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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Zymbal Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-057 789-61-7 beta-Thioguanidine deoxyriboside Rats Sprague Dawley Female Intraperitoneal Injection Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Rats Sprague Dawley Female Intraperitoneal Injection Zymbal Gland Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Rats Sprague Dawley Male Intraperitoneal Injection Zymbal Gland Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive SQUAMOUS CELL PAPILLOMA OR CARCINOMA Neoplastic Lesions
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive SQUAMOUS CELL PAPILLOMA OR CARCINOMA Neoplastic Lesions
Yes TR-092 122-66-7 Hydrazobenzene Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive (SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Mice B6C3F1 Female Dosed-Feed Zymbal Gland Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive CARCINOMA Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-127 99-59-2 5-Nitro-o-anisidine Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-127 99-59-2 5-Nitro-o-anisidine Rats F344/N Male Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Female Dosed-Feed Zymbal Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Zymbal Gland Clear Evidence Equivocal Evidence CARCINOMA 0/50 0/50 2/50 May Have Been Related
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Female Gavage Zymbal Gland Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Male Gavage Zymbal Gland Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Rats F344/N Female Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 0/45 5/40 5/44 14/46 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Female Dosed-Feed Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 0/50 2/50 7/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Rats F344/N Male Dosed-Feed Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 1/50 1/50 13/50 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Rats F344/N Male Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 2/32 6/46 10/42 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50 Neoplastic Lesions
Yes TR-359 298-81-7 8-Methoxypsoralen Rats F344/N Male Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 1/50 7/50 4/49 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 0/60 1/59 0/60 4/60 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 0/60 0/60 0/59 3/60 Neoplastic Lesions
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Rats F344/N Male Dosed-Feed Zymbal Gland Some Evidence Equivocal Evidence CARCINOMA 0/50 0/50 2/50 3/50 May Have Been Related
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 1/50 3/50 6/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Zymbal Gland Clear Evidence Equivocal Evidence ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80 May Have Been Related
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Zymbal Gland Clear Evidence Clear Evidence CARCINOMA 0/50 0/50 0/50 3/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Zymbal Gland Clear Evidence Equivocal Evidence (STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Zymbal Gland Clear Evidence Clear Evidence ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60 Neoplastic Lesions