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Glyphosate (1071-83-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1024122

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Glyphosate (1071-83-6).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology In Vitro Micronucleus study conclusions related to Glyphosate (1071-83-6).
In Vitro Micronucleus
View
  • Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Glyphosate (1071-83-6).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information

NTP. Glyphosate (1071-83-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TOX-16 Toxicity Studies of Glyphosate (CASRN 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1Mice
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Comparative investigation of the potential of glyphosate and glyphosate-based formulations (GBFs) to cause oxidative stress and DNA damage in human skin and liver cell systems Stephanie L. Smith-Roe1, Michael J. DeVito1, Caroll Co2, Sreenivasa C. Ramaiahgari1, Michael Easterling2, Julie R. Rice1, Paul E. Dunlap1, David M. Crizer1, Zhifeng Zhou1, B. Alex Merrick1, Guanhua Xie2, Shawn F. Harris2, Keith R. Shockley3, Arpit Tandon4, Ayse Oktay4, Deepak Mav4, Ruchir Shah4, Alexandre Borrel4, Vijay Gombar4, Scott A. Masten1, Richard S. Paules1, Stephen S. Ferguson1*

Affiliations
1Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
2DLH, LLC, Bethesda, Maryland, USA.
3Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
4Sciome, Durham, North Carolina, USA.

*Corresponding Author
Stephen S. Ferguson, Ph.D.
Mechanistic Toxicology Branch
Division of Translational Toxicology
National Institute of Environmental Health Sciences
111 TW Alexander Dr.
Building 101, Room E140B
P.O. Box 12233
Research Triangle Park, NC 27709
Email: stephen.ferguson@nih.gov; (984)287-3128

DOI: https://doi.org/10.22427/NTP-DATA-500-106-001-000-3
Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt

Environmental and Molecular Mutagenesis: https://onlinelibrary.wiley.com/doi/10.1002/em.22534
DOI: https://doi.org/10.22427/NTP-DATA-002-02220-0014-0000-3

Two data values for one concentration in the 4 h +S9 experimental condition were corrected after a quality assurance audit. This finding did not impact the interpretation of the study.

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C62011) of Glyphosate (1071-83-6) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C62011) of Glyphosate (1071-83-6) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C62011) of Glyphosate (1071-83-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C62011) of Glyphosate (1071-83-6) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Glyphosate (1071-83-6) in Litron MultiFlow DNA Damage Assay (p53, gamma-H2AX, Phospho-Histone H3) Study G88067 in Human TK6 Cells
Summary Data
Genetic Toxicity Evaluation of Glyphosate (1071-83-6) in Micronucleus Study A34848 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Glyphosate (1071-83-6) in Micronucleus Study G88067C in Human TK6 Cells
Summary and Detailed Data
Genetic Toxicity Evaluation of Glyphosate (1071-83-6) in Salmonella/E. coli Mutagenicity Test or Ames Test. Study G88067B
Summary Data
Genetic Toxicity Evaluation of Glyphosate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 149350
Summary Data
Genetic Toxicity Evaluation of Halex GT (1071-83-6) in Litron MultiFlow DNA Damage Assay (p53, gamma-H2AX, Phospho-Histone H3) Study G18026 in Human TK6 Cells
Summary Data
Genetic Toxicity Evaluation of Halex GT (1071-83-6) in Salmonella/E. coli Mutagenicity Test or Ames Test. Study G18026B
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0095) of Glyphosate (1071-83-6) in F344 Rats Exposed via Gavage, Intravenous and Intraperitoneal Injection
Data Summary

DTT Data Collections