No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Clitoral Gland
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Esophagus
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Esophagus
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Female |
Topical Application |
Forestomach
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Male |
Topical Application |
Forestomach
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Forestomach
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Forestomach
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Intestines (Large)
|
Clear Evidence |
Clear Evidence |
ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Intestines (Large)
|
Clear Evidence |
Clear Evidence |
ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Kidney Tubular Cell
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 1/50 4/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Kidney Tubular Cell
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 0/50 4/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Male |
Topical Application |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Liver
|
Clear Evidence |
Clear Evidence |
NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Liver
|
Clear Evidence |
Clear Evidence |
NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Female |
Topical Application |
Lung
|
Clear Evidence |
Equivocal Evidence |
ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50
|
May Have Been Related
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Male |
Topical Application |
Lung
|
Clear Evidence |
Clear Evidence |
ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Mammary Gland
|
Clear Evidence |
Clear Evidence |
ADENOCARCINOMA 0/50 0/50 5/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Mesothelium (Abdominal Cavity/Tunica Vaginalis)
|
Clear Evidence |
Clear Evidence |
0/50 1/50 4/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Nasal Cavity
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 44/50 49/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Nasal Cavity
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 48/50 48/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Oral Cavity
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Oral Cavity
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Female |
Topical Application |
Skin
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Mice |
B6C3F1 |
Male |
Topical Application |
Skin
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Skin
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Skin
|
Clear Evidence |
Clear Evidence |
SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50
|
Neoplastic Lesions
|
Yes
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Vascular System (Spleen)
|
Clear Evidence |
Clear Evidence |
HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Female |
Topical Application |
Zymbal Gland
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50
|
Neoplastic Lesions
|
No
|
TR-400
|
96-13-9 |
2,3-Dibromo-1-propanol |
Rats |
F344/N |
Male |
Topical Application |
Zymbal Gland
|
Clear Evidence |
Clear Evidence |
ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50
|
Neoplastic Lesions
|
No
|
TR-130
|
142-04-1 |
Aniline hydrochloride |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Unspecified
|
Negative |
|
Not applicable
|
Not applicable
|
No
|
TR-130
|
142-04-1 |
Aniline hydrochloride |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Unspecified
|
Negative |
|
Not applicable
|
Not applicable
|
No
|
TR-130
|
142-04-1 |
Aniline hydrochloride |
Rats |
F344/N |
Female |
Dosed-Feed |
Spleen
|
Positive |
Positive |
SARCOMA
|
Neoplastic Lesions
|
Yes
|
TR-130
|
142-04-1 |
Aniline hydrochloride |
Rats |
F344/N |
Male |
Dosed-Feed |
Vascular System (Spleen)
|
Positive |
Positive |
HEMANGIOSARCOMA; SARCOMA OR FIBROSARCOMA
|
Neoplastic Lesions
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Mice |
B6C3F1 |
Female |
Gavage |
Unspecified
|
No Evidence |
|
Not applicable
|
Not applicable
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Rats |
F344/N |
Male |
Gavage |
Adrenal Gland Medulla
|
Clear Evidence |
Equivocal Evidence |
PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49
|
May Have Been Related
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Rats |
F344/N |
Female |
Gavage |
Adrenal Gland Medulla
|
Equivocal Evidence |
Equivocal Evidence |
PHEOCHROMOCYTOMA 2/50 3/50 1/50 6/50
|
Neoplastic Lesions
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Mice |
B6C3F1 |
Male |
Gavage |
Liver
|
Some Evidence |
Some Evidence |
ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50
|
Neoplastic Lesions
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Rats |
F344/N |
Male |
Gavage |
Spleen
|
Clear Evidence |
Clear Evidence |
FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50
|
Neoplastic Lesions
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Rats |
F344/N |
Female |
Gavage |
Spleen
|
Equivocal Evidence |
Equivocal Evidence |
FIBROSARCOMA 0/50 0/50 1/50 0/50 OR OSTEOSARCOMA 0/50 0/50 0/50 1/50 COMBINED 0/50 0/50 1/50 1/50
|
Neoplastic Lesions
|
No
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Mice |
B6C3F1 |
Male |
Gavage |
Vascular System (Liver)
|
Some Evidence |
Some Evidence |
HEMANGIOSARCOMA 2/50 2/50 1/49 6/50
|
Neoplastic Lesions
|
Yes
|
TR-351
|
20265-96-7 |
p-Chloroaniline hydrochloride |
Mice |
B6C3F1 |
Male |
Gavage |
Vascular System (Spleen)
|
Some Evidence |
Some Evidence |
HEMANGIOSARCOMA 3/50 2/47 0/49 5/49
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Adrenal Gland Medulla
|
Clear Evidence |
Clear Evidence |
PHEOCHROMOCYTOMA 0/35 2/49 2/46 38/49
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Adrenal Gland Medulla
|
Clear Evidence |
Clear Evidence |
PHEOCHROMOCYTOMA 0/34 4/48 21/48 44/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/34 0/48 0/48 3/49 COMBINED 1/34 4/48 21/48 45/49
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Vascular System (Liver)
|
Clear Evidence |
Clear Evidence |
HEMANGIOSARCOMA 0/34 1/50 1/49 8/48
|
Neoplastic Lesions
|
Yes
|
TR-349
|
87-86-5 |
Pentachlorophenol, Dowicide EC-7 |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Vascular System (Spleen)
|
Clear Evidence |
Clear Evidence |
HEMANGIOSARCOMA 0/34 0/50 2/50 2/47
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, technical |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Adrenal Gland Medulla
|
Clear Evidence |
Clear Evidence |
PHEOCHROMOCYTOMA 0/31 10/45 23/45
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, technical |
Mice |
B6C3F1 |
Male |
Dosed-Feed |
Liver
|
Clear Evidence |
Clear Evidence |
ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, technical |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Liver
|
Some Evidence |
Some Evidence |
ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50
|
Neoplastic Lesions
|
No
|
TR-349
|
87-86-5 |
Pentachlorophenol, technical |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Vascular System (Liver)
|
Some Evidence |
Some Evidence |
HEMANGIOSARCOMA 0/33 2/49 4/50
|
Neoplastic Lesions
|
Yes
|
TR-349
|
87-86-5 |
Pentachlorophenol, technical |
Mice |
B6C3F1 |
Female |
Dosed-Feed |
Vascular System (Spleen)
|
Some Evidence |
Some Evidence |
HEMANGIOSARCOMA 0/33 1/50 3/47
|
Neoplastic Lesions
|