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Mesotrione (104206-82-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7032424

Study Results

Genetic Toxicology

An overview of Genetic Toxicology In Vitro Micronucleus study conclusions related to Mesotrione (104206-82-8).
In Vitro Micronucleus
View
  • Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Mesotrione (104206-82-8).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. Mesotrione (104206-82-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Comparative investigation of the potential of glyphosate and glyphosate-based formulations (GBFs) to cause oxidative stress and DNA damage in human skin and liver cell systems Stephanie L. Smith-Roe1, Michael J. DeVito1, Caroll Co2, Sreenivasa C. Ramaiahgari1, Michael Easterling2, Julie R. Rice1, Paul E. Dunlap1, David M. Crizer1, Zhifeng Zhou1, B. Alex Merrick1, Guanhua Xie2, Shawn F. Harris2, Keith R. Shockley3, Arpit Tandon4, Ayse Oktay4, Deepak Mav4, Ruchir Shah4, Alexandre Borrel4, Vijay Gombar4, Scott A. Masten1, Richard S. Paules1, Stephen S. Ferguson1*

Affiliations
1Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
2DLH, LLC, Bethesda, Maryland, USA.
3Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
4Sciome, Durham, North Carolina, USA.

*Corresponding Author
Stephen S. Ferguson, Ph.D.
Mechanistic Toxicology Branch
Division of Translational Toxicology
National Institute of Environmental Health Sciences
111 TW Alexander Dr.
Building 101, Room E140B
P.O. Box 12233
Research Triangle Park, NC 27709
Email: stephen.ferguson@nih.gov; (984)287-3128

DOI: https://doi.org/10.22427/NTP-DATA-500-106-001-000-3
Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt

Environmental and Molecular Mutagenesis: https://onlinelibrary.wiley.com/doi/10.1002/em.22534
DOI: https://doi.org/10.22427/NTP-DATA-002-02220-0014-0000-3

Two data values for one concentration in the 4 h +S9 experimental condition were corrected after a quality assurance audit. This finding did not impact the interpretation of the study.

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Mesotrione (104206-82-8) in Litron MultiFlow DNA Damage Assay (p53, gamma-H2AX, Phospho-Histone H3) Study G18020 in Human TK6 Cells
Summary Data
Genetic Toxicity Evaluation of Mesotrione (104206-82-8) in Salmonella/E. coli Mutagenicity Test or Ames Test. Study G18020B
Summary Data
Genetic Toxicity Evaluation of Mesotrione in Micronucleus Study G18020C in Human TK6 Cells
Summary and Detailed Data

DTT Data Collections