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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Spleen
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-020 80-08-0 4,4'-Sulfonyldianiline (Dapsone) Rats F344/N Male Dosed-Feed Spleen Positive Positive (FIBROMA, FIBROSARCOMA, SARCOMA) Neoplastic Lesions
Yes TR-130 142-04-1 Aniline hydrochloride Rats F344/N Female Dosed-Feed Spleen Positive Positive SARCOMA Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Female Dosed-Feed Spleen Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Male Dosed-Feed Spleen Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-154 103-33-3 Azobenzene Rats F344/N Female Dosed-Feed Spleen Positive Positive (FIBROSARCOMA) Neoplastic Lesions
Yes TR-154 103-33-3 Azobenzene Rats F344/N Male Dosed-Feed Spleen Positive Positive (SARCOMA, FIBROSARCOMA) Neoplastic Lesions
Yes TR-225 5160-02-1 D&C Red No. 9 Rats F344/N Male Dosed-Feed Spleen Positive Positive SARCOMA 0/50 0/50 26/48 Neoplastic Lesions
Yes TR-360 121-69-7 N,N-Dimethylaniline Rats F344/N Male Gavage Spleen Some Evidence Some Evidence SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50 Neoplastic Lesions
Yes TR-351 20265-96-7 p-Chloroaniline hydrochloride Rats F344/N Male Gavage Spleen Clear Evidence Clear Evidence FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice B6C3F1/N Male Inhalation Spleen Clear Evidence Equivocal Evidence hemangioscaroma May Have Been Related
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Spleen Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/48 0/45 1/47 4/46 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Spleen Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Spleen Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46 Neoplastic Lesions