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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Subcutaneous Tissue
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats F344/N Female Dosed-Feed Subcutaneous Tissue Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats F344/N Male Dosed-Feed Subcutaneous Tissue Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Rats Osborne Mendel Male Gavage Subcutaneous Tissue Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-081 512-56-1 Trimethylphosphate Rats F344/N Male Gavage Subcutaneous Tissue Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Male Dosed-Feed Subcutaneous Tissue Positive Positive (FIBROMA) Neoplastic Lesions
Yes TR-201 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice Swiss Webster Female Topical Application Subcutaneous Tissue Positive Positive FIBROSARCOMA 2/41 8/27 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Inhalation Subcutaneous Tissue Positive Positive FIBROSARCOMA 0/50 5/50 11/50 Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Female Gavage Subcutaneous Tissue Positive Positive FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50 Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats F344/N Male Gavage Subcutaneous Tissue Positive Positive FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50 Neoplastic Lesions
Yes TR-278 87-62-7 2,6-Xylidine Rats CD Female Dosed-Feed Subcutaneous Tissue Positive Equivocal Evidence FIBROMA 0/56 2/56 1/56 4/56; FIBROSARCOMA 1/56 0/56 1/56 3/56 May Have Been Related
Yes TR-278 87-62-7 2,6-Xylidine Rats CD Male Dosed-Feed Subcutaneous Tissue Positive Equivocal Evidence FIBROMA 0/56 1/56 2/56 4/56; FIBROSARCOMA 0/56 1/56 0/56 1/56 May Have Been Related
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Female Dosed-Feed Subcutaneous Tissue Clear Evidence Clear Evidence FIBROMA 0/50 15/50 10/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Male Dosed-Feed Subcutaneous Tissue Clear Evidence Clear Evidence FIBROMA 2/50 20/50 16/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Female Gavage Subcutaneous Tissue Clear Evidence Clear Evidence SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50 Neoplastic Lesions
Yes TR-341 67-20-9 Nitrofurantoin Rats F344/N Male Dosed-Feed Subcutaneous Tissue Some Evidence Equivocal Evidence FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50 May Have Been Related
Yes TR-359 298-81-7 8-Methoxypsoralen Rats F344/N Male Gavage Subcutaneous Tissue Clear Evidence Equivocal Evidence FIBROMA 1/50 5/50 7/49 May Have Been Related
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Subcutaneous Tissue Clear Evidence Equivocal Evidence NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80 May Have Been Related
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Subcutaneous Tissue Clear Evidence Clear Evidence SARCOMA 0/50 11/50 11/50 18/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Subcutaneous Tissue Clear Evidence Clear Evidence FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Subcutaneous Tissue Clear Evidence Clear Evidence SARCOMA 0/52 1/50 4/51 11/50 Neoplastic Lesions