TR-602: Technical Report Pathology Tables and Curves
Pathology Tables, Survival and Growth Curves from NTP
Short-Term, Long Term, Genetic Toxicology, Other Information Studies
https://doi.org/10.22427/NTP-DATA-TR-602
NCBI SRA
The 3-month Rat P10 was updated on May 5, 2021 to remove the 20,000 ppm group since those animals were only on study for a few days.
The PA48 tables were updated on August 31, 2021 to reflect a change in endpoint names
The Food and Chemical Consumption tables for the Chronic Rats study were updated on November 29, 2021 to account for an animal removal in treatment group 2000 ppm
Following files were updated on Mar 3,2022:
2 year rat study: Gestational and Lactational Body Weights, PND 4-28 Litter Size and Survival
3-month Rat Study: All Litter data tables
3-month Mouse Study: R06 Andrology Summary
TCPP is produced as an isomeric mixture of four isomers. All NTP studies of TCPP have utilized a procured isomeric mixture and details are provided in the associated Technical Report. The data tables herein reference TCPP with CASRN 13674-84-5, which represents the major isomer of the TCPP mixture.
NCBI SRA
The 3-month Rat P10 was updated on May 5, 2021 to remove the 20,000 ppm group since those animals were only on study for a few days.
The PA48 tables were updated on August 31, 2021 to reflect a change in endpoint names
The Food and Chemical Consumption tables for the Chronic Rats study were updated on November 29, 2021 to account for an animal removal in treatment group 2000 ppm
Following files were updated on Mar 3,2022:
2 year rat study: Gestational and Lactational Body Weights, PND 4-28 Litter Size and Survival
3-month Rat Study: All Litter data tables
3-month Mouse Study: R06 Andrology Summary
TCPP is produced as an isomeric mixture of four isomers. All NTP studies of TCPP have utilized a procured isomeric mixture and details are provided in the associated Technical Report. The data tables herein reference TCPP with CASRN 13674-84-5, which represents the major isomer of the TCPP mixture.
TR-602: Tris(Chloropropyl)phosphate
Short-Term
3-Month with Perinatal Study Tables - Rats
- Adjusted Pup Body Weights (189 KB)
- E03 - Growth Curves (57 KB)
- E04 - Mean Body Weights and Survival Table (12 KB)
- E05 - Clinical Observations Summary (18 KB)
- E06 - Mean Feed Consumption by Treatment Group (15 KB)
- E08 - Feed and Compound Consumption Table (22 KB)
- Gestational and Lactational Chemical Consumption (189 KB)
- Gestational and Lactational Food Consumption (193 KB)
- Gestational Body Weights (219 KB)
- Image Analysis of Thymus Size for Male and Female Rats (111 KB)
- Lactational Body Weights (188 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 KB)
- P04 - Neoplasms by Individual Animal (198 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (203 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (114 KB)
- P14 - Individual Animal Pathology Data (233 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 KB)
- PA06 - Organ Weights Summary (72 KB)
- PA41 - Clinical Chemistry Summary (152 KB)
- PA43 - Hematology Summary (205 KB)
- PND 1 Litter and Pup Body Weight Data (192 KB)
- PND 4-21 Live Litter Size and Survival (197 KB)
- R02 - Reproductive Performance Summary (39 KB)
- R06 - Andrology Summary (48 KB)
3-Month with Perinatal Individual Animal Data - Rats
- Female Individual Animal Clinical Observations (3 KB)
- Female Individual Animal Non Neoplastic Pathology Data (19 KB)
- Female Individual Animal Survival (9 KB)
- Female Individual Animal Terminal Body Weight Data (16 KB)
- Female Individual Body Weight Data (38 KB)
- Individual Animal Andrology Data (8 KB)
- Individual Animal Body Weight Data F1 Post Wean (65 KB)
- Individual Animal Clinical Chemistry Data (12 KB)
- Individual Animal Clinical Observation Data F1 Post Wean (57 KB)
- Individual Animal DamID and PupID Data (7 KB)
- Individual Animal Food Consumption Data F1 Post Wean (115 KB)
- Individual Animal Gross Pathology Data F1 (94 KB)
- Individual Animal Hematology Data (14 KB)
- Individual Animal Histo Pathology Data F1 (21 KB)
- Individual Animal Organ Weight Data (11 KB)
- Individual Animal Removal Reasons Data (9 KB)
- Individual Animal Reproductive Performance Data (8 KB)
- Male Individual Animal Body Weight (29 KB)
- Male Individual Animal Clinical Observations (6 KB)
- Male Individual Animal Non Neoplastic Pathology Data (31 KB)
- Male Individual Animal Survival (9 KB)
- Male Individual Animal Terminal Body Weight Data (16 KB)
3-Month Study Tables - Mice
- E03 - Growth Curves (432 KB)
- E04 - Mean Body Weights and Survival Table (18 KB)
- E05 - Clinical Observations Summary (11 KB)
- E06 - Mean Feed Consumption by Treatment Group (15 KB)
- E08 - Feed and Compound Consumption Table (23 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28 KB)
- P04 - Neoplasms by Individual Animal (200 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (198 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (52 KB)
- P14 - Individual Animal Pathology Data (257 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29 KB)
- PA06 - Organ Weights Summary (86 KB)
- PA43 - Hematology Summary (263 KB)
- R06 - Andrology Summary (47 KB)
3-Month Individual Animal Data - Mice
- Female Individual Animal Body Weight Data (35 KB)
- Female Individual Animal Non Neoplastic Pathology Data (11 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (26 KB)
- Individual Animal Andrology Data (8 KB)
- Individual Animal Hematology Data (17 KB)
- Individual Animal Organ Weight Data (11 KB)
- Male Individual Animal Body Weight Data (35 KB)
- Male Individual Animal Non Neoplastic Pathology Data (23 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal Terminal Body Weight Data (26 KB)
Long Term
Chronic with Perinatal Study Tables - Rats
- Adjusted Pup Body Weights (49 KB)
- E01 - Animal Removal Summary by Treatment Group (12 KB)
- E01 - Animal Removal Summary By Treatment Group - Dam Gestation (7 KB)
- E01 - Animal Removal Summary By Treatment Group - Dam Lactation (7 KB)
- E01 - Animal Removal Summary By Treatment Group - Female Pup (7 KB)
- E01 - Animal Removal Summary By Treatment Group - Male Pup (7 KB)
- E02 - Animals Removed from Experiment (170 KB)
- E02 - Animals Removed from Experiment - Dam Gestation (50 KB)
- E02 - Animals Removed from Experiment - Dam Lactation (32 KB)
- E02 - Animals Removed from Experiment - Female Pup (158 KB)
- E02 - Animals Removed from Experiment - Male Pup (168 KB)
- E03 - Growth Curves (71 KB)
- E03 - Growth Curves - Dam Gestation (28 KB)
- E03 - Growth Curves - Dam Lactation (29 KB)
- E03 - Growth Curves - Female Pup (28 KB)
- E03 - Growth Curves - Male Pup (28 KB)
- E04 - Mean Body Weights and Survival Table (20 KB)
- E05 - Clinical Observations Summary (26 KB)
- E06 - Mean Feed Consumption by Treatment Group (27 KB)
- E08 - Feed and Compound Consumption Table (41 KB)
- E12 - Animal History (2 MB)
- E12 - Animal History - Dam Gestation (308 KB)
- E12 - Animal History - Dam Lactation (285 KB)
- E12 - Animal History - Female Pup (2 MB)
- E12 - Animal History - Male Pup (2 MB)
- Gestational and Lactational Chemical Consumption (149 KB)
- Gestational and Lactational Food Consumption (152 KB)
- Gestational Body Weights (219 KB)
- I05 - Clinical Observation Summary.pdf (68 KB)
- Lactational Body Weights (193 KB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (63 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (66 KB)
- P04 - Neoplasms by Individual Animal (879 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (55 KB)
- P08 - Statistical Analysis of Primary Tumors (206 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 MB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (593 KB)
- P11 - Statistical Analysis of Survival Data (22 KB)
- P14 - Individual Animal Pathology Data (2 MB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (756 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (69 KB)
- P40 - Survival Curves (484 KB)
- PA48 - Summary of Tissue Concentration (77 KB)
- PND 1 Litter Size and Pup Body Weight Data (19 KB)
- PND 4-28 Live Litter Size and Survival (195 KB)
- R02 - Reproductive Performance Summary (39 KB)
Chronic with Perinatal Individual Animal Data - Rats
- Female Individual Animal Body Weight Data (491 KB)
- Female Individual Animal Body Weight Data All Animals - Dam Gestation (54 KB)
- Female Individual Animal Body Weight Data All Animals - Dam Lactation (52 KB)
- Female Individual Animal Body Weight Data All Animals - Female Pup (280 KB)
- Female Individual Animal Neoplastic Pathology Data (180 KB)
- Female Individual Animal Non Neoplastic Pathology Data (909 KB)
- Female Individual Animal Survival (41 KB)
- Female Individual Animal Survival Data - Female Pup (151 KB)
- Female Individual Animal Survival Data - Female Pup - Dam Gestation (32 KB)
- Female Individual Animal Survival Data - Female Pup - Dam Lactation (26 KB)
- Female Individual Animal Terminal Body Weight Data (70 KB)
- Female Individual Animal Terminal Body Weight Data - Dam Lactation (47 KB)
- Female Individual Animal Terminal Body Weight Data - Female Pup (268 KB)
- Female Individual Animal Terminal Body Weight Data - Female Pup - Dam Gestation (53 KB)
- Female Individual Body Weight All Animals (491 KB)
- Female Individual Clinical Observations (248 KB)
- Individual Animal Clinical Observations Data (10 KB)
- Individual Animal DamID and PupID Data (23 KB)
- Individual Animal Reproductive Performance Data (12 KB)
- Individual Animal Tissue Concentration Data (44 KB)
- Individual Pup Census and Litter Weight by Sex Data (29 KB)
- Male Individual Animal Body Weight Data All Animals - Male Pup (301 KB)
- Male Individual Animal Neoplastic Pathology Data (148 KB)
- Male Individual Animal Non Neoplastic Pathology Data (909 KB)
- Male Individual Animal Survival (41 KB)
- Male Individual Animal Survival Data - Male Pup (163 KB)
- Male Individual Animal Terminal Body Weight Data (70 KB)
- Male Individual Animal Terminal_Body Weight Data - Male Pup (290 KB)
- Male Individual Body Weight (462 KB)
- Male Individual Body Weight All Animals (462 KB)
- Male Individual Clinical Observations (166 KB)
Chronic Study Tables - Mice
- E01 - Animal Removal Summary by Treatment Group (8 KB)
- E02 - Animals Removed from Experiment (85 KB)
- E03 - Growth Curves (460 KB)
- E04 - Mean Body Weights and Survival Table (18 KB)
- E05 - Clinical Observations Summary (12 KB)
- E06 - Mean Feed Consumption by Treatment Group (25 KB)
- E08 - Feed Water and Compound Consumption Table (37 KB)
- E12 - Animal History (1 MB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (50 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (39 KB)
- P04 - Neoplasms by Individual Animal (649 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (44 KB)
- P08 - Statistical Analysis of Primary Tumors (155 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (580 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (161 KB)
- P11 - Statistical Analysis of Survival Data (16 KB)
- P14 - Individual Animal Pathology Data (1 MB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (546 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (41 KB)
- P40 - Survival Curves (439 KB)
- PA48 - Summary of Tissue Concentration (47 KB)
Individual Animal Data - Mice
- Female Individual Animal Body Weight Data All Animals (294 KB)
- Female Individual Animal Clinical Observations (19 KB)
- Female Individual Animal Neoplastic Pathology Data (106 KB)
- Female Individual Animal Non Neoplastic Pathology Data (344 KB)
- Female Individual Animal Survival Data (33 KB)
- Female Individual Animal Terminal Body Weight Data (56 KB)
- Male Individual Animal Body Weight Data All Animals (326 KB)
- Male Individual Animal Clinical Observations (30 KB)
- Male Individual Animal Neoplastic Pathology Data (119 KB)
- Male Individual Animal Non Neoplastic Pathology Data (207 KB)
- Male Individual Animal Survival Data (33 KB)
- Male Individual Animal Terminal Body Weight Data (56 KB)
Genetic Toxicology
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263 in Harlan Sprague-Dawley Rats
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263B in B6C3F1 Mice
- G04 - In Vivo Micronucleus Summary Data (191 KB)
- Individual Animal In Vivo Micronucleus Data (10 KB)
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20263C
- G06 - Ames Summary Data (83 KB)
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella Study 815918
- G06 - Ames Summary Data (197 KB)