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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Vascular System (Liver)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-026 1836-75-5 Nitrofen Mice B6C3F1 Female Dosed-Feed Vascular System (Liver) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-026 1836-75-5 Nitrofen Mice B6C3F1 Male Dosed-Feed Vascular System (Liver) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-351 20265-96-7 p-Chloroaniline hydrochloride Mice B6C3F1 Male Gavage Vascular System (Liver) Some Evidence Some Evidence HEMANGIOSARCOMA 2/50 2/50 1/49 6/50 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice B6C3F1 Female Dosed-Feed Vascular System (Liver) Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/34 1/50 1/49 8/48 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, technical Mice B6C3F1 Female Dosed-Feed Vascular System (Liver) Some Evidence Some Evidence HEMANGIOSARCOMA 0/33 2/49 4/50 Neoplastic Lesions
Yes TR-414 1825-21-4 Pentachloroanisole Mice B6C3F1 Male Gavage Vascular System (Liver) Some Evidence Some Evidence Hemangiosarcoma 2/50 8/50 10/50 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Female Inhalation Vascular System (Liver) Clear Evidence Clear Evidence HEMANGIOMA 0/48 5/48 2/47 1/47 OR HEMANGIOSARCOMA 0/48 27/48 27/47 34/47 COMBINED 0/48 31/48 28/47 35/47 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Male Inhalation Vascular System (Liver) Clear Evidence Clear Evidence HEMANGIOMA 0/48 10/48 5/48 2/48 OR HEMANGIOSARCOMA 0/48 21/48 27/48 37/48 COMBINED 0/48 26/48 30/48 38/48 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Female Inhalation Vascular System (Liver) Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/50 0/50 5/50 1/50 Neoplastic Lesions
Yes TR-484 111-76-2 2-Butoxyethanol (ethylene glycol monobutyl ether) Mice B6C3F1 Male Inhalation Vascular System (Liver) Some Evidence Some Evidence HEMANGIOSARCOMA 0/50 1/50 2/49 4/49 Neoplastic Lesions