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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 36/50 33/50 40/50 44/50	Neoplastic Lesions
Yes	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	interstitial cell adenoma	May Have Been Related
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	INTERSTITIAL CELL ADENOMA 39/50 40/50 48/50 47/50	May Have Been Related
Yes	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 33/50 37/50 44/50 48/50	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
Yes	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Testis	Some Evidence	Equivocal Evidence	Adenoma, interstitial cell 29/50 39/50 31/50 41/50	May Have Been Related
Yes	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Testis	Clear Evidence	Equivocal Evidence	interstitial cell, adenoma (7/50, 3/50, 3/50, 6/50, 15/50)	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Nasal Cavity	Clear Evidence	Clear Evidence	respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Female	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Spleen	Clear Evidence	Equivocal Evidence	hemangioscaroma	May Have Been Related
Yes	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	interstitial cell adenoma	May Have Been Related
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma	May Have Been Related
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma (1/49, 0/50, 5/50, 9/50, 5/48); hepatocellular carcinoma (0/49, 0/50, 0/50, 0/50, 8/48); hepatocellular adenoma or carcinoma (combined) (1/49, 0/50, 5/50, 9/50, 13/48)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma (0/50, 0/50, 1/50, 1/50, 13/49); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 2/49); hepatocellular adenoma or carcinoma (combined) (0/50, 0/50, 1/50, 1/50, 14/49)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma (0/50, 1/49, 0/50, 3/50, 8/49); hepatocellular carcinoma (1/50, 0/49, 0/50, 0/50, 3/49); hepatocellular adenoma or carcinoma (combined) (1/50, 1/49, 0/50, 3/50, 11/49)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma (0/50, 2/50, 0/50, 1/50, 6/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 6/50); hepatocellular adenoma or carcinoma (combined) (0/50, 2/50, 0/50, 1/50, 12/50)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	acinar adenoma or carcinoma (combined) (0/49, 0/50, 0/50, 2/50, 1/48)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	acinar adenoma or carcinoma (combined) (0/50, 0/50, 0/50, 1/50, 2/47)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	acinar adenoma (10/50, 7/49, 8/50, 36/50, 22/49); acinar carcinoma (0/50, 0/49, 0/50, 3/50, 1/49); acinar adenoma or carcinoma (combined) (10/50, 7/49, 8/50, 38/50, 22/49)	Neoplastic Lesions
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	acinar adenoma (1/49, 4/50, 5/50, 23/50, 30/50); acinar carcinoma (0/49, 1/50, 0/50, 1/50, 5/50); acinar adenoma or carcinoma (combined) (1/49, 5/50, 5/50, 23/50, 33/50)	Neoplastic Lesions
Yes	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Male	Dosed-Feed	Testis	Clear Evidence	Equivocal Evidence	interstitial cell, adenoma (7/50, 3/50, 3/50, 6/50, 15/50)	May Have Been Related
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Uterus	Clear Evidence	Equivocal Evidence	adenoma, adenocarcinoma, squamous cell carcinoma, or squamous cell papilloma (combined) (3/50, 1/50, 1/50, 3/50, 7/50)	May Have Been Related
No	TR-601	117-81-7	Di(2-ethylhexyl) Phthalate	Rats	Harlan Sprague-Dawley	Female	Dosed-Feed	Uterus	Clear Evidence	Clear Evidence	adenoma, adenocarcinoma, squamous cell carcinoma, or squamous cell papilloma (combined) (2/50, 4/50, 1/50, 6/50, 13/50)	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Mice	B6C3F1	Female	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Mice	B6C3F1	Male	Inhalation	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50	Neoplastic Lesions
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 36/50 33/50 40/50 44/50	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Female	Inhalation	Brain	Some Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 0/50 1/50 0/50, GLIOMA 0/50 0/50 0/50 1/50, MEDULOBLASTOMA 0/50 0/50 0/50 1/50, MENINGEAL GRANULAR CELL TUMOR 0/50 1/50 0/50 1/50, MENINGEAL SARCOMA 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 2/50 4/50 6/50 21/50 FIBROADENOMA OR CARCINOMA COMBINED 2/50 5/50 7/50 21/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Some Evidence	Some Evidence	FIBROADENOMA 19/50 35/50 32/50 32/50 MULTIPLE FIBROADENOMA 7/50 12/50 19/50 17/50	Neoplastic Lesions
Yes	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 33/50 37/50 44/50 48/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50	May Have Been Related
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	INTERSTITIAL CELL ADENOMA 39/50 40/50 48/50 47/50	May Have Been Related
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 5/48 2/47 1/47 OR HEMANGIOSARCOMA 0/48 27/48 27/47 34/47 COMBINED 0/48 31/48 28/47 35/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 10/48 5/48 2/48 OR HEMANGIOSARCOMA 0/48 21/48 27/48 37/48 COMBINED 0/48 26/48 30/48 38/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 5/50 1/50	Neoplastic Lesions
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Kidney	Some Evidence	Some Evidence	Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50	Neoplastic Lesions
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Female	Inhalation	Liver	Some Evidence	Some Evidence	Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50	Neoplastic Lesions
No	TR-561	119-64-2	Tetralin	Mice	B6C3F1/N	Female	Inhalation	Spleen	Equivocal Evidence	Equivocal Evidence	Hemangiosarcoma 1/50 0/50 1/50 4/50	May Have Been Related
Yes	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Testis	Some Evidence	Equivocal Evidence	Adenoma, interstitial cell 29/50 39/50 31/50 41/50	May Have Been Related
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Female	Inhalation	Uterus	Some Evidence	Some Evidence	Stromal polyp 6/50 10/50 9/50 17/50	Neoplastic Lesions