DART-02: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Developmental and Reproductive Toxicity Studies
West Virginia Chemical Spill
Supporting data files and reports are from studies conducted by NTP on chemicals associated with the Elk River spill in West Virginia. These data were used as the basis for the updates that NTP released in 2014-2016 (http://ntp.niehs.nih.gov/go/792827). The data and results for this study have been peer reviewed by an external expert.
If you need help accessing these data, please contact cdm@niehs.nih.gov.
Summary data PDF files originally released on October 2, 2015, were replaced on December 9, 2015, with versions with new formats. There are no changes to the data; the new files have a different format for improved readability. The Chemical Methods file was updated on July 8, 2016. The Materials and Methods files were updated on July 12, 2016.
Updated graph (I03) for higher quality image. Fetal summary (R10 and R11) and gross pathology (PA46) data tables were updated to reflect new statistics (October 15, 2018)
DOI:
https://doi.org/10.22427/NTP-DATA-DART-02
DART-02: 4-Methylcyclohexanemethanol (MCHM)
Prenatal Developmental Toxicity Dose Range Finding Study - Rats
- Animal Removal Summary (41 KB)
- Chemical Methods - WV Chemical Spill NTP Studies (430 KB)
- Clinical Observations Summary (108 KB)
- Fetal Defects (54 KB)
- Fetal Defect Summary (43 KB)
- Gross Pathology Summary (136 KB)
- Growth Curve (50 KB)
- Individual Animal Body Weights (44 KB)
- Individual Animal Clinical Observations (44 KB)
- Individual Animal Dam Findings (12 KB)
- Individual Animal Food Consumption (18 KB)
- Individual Animal Gross Pathology (47 KB)
- Individual Animal Implant Findings (65 KB)
- Individual Animal Organ Weights (13 KB)
- Individual Animal Removal Reasons (13 KB)
- Materials and Methods – Prenatal Developmental Toxicity Dose Range Finding Study (96 KB)
- Mean Body Weight Gain (55 KB)
- Mean Body Weights and Survival (122 KB)
- Mean Feed Consumption (57 KB)
- Organ Weights Summary (37 KB)
- Placental Findings (32 KB)
- Readme File - Prenatal Dose Range Finding Study (464 KB)
- Uterine Content Summary (79 KB)
Prenatal Developmental Toxicity Study- Rats
- Animal Removal Summary (31 KB)
- Chemical Methods - WV Chemical Spill NTP Studies (430 KB)
- Clinical Chemistry Summary (28 KB)
- Clinical Observations Summary (58 KB)
- Dam Pup Cross Reference (438 KB)
- Fetal Defect Cross Reference Summary (208 KB)
- Fetal Defects (358 KB)
- Fetal Defect Summary (112 KB)
- Gross Pathology Summary (149 KB)
- Growth Curve (49 KB)
- Hematology Summary (64 KB)
- Individual Animal Body Weights (131 KB)
- Individual Animal Clinical Chemistry (34 KB)
- Individual Animal Clinical Observations (114 KB)
- Individual Animal Dam Findings (15 KB)
- Individual Animal Food Consumption (33 KB)
- Individual Animal Gross Pathology (117 KB)
- Individual Animal Hematology (38 KB)
- Individual Animal Implant Findings (385 KB)
- Individual Animal Removal Reasons (15 KB)
- Materials and Methods – Prenatal Developmental Toxicity Study (158 KB)
- Mean Body Weight Gain (56 KB)
- Mean Body Weights and Survival (117 KB)
- Mean Feed Consumption (59 KB)
- Placental Findings (33 KB)
- Readme File - Prenatal Main Study (467 KB)
- Uterine Content Summary (82 KB)
Genetic Toxicology
Genetic Toxicity Evaluation of Crude MCHM (CRUDEMCHM) in Micronucleus Study G14013 in Harlan Sprague-Dawley Rats
- G14013 G04 In Vivo Micronucleus Summary Data (52 KB)
- G14013 Individual Animal In Vivo Micronucleus Data (8 KB)
Genetic Toxicity Evaluation of Crude MCHM in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G14013B
- G14013B G06 Ames Summary Data (79 KB)