Evaluation of the Chronic Toxicity and Carcinogenicity (C20614) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Harlan Sprague Dawley Rats Exposed via Dosed Feed (2 Year Females & 16 Week Males)
Long-Term
Interim (16 Week) of Chronic Study One (C20614) – Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (56 KB)
- E05 - Clinical Observations Summary (23 KB)
- E08 - Feed Water and Compound Consumption Table (32 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 KB)
- P04 - Neoplasms by Individual Animal (266 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (298 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 0-300, 0-1000 (61 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-0, 150-300, 300-1000 (55 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-300, 150-300 (28 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Females 0-1000, 300-1000 (57 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-150, 0-300 (71 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 150-150, 300-300 (71 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-150, 150-150 (47 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-300, 300-300 (65 KB)
- P14 - Individual Animal Pathology Data (269 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (267 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 KB)
- PA06 - Organ Weights Summary (161 KB)
- PA41 - Clinical Chemistry Summary (167 KB)
- PA45 - Liver Special Studies Summary (65 KB)
- PA48 - Tissue Concentration Summary (78 KB)
- R02 - Reproductive Performance Summary (37 KB)
Chronic Study One (C20614) - Male and Female Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (94 KB)
- E03 - Growth Curves - litter (0-0, 0-150, 0-300) male (31 KB)
- E03 - Growth Curves - litter (0-0, 0-300, 0-1000) female (34 KB)
- E03 - Growth Curves - litter (0-0, 150-150, 300-300) male (31 KB)
- E03 - Growth Curves - litter (0-0, 150-300, 300-1000) female (35 KB)
- E03 - Growth Curves - litter (0-150, 150-150) male (28 KB)
- E03 - Growth Curves - litter (0-300, 150-300) female (30 KB)
- E03 - Growth Curves - litter (0-300, 300-300) male (28 KB)
- E03 - Growth Curves - litter (0-1000, 300-1000) female (31 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0,0-150,0-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 0-300, 0-1000) female (11 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0,150-150,300-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-0, 150-300, 300-1000) female (11 KB)
- E04 - Mean Body Weights and Survival Table litter (0-150,150-150) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 150-300) female (10 KB)
- E04 - Mean Body Weights and Survival Table litter (0-300, 300-300) male (8 KB)
- E04 - Mean Body Weights and Survival Table litter (0-1000, 300-1000) female (10 KB)
- E05 - Clinical Observations Summary (23 KB)
- E08 - Feed Water and Compound Consumption Table (32 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (19 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (20 KB)
- F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (19 KB)
- F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (18 KB)
- F0 Female Harlan Sprague Dawley Rats Post-Cull Pup Body Weights (20 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Live Litter Size and Survival (22 KB)
- F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (21 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 KB)
- P04 - Neoplasms by Individual Animal (404 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (31 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 0-300 0-1000 (53 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-0 150-300 300-1000 (61 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-300 150-300 (39 KB)
- P08 - Statistical Analysis of Primary Tumors - litter 0-1000 300-1000 (58 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 0-300 0-1000 (72 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-0 150-300 300-1000 (54 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-300 150-300 (47 KB)
- P08 - Statistical Analysis of Primary Tumors - Uterine 0-1000 300-1000 (56 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (479 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 0-300, 0-1000) (150 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-0, 150-300, 300-1000) (153 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-300, 150-300) (115 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - litter (0-1000, 300-1000) (125 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 0-300 0-1000 (109 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-0 150-300 300-1000 (86 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-300 150-300 (80 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Uterine 0-1000 300-1000 (79 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 0-300, 0-1000) (12 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-0, 150-300, 300-1000) (12 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-300, 150-300) (11 KB)
- P11 - Statistical Analysis of Survival Data - litter (0-1000, 300-1000) (11 KB)
- P14 - Individual Animal Pathology Data (838 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (364 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 KB)
- P18_-_Incidence_Rates_of_Non-Neoplastic_Lesions_by_Anatomic_Site_with_Average_Severity_Grades-Uterine_Hyperplasia_ (2 MB)
- P40 - Survival Curves - 0-0, 0-300, 0-1000 (32 KB)
- P40 - Survival Curves - 0-0, 150-300, 300-1000 (32 KB)
- P40 - Survival Curves - 0-300, 150-300 (29 KB)
- P40 - Survival Curves - 0-1000, 300-1000 (30 KB)
- P40 - Survival Curves - All Treatments (34 KB)
Chronic Individual Animal Data of Study One (C20614) - Male and Female Rats
- Female Individual Animal Body Weight All Animals (596 KB)
- Female Individual Animal Neoplastic Pathology Data (156 KB)
- Female Individual Animal Non Neoplastic Pathology Data (1 MB)
- Female Individual Animal Survival Data (48 KB)
- Female Individual Animal Terminal Body Weight Data (83 KB)
- Female Individual Clinical Observations (232 KB)
- Individual Animal Clinical Chemistry Data (13 KB)
- Individual Animal DamID and PupID Data (25 KB)
- Individual Animal Liver Special Studies Data (7 KB)
- Individual Animal Organ Weight Data (13 KB)
- Individual Animal Reproductive Performance Data (11 KB)
- Individual Animal Tissue Concentration Data (9 KB)
- Male Individual Animal Body Weight All Animals (176 KB)
- Male Individual Animal Neoplastic Pathology Data (2 KB)
- Male Individual Animal Non Neoplastic Pathology Data (106 KB)
- Male Individual Animal Survival Data (45 KB)
- Male Individual Clinical Observations (3 KB)