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3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7030278

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB).
Micronucleus - Mice
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  • Male: Positive
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  • Male: Negative

Citation Information

NTP. 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Final Study Report Developmental Toxicity Evaluation of 3'-Azido-3'-Deoxythymidine (AZT; CASRN 30516-87-1) and 2',3'-Dideoxycytidine (ddC; CASRN 7481-89-2) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 15

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C20311) of AZT/Drug Combinations Transplacental Carcinogenesis Study (AIDSTHERAPEU ) in Male B6C3F1/NCTR Mice via In-Utero Exposure
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20311) of AZT/Drug Combinations Transplacental Carcinogenesis Study (AIDSTHERAPEU ) in Female B6C3F1/NCTR Mice via In-Utero Exposure
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine (AZTDDCCOMB) in Micronucleus Study 848765 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine (AZTDDCCOMB) in Micronucleus Study A72656 in CD-1 Mice
Summary and Individual Animal Data

Other NTP Studies

Prenatal Developmental Toxicity Study (TER97001) of 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
Toxicokinetic Evaluation (K89007) of 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxycytidine (AIDS Initiative) (DTXSID7030278) in Mouse
Data

DTT Data Collections