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TGx-DDI Biomarker for DNA Damage Classification

The TGx-DDI biomarker was developed as a toxicogenomics signature to identify chemicals that can cause DNA damage in human cells in culture. Biomarker development was undertaken as a collaborative effort between the Genomics Committee of the Health and Environmental Sciences Institute (HESI), Health Canada, Georgetown University, and the NTP.

The signature from 64 gene transcripts was generated using a training set of 28 agents: 13 DNA damage-inducing (DDI) and 15 non-DNA damage-inducing (NDDI) and forms the basis of this classification tool. The probability that a chemical will cause DNA damage is predicted based on similarity of the test chemical expression profile to the reference chemical profiles.