Melatonin (73-31-4)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1022421
Publications
Developmental Toxicity of Melatonin (CAS #73-31-4) Administered by Gavage to Sprague-Dawley CD Rats on Gestational Days 6 through 19
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in Long-Evans Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in Long-Evans Rats Exposed via Gavage. NTP Special Study
26-Week Evaluation of the Toxicity (C20001) of Prevention 3 (Melatonin) (73-31-4) in Tg.NK Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C96013) of Melatonin (73-31-4) in Long-Evans Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
6-Month Evaluation of the Toxicity (C20015) of Prevention 5 (Melatonin) (73-31-4) in Tg.NK Mice Exposed via Dosed Feed
Pathology Tables
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
6-Month Evaluation of the Toxicity (C99014C) of Prevention 2 (Silymarin + Melatonin) (SILYMARN+MEL) in Tg.NK Mice Exposed via Dosed Feed
Other NTP Studies
Prenatal Developmental Toxicity Pilot Study (TRP97001) of Melatonin (73-31-4) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (22 kB)
- Dam Data: Dam Feed Consumption (20 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (21 kB)
- Dam Data: Organ Weights (20 kB)
- Fetal Data: All Malformations (485 kB)
- Fetal Data: All Variations (484 kB)
- Fetal Data: Fetal Body Weights (480 kB)
- Live Litter: All Litter (482 kB)
- Live Litter: Live Litter (484 kB)
Prenatal Developmental Toxicity Study (TER96003) of Melatonin (73-31-4) in Sprague-Dawley Rats Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (24 kB)
- Dam Data: Dam Feed Consumption (22 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (22 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (590 kB)
- Fetal Data: All Variations (590 kB)
- Fetal Data: Fetal Body Weights (585 kB)
- Live Litter: All Litter (587 kB)
- Live Litter: Live Litter (590 kB)