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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Thyroid Gland Follicular Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-047 139-65-1 4,4'-Thiodianiline Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-112 17026-81-2 3-Amino-4-ethoxyacetanilide Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-129 2489-77-2 Trimethylthiourea Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-149 105-55-5 N,N'-Diethylthiourea Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-149 105-55-5 N,N'-Diethylthiourea Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Positive Positive ADENOMA OR CARCINOMA Neoplastic Lesions
Yes TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice B6C3F1 Female Gavage Thyroid Gland Follicular Cell Positive Positive ADENOMA 0/69 3/50 1/47 5/46 Neoplastic Lesions
Yes TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Rats Osborne Mendel Male Gavage Thyroid Gland Follicular Cell Positive Positive ADENOMA 1/69 5/48 6/50 10/50 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Female Dosed-Water Thyroid Gland Follicular Cell Positive Positive ADENOMA 0/50 1/47 13/50 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Male Dosed-Water Thyroid Gland Follicular Cell Positive Positive ADENOMA 0/47 3/49 16/49 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats F344/N Female Dosed-Water Thyroid Gland Follicular Cell Positive Positive ADENOMA 0/47 2/47 17/48 Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats F344/N Male Dosed-Water Thyroid Gland Follicular Cell Positive Positive CARCINOMA 0/49 0/47 7/48 Neoplastic Lesions
Yes TR-271 2784-94-3 HC Blue 1 Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence ADENOMA 0/47 0/49 5/50 May Have Been Related
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice B6C3F1 Female Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats F344/N Female Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50 Neoplastic Lesions
Yes TR-331 24382-04-5 Malonaldehyde, sodium salt Rats F344/N Male Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50 Neoplastic Lesions
Yes TR-388 96-45-7 Ethylene thiourea (ETU) Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50 Neoplastic Lesions
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence Some Evidence ADENOMA 0/50 0/49 1/50 5/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49 Neoplastic Lesions
Yes TR-408 7487-94-7 Mercuric chloride Rats F344/N Male Gavage Thyroid Gland Follicular Cell Some Evidence Equivocal Evidence ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50 May Have Been Related
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50 Neoplastic Lesions
Yes TR-340 5634-39-9 Iodinated glycerol Rats F344/N Male Gavage Thyroid Gland Follicular Cell Some Evidence Some Evidence CARCINOMA 0/49 5/49 1/49 Neoplastic Lesions
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Female Gavage Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50 May Have Been Related
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Male Gavage Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50 May Have Been Related
Yes TR-331 24382-04-5 Malonaldehyde, sodium salt Rats F344/N Female Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Mice B6C3F1 Male Inhalation Thyroid Gland Follicular Cell Some Evidence Equivocal Evidence ADENOMA 1/50 0/50 0/50 5/53 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52 Neoplastic Lesions
Yes TR-476 125-33-7 Primidone (primaclone) Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/49 3/48 3/50 6/50 Neoplastic Lesions
Yes TR-517 7775-09-9 Water disinfection byproducts (Sodium chlorate) Rats F344/N Male Dosed-Water Thyroid Gland Follicular Cell Some Evidence Some Evidence CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Male Inhalation Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Mice B6C3F1/N Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence Some Evidence ADENOMA 0/50 1/50 0/50 7/50 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice B6C3F1/N Male Inhalation Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence adenoma May Have Been Related
Yes TR-436 75-65-0 tert-Butyl alcohol Mice B6C3F1 Female Dosed-Water Thyroid Gland Follicular Cell Some Evidence Some Evidence ADENOMA 2/58 3/60 2/59 9/59 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Rats F344/N Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/49 0/48 0/42 5/48 CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48 Neoplastic Lesions
Yes TR-516 693-98-1 2-Methylimidazole Rats F344/N Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence Some Evidence ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50 Neoplastic Lesions
Yes TR-517 7775-09-9 Water disinfection byproducts (Sodium chlorate) Rats F344/N Female Dosed-Water Thyroid Gland Follicular Cell Some Evidence Some Evidence ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48 May Have Been Related
Yes TR-494 84-65-1 Anthraquinone Mice B6C3F1 Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence ADENOMA 0/50 0/50 2/49 2/46 May Have Been Related
Yes TR-487 115-11-7 Isobutene Rats F344/N Male Inhalation Thyroid Gland Follicular Cell Some Evidence Some Evidence CARCINOMA 1/48 0/48 0/48 5/50 Neoplastic Lesions
Yes TR-443 604-75-1 Oxazepam Mice B6C3F1 Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 4/50 5/50 6/50 Neoplastic Lesions
Yes TR-443 604-75-1 Oxazepam Mice Swiss Webster Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence Clear Evidence ADENOMA 0/50 4/50 5/50 6/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats F344/N Male Gavage Thyroid Gland Follicular Cell Clear Evidence Equivocal Evidence adenoma or carcinoma 1/50, 2/49, 2/50, 4/49 May Have Been Related
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Male Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 0/50 3/50 4/50 4/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Male Dosed-Water Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Male Dosed-Water Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48 Neoplastic Lesions
Yes TR-589 32534-81-9 Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] Rats Wistar Han Male Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 1/45 3/45 2/48 6/46 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Mice B6C3F1/N Male Gavage Thyroid Gland Follicular Cell Clear Evidence Clear Evidence adenoma 0/50, 0/50, 2/50, 2/50 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Rats F344/N Female Gavage Thyroid Gland Follicular Cell Some Evidence Some Evidence adenoma 1/49, 0/50, 3/49, 1/49; follicular cell, carcinoma 0/49, 0/50, 1/49, 1/49 Neoplastic Lesions
Yes TR-578 90045-36-6 Ginkgo biloba extract Rats F344/N Male Gavage Thyroid Gland Follicular Cell Some Evidence Some Evidence adenoma 2/50, 1/50, 3/49, 5/45 Neoplastic Lesions
Yes TR-586 CIMSTAR3800 Metal Working Fluids: CIMSTAR 3800 Mice B6C3F1/N Female Inhalation Thyroid Gland Follicular Cell Some Evidence Some Evidence carcinoma 0/50 0/48 0/50 3/50 Neoplastic Lesions