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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:
- Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
- Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
- Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Yes | TR-033 | 961-11-5 | Tetrachlorvinphos | Rats | Osborne Mendel | Female | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA | Neoplastic Lesions |
Yes | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
Yes | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA OR CARCINOMA, ADENOMA | Neoplastic Lesions |
Yes | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Female | Dosed-Water | Thyroid Gland C-Cell | Positive | Positive | ADENOMA 0/47 3/47 6/48 | Neoplastic Lesions |
Yes | TR-238 | 137-30-4 | Ziram | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | CARCINOMA 0/50 2/49 7/49 | Neoplastic Lesions |
Yes | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Female | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50 | Neoplastic Lesions |
Yes | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Female | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma (2/50, 8/50, 8/50, 14/50) | Neoplastic Lesions |
Yes | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Male | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma (2/50, 5/49, 3/49, 12/50) | Neoplastic Lesions |
Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Rats | F344/N | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Rats | F344/N | Female | Dosed-Feed | Clitoral Gland | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA, CARCINOMA) | Neoplastic Lesions |
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Lung | Positive | Positive | (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) | Neoplastic Lesions |
Yes | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Female | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA OR CARCINOMA, ADENOMA | Neoplastic Lesions |
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Mice | B6C3F1 | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA | Neoplastic Lesions |
No | TR-143 | 2243-62-1 | 1,5-Naphthalenediamine | Rats | F344/N | Female | Dosed-Feed | Uterus/Cervix | Positive | Positive | (POLYP) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Clitoral Gland | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Preputial Gland | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Skin | Positive | Positive | (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
Yes | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Mice | B6C3F1 | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Mice | B6C3F1 | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA OR CARCINOMA | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Female | Dosed-Feed | Zymbal Gland | Positive | Positive | (SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-084 | 39156-41-7 | 2,4-Diaminoanisole sulfate | Rats | F344/N | Male | Dosed-Feed | Zymbal Gland | Positive | Positive | (SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Male | Dosed-Water | Adrenal Gland Medulla | Positive | Positive | PHEOCHROMOCYTOMA 2/48 12/49 14/49 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Female | Dosed-Water | Hematopoietic System | Positive | Positive | LYMPHOMA 13/50 28/50 29/50 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Female | Dosed-Water | Liver | Positive | Positive | ADENOMA 3/50 9/50 12/50 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Male | Dosed-Water | Liver | Positive | Positive | CARCINOMA 10/49 33/50 29/50 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Male | Dosed-Water | Liver | Positive | Positive | NEOPLASTIC NODULE 1/50 12/50 25/50 | Neoplastic Lesions |
Yes | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Female | Dosed-Water | Thyroid Gland C-Cell | Positive | Positive | ADENOMA 0/47 3/47 6/48 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Female | Dosed-Water | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA 0/50 1/47 13/50 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Mice | B6C3F1 | Male | Dosed-Water | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA 0/47 3/49 16/49 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Female | Dosed-Water | Thyroid Gland Follicular Cell | Positive | Positive | ADENOMA 0/47 2/47 17/48 | Neoplastic Lesions |
No | TR-248 | 13552-44-8 | 4,4'-Methylenedianiline dihydrochloride | Rats | F344/N | Male | Dosed-Water | Thyroid Gland Follicular Cell | Positive | Positive | CARCINOMA 0/49 0/47 7/48 | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Female | Inhalation | Adrenal Gland Medulla | Some Evidence | Some Evidence | benign pheochromocytoma (0/49, 3/50, 4/50, 6/50) | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Mice | B6C3F1 | Female | Inhalation | Harderian Gland | Clear Evidence | Clear Evidence | adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50) | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Mice | B6C3F1 | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50) | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Mice | B6C3F1 | Male | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50) | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Male | Inhalation | Lung | Some Evidence | Equivocal Evidence | alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50) | May Have Been Related |
Yes | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Female | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma (2/50, 8/50, 8/50, 14/50) | Neoplastic Lesions |
Yes | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Male | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma (2/50, 5/49, 3/49, 12/50) | Neoplastic Lesions |
No | TR-594 | 98-56-6 | p-Chloro-a,a,a-trifluorotoluene | Rats | Harlan Sprague-Dawley | Female | Inhalation | Uterus | Some Evidence | Some Evidence | adenocarcinoma (1/50, 1/50, 0/50, 5/50); stromal polyp (7/50, 9/50, 16/50, 12/50) | Neoplastic Lesions |
No | TR-033 | 961-11-5 | Tetrachlorvinphos | Rats | Osborne Mendel | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-033 | 961-11-5 | Tetrachlorvinphos | Rats | Osborne Mendel | Female | Dosed-Feed | Adrenal Gland Cortex | Positive | Positive | ADENOMA | Neoplastic Lesions |
No | TR-033 | 961-11-5 | Tetrachlorvinphos | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (NEOPLASTIC NODULE) | Neoplastic Lesions |
No | TR-033 | 961-11-5 | Tetrachlorvinphos | Mice | B6C3F1 | Male | Dosed-Feed | Liver | Positive | Positive | (CARCINOMA) | Neoplastic Lesions |
Yes | TR-033 | 961-11-5 | Tetrachlorvinphos | Rats | Osborne Mendel | Female | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | ADENOMA | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Female | Inhalation | All Organs | Some Evidence | Equivocal Evidence | malignant mesothelioma 0/50 1/50 1/50 0/50 | May Have Been Related |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Female | Inhalation | All Organs | Clear Evidence | Clear Evidence | hemangioma or hemangiosarcoma 4/50 6/50 6/50 11/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Male | Inhalation | All Organs | Clear Evidence | Clear Evidence | malignant mesothelioma 1/50 12/50 28/50 23/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Female | Inhalation | All Organs | Some Evidence | Some Evidence | mononuclear cell leukemia 10/50 11/50 13/50 25/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Female | Inhalation | Intestines (Small) | Clear Evidence | Equivocal Evidence | (Duodenum, Jejunum, or Ileum): carcinoma 1/50 1/50 1/50 3/50 | May Have Been Related |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Male | Inhalation | Kidney | Clear Evidence | Clear Evidence | renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Male | Inhalation | Kidney | Clear Evidence | Clear Evidence | renal tubule carcinoma 0/50 2/50 1/49 1/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Male | Inhalation | Liver | Clear Evidence | Equivocal Evidence | hepatocholangiocarcionoma 1/50 2/50 2/50 3/50 | May Have Been Related |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50 | Neoplastic Lesions |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Mice | B6C3F1/N | Female | Inhalation | Lung | Clear Evidence | Equivocal Evidence | alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49 | May Have Been Related |
No | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Male | Inhalation | Nasal Cavity | Clear Evidence | Clear Evidence | respiratory epithelium, adenoma 0/49 0/50 1/50 4/50 | Neoplastic Lesions |
Yes | TR-582 | 75-35-4 | Vinylidene Chloride | Rats | F344/N | Female | Inhalation | Thyroid Gland C-Cell | Some Evidence | Some Evidence | adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50 | Neoplastic Lesions |
No | TR-238 | 137-30-4 | Ziram | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-238 | 137-30-4 | Ziram | Rats | F344/N | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
No | TR-238 | 137-30-4 | Ziram | Mice | B6C3F1 | Female | Dosed-Feed | Lung | Equivocal Evidence | Equivocal | ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 5/49 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/49 1/50 COMBINED 4/50 6/49 11/50 | Neoplastic Lesions |
Yes | TR-238 | 137-30-4 | Ziram | Rats | F344/N | Male | Dosed-Feed | Thyroid Gland C-Cell | Positive | Positive | CARCINOMA 0/50 2/49 7/49 | Neoplastic Lesions |