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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Uterus/Cervix
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-032 3778-73-2 Isophosphamide Rats Sprague Dawley Female Intraperitoneal Injection Uterus/Cervix Positive Positive (LEIOMYOSARCOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Female Intraperitoneal Injection Uterus/Cervix Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice B6C3F1 Female Gavage Uterus/Cervix Positive Positive (POLYP, SARCOMA) Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Female Dosed-Feed Uterus/Cervix Positive Positive ADENOCARCINOMA Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Female Dosed-Feed Uterus/Cervix Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-078 21416-87-5 ICRF-159 Rats Sprague Dawley Female Intraperitoneal Injection Uterus/Cervix Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-081 512-56-1 Trimethylphosphate Mice B6C3F1 Female Gavage Uterus/Cervix Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-083 1596-84-5 Daminozide Rats F344/N Female Dosed-Feed Uterus/Cervix Positive Positive (ADENOCARCINOMA, LEIOMYOSARCOMA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Female Dosed-Feed Uterus/Cervix Positive Positive (POLYP) Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Rats F344/N Female Dosed-Feed Uterus/Cervix Positive Positive (POLYP) Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Female Gavage Uterus/Cervix Clear Evidence Clear Evidence CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Uterus/Cervix Clear Evidence Clear Evidence ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50 Neoplastic Lesions
Yes TR-346 75-00-3 Chloroethane Mice B6C3F1 Female Inhalation Uterus/Cervix Clear Evidence Clear Evidence ENDOMETRIAL CARCINOMA 0/49 43/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Female Gavage Uterus/Cervix Clear Evidence Clear Evidence ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54 Neoplastic Lesions
Yes TR-363 74-96-4 Bromoethane (ethyl bromide) Mice B6C3F1 Female Inhalation Uterus/Cervix Clear Evidence Clear Evidence ADENOMA 0/50 1/50 1/47 6/48, ADENOCARCINOMA 0/50 2/50 3/47 19/48, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/47 3/48 COMBINED 0/50 4/50 5/47 27/48 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Female Inhalation Uterus/Cervix Clear Evidence Clear Evidence ADENOCARCINOMA 0/49 1/47 5/49 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Uterus/Cervix Clear Evidence Clear Evidence ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59 Neoplastic Lesions
Yes TR-525 57117-31-4 Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran)) Rats Harlan Sprague-Dawley Female Gavage Uterus/Cervix Some Evidence Equivocal Evidence CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50 May Have Been Related
Yes TR-530 TEFBINARYMIX Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153) Rats Harlan Sprague-Dawley Female Gavage Uterus/Cervix Clear Evidence Equivocal Evidence SQUAMOUS CELL CARCINOMA 1/53 1/53 1/53 4/53 0/53 May Have Been Related
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Uterus/Cervix Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/48 0/47 0/48 2/46 Neoplastic Lesions
Yes TR-521 1746-01-6 Toxic equivalency factor evaluation (TCDD) Rats Harlan Sprague-Dawley Female Gavage Uterus/Cervix Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/53 0/54 0/53 0/53 5/53 0/53 2/50 Neoplastic Lesions