Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

tris(Aziridinyl)-phosphine sulfide (52-24-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021339

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to tris(Aziridinyl)-phosphine sulfide (52-24-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. tris(Aziridinyl)-phosphine sulfide (52-24-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-058 Bioassay of Thio-TEPA for Possible Carcinogenicity (CASRN 52-24-4)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 373221
Summary Data

DTT Data Collections