No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
PERINATAL AND POSTWEANING STUDY (STUDY 1)
|
May Have Been Related
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
POSTWEANING-ONLY STUDY (STUDY 2)
|
May Have Been Related
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
PERINATAL AND POSTWEANING STUDY (STUDY 1)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
POSTWEANING-ONLY STUDY (STUDY 2)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
PERINATAL AND POSTWEANING STUDY (STUDY 1)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
All Organs
|
Clear Evidence |
|
POSTWEANING-ONLY STUDY (STUDY 2)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
|
hepatocellular adenoma (0/50, 0/50, 1/50, 1/50, 13/49); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 2/49); hepatocellular adenoma or carcinoma (combined) (0/50, 0/50, 1/50, 1/50, 14/49)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
|
hepatocellular adenoma (1/49, 0/50, 5/50, 9/50, 5/48); hepatocellular carcinoma (0/49, 0/50, 0/50, 0/50, 8/48); hepatocellular adenoma or carcinoma (combined) (1/49, 0/50, 5/50, 9/50, 13/48)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
|
hepatocellular adenoma (0/50, 2/50, 0/50, 1/50, 6/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50, 6/50); hepatocellular adenoma or carcinoma (combined) (0/50, 2/50, 0/50, 1/50, 12/50)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
|
hepatocellular adenoma (0/50, 1/49, 0/50, 3/50, 8/49); hepatocellular carcinoma (1/50, 0/49, 0/50, 0/50, 3/49); hepatocellular adenoma or carcinoma (combined) (1/50, 1/49, 0/50, 3/50, 11/49)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
|
acinar adenoma or carcinoma (combined) (0/49, 0/50, 0/50, 2/50, 1/48)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
|
acinar adenoma or carcinoma (combined) (0/50, 0/50, 0/50, 1/50, 2/47)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
|
acinar adenoma (10/50, 7/49, 8/50, 36/50, 22/49); acinar carcinoma (0/50, 0/49, 0/50, 3/50, 1/49); acinar adenoma or carcinoma (combined) (10/50, 7/49, 8/50, 38/50, 22/49)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
|
acinar adenoma (1/49, 4/50, 5/50, 23/50, 30/50); acinar carcinoma (0/49, 1/50, 0/50, 1/50, 5/50); acinar adenoma or carcinoma (combined) (1/49, 5/50, 5/50, 23/50, 33/50)
|
Neoplastic Lesions
|
No
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Testis
|
Clear Evidence |
|
interstitial cell, adenoma (7/50, 3/50, 3/50, 6/50, 15/50)
|
May Have Been Related
|
Yes
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Uterus
|
Clear Evidence |
|
adenoma, adenocarcinoma, squamous cell carcinoma, or squamous cell papilloma (combined) (3/50, 1/50, 1/50, 3/50, 7/50)
|
May Have Been Related
|
Yes
|
TR-601
|
117-81-7 |
Di(2-ethylhexyl) Phthalate |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Uterus
|
Clear Evidence |
|
adenoma, adenocarcinoma, squamous cell carcinoma, or squamous cell papilloma (combined) (2/50, 4/50, 1/50, 6/50, 13/50)
|
Neoplastic Lesions
|
No
|
TR-584
|
700-06-1 |
Indole-3-carbinol |
Mice |
B6C3F1 |
Male |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular adenoma 26/50 32/50 31/49 41/50 hepatocellular carcinoma 12/50 11/50 29/49 14/50 hepatoblastoma 3/50 4/50 4/49 14/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/50 36/50 44/49 45/50
|
Neoplastic Lesions
|
No
|
TR-584
|
700-06-1 |
Indole-3-carbinol |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Skin
|
Some Evidence |
Equivocal Evidence |
fibroma 1/50 0/50 0/50 4/50 fibrosarcoma 1/50 0/50 0/50 1/50 fibroma or fibrosarcoma 2/50 0/50 0/50 5/50
|
May Have Been Related
|
Yes
|
TR-584
|
700-06-1 |
Indole-3-carbinol |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Uterus
|
Some Evidence |
Some Evidence |
adenocarcinoma (standard evaluation) 0/50 1/50 4/50 4/50 (standard and extended evaluations) combined 5/50 4/50 13/50 10/50
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Rats |
Harlan Sprague-Dawley |
Female |
Inhalation |
Adrenal Gland Medulla
|
Some Evidence |
Some Evidence |
benign pheochromocytoma (0/49, 3/50, 4/50, 6/50)
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Mice |
B6C3F1 |
Female |
Inhalation |
Harderian Gland
|
Clear Evidence |
Clear Evidence |
adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50)
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Mice |
B6C3F1 |
Female |
Inhalation |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50)
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Mice |
B6C3F1 |
Male |
Inhalation |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50)
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Rats |
Harlan Sprague-Dawley |
Male |
Inhalation |
Lung
|
Some Evidence |
Equivocal Evidence |
alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50)
|
May Have Been Related
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Rats |
Harlan Sprague-Dawley |
Female |
Inhalation |
Thyroid Gland C-Cell
|
Some Evidence |
Some Evidence |
adenoma (2/50, 8/50, 8/50, 14/50)
|
Neoplastic Lesions
|
No
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Rats |
Harlan Sprague-Dawley |
Male |
Inhalation |
Thyroid Gland C-Cell
|
Some Evidence |
Some Evidence |
adenoma (2/50, 5/49, 3/49, 12/50)
|
Neoplastic Lesions
|
Yes
|
TR-594
|
98-56-6 |
p-Chloro-a,a,a-trifluorotoluene |
Rats |
Harlan Sprague-Dawley |
Female |
Inhalation |
Uterus
|
Some Evidence |
Some Evidence |
adenocarcinoma (1/50, 1/50, 0/50, 5/50); stromal polyp (7/50, 9/50, 16/50, 12/50)
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Mice |
B6C3F1 |
Female |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular adenoma 5/50 7/49 32/50 46/49 hepatocellular carcinoma 4/50 2/49 6/50 27/49 hepatocellular adenoma or carcinoma 8/50 8/49 33/50 47/49
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Mice |
B6C3F1 |
Male |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular adenoma 23/50 35/50 49/50 40/50 hepatocellular carcinoma 18/50 15/50 30/50 45/50 hepatocellular adenoma or carcinoma 31/50 40/50 49/50 47/50 hepatoblastoma 1/50 1/50 16/50 5/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 31/50 40/50 49/50 47/50
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Rats |
Wistar Han |
Female |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
cholangiocarcinoma 0/50 0/49 0/50 2/47 hepatocholangioma 0/50 0/49 0/50 8/47 hepatocellular adenoma 3/50 2/49 8/50 16/47 hepatocellular carcinoma 0/50 0/49 1/50 6/47 hepatocellular adenoma or carcinoma 3/50 2/49 8/50 17/47) hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/50 2/49 8/50 21/47
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Rats |
Wistar Han |
Male |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
hepatocellular adenoma or carcinoma 3/49 2/50 4/50 9/50; hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/49 2/50 4/50 11/50
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Rats |
Wistar Han |
Male |
Gavage |
Pituitary Gland
|
Clear Evidence |
Clear Evidence |
(pars distalis): adenoma 19/49 12/49 22/50 35/50
|
Neoplastic Lesions
|
No
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Rats |
Wistar Han |
Male |
Gavage |
Thyroid Gland Follicular Cell
|
Clear Evidence |
Clear Evidence |
adenoma 1/45 3/45 2/48 6/46
|
Neoplastic Lesions
|
Yes
|
TR-589
|
32534-81-9 |
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] |
Rats |
Wistar Han |
Female |
Gavage |
Uterus
|
Clear Evidence |
Equivocal Evidence |
stromal polyp or stromal sarcoma (original and residual evaluations, combined) 4/50 12/50 12/50 9/49
|
May Have Been Related
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Unspecified
|
Clear Evidence |
|
Not applicable
|
Not applicable
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Unspecified
|
Some Evidence |
|
Not applicable
|
Not applicable
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Liver
|
Some Evidence |
Equivocal Evidence |
Perinatal + Postweaning: hepatocellular carcinoma (1/50, 0/50, 4/50)
|
May Have Been Related
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Liver
|
Some Evidence |
Equivocal Evidence |
Postweaning: hepatocellular carcinoma (1/50, 1/50, 3/49)
|
May Have Been Related
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
Perinatal + Postweaning: hepatocellular adenoma (0/50, 1/50, 5/50, 10/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 4/50); hepatocellular adenoma or carcinoma (0/50, 1/50, 5/50, 12/50)
|
Neoplastic Lesions
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
Postweaning: hepatocellular adenoma (0/50, 0/50, 7/50, 11/50); hepatocellular carcinoma (0/50, 0/50, 0/50, 0/50); hepatocellular adenoma or carcinoma (0/50, 0/50, 7/50,11/50)
|
Neoplastic Lesions
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
Clear Evidence |
Postweaning: acinar cell adenoma (3/50, 28/50, 26/50, 32/50); acinar cell adenocarcinoma (0/50, 3/50, 1/50, 3/50), acinar cell adenoma or adenocarcinoma (3/50, 29/50, 26/50, 32/50)
|
Neoplastic Lesions
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Pancreas Acinar Cell
|
Clear Evidence |
Clear Evidence |
Perinatal + Postweaning: acinar cell adenoma (7/50, 18/50, 30/50, 30/50); acinar cell adenocarcinoma (0/50, 2/50, 1/50, 3/50), acinar cell adenoma or adenocarcinoma (7/50, 20/50, 30/50, 30/50)
|
Neoplastic Lesions
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Pancreas Acinar Cell
|
Some Evidence |
Some Evidence |
Postweaning: acinar cell adenoma (0/50, 0/50, 1/49); acinar cell adenocarcinoma (0/50, 0/50, 1/49); acinar cell adenoma or adenocarcinoma (0/50, 0/50, 2/49)
|
Neoplastic Lesions
|
No
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Pancreas Acinar Cell
|
Some Evidence |
Some Evidence |
Perinatal + Postweaning: acinar cell adenoma (0/50, 0/50, 3/50); acinar cell adenocarcinoma (0/50, 0/50, 2/50); acinar cell adenoma or adenocarcinoma (0/50, 0/50, 5/50)
|
Neoplastic Lesions
|
Yes
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Uterus
|
Some Evidence |
Equivocal Evidence |
Perinatal + Postweaning: adenocarcinoma (1/50, 3/50, 5/50)
|
May Have Been Related
|
Yes
|
TR-598
|
335-67-1 |
Perfluorooctanoic acid (PFOA) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Uterus
|
Some Evidence |
Equivocal Evidence |
Postweaning: adenocarcinoma (1/50, 5/50, 8/50)
|
May Have Been Related
|
No
|
TR-587
|
79-94-7 |
Tetrabromobisphenol A |
Mice |
B6C3F1/N |
Male |
Gavage |
All Organs
|
Some Evidence |
Equivocal Evidence |
(Hemangiosarcoma) 1/50 5/50 8/50
|
May Have Been Related
|
No
|
TR-587
|
79-94-7 |
Tetrabromobisphenol A |
Mice |
B6C3F1/N |
Male |
Gavage |
Intestines (Large)
|
Some Evidence |
Equivocal Evidence |
(cecum or colon) adenoma or carcinoma 0/50 0/50 3/50
|
May Have Been Related
|
No
|
TR-587
|
79-94-7 |
Tetrabromobisphenol A |
Mice |
B6C3F1/N |
Male |
Gavage |
Liver
|
Some Evidence |
Some Evidence |
hepatoblastoma 2/50 11/50 8/50
|
Neoplastic Lesions
|
No
|
TR-587
|
79-94-7 |
Tetrabromobisphenol A |
Rats |
Wistar Han |
Male |
Gavage |
Testis
|
Equivocal Evidence |
Equivocal Evidence |
interstitial cell, adenoma 0/50 0/50 1/50 3/50
|
May Have Been Related
|
Yes
|
TR-587
|
79-94-7 |
Tetrabromobisphenol A |
Rats |
Wistar Han |
Female |
Gavage |
Uterus
|
Clear Evidence |
Clear Evidence |
adenoma (original transverse review) 0/50 0/50 3/50 4/50 adenocarcinoma (original transverse review) 3/50 3/50 8/50 9/50 )original transverse and residual longitudinal reviews, combined) 4/50 10/50 15/50 16/50 malignant mixed Müllerian tumor (original transverse review) 0/50 4/50 0/50 2/50 adenoma, adenocarcinoma, or malignant mixed Müllerian tumor (original transverse review) 3/50 7/50 11/50 13/50 )original transverse and residual longitudinal reviews, combined) 6/50 11/50 16/50 19/50
|
Neoplastic Lesions
|
No
|
TR-561
|
119-64-2 |
Tetralin |
Rats |
F344/N |
Male |
Inhalation |
Kidney
|
Some Evidence |
Some Evidence |
Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50
|
Neoplastic Lesions
|
No
|
TR-561
|
119-64-2 |
Tetralin |
Rats |
F344/N |
Female |
Inhalation |
Liver
|
Some Evidence |
Some Evidence |
Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50
|
Neoplastic Lesions
|
No
|
TR-561
|
119-64-2 |
Tetralin |
Mice |
B6C3F1/N |
Female |
Inhalation |
Spleen
|
Equivocal Evidence |
Equivocal Evidence |
Hemangiosarcoma 1/50 0/50 1/50 4/50
|
May Have Been Related
|
No
|
TR-561
|
119-64-2 |
Tetralin |
Rats |
F344/N |
Male |
Inhalation |
Testis
|
Some Evidence |
Equivocal Evidence |
Adenoma, interstitial cell 29/50 39/50 31/50 41/50
|
May Have Been Related
|
Yes
|
TR-561
|
119-64-2 |
Tetralin |
Rats |
F344/N |
Female |
Inhalation |
Uterus
|
Some Evidence |
Some Evidence |
Stromal polyp 6/50 10/50 9/50 17/50
|
Neoplastic Lesions
|
No
|
TR-559
|
31508-00-6 |
Toxic equivalency factor evaluation (PCB 118) |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Liver
|
Clear Evidence |
Clear Evidence |
Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49
|
Neoplastic Lesions
|
No
|
TR-559
|
31508-00-6 |
Toxic equivalency factor evaluation (PCB 118) |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Lung
|
Clear Evidence |
Clear Evidence |
Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50
|
Neoplastic Lesions
|
No
|
TR-559
|
31508-00-6 |
Toxic equivalency factor evaluation (PCB 118) |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Pancreas Acinar Cell
|
Clear Evidence |
Equivocal Evidence |
Adenoma 0/52 0/52 0/52 2/52 3/52 1/47 0/49 adenoma or carcinoma 0/50 0/52 0/52 2/52 3/52 2/47 0/49
|
May Have Been Related
|
Yes
|
TR-559
|
31508-00-6 |
Toxic equivalency factor evaluation (PCB 118) |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Uterus
|
Clear Evidence |
Equivocal Evidence |
Squamous cell carcinoma: 0/52 0/52 3/52 1/52 1/52 0/52 1/50
|
May Have Been Related
|
Yes
|
TR-559
|
31508-00-6 |
Toxic equivalency factor evaluation (PCB 118) |
Rats |
Harlan Sprague-Dawley |
Female |
Gavage |
Uterus
|
Clear Evidence |
Clear Evidence |
Carcinoma 2/52 2/52 1/52 3/52 4/52 3/52 11/50
|
Neoplastic Lesions
|
No
|
TR-576
|
15625-89-5 |
Trimethylolpropane triacrylate |
Mice |
B6C3F1 |
Female |
Topical Application |
Liver
|
Some Evidence |
Some Evidence |
hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50
|
Neoplastic Lesions
|
No
|
TR-576
|
15625-89-5 |
Trimethylolpropane triacrylate |
Rats |
F344/N |
Male |
Topical Application |
Mesothelium (Abdominal Cavity/Tunica Vaginalis)
|
Equivocal Evidence |
Equivocal Evidence |
Malignant Mesothelioma 0/50, 2/50, 2/50, 5/50
|
May Have Been Related
|
Yes
|
TR-576
|
15625-89-5 |
Trimethylolpropane triacrylate |
Mice |
B6C3F1 |
Female |
Topical Application |
Uterus
|
Some Evidence |
Some Evidence |
stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
|
Neoplastic Lesions
|
No
|
TR-602
|
13674-84-5 |
Tris(Chloropropyl) Phosphate (TCPP) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Liver
|
Some Evidence |
|
hepatocellular adenoma (1/50, 3/50, 0/50, 3/50, 3/50)
|
May Have Been Related
|
No
|
TR-602
|
13674-84-5 |
Tris(Chloropropyl) Phosphate (TCPP) |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
|
hepatocellular adenoma (includes multiple) (11/50, 5/50, 13/50, 23/50); hepatocellular carcinoma (includes multiple) (1/50, 2/50, 5/50, 10/50); hepatocellular adenoma or carcinoma (combined) (12/50, 7/50, 16/50, 29/50)
|
Neoplastic Lesions
|
No
|
TR-602
|
13674-84-5 |
Tris(Chloropropyl) Phosphate (TCPP) |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Liver
|
Some Evidence |
|
hepatocellular carcinoma (includes multiple) (5/50, 14/50, 17/50, 14/50)
|
Neoplastic Lesions
|
No
|
TR-602
|
13674-84-5 |
Tris(Chloropropyl) Phosphate (TCPP) |
Rats |
Harlan Sprague-Dawley |
Male |
Dosed-Feed |
Liver
|
Some Evidence |
|
hepatocellular adenoma or carcinoma (combined) (1/50, 0/50, 1/50, 7/50, 6/49)
|
Neoplastic Lesions
|
Yes
|
TR-602
|
13674-84-5 |
Tris(Chloropropyl) Phosphate (TCPP) |
Rats |
Harlan Sprague-Dawley |
Female |
Dosed-Feed |
Uterus
|
Some Evidence |
|
adenoma or adenocarcinoma (combined) (3/50, 4/50, 6/50, 8/49, 9/50)
|
Neoplastic Lesions
|