Hexachlorobenzene (118-74-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020682
Publications
TOX-77
Toxicity Studies of Hexachlorobenzene Administered by Gavage to Female Sprague Dawley (Hsd:Sprague Dawley SD) Rats
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Study Data
Toxicity and Carcinogenicity Studies
5-day study (C10546) of hexachlorobenzene (118-74-1) delivered via Gavage in HSD Rat
Study Tables
- I01 - Animal Removal Summary (31 kB)
- I03 - Growth Curve (334 kB)
- I03C - Growth Curve (366 kB)
- I04 -Mean Body Weight Summary (65 kB)
- I04G - Mean Body Weight Gain (53 kB)
- I05 - Clinical Observations Summary (48 kB)
- PA06 - Organ Weights Summary (56 kB)
Individual Animal Data
3-Month Evaluation of the Toxicity (C98004) of Hexachlorobenzene (118-74-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E03 - Initial and Current Body Weight (35 kB)
- E40 - Growth and Survival Curve (65 kB)
- E41 - Mean Body Weights and Survival Table (37 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (49 kB)
- P04 - Neoplasms by Individual Animal (82 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (43 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (87 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (45 kB)
- P14 - Individual Animal Pathology Data (184 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (50 kB)
- P40 - Survival Curves (75 kB)
- PA06 - Organ Weights Summary (111 kB)
- PA45 - Liver Special Studies Summary (40 kB)
- PA48 - Summary of Tissue Concentration (75 kB)
- PA49 - Summary of Cytochrome Activity (66 kB)
- R07 - Hormone Summary (43 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (48 kB)
- Female Individual Animal Clinical Observations (13 kB)
- Female Individual Animal Neoplastic Pathology Data (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (129 kB)
- Female Individual Animal Survival Data (14 kB)
- Individual Animal Cytochrome Activity Data (12 kB)
- Individual Animal Hormone Data (8 kB)
- Individual Animal Liver Special Studies Data (8 kB)
- Individual Animal Organ Weight Data (12 kB)
- Individual Animal Tissue Concentration Data (25 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Hexachlorobenzene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 880475
Summary Data
- G06 - Ames Summary Data (137 KB)
Other NTP Studies
Toxicokinetic Evaluation (K05130 - S0654_S0811) of Hexachlorobenzene (DTXSID2020682) in Rat
Data
- Annotated Group Parameters - K05130 (combined data of S0654 and S0811) (27 kB)
- Annotated Individual Animal Data - S0654 (187 kB)
- Annotated Individual Animal Data - S0811 (292 kB)
- Original Data - S0654 (45 kB)
- Original Data - S0811 (66 kB)
- Summary data - K05130 (combined data of S0654 and S0811) (240 kB)