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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-112	17026-81-2	3-Amino-4-ethoxyacetanilide	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-129	2489-77-2	Trimethylthiourea	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-143	2243-62-1	1,5-Naphthalenediamine	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-149	105-55-5	N,N'-Diethylthiourea	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-149	105-55-5	N,N'-Diethylthiourea	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/69 3/50 1/47 5/46	Neoplastic Lesions
Yes	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Rats	Osborne Mendel	Male	Gavage	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 1/69 5/48 6/50 10/50	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/50 1/47 13/50	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 3/49 16/49	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 2/47 17/48	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA 0/49 0/47 7/48	Neoplastic Lesions
Yes	TR-271	2784-94-3	HC Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/47 0/49 5/50	May Have Been Related
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50	Neoplastic Lesions
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/49 1/50 5/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
Yes	TR-408	7487-94-7	Mercuric chloride	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Equivocal Evidence	ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50	May Have Been Related
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
Yes	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/49 5/49 1/49	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50	May Have Been Related
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50	May Have Been Related
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50	Neoplastic Lesions
Yes	TR-448	542-56-3	Isobutyl nitrite	Mice	B6C3F1	Male	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Equivocal Evidence	ADENOMA 1/50 0/50 0/50 5/53	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
Yes	TR-476	125-33-7	Primidone (primaclone)	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 3/48 3/50 6/50	Neoplastic Lesions
Yes	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Rats	F344/N	Male	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Mice	B6C3F1/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 0/50 7/50	Neoplastic Lesions
Yes	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma	May Have Been Related
Yes	TR-436	75-65-0	tert-Butyl alcohol	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 2/58 3/60 2/59 9/59	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/48 0/42 5/48 CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50	Neoplastic Lesions
Yes	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Rats	F344/N	Female	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48	May Have Been Related
Yes	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 2/49 2/46	May Have Been Related
Yes	TR-487	115-11-7	Isobutene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 1/48 0/48 0/48 5/50	Neoplastic Lesions
Yes	TR-443	604-75-1	Oxazepam	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50	Neoplastic Lesions
Yes	TR-443	604-75-1	Oxazepam	Mice	Swiss Webster	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
Yes	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma or carcinoma 1/50, 2/49, 2/50, 4/49	May Have Been Related
Yes	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/50 3/50 4/50 4/50	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
Yes	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 1/45 3/45 2/48 6/46	Neoplastic Lesions
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Mice	B6C3F1/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/50, 0/50, 2/50, 2/50	Neoplastic Lesions
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	adenoma 1/49, 0/50, 3/49, 1/49; follicular cell, carcinoma 0/49, 0/50, 1/49, 1/49	Neoplastic Lesions
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	adenoma 2/50, 1/50, 3/49, 5/45	Neoplastic Lesions
Yes	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Mice	B6C3F1/N	Female	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	carcinoma 0/50 0/48 0/50 3/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Mice	B6C3F1	Female	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland C-Cell	Positive	Positive	ADENOMA OR CARCINOMA, ADENOMA	Neoplastic Lesions
Yes	TR-143	2243-62-1	1,5-Naphthalenediamine	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-143	2243-62-1	1,5-Naphthalenediamine	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(POLYP)	Neoplastic Lesions
No	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 0/49 2/50 4/50	May Have Been Related
No	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Male	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 1/50 3/50 3/50	May Have Been Related
No	TR-516	693-98-1	2-Methylimidazole	Mice	B6C3F1/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 3/50 4/49 6/49 10/50	Neoplastic Lesions
No	TR-516	693-98-1	2-Methylimidazole	Mice	B6C3F1/N	Male	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/48 0/42 5/48 CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Mice	B6C3F1/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 0/50 7/50	Neoplastic Lesions
Yes	TR-516	693-98-1	2-Methylimidazole	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Mice	B6C3F1	Female	Gavage	Liver	Positive	Positive	CARCINOMA 1/73 2/50 2/48 6/47	Neoplastic Lesions
No	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Mice	B6C3F1	Male	Gavage	Liver	Positive	Positive	CARCINOMA 8/73 9/49 8/49 17/50	Neoplastic Lesions
No	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Rats	Osborne Mendel	Female	Gavage	Liver	Positive	Positive	NEOPLASTIC NODULE 5/75 1/49 3/50 12/49	Neoplastic Lesions
Yes	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/69 3/50 1/47 5/46	Neoplastic Lesions
Yes	TR-209	1746-01-6	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Rats	Osborne Mendel	Male	Gavage	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 1/69 5/48 6/50 10/50	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland C-Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-112	17026-81-2	3-Amino-4-ethoxyacetanilide	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-112	17026-81-2	3-Amino-4-ethoxyacetanilide	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-112	17026-81-2	3-Amino-4-ethoxyacetanilide	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-112	17026-81-2	3-Amino-4-ethoxyacetanilide	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Adrenal Gland Cortex	Clear Evidence	Equivocal Evidence	Adenoma 1/50 1/50 3/50 4/49	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	All Organs	Clear Evidence	Equivocal Evidence	Malignant Lymphoma: 2/50 5/50 8/50 7/50	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell carcinoma 0/50 1/50 1/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell carcinoma 0/50 1/50 1/49 3/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	Squamous cell papilloma or carcinoma 0/50 1/50 0/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Liver	Clear Evidence	Clear Evidence	Cholangiocarcinoma 1/50 1/50 1/49 3/49	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Liver	Clear Evidence	Clear Evidence	Cholangiocarcinoma 0/50 4/50 4/50 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Lung	Clear Evidence	Clear Evidence	Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Lung	Clear Evidence	Clear Evidence	Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	Mucosa: Gingival squamous cell carcinoma 0/50 0/50 4/50 6/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	Mucosa: Gingival squamous cell carcinoma 1/50 5/50 4/50 5/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Skin	Clear Evidence	Clear Evidence	Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Thoracic Cavity	Clear Evidence	Equivocal Evidence	Malignant Schwannoma: 0/50 0/50 1/50 3/50	May Have Been Related
Yes	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Rats	Harlan Sprague-Dawley	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/50 3/50 4/50 4/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Ureter	Clear Evidence	Equivocal Evidence	Transitional epithelial carcinoma: 0/0 0/1 0/0 1/2	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Ureter	Clear Evidence	Equivocal Evidence	Transitional epithelial carcinoma: 0/43 0/45 1/47 0/50	May Have Been Related
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Female	Gavage	Urinary System	Clear Evidence	Clear Evidence	Urethra: Transitional epithelial gland carcinoma 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-558	14047-09-7	3,3',4,4'-Tetrachloroazobenzene	Mice	B6C3F1/N	Male	Gavage	Urinary System	Clear Evidence	Clear Evidence	Urethra: Transitional epithelial gland carcinoma 0/50 32/50 46/49 49/50	Neoplastic Lesions
No	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Mice	B6C3F1	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-186	101-61-1	4,4'-Methylenebis(N,N-dimethyl)benzenamine	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Adrenal Gland Medulla	Positive	Positive	PHEOCHROMOCYTOMA 2/48 12/49 14/49	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Hematopoietic System	Positive	Positive	LYMPHOMA 13/50 28/50 29/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Liver	Positive	Positive	ADENOMA 3/50 9/50 12/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Liver	Positive	Positive	CARCINOMA 10/49 33/50 29/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Positive	Positive	NEOPLASTIC NODULE 1/50 12/50 25/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Female	Dosed-Water	Thyroid Gland C-Cell	Positive	Positive	ADENOMA 0/47 3/47 6/48	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/50 1/47 13/50	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 3/49 16/49	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 2/47 17/48	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA 0/49 0/47 7/48	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 3/50 9/50 5/50 3/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 6/50 4/50 3/50	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48	May Have Been Related
Yes	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 2/49 2/46	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Equivocal Evidence	LYMPHOMA 17/50 24/50 25/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 3/49 19/50 37/49	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 10/50 20/50 27/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 8/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 0/50 15/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/50 20/50 16/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 1/50 13/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 0/50 6/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 1/50 10/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Skin	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50	May Have Been Related
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/49 1/50 5/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50 3/50	May Have Been Related
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	LEUKEMIA 7/50 12/50 14/50	May Have Been Related
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Nasal Cavity	Clear Evidence	Clear Evidence	respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Female	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Spleen	Clear Evidence	Equivocal Evidence	hemangioscaroma	May Have Been Related
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	interstitial cell adenoma	May Have Been Related
Yes	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma	May Have Been Related
No	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50	Neoplastic Lesions
No	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50	Neoplastic Lesions
No	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Female	Dosed-Feed	Pituitary Gland	Clear Evidence	Clear Evidence	ADENOMA 10/47 19/49 26/49; CARCINOMA 1/47 0/49 0/49	Neoplastic Lesions
No	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Male	Dosed-Feed	Pituitary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/44 0/42 8/41	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49	Neoplastic Lesions
Yes	TR-388	96-45-7	Ethylene thiourea (ETU)	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50	Neoplastic Lesions
No	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Male	Gavage	All Organs	Some Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 9/50, 12/50, 22/50, 21/50	May Have Been Related
No	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Male	Gavage	Liver	Some Evidence	Equivocal Evidence	hepatocellular adenoma 0/50, 3/50, 3/50, 0/50	May Have Been Related
No	TR-578	90045-36-6	Ginkgo biloba extract	Mice	B6C3F1/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 17/50, 37/50, 41/50, 48/50; hepatocellular carcinoma 9/50, 10/50, 15/50, 44/50; hepatoblastoma 1/50, 1/50, 8/50, 11/50	Neoplastic Lesions
No	TR-578	90045-36-6	Ginkgo biloba extract	Mice	B6C3F1/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma 22/50, 31/50, 41/50, 47/50; hepatoblastoma 3/50, 28/50, 36/50, 38/50	Neoplastic Lesions
No	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Female	Gavage	Nasal Cavity	Some Evidence	Equivocal Evidence	respiratory epithelium, adenoma 0/49, 0/49, 2/50, 0/46	May Have Been Related
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Mice	B6C3F1/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/50, 0/50, 2/50, 2/50	Neoplastic Lesions
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	adenoma 1/49, 0/50, 3/49, 1/49; follicular cell, carcinoma 0/49, 0/50, 1/49, 1/49	Neoplastic Lesions
Yes	TR-578	90045-36-6	Ginkgo biloba extract	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	adenoma 2/50, 1/50, 3/49, 5/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-271	2784-94-3	HC Blue 1	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 1/50 24/48 47/49	Neoplastic Lesions
No	TR-271	2784-94-3	HC Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 11/50 20/50 30/50	Neoplastic Lesions
No	TR-271	2784-94-3	HC Blue 1	Rats	F344/N	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal Evidence	NEOPLASTIC NODULE 0/49 0/50 3/50; CARCINOMA 1/49 0/50 6/50	Neoplastic Lesions
No	TR-271	2784-94-3	HC Blue 1	Rats	F344/N	Female	Dosed-Feed	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50	Neoplastic Lesions
Yes	TR-271	2784-94-3	HC Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/47 0/49 5/50	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Some Evidence	Some Evidence	ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 29/50 24/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Nasal Cavity	Some Evidence	Equivocal Evidence	ADENOMA 0/48 0/47 2/49	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Pituitary Gland	Some Evidence	Some Evidence	ADENOMA 10/47 15/45 24/46	Neoplastic Lesions
Yes	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/49 5/49 1/49	Neoplastic Lesions
Yes	TR-487	115-11-7	Isobutene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 1/48 0/48 0/48 5/50	Neoplastic Lesions
No	TR-448	542-56-3	Isobutyl nitrite	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46	Neoplastic Lesions
No	TR-448	542-56-3	Isobutyl nitrite	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46	Neoplastic Lesions
No	TR-448	542-56-3	Isobutyl nitrite	Mice	B6C3F1	Female	Inhalation	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50	Neoplastic Lesions
No	TR-448	542-56-3	Isobutyl nitrite	Mice	B6C3F1	Male	Inhalation	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53	Neoplastic Lesions
Yes	TR-448	542-56-3	Isobutyl nitrite	Mice	B6C3F1	Male	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Equivocal Evidence	ADENOMA 1/50 0/50 0/50 5/53	May Have Been Related
No	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 9/50 1/49	May Have Been Related
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50	Neoplastic Lesions
Yes	TR-331	24382-04-5	Malonaldehyde, sodium salt	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50	Neoplastic Lesions
No	TR-408	7487-94-7	Mercuric chloride	Rats	F344/N	Female	Gavage	Forestomach	Equivocal Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/49 2/50	Neoplastic Lesions
No	TR-408	7487-94-7	Mercuric chloride	Rats	F344/N	Male	Gavage	Forestomach	Some Evidence	Some Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50	Neoplastic Lesions
No	TR-408	7487-94-7	Mercuric chloride	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 2/49 OR ADENOCARCINOMA 0/50 0/50 1/49	Neoplastic Lesions
Yes	TR-408	7487-94-7	Mercuric chloride	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Equivocal Evidence	ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50	May Have Been Related
No	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Mice	B6C3F1/N	Female	Inhalation	Lung	Some Evidence	Some Evidence	alveolar/bronchiolar carcinoma 4/50 1/50 4/50 8/50 alveolar/bronchiolar adenoma or carcinoma 4/50 5/50 6/50 12/50	Neoplastic Lesions
No	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Rats	Wistar Han	Male	Inhalation	Prostate Gland	Equivocal Evidence	Equivocal Evidence	adenoma 1/50 1/50 1/50 3/50 adenoma or carcinoma 1/50 1/50 2/50 3/50	May Have Been Related
No	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Rats	Wistar Han	Female	Inhalation	Skin	Equivocal Evidence	Equivocal Evidence	squamous cell papilloma or keratoacanthoma 0/50 0/50 0/50 4/50	May Have Been Related
Yes	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Mice	B6C3F1/N	Female	Inhalation	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	carcinoma 0/50 0/48 0/50 3/50	Neoplastic Lesions
No	TR-586	CIMSTAR3800	Metal Working Fluids: CIMSTAR 3800	Rats	Wistar Han	Female	Inhalation	Uterus	Equivocal Evidence	Equivocal Evidence	adenocarcinoma or mixed malignant Mullerian tumor (original and residual longitudinal evaluation combined) 1/50 4/50 5/50 6/50	May Have Been Related
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Mice	B6C3F1/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/50, 5/50, 6/50, 7/50; squamous cell papilloma or carcinoma 1/50, 6/50, 6/50, 7/50	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Mice	B6C3F1/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 17/50, 19/50, 37/50, 44/50; hepatocellular carcinoma 6/50, 13/50, 18/50, 31/50; hepatoblastoma 0/50, 1/50, 0/50, 4/50	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Mice	B6C3F1/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma, multiple 17/50, 19/50, 27/50, 26/50; hepatocellular carcinoma 22/50, 25/50, 30/50, 36/50; hepatoblastoma 1/50, 5/50, 10/50, 8/50	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma 0/50, 0/50, 0/50, 4/49; hepatocellular adenoma or carcinoma 0/50, 1/50, 1/50, 7/49	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma 0/50, 0/50, 1/50, 6/50; hepatocellular adenoma or carcinoma 0/50, 0/50, 2/50, 6/50	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Mice	B6C3F1/N	Female	Gavage	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 2/50, 4/50, 8/50, 12/50; alveolar/bronchiolar adenoma or carcinoma 2/50, 5/50, 9/50, 13/50	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Female	Gavage	Nasal Cavity	Clear Evidence	Clear Evidence	transitional epithelium, adenoma 0/50, 1/49, 0/50, 2/49	Neoplastic Lesions
No	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Male	Gavage	Nasal Cavity	Clear Evidence	Clear Evidence	transitional epithelium, adenoma 0/50, 3/49, 2/50, 11/49; transitional epithelium, adenoma or carcinoma 0/50, 3/49, 2/50, 13/49	Neoplastic Lesions
Yes	TR-579	99-97-8	N,N-Dimethyl-p-toluidine	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma or carcinoma 1/50, 2/49, 2/50, 4/49	May Have Been Related
No	TR-149	105-55-5	N,N'-Diethylthiourea	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-149	105-55-5	N,N'-Diethylthiourea	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-149	105-55-5	N,N'-Diethylthiourea	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-149	105-55-5	N,N'-Diethylthiourea	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-443	604-75-1	Oxazepam	Mice	Swiss Webster	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	(SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50	Neoplastic Lesions
No	TR-443	604-75-1	Oxazepam	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	(SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50	Neoplastic Lesions
No	TR-443	604-75-1	Oxazepam	Mice	Swiss Webster	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	(SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50	Neoplastic Lesions
No	TR-443	604-75-1	Oxazepam	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	(SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50	Neoplastic Lesions
Yes	TR-443	604-75-1	Oxazepam	Mice	Swiss Webster	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50	Neoplastic Lesions
Yes	TR-443	604-75-1	Oxazepam	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 5/50 7/49 32/50 46/49 hepatocellular carcinoma 4/50 2/49 6/50 27/49 hepatocellular adenoma or carcinoma 8/50 8/49 33/50 47/49	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 23/50 35/50 49/50 40/50 hepatocellular carcinoma 18/50 15/50 30/50 45/50 hepatocellular adenoma or carcinoma 31/50 40/50 49/50 47/50 hepatoblastoma 1/50 1/50 16/50 5/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 31/50 40/50 49/50 47/50	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Female	Gavage	Liver	Clear Evidence	Clear Evidence	cholangiocarcinoma 0/50 0/49 0/50 2/47 hepatocholangioma 0/50 0/49 0/50 8/47 hepatocellular adenoma 3/50 2/49 8/50 16/47 hepatocellular carcinoma 0/50 0/49 1/50 6/47 hepatocellular adenoma or carcinoma 3/50 2/49 8/50 17/47) hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/50 2/49 8/50 21/47	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Male	Gavage	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma or carcinoma 3/49 2/50 4/50 9/50; hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/49 2/50 4/50 11/50	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Male	Gavage	Pituitary Gland	Clear Evidence	Clear Evidence	(pars distalis): adenoma 19/49 12/49 22/50 35/50	Neoplastic Lesions
Yes	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 1/45 3/45 2/48 6/46	Neoplastic Lesions
No	TR-589	32534-81-9	Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]	Rats	Wistar Han	Female	Gavage	Uterus	Clear Evidence	Equivocal Evidence	stromal polyp or stromal sarcoma (original and residual evaluations, combined) 4/50 12/50 12/50 9/49	May Have Been Related
No	TR-476	125-33-7	Primidone (primaclone)	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	(SINGLE SECTIONS) ADENOMA 2/50 1/50 1/50 1/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 2/50 1/50 1/50 2/50; (SINGLE AND STEP SECTIONS) ADENOMA 4/50 2/50 4/50 6/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 4/50 2/50 4/50 7/50	Neoplastic Lesions
No	TR-476	125-33-7	Primidone (primaclone)	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 15/50 42/50 45/49 47/50, CARCINOMA 3/50 11/50 19/49 38/50 OR HEPATOBLASTOMA 1/50 4/50 4/49 4/50 COMBINED 16/50 42/50 46/49 50/50	Neoplastic Lesions
No	TR-476	125-33-7	Primidone (primaclone)	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 22/50 41/50 39/50 32/50, CARCINOMA 12/50 31/50 35/50 38/50 OR HEPATOBLASTOMA 0/50 17/50 26/50 7/50 COMBINED 31/50 49/50 49/50 46/50	Neoplastic Lesions
Yes	TR-476	125-33-7	Primidone (primaclone)	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 3/48 3/50 6/50	Neoplastic Lesions
No	TR-476	125-33-7	Primidone (primaclone)	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 6/49 3/49 OR CARCINOMA 1/50 3/50 1/49 1/49 COMBINED 2/50 4/50 7/49 4/49	Neoplastic Lesions
No	TR-436	75-65-0	tert-Butyl alcohol	Rats	F344/N	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50	Neoplastic Lesions
No	TR-436	75-65-0	tert-Butyl alcohol	Mice	B6C3F1	Male	Dosed-Water	Thyroid Gland Follicular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57	Neoplastic Lesions
Yes	TR-436	75-65-0	tert-Butyl alcohol	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 2/58 3/60 2/59 9/59	Neoplastic Lesions
No	TR-129	2489-77-2	Trimethylthiourea	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-129	2489-77-2	Trimethylthiourea	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-129	2489-77-2	Trimethylthiourea	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-129	2489-77-2	Trimethylthiourea	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Female	Gavage	Harderian Gland	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 5/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 5/50 24/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 3/50	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50	May Have Been Related
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50	May Have Been Related
No	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Mice	B6C3F1	Male	Dosed-Water	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Mice	B6C3F1	Female	Dosed-Water	Pancreas Islet Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/46 2/47 2/49 4/49	Neoplastic Lesions
Yes	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Rats	F344/N	Female	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46	Neoplastic Lesions
Yes	TR-517	7775-09-9	Water disinfection byproducts (Sodium chlorate)	Rats	F344/N	Male	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47	Neoplastic Lesions