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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-094	119-34-6	4-Amino-2-nitrophenol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-105	102-50-1	m-Cresidine	Rats	F344/N	Female	Gavage	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-105	102-50-1	m-Cresidine	Rats	F344/N	Male	Gavage	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Mice	B6C3F1	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Mice	B6C3F1	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(PAPILLOMA, CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(PAPILLOMA, CARCINOMA)	Neoplastic Lesions
Yes	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-164	86-30-6	N-Nitrosodiphenylamine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-164	86-30-6	N-Nitrosodiphenylamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-179	105-11-3	p-Benzoquinone dioxime	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA OR CARCINOMA OR SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-216	2432-99-7	11-Aminoundecanoic acid	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL CARCINOMA 0/48 0/48 7/49	Neoplastic Lesions
Yes	TR-234	57-06-7	Allyl isothiocyanate	Rats	F344/N	Male	Gavage	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL PAPILLOMA 0/49 2/49 4/49	Neoplastic Lesions
Yes	TR-245	108-78-1	Melamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL CARCINOMA 0/45 0/50 8/49	Neoplastic Lesions
Yes	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Mice	B6C3F1	Female	Gavage	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48	Neoplastic Lesions
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49	Neoplastic Lesions
Yes	TR-457	599-79-1	Salicylazosulfapyridine	Rats	F344/N	Female	Gavage	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50	Neoplastic Lesions
Yes	TR-457	599-79-1	Salicylazosulfapyridine	Rats	F344/N	Male	Gavage	Urinary Bladder	Some Evidence	Some Evidence	(CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50	Neoplastic Lesions
Yes	TR-563	89-82-7	Pulegone	Rats	F344/N	Female	Gavage	Urinary Bladder	Some Evidence	Some Evidence	Papilloma 0/50 0/49 1/50 3/47 papilloma or carcinoma 0/50 0/49 1/50 5/47	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50	Neoplastic Lesions
No	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/52 1/52 9/52; SQUAMOUS CELL CARCINOMA 0/52 0/52 4/52	Neoplastic Lesions
No	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Rats	F344/N	Female	Gavage	Forestomach	Some Evidence	Some Evidence	SQUAMOUS CELL PAPILLOMA 0/52 2/52 3/52	Neoplastic Lesions
No	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 1/52 6/52 7/52	Neoplastic Lesions
No	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50	Neoplastic Lesions
Yes	TR-269	542-75-6	1,3-Dichloropropene (Telone II)	Mice	B6C3F1	Female	Gavage	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48	Neoplastic Lesions
No	TR-216	2432-99-7	11-Aminoundecanoic acid	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-216	2432-99-7	11-Aminoundecanoic acid	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-216	2432-99-7	11-Aminoundecanoic acid	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Equivocal Evidence	Equivocal	LYMPHOMA 2/50 9/50 4/50	Neoplastic Lesions
No	TR-216	2432-99-7	11-Aminoundecanoic acid	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	NEOPLASTIC NODULE 1/50 9/50 8/50	Neoplastic Lesions
Yes	TR-216	2432-99-7	11-Aminoundecanoic acid	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL CARCINOMA 0/48 0/48 7/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-094	119-34-6	4-Amino-2-nitrophenol	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-094	119-34-6	4-Amino-2-nitrophenol	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-094	119-34-6	4-Amino-2-nitrophenol	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Equivocal Evidence	Equivocal	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-094	119-34-6	4-Amino-2-nitrophenol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Female	Dosed-Feed	Forestomach	Positive	Positive	(SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Male	Dosed-Feed	Forestomach	Positive	Positive	(SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-063	95-83-0	4-Chloro-o-phenylenediamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-234	57-06-7	Allyl isothiocyanate	Mice	B6C3F1	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-234	57-06-7	Allyl isothiocyanate	Mice	B6C3F1	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-234	57-06-7	Allyl isothiocyanate	Rats	F344/N	Female	Gavage	Subcutaneous Tissue	Equivocal Evidence	Equivocal	FIBROSARCOMA 0/50 0/50 3/50	Neoplastic Lesions
Yes	TR-234	57-06-7	Allyl isothiocyanate	Rats	F344/N	Male	Gavage	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL PAPILLOMA 0/49 2/49 4/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 3/50 9/50 5/50 3/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 6/50 4/50 3/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 2/49 2/46	May Have Been Related
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Mice	B6C3F1	Male	Dosed-Feed	Lung	Equivocal Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50	Neoplastic Lesions
No	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50	May Have Been Related
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48	Neoplastic Lesions
Yes	TR-299	2475-45-8	C.I. Disperse Blue 1	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-105	102-50-1	m-Cresidine	Mice	B6C3F1	Male	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-105	102-50-1	m-Cresidine	Mice	B6C3F1	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-105	102-50-1	m-Cresidine	Rats	F344/N	Female	Gavage	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-105	102-50-1	m-Cresidine	Rats	F344/N	Male	Gavage	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-245	108-78-1	Melamine	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-245	108-78-1	Melamine	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-245	108-78-1	Melamine	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-245	108-78-1	Melamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	TRANSITIONAL CELL CARCINOMA 0/45 0/50 8/49	Neoplastic Lesions
No	TR-164	86-30-6	N-Nitrosodiphenylamine	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-164	86-30-6	N-Nitrosodiphenylamine	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-164	86-30-6	N-Nitrosodiphenylamine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-164	86-30-6	N-Nitrosodiphenylamine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Male	Dosed-Feed	Ureter	Positive	Positive	(ADENOMA OR PAPILLOMA)	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Equivocal Evidence	Equivocal	PAPILLOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Equivocal Evidence	Equivocal	ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA OR CARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Ureter	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Ureter	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Equivocal Evidence	Equivocal	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-089	134-29-2	o-Anisidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	(STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 14/50 2/50 36/50 18/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOMA OR FIBROADENOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Positive	Positive	MESOTHELIOMA	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Spleen	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Spleen	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Positive	Positive	(FIBROMA)	Neoplastic Lesions
Yes	TR-153	636-21-5	o-Toluidine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-153	636-21-5	o-Toluidine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-179	105-11-3	p-Benzoquinone dioxime	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-179	105-11-3	p-Benzoquinone dioxime	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-179	105-11-3	p-Benzoquinone dioxime	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-179	105-11-3	p-Benzoquinone dioxime	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL PAPILLOMA OR CARCINOMA OR SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-142	120-71-8	p-Cresidine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE OR CARCINOMA)	Neoplastic Lesions
No	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Female	Dosed-Feed	Nasal Cavity	Positive	Positive	(NEUROBLASTOMA)	Neoplastic Lesions
No	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Male	Dosed-Feed	Nasal Cavity	Positive	Positive	(NEUROBLASTOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Mice	B6C3F1	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Mice	B6C3F1	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(PAPILLOMA, CARCINOMA)	Neoplastic Lesions
Yes	TR-142	120-71-8	p-Cresidine	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Positive	Positive	(PAPILLOMA, CARCINOMA)	Neoplastic Lesions
No	TR-563	89-82-7	Pulegone	Mice	B6C3F1/N	Female	Gavage	All Organs	Clear Evidence	Equivocal Evidence	Osteoma or osteosarcoma: 0/49 0/50 3/50 1/50	May Have Been Related
No	TR-563	89-82-7	Pulegone	Mice	B6C3F1/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	Hepatocellular: Adenoma 13/49 15/50 13/50 27/50 adenoma, carcinoma or hepatoblastoma 17/49 15/50 15/50 33/50	Neoplastic Lesions
No	TR-563	89-82-7	Pulegone	Mice	B6C3F1/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	Hepatocellular: Adenoma 22/50 31/50 35/50 28/50 adenoma, carcinoma, or hepatoblastoma 29/50 37/50 42/50 36/50	Neoplastic Lesions
Yes	TR-563	89-82-7	Pulegone	Rats	F344/N	Female	Gavage	Urinary Bladder	Some Evidence	Some Evidence	Papilloma 0/50 0/49 1/50 3/47 papilloma or carcinoma 0/50 0/49 1/50 5/47	Neoplastic Lesions
No	TR-457	599-79-1	Salicylazosulfapyridine	Rats	F344/N	Female	Gavage	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-457	599-79-1	Salicylazosulfapyridine	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49	Neoplastic Lesions
No	TR-457	599-79-1	Salicylazosulfapyridine	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50	Neoplastic Lesions
Yes	TR-457	599-79-1	Salicylazosulfapyridine	Rats	F344/N	Female	Gavage	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50	Neoplastic Lesions
Yes	TR-457	599-79-1	Salicylazosulfapyridine	Rats	F344/N	Male	Gavage	Urinary Bladder	Some Evidence	Some Evidence	(CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50	Neoplastic Lesions