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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-057	789-61-7	beta-Thioguanidine deoxyriboside	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-092	122-66-7	Hydrazobenzene	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50	May Have Been Related
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 7/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 1/50 13/50	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
Yes	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 7/50 4/49	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50 3/50	May Have Been Related
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 6/49 12/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 5/50 21/50 36/49 29/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/50 2/48 1/49	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 4/42 10/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 5/40 0/44	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 1/50 10/49 10/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 0/50 23/50 29/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ACINAR CELL CARCINOMA 0/50 2/49 6/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/49 6/45 12/48	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 11/48 18/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 16/49 7/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 44/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 48/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Vascular System (Spleen)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Preputial Gland	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland C-Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-084	39156-41-7	2,4-Diaminoanisole sulfate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-093	6109-97-3	3-Amino-9-ethylcarbazole HCl	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 2/44 3/75 1/60	May Have Been Related
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/60 2/45 14/75 20/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(POLYP)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Mice	B6C3F1	Male	Dosed-Feed	Liver	Equivocal Evidence	Equivocal	(CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-127	99-59-2	5-Nitro-o-anisidine	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Clitoral Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Male	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-118	602-87-9	5-Nitroacenaphthene	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Positive	Positive	(TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA)	Neoplastic Lesions
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
Yes	TR-118	602-87-9	5-Nitroacenaphthene	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49	Neoplastic Lesions
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 9/50 9/49	May Have Been Related
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 5/50 7/49	May Have Been Related
Yes	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 7/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
No	TR-057	789-61-7	beta-Thioguanidine deoxyriboside	Mice	B6C3F1	Female	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-057	789-61-7	beta-Thioguanidine deoxyriboside	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-057	789-61-7	beta-Thioguanidine deoxyriboside	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Equivocal Evidence	Equivocal	(CARCINOMA)	Neoplastic Lesions
Yes	TR-057	789-61-7	beta-Thioguanidine deoxyriboside	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 3/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 0/35 1/65 2/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 3/35 6/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Equivocal Evidence	LYMPHOMA 17/50 24/50 25/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 3/49 19/50 37/49	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 10/50 20/50 27/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 8/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 0/50 15/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/50 20/50 16/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 7/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 1/50 13/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 1/35 1/65 2/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/35 1/65 3/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 2/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 0/50 6/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 1/50 10/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Skin	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50	May Have Been Related
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/49 1/50 5/50	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Forestomach	Positive	Positive	SQUAMOUS CELL CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Forestomach	Positive	Positive	SQUAMOUS CELL CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOMA OR HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
Yes	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
Yes	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-092	122-66-7	Hydrazobenzene	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-092	122-66-7	Hydrazobenzene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-092	122-66-7	Hydrazobenzene	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE)	Neoplastic Lesions
No	TR-092	122-66-7	Hydrazobenzene	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-092	122-66-7	Hydrazobenzene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-092	122-66-7	Hydrazobenzene	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Preputial Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions