COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Skin
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-054 121-14-2 2,4-Dinitrotoluene Rats F344/N Male Dosed-Feed Skin Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Mice B6C3F1 Male Intraperitoneal Injection Skin Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Rats Sprague Dawley Female Intraperitoneal Injection Skin Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Rats Sprague Dawley Male Intraperitoneal Injection Skin Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Male Dosed-Feed Skin Positive Positive (PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Male Dosed-Feed Skin Positive Positive (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
Yes TR-127 99-59-2 5-Nitro-o-anisidine Rats F344/N Male Dosed-Feed Skin Positive Positive (TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Male Dosed-Feed Skin Positive Positive (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-146 139-94-6 Nithiazide Rats F344/N Female Dosed-Feed Skin Positive Positive (FIBROADENOMA OR CYSTADENOMA) Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Rats F344/N Male Gavage Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Male Dosed-Feed Skin Clear Evidence Clear Evidence TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Female Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Female Gavage Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Male Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60 Neoplastic Lesions
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Rats F344/N Male Dosed-Feed Skin Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50 May Have Been Related
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice B6C3F1 Female Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice B6C3F1 Male Topical Application Skin Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Rats F344/N Female Topical Application Skin Clear Evidence Clear Evidence BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50 Neoplastic Lesions
Yes TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Rats F344/N Male Topical Application Skin Clear Evidence Clear Evidence BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Skin Clear Evidence Clear Evidence SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Skin Clear Evidence Clear Evidence BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Skin Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47) Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Female Dosed-Feed Skin Clear Evidence Clear Evidence (SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Skin Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48) Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Skin Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/48 0/48 0/46 2/48 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Male Gavage Skin Clear Evidence Clear Evidence FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Skin Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48) Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Skin Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Male Inhalation Skin Clear Evidence Equivocal Evidence FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50 May Have Been Related
Yes TR-485 434-07-1 Oxymetholone Rats F344/N Female Gavage Skin Clear Evidence Clear Evidence COMBINED 0/50 0/50 4/50 5/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats F344/N Male Dosed-Feed Skin Clear Evidence Clear Evidence (SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Skin Clear Evidence Clear Evidence subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Skin Clear Evidence Clear Evidence fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Skin Clear Evidence Clear Evidence fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Male Dosed-Water Skin Clear Evidence Clear Evidence squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46 Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Mice B6C3F1 Female Inhalation Skin Clear Evidence Equivocal Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 2/50) May Have Been Related
Yes TR-590 1309-64-4 Antimony Trioxide Mice B6C3F1 Male Inhalation Skin Clear Evidence Clear Evidence fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50) Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Female Inhalation Skin Clear Evidence Equivocal Evidence Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50 May Have Been Related
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Male Inhalation Skin Some Evidence Some Evidence Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50 Neoplastic Lesions
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Male Dosed-Water Skin Clear Evidence Clear Evidence (subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50 Neoplastic Lesions
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Rats F344/N Female Dosed-Water Skin Some Evidence Equivocal Evidence Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50 May Have Been Related
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Male Dosed-Water Skin Clear Evidence Clear Evidence squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50 Neoplastic Lesions
Yes TR-584 700-06-1 Indole-3-carbinol Rats Harlan Sprague-Dawley Female Gavage Skin Some Evidence Equivocal Evidence fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50 May Have Been Related
Yes TR-569 30516-87-1 AZT + NVP + 3TC Mice MV Male Gavage Skin Some Evidence Some Evidence (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP Neoplastic Lesions
Yes TR-574 87-66-1 Pyrogallol Mice B6C3F1/N Female Topical Application Skin Some Evidence Some Evidence (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice B6C3F1/N Female Gavage Skin Clear Evidence Clear Evidence Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50 Neoplastic Lesions