87-1	AZT + NVP + 3TC	Mice	MV	Male	Gavage	Skin	Some Evidence	Some Evidence	(subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP	Neoplastic Lesions
Yes	TR-574	87-66-1	Pyrogallol	Mice	B6C3F1/N	Female	Topical Application	Skin	Some Evidence	Some Evidence	(site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50	Neoplastic Lesions
Yes	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Skin	Clear Evidence	Clear Evidence	Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 1/50 2/50 5/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Intestines (Large)	Some Evidence	Some Evidence	Adenoma 0/50 0/50 2/50 1/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Equivocal Evidence	Malignant: 0/50 2/50 2/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Pancreas Islet Cell	Some Evidence	Equivocal Evidence	Adenoma 0/50 5/50 4/50 5/50	May Have Been Related
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50	May Have Been Related
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Skin	Some Evidence	Some Evidence	Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 44/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 48/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Vascular System (Spleen)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland C-Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-054	121-14-2	2,4-Dinitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-054	121-14-2	2,4-Dinitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-054	121-14-2	2,4-Dinitrotoluene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(FIBROADENOMA)	Neoplastic Lesions
Yes	TR-054	121-14-2	2,4-Dinitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(FIBROMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 2/44 3/75 1/60	May Have Been Related
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/60 2/45 14/75 20/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(POLYP)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Adrenal Gland Cortex	Clear Evidence	Equivocal Evidence	Adenoma 1/50 1/50 3/50 4/49	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	All Organs	Clear Evidence	Equivocal Evidence	Malignant Lymphoma: 2/50 5/50 8/50 7/50	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell carcinoma 0/50 1/50 1/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell carcinoma 0/50 1/50 1/49 3/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell papilloma or carcinoma 0/50 1/50 0/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Liver	Clear Evidence	Clear Evidence	Cholangiocarcinoma 1/50 1/50 1/49 3/49	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Liver	Clear Evidence	Clear Evidence	Cholangiocarcinoma 0/50 4/50 4/50 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Lung	Clear Evidence	Clear Evidence	Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Lung	Clear Evidence	Clear Evidence	Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	Mucosa: Gingival squamous cell carcinoma 0/50 0/50 4/50 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	Mucosa: Gingival squamous cell carcinoma 1/50 5/50 4/50 5/50	Neoplastic Lesions
Yes	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Skin	Clear Evidence	Clear Evidence	Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Thoracic Cavity	Clear Evidence	Equivocal Evidence	Malignant Schwannoma: 0/50 0/50 1/50 3/50	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/50 3/50 4/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Ureter	Clear Evidence	Equivocal Evidence	Transitional epithelial carcinoma: 0/0 0/1 0/0 1/2	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Ureter	Clear Evidence	Equivocal Evidence	Transitional epithelial carcinoma: 0/43 0/45 1/47 0/50	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Urinary System	Clear Evidence	Clear Evidence	Urethra: Transitional epithelial gland carcinoma 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Urinary System	Clear Evidence	Clear Evidence	Urethra: Transitional epithelial gland carcinoma 0/50 32/50 46/49 49/50	Neoplastic Lesions
No	TR-569	30516-87-1	3'-Azido-3'-deoxythymidine (AIDS)	Mice	B6C3F1	Female	Gavage	Unspecified	Equivocal Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	3'-Azido-3'-deoxythymidine (AIDS)	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	3'-Azido-3'-deoxythymidine (AIDS)	Mice	MV	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	3'-Azido-3'-deoxythymidine (AIDS)	Mice	MV	Female	Gavage	Skin	Equivocal Evidence	Equivocal Evidence	(subcutaneous tissue): fibrosarcoma or sarcoma 2/63 0/46 4/47 5/48 -- AZT	May Have Been Related
No	TR-569	30516-87-1	3'-Azido-3'-deoxythymidine (AIDS)	Mice	MV	Female	Gavage	Thyroid Gland Follicular Cell	Equivocal Evidence	Equivocal Evidence	adenoma 0/59 1/46 0/46 3/47; adenoma or carcinoma 0/59 1/46 0/46 4/47 -- AZT	May Have Been Related
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50	May Have Been Related
No	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50	Neoplastic Lesions
Yes	TR-362	106-87-6	4-Vinyl-1-cyclohexene diepoxide	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Mice	B6C3F1	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal	(CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Rats	Wistar Han	Female	Inhalation	Adrenal Gland Medulla	Some Evidence	Some Evidence	benign pheochromocytoma (0/49, 2/49, 2/49, 6/50); benign or malignant pheochromocytoma (0/49, 2/49, 2/49, 7/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Rats	Wistar Han	Male	Inhalation	Adrenal Gland Medulla	Some Evidence	Some Evidence	benign pheochromocytoma (1/49, 0/50, 2/49, 7/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Female	Inhalation	All Organs	Clear Evidence	Clear Evidence	malignant lymphoma (7/50, 17/50, 20/50, 27/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Rats	Wistar Han	Female	Inhalation	Lung	Some Evidence	Equivocal Evidence	cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50)	May Have Been Related
No	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Rats	Wistar Han	Female	Inhalation	Lung	Some Evidence	Some Evidence	alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50)	Neoplastic Lesions
No	TR-590	1309-64-4	Antimony Trioxide	Rats	Wistar Han	Male	Inhalation	Lung	Some Evidence	Some Evidence	alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50)	Neoplastic Lesions
Yes	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	squamous cell carcinoma (0/50, 0/50, 0/50, 2/50)	May Have Been Related
Yes	TR-590	1309-64-4	Antimony Trioxide	Mice	B6C3F1	Male	Inhalation	Skin	Clear Evidence	Clear Evidence	fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50)	Neoplastic Lesions
No	TR-569	30516-87-1	AZT + 3TC	Mice	MV	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	AZT + 3TC	Mice	MV	Female	Gavage	Lung	Equivocal Evidence	Equivocal Evidence	alveolar/bronchiolar adenoma 2/62 1/48 3/50 6/48 -- AZT/3TC	May Have Been Related
No	TR-569	30516-87-1	AZT + NFV + 3TC	Mice	MV	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	AZT + NFV + 3TC	Mice	MV	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-569	30516-87-1	AZT + NVP + 3TC	Mice	MV	Female	Gavage	Skin	Equivocal Evidence	Equivocal Evidence	(subcutaneous tissue): fibrosarcoma 1/63 0/47 7/47 0/49 -- AZT/3TC/NVP	May Have Been Related
Yes	TR-569	30516-87-1	AZT + NVP + 3TC	Mice	MV	Male	Gavage	Skin	Some Evidence	Some Evidence	(subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 3/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 0/35 1/65 2/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 3/35 6/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Equivocal Evidence	LYMPHOMA 17/50 24/50 25/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 3/49 19/50 37/49	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 10/50 20/50 27/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 8/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50	May Have Been Related
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 0/50 15/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/50 20/50 16/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 1/50 13/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 1/35 1/65 2/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/35 1/65 3/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 2/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 0/50 6/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 1/50 10/50	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Skin	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50	May Have Been Related
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/49 1/50 5/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50 3/50	May Have Been Related
No	TR-510	64-17-5	Ethanol	Mice	MV	Female	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-510	64-17-5	Ethanol	Mice	MV	Male	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Intestines (Large)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 8/50 3/50 2/50	May Have Been Related
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Skin	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50	May Have Been Related
No	TR-584	700-06-1	Indole-3-carbinol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 26/50 32/50 31/49 41/50 hepatocellular carcinoma 12/50 11/50 29/49 14/50 hepatoblastoma 3/50 4/50 4/49 14/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/50 36/50 44/49 45/50	Neoplastic Lesions
Yes	TR-584	700-06-1	Indole-3-carbinol	Rats	Harlan Sprague-Dawley	Female	Gavage	Skin	Some Evidence	Equivocal Evidence	fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50	May Have Been Related
No	TR-584	700-06-1	Indole-3-carbinol	Rats	Harlan Sprague-Dawley	Female	Gavage	Uterus	Some Evidence	Some Evidence	adenocarcinoma (standard evaluation) 0/50 1/50 4/50 4/50 (standard and extended evaluations) combined 5/50 4/50 13/50 10/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 1/50 3/50	May Have Been Related
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	MALIGNANT NEUROENDOCRINE TUMOR 0/49 0/48 0/49 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 0/50 0/50 13/50 9/50 5/50 OR MALIGNANT NEUROENDOCRINE TUMOR 0/50 1/50 12/50 26/50 36/50 COMBINED 0/50 1/50 25/50 34/50 41/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 1/50 0/50 0/50 3/50 2/50 OR MALIGNANT NEURENDOCRINE TUMOR 0/50 0/50 0/50 4/50 2/50 COMBINED 1/50 0/50 0/50 7/50 4/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 5/50 5/50 15/50 13/50 6/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50	Neoplastic Lesions
No	TR-146	139-94-6	Nithiazide	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-146	139-94-6	Nithiazide	Mice	B6C3F1	Female	Dosed-Feed	Liver	Equivocal Evidence	Equivocal	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-146	139-94-6	Nithiazide	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-146	139-94-6	Nithiazide	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(FIBROADENOMA OR CYSTADENOMA)	Neoplastic Lesions
Yes	TR-146	139-94-6	Nithiazide	Rats	F344/N	Female	Dosed-Feed	Skin	Positive	Positive	(FIBROADENOMA OR CYSTADENOMA)	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/60 2/60 3/60 50/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 4/60 17/60 55/60 60/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 1/60 4/60 3/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 12/60 9/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 1/60 6/60	May Have Been Related
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 23/60 47/60 52/60 56/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60	Neoplastic Lesions
No	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Male	Gavage	Adrenal Gland Medulla	Equivocal Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 19/51 21/50 21/50 29/49 COMBINED 19/51 25/50 21/50 29/49	May Have Been Related
No	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA (STANDARD) 0/51 1/50 0/50 2/49 (EXTENDED) 4/51 12/50 1/50 5/49 COMBINED 4/51 13/50 1/50 6/49	May Have Been Related
No	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 1/50 1/50 8/49 COMBINED 1/50 1/50 1/50 10/49	Neoplastic Lesions
No	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ADEMONA 0/50 0/50 6/50 1/49 COMBINED 0/50 0/50 7/50 1/49	Neoplastic Lesions
No	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Male	Gavage	Skin	Equivocal Evidence	Equivocal Evidence	FIBROMA 0/51 5/50 2/49 2/50 COMBINED 0/51 7/50 2/49 2/50	May Have Been Related
Yes	TR-485	434-07-1	Oxymetholone	Rats	F344/N	Female	Gavage	Skin	Clear Evidence	Clear Evidence	COMBINED 0/50 0/50 4/50 5/50	Neoplastic Lesions
No	TR-574	87-66-1	Pyrogallol	Mice	B6C3F1/N	Male	Topical Application	Skin	Equivocal Evidence	Equivocal Evidence	(site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 2/50	May Have Been Related
Yes	TR-574	87-66-1	Pyrogallol	Mice	B6C3F1/N	Female	Topical Application	Skin	Some Evidence	Some Evidence	(site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Preputial Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 1/47 5/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 0/46 2/48	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/45 1/47 4/46	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 0/48 2/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47)	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	malignant mesothelioma 1/50 12/50 18/50 37/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 3/50 1/50	May Have Been Related
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 4/50 3/50	May Have Been Related
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 28/50 47/50 47/50 39/50 carcinoma 0/50 1/50 3/50 8/50 fibroadenoma, adenoma, or carcinoma 28/50 47/50 48/50 42/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	(oral mucosa and tongue): squamous cell papilloma or squamous cell carcinoma 1/50 0/50 3/50 3/50	May Have Been Related
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50	Neoplastic Lesions
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50	Neoplastic Lesions
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Mice	B6C3F1/N	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	Squamous cell papilloma 1/50 0/50 5/50 14/50	Neoplastic Lesions
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Mice	B6C3F1/N	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	Squamous cell papilloma or carcinoma 0/50 1/50 0/50 5/50	Neoplastic Lesions
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Rats	F344/N	Male	Dosed-Water	Glandular Stomach	Clear Evidence	Clear Evidence	Adenoma 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50	May Have Been Related
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50	Neoplastic Lesions
No	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Some Evidence	Some Evidence	Squamous cell papilloma 1/50 0/50 4/50 0/50	Neoplastic Lesions
Yes	TR-544	3252-43-5	Water disinfection byproducts (Dibromoacetonitrile)	Rats	F344/N	Female	Dosed-Water	Skin	Some Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50	May Have Been Related