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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Vascular System (Unspecified)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Rats Osborne Mendel Male Gavage Vascular System (Unspecified) Positive Positive (HEMANGIOSARCOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Rats Osborne Mendel Male Gavage Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOMA OR HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-107 99-55-8 5-Nitro-o-toluidine Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-107 99-55-8 5-Nitro-o-toluidine Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOMA OR HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-153 636-21-5 o-Toluidine hydrochloride Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-187 95-79-4 5-Chloro-o-toluidine Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-187 95-79-4 5-Chloro-o-toluidine Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-165 3165-93-3 4-Chloro-o-toluidine hydrochloride Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-165 3165-93-3 4-Chloro-o-toluidine hydrochloride Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-181 90-94-8 Michler's ketone Mice B6C3F1 Male Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Inhalation Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA 0/50 11/50 23/50 Neoplastic Lesions
Yes TR-233 2185-92-4 2-Biphenylamine hydrochloride Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA 0/49 1/50 7/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Female Inhalation Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA 0/50 0/50 5/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats F344/N Male Inhalation Vascular System (Unspecified) Positive Positive HEMANGIOSARCOMA 0/50 1/50 15/50 Neoplastic Lesions
Yes TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Mice B6C3F1 Female Gavage Vascular System (Unspecified) Positive Positive HEMANGIOMA 0/50 1/50 2/50 OR HEMANGIOSARCOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 5/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Male Inhalation Vascular System (Unspecified) Clear Evidence Clear Evidence HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Vascular System (Unspecified) Clear Evidence Clear Evidence HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Vascular System (Unspecified) Clear Evidence Equivocal Evidence HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50 May Have Been Related