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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:
- Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
- Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
- Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Yes | TR-054 | 121-14-2 | 2,4-Dinitrotoluene | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (FIBROMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Mice | B6C3F1 | Male | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Female | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Male | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (PAPILLOMA OR CARCINOMA) | Neoplastic Lesions |
Yes | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
Yes | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA) | Neoplastic Lesions |
Yes | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-146 | 139-94-6 | Nithiazide | Rats | F344/N | Female | Dosed-Feed | Skin | Positive | Positive | (FIBROADENOMA OR CYSTADENOMA) | Neoplastic Lesions |
Yes | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50 | Neoplastic Lesions |
Yes | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50 | Neoplastic Lesions |
Yes | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50 | Neoplastic Lesions |
Yes | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50 | Neoplastic Lesions |
Yes | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60 | Neoplastic Lesions |
Yes | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Male | Dosed-Feed | Skin | Some Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50 | May Have Been Related |
Yes | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Rats | F344/N | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Rats | F344/N | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50 | Neoplastic Lesions |
Yes | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60 | Neoplastic Lesions |
Yes | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60 | Neoplastic Lesions |
Yes | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50 | Neoplastic Lesions |
Yes | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60 | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47) | Neoplastic Lesions |
Yes | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Female | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | (SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60 | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48) | Neoplastic Lesions |
Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/48 0/46 2/48 | Neoplastic Lesions |
Yes | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50 | Neoplastic Lesions |
Yes | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60 | Neoplastic Lesions |
Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48) | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47 | Neoplastic Lesions |
Yes | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Male | Inhalation | Skin | Clear Evidence | Equivocal Evidence | FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50 | May Have Been Related |
Yes | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Female | Gavage | Skin | Clear Evidence | Clear Evidence | COMBINED 0/50 0/50 4/50 5/50 | Neoplastic Lesions |
Yes | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | (SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60 | Neoplastic Lesions |
Yes | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48 | Neoplastic Lesions |
Yes | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43 | Neoplastic Lesions |
Yes | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45 | Neoplastic Lesions |
Yes | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46 | Neoplastic Lesions |
Yes | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Female | Inhalation | Skin | Clear Evidence | Equivocal Evidence | squamous cell carcinoma (0/50, 0/50, 0/50, 2/50) | May Have Been Related |
Yes | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Male | Inhalation | Skin | Clear Evidence | Clear Evidence | fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50) | Neoplastic Lesions |
Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Female | Inhalation | Skin | Clear Evidence | Equivocal Evidence | Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50 | May Have Been Related |
Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Skin | Some Evidence | Some Evidence | Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50 | Neoplastic Lesions |
Yes | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50 | Neoplastic Lesions |
Yes | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Rats | F344/N | Female | Dosed-Water | Skin | Some Evidence | Equivocal Evidence | Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50 | May Have Been Related |
Yes | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50 | Neoplastic Lesions |
Yes | TR-584 | 700-06-1 | Indole-3-carbinol | Rats | Harlan Sprague-Dawley | Female | Gavage | Skin | Some Evidence | Equivocal Evidence | fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50 | May Have Been Related |
Yes | TR-569 | 30516-87-1 | AZT + NVP + 3TC | Mice | MV | Male | Gavage | Skin | Some Evidence | Some Evidence | (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP | Neoplastic Lesions |
Yes | TR-574 | 87-66-1 | Pyrogallol | Mice | B6C3F1/N | Female | Topical Application | Skin | Some Evidence | Some Evidence | (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50 | Neoplastic Lesions |
Yes | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Skin | Clear Evidence | Clear Evidence | Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50 | Neoplastic Lesions |
Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Female | Inhalation | Intestines (Large) | Clear Evidence | Clear Evidence | Adenoma 0/50 1/50 2/50 5/50 | Neoplastic Lesions |
No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Intestines (Large) | Some Evidence | Some Evidence | Adenoma 0/50 0/50 2/50 1/50 | Neoplastic Lesions |
No | TR-564 | 106-94-5 | 1-Bromopropane | Mice | B6C3F1/N | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50 | Neoplastic Lesions |
No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Some Evidence | Equivocal Evidence | Malignant: 0/50 2/50 2/50 4/50 | May Have Been Related |
No | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Pancreas Islet Cell | Some Evidence | Equivocal Evidence | Adenoma 0/50 5/50 4/50 5/50 | May Have Been Related |
Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Female | Inhalation | Skin | Clear Evidence | Equivocal Evidence | Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50 | May Have Been Related |
Yes | TR-564 | 106-94-5 | 1-Bromopropane | Rats | F344/N | Male | Inhalation | Skin | Some Evidence | Some Evidence | Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Female | Dosed-Feed | Esophagus | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Esophagus | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Forestomach | Clear Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Male | Dosed-Feed | Forestomach | Clear Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Male | Dosed-Feed | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Hematopoietic System | Clear Evidence | Clear Evidence | MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Intestines (Small) | Clear Evidence | Clear Evidence | ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Kidney Tubular Cell | Clear Evidence | Equivocal Evidence | ADENOMA 0/51 0/53 1/51 3/55 1/59 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Male | Dosed-Feed | Kidney Tubular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/51 3/50 2/49 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Male | Dosed-Feed | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Mammary Gland | Clear Evidence | Equivocal Evidence | CARCINOMA 0/52 0/50 1/51 2/50 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 25/50 45/51 46/53 45/52 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Female | Dosed-Feed | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Pancreas Acinar Cell | Clear Evidence | Equivocal Evidence | ADENOMA 1/51 2/53 4/51 3/53 3/59 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Seminal Vesicle | Clear Evidence | Clear Evidence | ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59 | Neoplastic Lesions |
Yes | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Subcutaneous Tissue | Clear Evidence | Clear Evidence | SARCOMA 0/52 1/50 4/51 11/50 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Subcutaneous Tissue | Clear Evidence | Clear Evidence | FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Urinary Bladder | Clear Evidence | Clear Evidence | TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59 | Neoplastic Lesions |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Mice | B6C3F1 | Female | Dosed-Feed | Vascular System (Unspecified) | Clear Evidence | Equivocal Evidence | HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50 | May Have Been Related |
No | TR-452 | 3296-90-0 | 2,2-bis(Bromomethyl)-1,3-propanediol | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Esophagus | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Esophagus | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Female | Topical Application | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Kidney Tubular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/50 4/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Kidney Tubular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/50 4/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Female | Topical Application | Lung | Clear Evidence | Equivocal Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50 | May Have Been Related |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Mammary Gland | Clear Evidence | Clear Evidence | ADENOCARCINOMA 0/50 0/50 5/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | 0/50 1/50 4/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Nasal Cavity | Clear Evidence | Clear Evidence | ADENOMA 0/50 44/50 49/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Nasal Cavity | Clear Evidence | Clear Evidence | ADENOMA 0/50 48/50 48/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Mice | B6C3F1 | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50 | Neoplastic Lesions |
Yes | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Vascular System (Spleen) | Clear Evidence | Clear Evidence | HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Female | Topical Application | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50 | Neoplastic Lesions |
No | TR-400 | 96-13-9 | 2,3-Dibromo-1-propanol | Rats | F344/N | Male | Topical Application | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50 | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Clitoral Gland | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Preputial Gland | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
Yes | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Mice | B6C3F1 | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Mice | B6C3F1 | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Positive | Positive | (SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Positive | Positive | (SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-054 | 121-14-2 | 2,4-Dinitrotoluene | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-054 | 121-14-2 | 2,4-Dinitrotoluene | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-054 | 121-14-2 | 2,4-Dinitrotoluene | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Positive | Positive | (FIBROADENOMA) | Neoplastic Lesions |
Yes | TR-054 | 121-14-2 | 2,4-Dinitrotoluene | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (FIBROMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
Yes | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (PAPILLOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Female | Dosed-Feed | Uterus/Cervix | Positive | Positive | (ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-093 | 6109-97-3 | 3-Amino-9-ethylcarbazole HCl | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | ASTROCYTOMA 0/60 2/44 3/75 1/60 | May Have Been Related |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | ADENOCARCINOMA 1/60 2/45 14/75 20/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MESOTHELIOMA 2/60 1/45 7/75 6/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Preputial Gland | Clear Evidence | Clear Evidence | ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59 | Neoplastic Lesions |
Yes | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60 | Neoplastic Lesions |
Yes | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Uterus/Cervix | Clear Evidence | Clear Evidence | ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60 | Neoplastic Lesions |
No | TR-372 | 20325-40-0 | 3,3'-Dimethoxybenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60 | Neoplastic Lesions |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Female | Dosed-Feed | Hematopoietic System | Positive | Positive | (LYMPHOMA OR LEUKEMIA) | Neoplastic Lesions |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Male | Dosed-Feed | Hematopoietic System | Positive | Positive | (LYMPHOMA OR LEUKEMIA) | Neoplastic Lesions |
Yes | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Female | Dosed-Feed | Uterus/Cervix | Positive | Positive | (POLYP) | Neoplastic Lesions |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-128 | 91-93-0 | 3,3'-Dimethoxybenzidine-4,4'-diisocyanate | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60 | May Have Been Related |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60 | May Have Been Related |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Hematopoietic System | Clear Evidence | Equivocal Evidence | MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60 | May Have Been Related |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | ADENOCARCINOMA 0/60 1/45 3/75 6/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MESOTHELIOMA 0/60 0/45 3/75 4/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Preputial Gland | Clear Evidence | Clear Evidence | ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60 | Neoplastic Lesions |
Yes | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60 | Neoplastic Lesions |
Yes | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Female | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60 | Neoplastic Lesions |
No | TR-390 | 612-82-8 | 3,3'-Dimethylbenzidine dihydrochloride | Rats | F344/N | Male | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Adrenal Gland Cortex | Clear Evidence | Equivocal Evidence | Adenoma 1/50 1/50 3/50 4/49 | May Have Been Related |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | All Organs | Clear Evidence | Equivocal Evidence | Malignant Lymphoma: 2/50 5/50 8/50 7/50 | May Have Been Related |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Forestomach | Clear Evidence | Clear Evidence | Squamous cell carcinoma 0/50 1/50 1/50 4/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Male | Gavage | Forestomach | Clear Evidence | Clear Evidence | Squamous cell carcinoma 0/50 1/50 1/49 3/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Forestomach | Clear Evidence | Clear Evidence | Squamous cell papilloma or carcinoma 0/50 1/50 0/50 4/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Liver | Clear Evidence | Clear Evidence | Cholangiocarcinoma 1/50 1/50 1/49 3/49 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Liver | Clear Evidence | Clear Evidence | Cholangiocarcinoma 0/50 4/50 4/50 6/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Lung | Clear Evidence | Clear Evidence | Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Male | Gavage | Lung | Clear Evidence | Clear Evidence | Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Lung | Clear Evidence | Clear Evidence | Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Lung | Clear Evidence | Clear Evidence | Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Female | Gavage | Oral Cavity | Clear Evidence | Clear Evidence | Mucosa: Gingival squamous cell carcinoma 0/50 0/50 4/50 6/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Oral Cavity | Clear Evidence | Clear Evidence | Mucosa: Gingival squamous cell carcinoma 1/50 5/50 4/50 5/50 | Neoplastic Lesions |
Yes | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Skin | Clear Evidence | Clear Evidence | Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Thoracic Cavity | Clear Evidence | Equivocal Evidence | Malignant Schwannoma: 0/50 0/50 1/50 3/50 | May Have Been Related |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Rats | Harlan Sprague-Dawley | Male | Gavage | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/50 3/50 4/50 4/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Ureter | Clear Evidence | Equivocal Evidence | Transitional epithelial carcinoma: 0/0 0/1 0/0 1/2 | May Have Been Related |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Male | Gavage | Ureter | Clear Evidence | Equivocal Evidence | Transitional epithelial carcinoma: 0/43 0/45 1/47 0/50 | May Have Been Related |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Female | Gavage | Urinary System | Clear Evidence | Clear Evidence | Urethra: Transitional epithelial gland carcinoma 0/50 0/50 0/50 2/50 | Neoplastic Lesions |
No | TR-558 | 14047-09-7 | 3,3',4,4'-Tetrachloroazobenzene | Mice | B6C3F1/N | Male | Gavage | Urinary System | Clear Evidence | Clear Evidence | Urethra: Transitional epithelial gland carcinoma 0/50 32/50 46/49 49/50 | Neoplastic Lesions |
No | TR-569 | 30516-87-1 | 3'-Azido-3'-deoxythymidine (AIDS) | Mice | B6C3F1 | Female | Gavage | Unspecified | Equivocal Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | 3'-Azido-3'-deoxythymidine (AIDS) | Mice | B6C3F1 | Male | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | 3'-Azido-3'-deoxythymidine (AIDS) | Mice | MV | Male | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | 3'-Azido-3'-deoxythymidine (AIDS) | Mice | MV | Female | Gavage | Skin | Equivocal Evidence | Equivocal Evidence | (subcutaneous tissue): fibrosarcoma or sarcoma 2/63 0/46 4/47 5/48 -- AZT | May Have Been Related |
No | TR-569 | 30516-87-1 | 3'-Azido-3'-deoxythymidine (AIDS) | Mice | MV | Female | Gavage | Thyroid Gland Follicular Cell | Equivocal Evidence | Equivocal Evidence | adenoma 0/59 1/46 0/46 3/47; adenoma or carcinoma 0/59 1/46 0/46 4/47 -- AZT | May Have Been Related |
No | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Female | Topical Application | Lung | Clear Evidence | Equivocal Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 5/50 8/50 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 3/50 1/50 COMBINED 4/50 9/50 11/50 7/50 | May Have Been Related |
No | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Female | Topical Application | Ovary | Clear Evidence | Clear Evidence | BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Mice | B6C3F1 | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Rats | F344/N | Female | Topical Application | Skin | Clear Evidence | Clear Evidence | BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50 | Neoplastic Lesions |
Yes | TR-362 | 106-87-6 | 4-Vinyl-1-cyclohexene diepoxide | Rats | F344/N | Male | Topical Application | Skin | Clear Evidence | Clear Evidence | BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50 | Neoplastic Lesions |
No | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Rats | F344/N | Female | Dosed-Feed | Clitoral Gland | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions |
No | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Equivocal Evidence | Equivocal | (CARCINOMA) | Neoplastic Lesions |
No | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
Yes | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-127 | 99-59-2 | 5-Nitro-o-anisidine | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | carcinoma 1/4 6/48 12/47 3/48 8/47 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis | Clear Evidence | Clear Evidence | malignant mesothelioma 2/48 2/48 1/48 5/48 8/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis or Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 2/48 2/48 1/48 5/48 8/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 4/46 0/46 2/48 5/45 8/42 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 0/45 8/44 20/48 32/47 31/43 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | malignant Schwannoma 2/48 1/48 0/48 2/48 4/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | malignant Schwannoma 1/48 2/48 3/48 4/48 6/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | adenoma 0/48 0/48 1/48 1/48 3/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | fibroadenoma 16/48 18/48 24/46 22/47 31/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Pancreas Islet Cell | Clear Evidence | Clear Evidence | adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48 | Neoplastic Lesions |
Yes | TR-575 | 79-06-1 | Acrylamide | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43 | Neoplastic Lesions |
Yes | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 1/48 2/48 1/48 1/48 5/48 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Female | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47 | Neoplastic Lesions |
No | TR-575 | 79-06-1 | Acrylamide | Rats | F344 (NCTR) | Male | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48 | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Rats | Wistar Han | Female | Inhalation | Adrenal Gland Medulla | Some Evidence | Some Evidence | benign pheochromocytoma (0/49, 2/49, 2/49, 6/50); benign or malignant pheochromocytoma (0/49, 2/49, 2/49, 7/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Rats | Wistar Han | Male | Inhalation | Adrenal Gland Medulla | Some Evidence | Some Evidence | benign pheochromocytoma (1/49, 0/50, 2/49, 7/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Female | Inhalation | All Organs | Clear Evidence | Clear Evidence | malignant lymphoma (7/50, 17/50, 20/50, 27/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Rats | Wistar Han | Female | Inhalation | Lung | Some Evidence | Equivocal Evidence | cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) | May Have Been Related |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Rats | Wistar Han | Female | Inhalation | Lung | Some Evidence | Some Evidence | alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50) | Neoplastic Lesions |
No | TR-590 | 1309-64-4 | Antimony Trioxide | Rats | Wistar Han | Male | Inhalation | Lung | Some Evidence | Some Evidence | alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50) | Neoplastic Lesions |
Yes | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Female | Inhalation | Skin | Clear Evidence | Equivocal Evidence | squamous cell carcinoma (0/50, 0/50, 0/50, 2/50) | May Have Been Related |
Yes | TR-590 | 1309-64-4 | Antimony Trioxide | Mice | B6C3F1 | Male | Inhalation | Skin | Clear Evidence | Clear Evidence | fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50) | Neoplastic Lesions |
No | TR-569 | 30516-87-1 | AZT + 3TC | Mice | MV | Male | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | AZT + 3TC | Mice | MV | Female | Gavage | Lung | Equivocal Evidence | Equivocal Evidence | alveolar/bronchiolar adenoma 2/62 1/48 3/50 6/48 -- AZT/3TC | May Have Been Related |
No | TR-569 | 30516-87-1 | AZT + NFV + 3TC | Mice | MV | Female | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | AZT + NFV + 3TC | Mice | MV | Male | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
No | TR-569 | 30516-87-1 | AZT + NVP + 3TC | Mice | MV | Female | Gavage | Skin | Equivocal Evidence | Equivocal Evidence | (subcutaneous tissue): fibrosarcoma 1/63 0/47 7/47 0/49 -- AZT/3TC/NVP | May Have Been Related |
Yes | TR-569 | 30516-87-1 | AZT + NVP + 3TC | Mice | MV | Male | Gavage | Skin | Some Evidence | Some Evidence | (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Male | Gavage | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 0/49 9/46 13/49 11/48 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Female | Gavage | Hematopoietic System | Clear Evidence | Clear Evidence | LYMPHOMA 15/49 25/45 26/50 22/49 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Male | Gavage | Hematopoietic System | Clear Evidence | Clear Evidence | LYMPHOMA 4/49 10/48 10/50 15/49 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Female | Gavage | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Male | Gavage | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Female | Gavage | Mammary Gland | Clear Evidence | Clear Evidence | CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Female | Gavage | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Male | Gavage | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Female | Gavage | Ovary | Clear Evidence | Clear Evidence | BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Male | Gavage | Preputial Gland | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35 | Neoplastic Lesions |
Yes | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Female | Gavage | Zymbal Gland | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Mice | B6C3F1 | Male | Gavage | Zymbal Gland | Clear Evidence | Clear Evidence | SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Female | Gavage | Zymbal Gland | Clear Evidence | Clear Evidence | CARCINOMA 0/45 5/40 5/44 14/46 | Neoplastic Lesions |
No | TR-289 | 71-43-2 | Benzene | Rats | F344/N | Male | Gavage | Zymbal Gland | Clear Evidence | Clear Evidence | CARCINOMA 2/32 6/46 10/42 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Adrenal Gland Medulla | Clear Evidence | Equivocal Evidence | PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Adrenal Gland Medulla | Clear Evidence | Equivocal Evidence | PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Hematopoietic System | Clear Evidence | Equivocal Evidence | MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | NEOPLASMS 0/50 1/35 0/65 3/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Intestines (Small) | Clear Evidence | Clear Evidence | NEOPLASMS 0/50 0/35 1/65 2/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Lung | Clear Evidence | Equivocal Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Mammary Gland | Clear Evidence | Equivocal Evidence | ADENOCARCINOMA 0/50 3/35 6/65 3/50 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Oral Cavity | Clear Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50 | May Have Been Related |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50 | Neoplastic Lesions |
Yes | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50 | Neoplastic Lesions |
Yes | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Female | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50 | Neoplastic Lesions |
No | TR-405 | 6459-94-5 | C.I. Acid Red 114 | Rats | F344/N | Male | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Hematopoietic System | Clear Evidence | Equivocal Evidence | LYMPHOMA 17/50 24/50 25/50 | May Have Been Related |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 3/49 19/50 37/49 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 10/50 20/50 27/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | CARCINOMA 0/50 2/50 8/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Clear Evidence | Equivocal Evidence | ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50 | May Have Been Related |
Yes | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Female | Dosed-Feed | Subcutaneous Tissue | Clear Evidence | Clear Evidence | FIBROMA 0/50 15/50 10/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Subcutaneous Tissue | Clear Evidence | Clear Evidence | FIBROMA 2/50 20/50 16/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Clear Evidence | Clear Evidence | CARCINOMA 0/50 2/50 7/50 | Neoplastic Lesions |
No | TR-285 | 569-61-9 | C.I. Basic Red 9 Monohydrochloride | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Clear Evidence | Clear Evidence | CARCINOMA 1/50 1/50 13/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | ASTROCYTOMA 0/50 1/35 1/65 2/50 | May Have Been Related |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Hematopoietic System | Clear Evidence | Equivocal Evidence | MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50 | May Have Been Related |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Hematopoietic System | Clear Evidence | Clear Evidence | MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/50 0/35 3/65 1/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Intestines (Large) | Clear Evidence | Clear Evidence | NEOPLASMS 0/50 1/35 6/65 8/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Intestines (Small) | Clear Evidence | Clear Evidence | ADENOCARCINOMA 0/50 0/35 1/65 3/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Intestines (Small) | Clear Evidence | Clear Evidence | NEOPLASMS 0/50 1/35 0/65 2/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Preputial Gland | Clear Evidence | Clear Evidence | ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48 | Neoplastic Lesions |
Yes | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50 | Neoplastic Lesions |
Yes | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Uterus/Cervix | Clear Evidence | Clear Evidence | ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Female | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50 | Neoplastic Lesions |
No | TR-397 | 2429-74-5 | C.I. Direct Blue 15 | Rats | F344/N | Male | Dosed-Water | Zymbal Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50 | Neoplastic Lesions |
No | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Male | Dosed-Feed | Adrenal Gland Medulla | Some Evidence | Some Evidence | PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50 | Neoplastic Lesions |
No | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Mice | B6C3F1 | Male | Dosed-Feed | Kidney Tubular Cell | Some Evidence | Some Evidence | ADENOMA 0/50 0/50 0/50 6/50 | Neoplastic Lesions |
No | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Female | Dosed-Feed | Liver | Some Evidence | Some Evidence | ADENOMA 0/50 0/50 1/50 10/50 | Neoplastic Lesions |
Yes | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Male | Dosed-Feed | Skin | Some Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50 | May Have Been Related |
No | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Mice | B6C3F1 | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Some Evidence | Some Evidence | ADENOMA 0/50 0/49 1/50 5/50 | Neoplastic Lesions |
No | TR-407 | 2425-85-6 | C.I. Pigment Red 3 | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Some Evidence | Equivocal Evidence | CARCINOMA 0/50 0/50 2/50 3/50 | May Have Been Related |
No | TR-510 | 64-17-5 | Ethanol | Mice | MV | Female | Dosed-Water | Unspecified | Inadequate Study | Not applicable | Not applicable | |
No | TR-510 | 64-17-5 | Ethanol | Mice | MV | Male | Dosed-Water | Unspecified | Inadequate Study | Not applicable | Not applicable | |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | All Organs | Clear Evidence | Equivocal Evidence | Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48 | May Have Been Related |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | All Organs | Clear Evidence | Clear Evidence | Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Clitoral Gland | Clear Evidence | Clear Evidence | carcinoma 4/48 6/48 7/48 11/48 14/47 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis | Clear Evidence | Clear Evidence | malignant mesothelioma 0/48 1/45 3/48 10/47 17/47 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Epididymis or Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 0/48 1/48 3/48 10/47 17/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 1/45 1/45 1/47 5/45 9/44 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | squamous cell papilloma 0/48 1/48 0/48 0/47 3/46 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 2/45 19/47 20/47 24/46 40/46 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 3/47 17/47 23/47 32/46 42/47 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | malignant schwannoma 2/48 3/48 3/48 7/47 8/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | fibroadenoma 16/48 26/48 35/48 33/48 36/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Equivocal Evidence | granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44 | May Have Been Related |
Yes | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45 | Neoplastic Lesions |
Yes | TR-588 | 5694-00-8 | Glycidamide | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Testis | Clear Evidence | Clear Evidence | malignant mesothelioma 0/48 1/47 3/48 6/47 13/48 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Female | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47 | Neoplastic Lesions |
No | TR-588 | 5694-00-8 | Glycidamide | Rats | F344 (NCTR) | Male | Dosed-Water | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Brain | Clear Evidence | Clear Evidence | GLIOMA 0/50 4/50 4/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Brain | Clear Evidence | Clear Evidence | GLIOMA 0/50 5/50 6/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Clitoral Gland | Clear Evidence | Clear Evidence | ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Epididymis | Clear Evidence | Equivocal Evidence | SARCOMA 0/50 0/50 2/50 | May Have Been Related |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Glandular Stomach | Clear Evidence | Equivocal Evidence | FIBROSARCOMA 0/50 0/50 2/50 | May Have Been Related |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Hematopoietic System | Clear Evidence | Clear Evidence | LEUKEMIA 13/50 14/50 20/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Kidney Tubular Cell | Clear Evidence | Clear Evidence | ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Mammary Gland | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 3/50 8/50 7/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MESOTHELIOMA 3/50 34/50 39/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Oral Cavity | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 | Neoplastic Lesions |
Yes | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Subcutaneous Tissue | Clear Evidence | Clear Evidence | SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Female | Gavage | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Thyroid Gland Follicular Cell | Clear Evidence | Clear Evidence | ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Male | Gavage | Urinary Bladder | Clear Evidence | Equivocal Evidence | CARCINOMA 0/50 1/50 1/50 | May Have Been Related |
No | TR-374 | 556-52-5 | Glycidol | Mice | B6C3F1 | Female | Gavage | Uterus/Cervix | Clear Evidence | Clear Evidence | CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50 | Neoplastic Lesions |
No | TR-374 | 556-52-5 | Glycidol | Rats | F344/N | Male | Gavage | Zymbal Gland | Clear Evidence | Clear Evidence | CARCINOMA 1/50 3/50 6/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Female | Inhalation | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Male | Inhalation | Adrenal Gland Medulla | Clear Evidence | Clear Evidence | BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Female | Inhalation | Hematopoietic System | Clear Evidence | Equivocal Evidence | MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50 | May Have Been Related |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Male | Inhalation | Hematopoietic System | Clear Evidence | Equivocal Evidence | MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50 | May Have Been Related |
No | TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Male | Inhalation | Intestines (Large) | Clear Evidence | Equivocal Evidence | CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50 | May Have Been Related |
No | TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Mice | B6C3F1 | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50 | Neoplastic Lesions |
No | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Female | Inhalation | Mammary Gland | Clear Evidence | Equivocal Evidence | CARCINOMA 0/50 8/50 3/50 2/50 | May Have Been Related |
Yes | TR-499 | 22398-80-7 | Indium phosphide | Rats | F344/N | Male | Inhalation | Skin | Clear Evidence | Equivocal Evidence | FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50 | May Have Been Related |
No | TR-584 | 700-06-1 | Indole-3-carbinol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 26/50 32/50 31/49 41/50 hepatocellular carcinoma 12/50 11/50 29/49 14/50 hepatoblastoma 3/50 4/50 4/49 14/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/50 36/50 44/49 45/50 | Neoplastic Lesions |
Yes | TR-584 | 700-06-1 | Indole-3-carbinol | Rats | Harlan Sprague-Dawley | Female | Gavage | Skin | Some Evidence | Equivocal Evidence | fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50 | May Have Been Related |
No | TR-584 | 700-06-1 | Indole-3-carbinol | Rats | Harlan Sprague-Dawley | Female | Gavage | Uterus | Some Evidence | Some Evidence | adenocarcinoma (standard evaluation) 0/50 1/50 4/50 4/50 (standard and extended evaluations) combined 5/50 4/50 13/50 10/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Female | Gavage | Forestomach | Clear Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 1/50 3/50 | May Have Been Related |
No | TR-491 | 93-15-2 | Methyleugenol | Mice | B6C3F1 | Male | Gavage | Glandular Stomach | Clear Evidence | Clear Evidence | MALIGNANT NEUROENDOCRINE TUMOR 0/49 0/48 0/49 2/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Female | Gavage | Glandular Stomach | Clear Evidence | Clear Evidence | BENIGN NEUROENDOCRINE TUMOR 0/50 0/50 13/50 9/50 5/50 OR MALIGNANT NEUROENDOCRINE TUMOR 0/50 1/50 12/50 26/50 36/50 COMBINED 0/50 1/50 25/50 34/50 41/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Glandular Stomach | Clear Evidence | Clear Evidence | BENIGN NEUROENDOCRINE TUMOR 1/50 0/50 0/50 3/50 2/50 OR MALIGNANT NEURENDOCRINE TUMOR 0/50 0/50 0/50 4/50 2/50 COMBINED 1/50 0/50 0/50 7/50 4/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Kidney Tubular Cell | Clear Evidence | Clear Evidence | ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Mice | B6C3F1 | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Mice | B6C3F1 | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 5/50 5/50 15/50 13/50 6/50 | Neoplastic Lesions |
No | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50 | Neoplastic Lesions |
Yes | TR-491 | 93-15-2 | Methyleugenol | Rats | F344/N | Male | Gavage | Skin | Clear Evidence | Clear Evidence | FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50 | Neoplastic Lesions |
No | TR-146 | 139-94-6 | Nithiazide | Rats | F344/N | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-146 | 139-94-6 | Nithiazide | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Equivocal Evidence | Equivocal | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-146 | 139-94-6 | Nithiazide | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-146 | 139-94-6 | Nithiazide | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Positive | Positive | (FIBROADENOMA OR CYSTADENOMA) | Neoplastic Lesions |
Yes | TR-146 | 139-94-6 | Nithiazide | Rats | F344/N | Female | Dosed-Feed | Skin | Positive | Positive | (FIBROADENOMA OR CYSTADENOMA) | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Female | Dosed-Feed | Hematopoietic System | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/60 2/60 3/60 50/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Male | Dosed-Feed | Hematopoietic System | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 4/60 17/60 55/60 60/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Female | Dosed-Feed | Intestines (Large) | Clear Evidence | Clear Evidence | (CECUM) CARCINOMA 0/60 1/60 4/60 3/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Male | Dosed-Feed | Intestines (Large) | Clear Evidence | Clear Evidence | (CECUM) CARCINOMA 0/60 12/60 9/60 0/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Female | Dosed-Feed | Liver | Clear Evidence | Equivocal Evidence | ADENOMA 1/60 0/59 1/60 6/60 | May Have Been Related |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Liver | Clear Evidence | Clear Evidence | ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 23/60 47/60 52/60 56/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Mammary Gland | Clear Evidence | Clear Evidence | FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60 | Neoplastic Lesions |
No | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Clear Evidence | Clear Evidence | MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60 | Neoplastic Lesions |
Yes | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Female | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | (SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60 | Neoplastic Lesions |
Yes | TR-504 | 88-72-2 | o-Nitrotoluene | Rats | F344/N | Male | Dosed-Feed | Skin | Clear Evidence | Clear Evidence | (SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60 | Neoplastic Lesions |
No | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Male | Gavage | Adrenal Gland Medulla | Equivocal Evidence | Equivocal Evidence | PHEOCHROMOCYTOMA 19/51 21/50 21/50 29/49 COMBINED 19/51 25/50 21/50 29/49 | May Have Been Related |
No | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Male | Gavage | Kidney Tubular Cell | Equivocal Evidence | Equivocal Evidence | ADENOMA (STANDARD) 0/51 1/50 0/50 2/49 (EXTENDED) 4/51 12/50 1/50 5/49 COMBINED 4/51 13/50 1/50 6/49 | May Have Been Related |
No | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Female | Gavage | Liver | Clear Evidence | Clear Evidence | ADENOMA 1/50 1/50 1/50 8/49 COMBINED 1/50 1/50 1/50 10/49 | Neoplastic Lesions |
No | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Female | Gavage | Lung | Clear Evidence | Clear Evidence | ADEMONA 0/50 0/50 6/50 1/49 COMBINED 0/50 0/50 7/50 1/49 | Neoplastic Lesions |
No | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Male | Gavage | Skin | Equivocal Evidence | Equivocal Evidence | FIBROMA 0/51 5/50 2/49 2/50 COMBINED 0/51 7/50 2/49 2/50 | May Have Been Related |
Yes | TR-485 | 434-07-1 | Oxymetholone | Rats | F344/N | Female | Gavage | Skin | Clear Evidence | Clear Evidence | COMBINED 0/50 0/50 4/50 5/50 | Neoplastic Lesions |
No | TR-574 | 87-66-1 | Pyrogallol | Mice | B6C3F1/N | Male | Topical Application | Skin | Equivocal Evidence | Equivocal Evidence | (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 2/50 | May Have Been Related |
Yes | TR-574 | 87-66-1 | Pyrogallol | Mice | B6C3F1/N | Female | Topical Application | Skin | Some Evidence | Some Evidence | (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50 | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Mice | B6C3F1 | Female | Intraperitoneal Injection | Hematopoietic System | Positive | Positive | (LYMPHOMA, LEUKEMIA) | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Mice | B6C3F1 | Male | Intraperitoneal Injection | Hematopoietic System | Positive | Positive | (LYMPHOMA, LEUKEMIA) | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Male | Intraperitoneal Injection | Hematopoietic System | Positive | Positive | (LYMPHOMA OR LEUKEMIA) | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Mice | B6C3F1 | Male | Intraperitoneal Injection | Preputial Gland | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Mice | B6C3F1 | Male | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Female | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
Yes | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Male | Intraperitoneal Injection | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Female | Intraperitoneal Injection | Zymbal Gland | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
No | TR-058 | 52-24-4 | tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) | Rats | Sprague Dawley | Male | Intraperitoneal Injection | Zymbal Gland | Positive | Positive | (SQUAMOUS CELL CARCINOMA) | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/48 1/47 5/48 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39 | Neoplastic Lesions |
Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/48 0/46 2/48 | Neoplastic Lesions |
Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48) | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/45 1/47 4/46 | Neoplastic Lesions |
No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Uterus/Cervix | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/47 0/48 2/46 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45 | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47 | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47) | Neoplastic Lesions |
Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48) | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46 | Neoplastic Lesions |
No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | All Organs | Clear Evidence | Clear Evidence | malignant mesothelioma 1/50 12/50 18/50 37/50 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Female | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 3/50 1/50 | May Have Been Related |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Brain | Clear Evidence | Equivocal Evidence | glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 4/50 3/50 | May Have Been Related |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Mice | B6C3F1/N | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Mice | B6C3F1/N | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | fibroadenoma 28/50 47/50 47/50 39/50 carcinoma 0/50 1/50 3/50 8/50 fibroadenoma, adenoma, or carcinoma 28/50 47/50 48/50 42/50 | Neoplastic Lesions |
No | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Oral Cavity | Clear Evidence | Equivocal Evidence | (oral mucosa and tongue): squamous cell papilloma or squamous cell carcinoma 1/50 0/50 3/50 3/50 | May Have Been Related |
Yes | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50 | Neoplastic Lesions |
Yes | TR-583 | 71133-14-7 | Water disinfection byproducts (Bromodichloroacetic Acid) | Rats | F344/NTac | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50 | Neoplastic Lesions |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Mice | B6C3F1/N | Female | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | Squamous cell papilloma 1/50 0/50 5/50 14/50 | Neoplastic Lesions |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Mice | B6C3F1/N | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | Squamous cell papilloma or carcinoma 0/50 1/50 0/50 5/50 | Neoplastic Lesions |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Rats | F344/N | Male | Dosed-Water | Glandular Stomach | Clear Evidence | Clear Evidence | Adenoma 0/50 0/50 0/50 2/50 | Neoplastic Lesions |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Mice | B6C3F1/N | Male | Dosed-Water | Liver | Clear Evidence | Equivocal Evidence | Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50 | May Have Been Related |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Rats | F344/N | Male | Dosed-Water | Oral Cavity | Clear Evidence | Clear Evidence | Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50 | Neoplastic Lesions |
No | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Rats | F344/N | Female | Dosed-Water | Oral Cavity | Some Evidence | Some Evidence | Squamous cell papilloma 1/50 0/50 4/50 0/50 | Neoplastic Lesions |
Yes | TR-544 | 3252-43-5 | Water disinfection byproducts (Dibromoacetonitrile) | Rats | F344/N | Female | Dosed-Water | Skin | Some Evidence | Equivocal Evidence | Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50 | May Have Been Related |