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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Urinary Bladder
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-006 139-13-9 Nitrilotriacetic acid (NTA) Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-094 119-34-6 4-Amino-2-nitrophenol Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Mice B6C3F1 Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Mice B6C3F1 Male Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-089 134-29-2 o-Anisidine hydrochloride Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-105 102-50-1 m-Cresidine Rats F344/N Female Gavage Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-105 102-50-1 m-Cresidine Rats F344/N Male Gavage Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Mice B6C3F1 Female Dosed-Feed Urinary Bladder Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Mice B6C3F1 Male Dosed-Feed Urinary Bladder Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (PAPILLOMA, CARCINOMA) Neoplastic Lesions
Yes TR-142 120-71-8 p-Cresidine Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive (PAPILLOMA, CARCINOMA) Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-164 86-30-6 N-Nitrosodiphenylamine Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-164 86-30-6 N-Nitrosodiphenylamine Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
Yes TR-179 105-11-3 p-Benzoquinone dioxime Rats F344/N Female Dosed-Feed Urinary Bladder Positive Positive (TRANSITIONAL CELL PAPILLOMA OR CARCINOMA OR SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-216 2432-99-7 11-Aminoundecanoic acid Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive TRANSITIONAL CELL CARCINOMA 0/48 0/48 7/49 Neoplastic Lesions
Yes TR-234 57-06-7 Allyl isothiocyanate Rats F344/N Male Gavage Urinary Bladder Positive Positive TRANSITIONAL CELL PAPILLOMA 0/49 2/49 4/49 Neoplastic Lesions
Yes TR-245 108-78-1 Melamine Rats F344/N Male Dosed-Feed Urinary Bladder Positive Positive TRANSITIONAL CELL CARCINOMA 0/45 0/50 8/49 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice B6C3F1 Female Gavage Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48 Neoplastic Lesions
Yes TR-299 2475-45-8 C.I. Disperse Blue 1 Rats F344/N Female Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Urinary Bladder Clear Evidence Equivocal Evidence CARCINOMA 0/50 1/50 1/50 May Have Been Related
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Female Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Female Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Male Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Female Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49 Neoplastic Lesions
Yes TR-494 84-65-1 Anthraquinone Rats F344/N Male Dosed-Feed Urinary Bladder Some Evidence Some Evidence TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats F344/N Female Inhalation Urinary Bladder Clear Evidence Equivocal Evidence TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50 May Have Been Related
Yes TR-467 126-99-8 Chloroprene Rats F344/N Male Inhalation Urinary Bladder Clear Evidence Equivocal Evidence TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59 Neoplastic Lesions
Yes TR-299 2475-45-8 C.I. Disperse Blue 1 Rats F344/N Male Dosed-Feed Urinary Bladder Clear Evidence Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49 Neoplastic Lesions
Yes TR-457 599-79-1 Salicylazosulfapyridine Rats F344/N Female Gavage Urinary Bladder Some Evidence Some Evidence TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50 Neoplastic Lesions
Yes TR-457 599-79-1 Salicylazosulfapyridine Rats F344/N Male Gavage Urinary Bladder Some Evidence Some Evidence (CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50 Neoplastic Lesions
Yes TR-563 89-82-7 Pulegone Rats F344/N Female Gavage Urinary Bladder Some Evidence Some Evidence Papilloma 0/50 0/49 1/50 3/47 papilloma or carcinoma 0/50 0/49 1/50 5/47 Neoplastic Lesions