Evaluation of the Chronic Toxicity and Carcinogenicity (C20614B) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Male Harlan Sprague Dawley Rats Exposed via Dosed Feed

Long-Term

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Interim (16 Week) of Chronic Study Two (C20614B) – Male Rats

• E01 - Animal Removal Summary By Treatment Group (12 KB)
• E02 - Animals Removed from Experiment (46 KB)
• E05 - Clinical Observations Summary (24 KB)
• E08 - Feed Water and Compound Consumption Table (33 KB)
• P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (25 KB)
• P04 - Neoplasms by Individual Animal (96 KB)
• P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (27 KB)
• P09 - Non-Neoplastic Lesions by Individual Animal (98 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 0-20, 0-40, 0-80 (24 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-0, 300-0 (13 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-20, 300-20 (22 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-40, 300-40 (19 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 0-80, 300-80 (22 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - Males 300-0, 300-20, 300-40, 300-80 (24 KB)
• P14 - Individual Animal Pathology Data (162 KB)
• P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (96 KB)
• P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (26 KB)
• PA48 - Tissue Concentration Summary (73 KB)
• R02 - Reproductive Performance Summary (35 KB)

Chronic Study Two (C20614B) – Male Rats

• E01 - Animal Removal Summary By Treatment Group (12 KB)
• E02 - Animals Removed from Experiment (116 KB)
• E03 - Growth Curves - litter (0-0, 0-20, 0-40, 0-80) (36 KB)
• E03 - Growth Curves - litter (0-0, 300-0) (30 KB)
• E03 - Growth Curves - litter (0-20, 300-20) (30 KB)
• E03 - Growth Curves - litter (0-40, 300-40) (31 KB)
• E03 - Growth Curves - litter (0-80, 300-80) (29 KB)
• E03 - Growth Curves - litter (300-0, 300-20, 300-40, 300-80) (36 KB)
• E04 - Mean Body Weights and Survival Table litter (0-0, 0-20, 0-40, 0-80) (12 KB)
• E04 - Mean Body Weights and Survival Table litter (0-0, 300-0) (10 KB)
• E04 - Mean Body Weights and Survival Table litter (0-20, 300-20) (10 KB)
• E04 - Mean Body Weights and Survival Table litter (0-40, 300-40) (10 KB)
• E04 - Mean Body Weights and Survival Table litter (0-80, 300-80) (10 KB)
• E04 - Mean Body Weights and Survival Table litter (300-0, 300-20, 300-40, 300-80) (12 KB)
• E05 - Clinical Observations Summary (24 KB)
• E08 - Feed Water and Compound Consumption Table (33 KB)
• F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Chemical Consumption (18 KB)
• F0 Female Harlan Sprague Dawley Rats Gestational and Lactational Food Consumption (18 KB)
• F0 Female Harlan Sprague Dawley Rats Gestational Body and Body Weight Gains (17 KB)
• F0 Female Harlan Sprague Dawley Rats Lactational Body and Body Weight Gains (16 KB)
• F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: Male Pup Body Weights (16 KB)
• F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND1 Data (18 KB)
• F0 Litter Data Analysis in Female Harlan Sprague Dawley Rats: PND4 Data (16 KB)
• P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (63 KB)
• P04 - Neoplasms by Individual Animal (639 KB)
• P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (50 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(0-0, 0-20, 0-40, 0-80) (76 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(0-0, 300-0) (59 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(0-20, 300-20) (66 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(0-40, 300-40) (46 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(0-80, 300-80) (48 KB)
• P08 - Statistical Analysis of Primary Tumors - litter(300-0, 300-40, 300-60, 300-80) (76 KB)
• P09 - Non-Neoplastic Lesions by Individual Animal (811 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 0-20, 0-40, 0-80) (178 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-0, 300-0) (130 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-20, 300-20) (132 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-40, 300-40) (139 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(0-80, 300-80) (128 KB)
• P10 - Statistical Analysis of Non-Neoplastic Lesions - litter(300-0, 300-20, 300-40, 300-80) (169 KB)
• P11 - Statistical Analysis of Survival Data - litter (0-0, 0-20, 0-40, 0-80) (11 KB)
• P11 - Statistical Analysis of Survival Data - litter (0-0, 300-0) (11 KB)
• P11 - Statistical Analysis of Survival Data - litter (0-20, 300-20) (11 KB)
• P11 - Statistical Analysis of Survival Data - litter (0-40, 300-40) (11 KB)
• P11 - Statistical Analysis of Survival Data - litter (0-80, 300-80) (11 KB)
• P11 - Statistical Analysis of Survival Data - litter (300-0, 300-20, 300-40, 300-80) (11 KB)
• P14 - Individual Animal Pathology Data (1 MB)
• P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (571 KB)
• P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (65 KB)
• P40 - Survival Curves - 0-0, 0-20, 0-40, 0-80 (30 KB)
• P40 - Survival Curves - 0-0, 300-0 (28 KB)
• P40 - Survival Curves - 0-20, 300-20 (28 KB)
• P40 - Survival Curves - 0-40, 300-40 (29 KB)
• P40 - Survival Curves - 0-80, 300-80 (29 KB)
• P40 - Survival Curves - 300-0, 300-20, 300-40, 300-80 (30 KB)
• P40 - Survival Curves - All Treatment Groups (35 KB)

Chronic Individual Animal Data of Study Two (C20614B) - Male Rats

• 002-02657-0004-0000-6 Male IndividualBodyWeightAllAnimals (1 MB)
• Individual Animal Clinical Chemistry Data (11 KB)
• Individual Animal DamID and PupID Data (23 KB)
• Individual Animal Liver Special Studies Data (8 KB)
• Individual Animal Organ Weight Data (11 KB)
• Individual Animal Reproductive Performance Data (16 KB)
• Individual Animal Tissue Concentration Data (12 KB)
• Male Individual Animal Neoplastic Pathology Data (218 KB)
• Male Individual Animal Non Neoplastic Pathology Data (2 MB)
• Male Individual Animal Survival Data (76 KB)
• Male Individual Animal Terminal Body Weight Data (131 KB)
• Male Individual Clinical Observations (221 KB)