1-ethyl-3-methylimidazolium chloride (65039-09-0)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1041180
Publications
TOX-103
Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
Evaluation of Skin Sensitization Induced by Four Ionic Liquids
Rachel Frawley, Dori Germolec, Victor Johnson, Travis Gulledge, Wimolnut Manheng, Kimber White Jr, Keith R Shockley, Shawn F Harris, Michelle Hooth, Kristen Ryan
Note: Data from this study are available upon request
DOI: https://doi.org/10.22427/NTP-DATA-002-03253-0003-0000-8
Note: Data from this study are available upon request
DOI: https://doi.org/10.22427/NTP-DATA-002-03253-0003-0000-8
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C05049) of Ionic liquid Toxicity (IONICLIQUIDS) in Harlan Sprague-Dawley Rats Exposed via Dosed Water
Study Tables
- E03 - Growth Curves - BMIM (341 kB)
- E03 - Growth Curves - Bmpy (356 kB)
- E03 - Growth Curves - EMIM (370 kB)
- E03 - Growth Curves - NBuPy (358 kB)
- E04 - Mean Body Weights and Survival Table - BMIM (12 kB)
- E04 - Mean Body Weights and Survival Table - Bmpy (11 kB)
- E04 - Mean Body Weights and Survival Table - EMIM (12 kB)
- E04 - Mean Body Weights and Survival Table - NBuPy (11 kB)
- E05 - Clinical Observations Summary - BMIM (88 kB)
- E05 - Clinical Observations Summary - EMIM (115 kB)
- E05 - Clinical Observations Summary - NBuPy (71 kB)
- E07 - Mean Water Consumption by Treatment Group - BMIM (16 kB)
- E07 - Mean Water Consumption by Treatment Group - Bmpy (14 kB)
- E07 - Mean Water Consumption by Treatment Group - EMIM (14 kB)
- E07 - Mean Water Consumption by Treatment Group - NBuPy (14 kB)
- E08 - Water and Compound Consumption Table - BMIM (18 kB)
- E08 - Water and Compound Consumption Table - Bmpy (18 kB)
- E08 - Water and Compound Consumption Table - EMIM (19 kB)
- E08 - Water and Compound Consumption Table - NBuPy (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - BMIM (19 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - Bmpy (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - EMIM (21 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - NBuPy (19 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - BMIM (67 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - Bmpy (76 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - EMIM (110 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - NBuPy (90 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - BMIM (23 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Bmpy (20 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - EMIM (49 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - NBuPy (30 kB)
- P14 - Individual Animal Pathology Data - BMIM (80 kB)
- P14 - Individual Animal Pathology Data - Bmpy (80 kB)
- P14 - Individual Animal Pathology Data - EMIM (96 kB)
- P14 - Individual Animal Pathology Data - NBuPy (80 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - BMIM (20 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - Bmpy (20 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - EMIM (21 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - NBuPy (20 kB)
- PA06 - Organ Weights Summary - BMIM (70 kB)
- PA06 - Organ Weights Summary - Bmpy (70 kB)
- PA06 - Organ Weights Summary - EMIM (77 kB)
- PA06 - Organ Weights Summary - NBuPy (69 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals - BMIM (32 kB)
- Female Individual Animal Body Weight Data All Animals - Bmpy (55 kB)
- Female Individual Animal Body Weight Data All Animals - EMIM (55 kB)
- Female Individual Animal Body Weight Data All Animals - NBuPy (31 kB)
- Female Individual Animal Clinical Observations - BMIM (54 kB)
- Female Individual Animal Clinical Observations - EMIM (56 kB)
- Female Individual Animal Clinical Observations - NBuPy (54 kB)
- Female Individual Animal Neoplastic Pathology Data - EMIM (57 kB)
- Female Individual Animal Non Neoplastic Pathology Data - BMIM (59 kB)
- Female Individual Animal Non Neoplastic Pathology Data - Bmpy (59 kB)
- Female Individual Animal Non Neoplastic Pathology Data - EMIM (34 kB)
- Female Individual Animal Non Neoplastic Pathology Data - NBuPy (31 kB)
- Female Individual Animal Survival Data - BMIM (30 kB)
- Female Individual Animal Survival Data - Bmpy (53 kB)
- Female Individual Animal Survival Data - EMIM (54 kB)
- Female Individual Animal Survival Data - NBuPy (53 kB)
- Female Individual Animal Terminal Body Weight Data - BMIM (49 kB)
- Female Individual Animal Terminal Body Weight Data - Bmpy (49 kB)
- Female Individual Animal Terminal Body Weight Data - EMIM (49 kB)
- Female Individual Animal Terminal Body Weight Data - NBuPy (48 kB)
- Individual Animal Organ Weight Data - BMIM (8 kB)
- Individual Animal Organ Weight Data - Bmpy (8 kB)
- Individual Animal Organ Weight Data - EMIM (8 kB)
- Individual Animal Organ Weight Data - NBuPy (8 kB)
- Male Individual Animal Body Weight Data All Animals - BMIM (54 kB)
- Male Individual Animal Body Weight Data All Animals - Bmpy (55 kB)
- Male Individual Animal Body Weight Data All Animals - EMIM (55 kB)
- Male Individual Animal Body Weight Data All Animals - NBuPy (54 kB)
- Male Individual Animal Clinical Observations - EMIM (56 kB)
- Male Individual Animal Clinical Observations - NBuPy (54 kB)
- Male Individual Animal Non Neoplastic Pathology Data - All (31 kB)
- Male Individual Animal Non Neoplastic Pathology Data - BMIM (60 kB)
- Male Individual Animal Non Neoplastic Pathology Data - EMIM (63 kB)
- Male Individual Animal Non Neoplastic Pathology Data - NBuPy (60 kB)
- Male Individual Animal Survival Data - BMIM (53 kB)
- Male Individual Animal Survival Data - Bmpy (53 kB)
- Male Individual Animal Survival Data - EMIM (54 kB)
- Male Individual Animal Survival Data - NBuPy (53 kB)
- Male Individual Animal Terminal Body Weight Data - BMIM (48 kB)
- Male Individual Animal Terminal Body Weight Data - Bmpy (48 kB)
- Male Individual Animal Terminal Body Weight Data - EMIM (31 kB)
- Male Individual Animal Terminal Body Weight Data - NBuPy (31 kB)
2-Week Evaluation of the Toxicity (C05049) of Ionic liquid Toxicity (IONICLIQUIDS) in B6C3F1 Mice Exposed via Dosed Water
Study Tables
- E03 - Growth Curves - BMIM (348 kB)
- E03 - Growth Curves - Bmpy (348 kB)
- E03 - Growth Curves - EMIM (364 kB)
- E03 - Growth Curves - NBuPy (351 kB)
- E04 - Mean Body Weights and Survival Table - BMIM (11 kB)
- E04 - Mean Body Weights and Survival Table - Bmpy (11 kB)
- E04 - Mean Body Weights and Survival Table - EMIM (11 kB)
- E04 - Mean Body Weights and Survival Table - NBuPy (11 kB)
- E05 - Clinical Observations Summary - BMIM (213 kB)
- E05 - Clinical Observations Summary - Bmpy (715 kB)
- E05 - Clinical Observations Summary - EMIM (110 kB)
- E05 - Clinical Observations Summary - NBuPy (117 kB)
- E07 - Mean Water Consumption by Treatment Group - BMIM (14 kB)
- E07 - Mean Water Consumption by Treatment Group - Bmpy (14 kB)
- E07 - Mean Water Consumption by Treatment Group - EMIM (14 kB)
- E07 - Mean Water Consumption by Treatment Group - NBuPy (14 kB)
- E08 - Water and Compound Consumption Table - BMIM (18 kB)
- E08 - Water and Compound Consumption Table - Bmpy (18 kB)
- E08 - Water and Compound Consumption Table - EMIM (19 kB)
- E08 - Water and Compound Consumption Table - NBuPy (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - BMIM (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - EMIM (19 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - BMIM (69 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal - EMIM (91 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - BMIM (16 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - EMIM (22 kB)
- P14 - Individual Animal Pathology Data - BMIM (79 kB)
- P14 - Individual Animal Pathology Data - Bmpy (78 kB)
- P14 - Individual Animal Pathology Data - EMIM (93 kB)
- P14 - Individual Animal Pathology Data - NBuPy (78 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - BMIM (18 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades - EMIM (20 kB)
- PA06 - Organ Weights Summary - BMIM (70 kB)
- PA06 - Organ Weights Summary - Bmpy (70 kB)
- PA06 - Organ Weights Summary - EMIM (78 kB)
- PA06 - Organ Weights Summary - NBuPy (70 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals - BMIM (55 kB)
- Female Individual Animal Body Weight Data All Animals - Bmpy (55 kB)
- Female Individual Animal Body Weight Data All Animals - EMIM (55 kB)
- Female Individual Animal Body Weight Data All Animals - NBuPy (55 kB)
- Female Individual Animal Clinical Observations - EMIM (55 kB)
- Female Individual Animal Clinical Observations - NBuPy (54 kB)
- Female Individual Animal Non Neoplastic Pathology Data - EMIM (59 kB)
- Female Individual Animal Survival Data - BMIM (53 kB)
- Female Individual Animal Survival Data - Bmpy (53 kB)
- Female Individual Animal Survival Data - EMIM (54 kB)
- Female Individual Animal Survival Data - NBuPy (53 kB)
- Female Individual Animal Terminal Body Weight Data - BMIM (48 kB)
- Female Individual Animal Terminal Body Weight Data - Bmpy (48 kB)
- Female Individual Animal Terminal Body Weight Data - EMIM (49 kB)
- Female Individual Animal Terminal Body Weight Data - NBuPy (48 kB)
- Individual Animal Organ Weight Data - BMIM (7 kB)
- Individual Animal Organ Weight Data - Bmpy (7 kB)
- Individual Animal Organ Weight Data - EMIM (8 kB)
- Individual Animal Organ Weight Data - NBuPy (7 kB)
- Male Individual Animal Body Weight Data All Animals - BMIM (54 kB)
- Male Individual Animal Body Weight Data All Animals - Bmpy (54 kB)
- Male Individual Animal Body Weight Data All Animals - EMIM (55 kB)
- Male Individual Animal Body Weight Data All Animals - NBuPy (54 kB)
- Male Individual Animal Clinical Observations - BMIM (54 kB)
- Male Individual Animal Clinical Observations - Bmpy (54 kB)
- Male Individual Animal Clinical Observations - EMIM (56 kB)
- Male Individual Animal Clinical Observations - NBuPy (54 kB)
- Male Individual Animal Non Neoplastic Pathology Data - BMIM (59 kB)
- Male Individual Animal Non Neoplastic Pathology Data - EMIM (60 kB)
- Male Individual Animal Survival Data - BMIM (53 kB)
- Male Individual Animal Survival Data - Bmpy (53 kB)
- Male Individual Animal Survival Data - EMIM (54 kB)
- Male Individual Animal Survival Data - NBuPy (53 kB)
- Male Individual Animal Terminal Body Weight Data - BMIM (48 kB)
- Male Individual Animal Terminal Body Weight Data - Bmpy (48 kB)
- Male Individual Animal Terminal Body Weight Data - EMIM (49 kB)
- Male Individual Animal Terminal Body Weight Data - NBuPy (48 kB)
Evaluation of the Prechronic Toxicity (C07018) of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride (65039-09-0 ) in Harlan Sprague-Dawley Rats Exposed Via Dosed Water
Study Tables
- E03 - Growth Curves (466 kB)
- E04 - Mean Body Weights and Survival Table (13 kB)
- E05 - Clinical Observations Summary (9 kB)
- E07 - Mean Water Consumption By Treatment Group (15 kB)
- E08 - Feed Water and Compound Consumption Table (21 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 kB)
- P04 - Neoplasms by Individual Animal (158 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (135 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (135 kB)
- P11 - Statistical Analysis of Survival Data (23 kB)
- P14 - Individual Animal Pathology Data (188 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (158 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 kB)
- P40 - Survival Curves (441 kB)
- PA06 - Organ Weights Summary (70 kB)
- PA41 - Clinical Chemistry Summary (177 kB)
- PA43 - Hematology Summary (201 kB)
- Vaginal Cytology Markov Model (195 kB)
- Vaginal Cytology Plots (88 kB)
- Vaginal Cytology Summary (25 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (24 kB)
- Female Individual Animal Non Neoplastic Pathology Data (21 kB)
- Female Individual Animal Survival Data (8 kB)
- Female Individual Animal Terminal Body Weight Data (13 kB)
- Individual Animal Clinical Chemistry Data (12 kB)
- Individual Animal Hematology Data (14 kB)
- Individual Animal Organ Weight Data (10 kB)
- Male Individual Animal Body Weight Data All Animals (24 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (17 kB)
- Male Individual Animal Survival Data (8 kB)
- Male Individual Animal Terminal Body Weight Data (13 kB)
Evaluation of the Prechronic Toxicity (C07018) of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride (65039-09-0 ) in B6C3F1, Mouse Exposed Via Dosed Water
Study Tables
- E03 - Growth Curves (437 kB)
- E04 - Mean Body Weights and Survival Table (13 kB)
- E07 - Mean Water Consumption By Treatment Group (15 kB)
- E08 - Feed Water and Compound Consumption Table (21 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (21 kB)
- P04 - Neoplasms by Individual Animal (145 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (147 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (66 kB)
- P11 - Statistical Analysis of Survival Data (16 kB)
- P14 - Individual Animal Pathology Data (136 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (146 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (22 kB)
- P40 - Survival Curves (448 kB)
- PA06 - Organ Weights Summary (70 kB)
- PA43 - Hematology Summary (201 kB)
- Vaginal Cytology Markov Model (189 kB)
- Vaginal Cytology Plots (90 kB)
- Vaginal Cytology Summary (27 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (24 kB)
- Female Individual Animal Clinical Observations (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (20 kB)
- Female Individual Animal Survival Data (8 kB)
- Female Individual Animal Terminal Body Weight Data (13 kB)
- Individual Animal Hematology Data (14 kB)
- Individual Animal Organ Weight Data (9 kB)
- Male Individual Animal Body Weight Data All Animals (24 kB)
- Male Individual Animal Non Neoplastic Pathology Data (13 kB)
- Male Individual Animal Survival Data (8 kB)
- Male Individual Animal Terminal Body Weight Data (13 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride (65039-09-0) in Micronucleus Study G07018 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride (65039-09-0) in Micronucleus Study G07018B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A09944
Summary Data
- G06 - Ames Summary Data (69 KB)