DART-03: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Developmental and Reproductive Toxicity, Genetic Toxicology Studies
Food consumption table (I06) was updated to include statistical analysis on October 26, 2017.
Updated graph (I03) for higher quality image (October 15, 2018)
Fetal Defect Tables (R10 and R11) were updated to include comments in the observations on November 22, 2019.
DOI: https://doi.org/10.22427/NTP-DATA-002-03277-0000-0000-1
Updated graph (I03) for higher quality image (October 15, 2018)
Fetal Defect Tables (R10 and R11) were updated to include comments in the observations on November 22, 2019.
DOI: https://doi.org/10.22427/NTP-DATA-002-03277-0000-0000-1
DART-03: Vinpocetine
Developmental and Reproductive Toxicity
Prenatal Developmental Toxicity Dose Range Finding Study - Rats
- I01 - Animal Removal Summary (34 KB)
- I03 - Growth Curve (56 KB)
- I04 - Mean Body Weights and Survival (151 KB)
- I04G - Mean Body Weight Gain (74 KB)
- I05 - Clinical Observations Summary (88 KB)
- I06 - Mean Feed Consumption (91 KB)
- PA46 - Gross Pathology Summary (146 KB)
- R09 - Uterine Content Summary (99 KB)
- R10 - Fetal Defects (40 KB)
- R11 - Fetal Defect Summary (49 KB)
- R12 - Placental Findings (37 KB)
- R13 - Fetal Defect Cross Reference Summary (54 KB)
Prenatal Developmental Toxicity Dose Range Finding Individual Animal Data - Rats
- Individual Animal Body Weight Data (43 KB)
- Individual Animal Clinical Observations Data (56 KB)
- Individual Animal Consumption Data (27 KB)
- Individual Animal Gross Pathology Data (74 KB)
- Individual Animal Removal Reasons (6 KB)
- Individual Animal Teratology Dam Data (12 KB)
- Individual Animal Teratology Fetal Weight (40 KB)
- Individual Animal Teratology Implant Findings (91 KB)
Prenatal Developmental Toxicity Study - Rats
- I01 - Animal Removal Summary.pdf (32 KB)
- I03 - Growth Curve.pdf (48 KB)
- I04 - Mean Body Weights and Survival (97 KB)
- I04G - Mean Body Weight Gain.pdf (56 KB)
- I05 - Clinical Observations Summary (63 KB)
- I06 - Mean Feed Consumption (73 KB)
- PA46 - Gross Pathology Summary (114 KB)
- R09 - Uterine Content Summary (80 KB)
- R10 - Fetal Defects (259 KB)
- R11 - Fetal Defect Summary (98 KB)
- R12 - Placental Findings (34 KB)
- R13 - Fetal Defect Cross Reference Summary (176 KB)
Prenatal Developmental Toxicity Individual Animal Data - Rats
- Individual Animal Body Weight Data (60 KB)
- Individual Animal Clinical Observations Data (68 KB)
- Individual Animal Consumption Data (37 KB)
- Individual Animal Gross Pathology Data (98 KB)
- Individual Animal Removal Reasons (6 KB)
- Individual Animal Teratology Dam Data (14 KB)
- Individual Animal Teratology Fetal Weight (54 KB)
- Individual Animal Teratology Implant Findings (280 KB)
Prenatal Developmental Toxicity Dose Range Finding Study - Rabbits
- I01 - Animal Removal Summary (35 KB)
- I03 - Growth Curve (55 KB)
- I04 - Mean Body Weights and Survival (174 KB)
- I04G - Mean Body Weight Gain (73 KB)
- I05 - Clinical Observations Summary (62 KB)
- I06 - Mean Feed Consumption (98 KB)
- PA46 - Gross Pathology Summary (134 KB)
- R09 - Uterine Content Summary (90 KB)
- R10 - Fetal Defects (42 KB)
- R11 - Fetal Defect Summary (52 KB)
- R12 - Placental Findings (35 KB)
- R13 - Fetal Defect Cross Reference Summary (46 KB)
Prenatal Developmental Toxicity Dose Range Finding Individual Animal Data - Rabbits
- Individual Animal Body Weight Data (44 KB)
- Individual Animal Clinical Observations Data (43 KB)
- Individual Animal Consumption Data (29 KB)
- Individual Animal Gross Pathology Data (47 KB)
- Individual Animal Removal Reasons (5 KB)
- Individual Animal Teratology Dam Data (11 KB)
- Individual Animal Teratology Fetal Weight (24 KB)
- Individual Animal Teratology Implant Findings (53 KB)
Genetic Toxicology
Genetic Toxicity Evaluation of Vinpocetine (42971-09-5) in DNA Damage Study G12103D in B6C3F1 Mice
- G01 - In Vivo Alkaline Comet Summary Data (51 KB)
- Individual Animal In Vivo Alkaline Comet Data (13 KB)
Genetic Toxicity Evaluation of Vinpocetine (42971-09-5) in Micronucleus Study G12103C in B6C3F1 Mice
Genetic Toxicity Evaluation of Vinpocetine (42971-09-5) in Micronucleus Study G12103E in Human TK6 Cells
- G12103E G03 In Vitro Micronucleus Summary Data (73 KB)
- G12103E Individual Animal MNInVitro Data (15 KB)
Genetic Toxicity Evaluation of Vinpocetine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G12103
- G12103 G06 Ames Summary Data (73 KB)