Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

AZT+3TC combination (AZT3TCCOMBO)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to AZT+3TC combination (AZT3TCCOMBO).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Positive
View
  • Male: Positive
View
  • Male: Positive
View
  • Male: Negative
View
  • Male: Negative

Citation Information

NTP. AZT+3TC combination (AZT3TCCOMBO). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and (-)2',3'-Dideoxy-3'-thiacytidine (3TC; CASRN 134678-17-4) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 16
Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and (-) 2', 3'-Dideoxy-3'-thiacytidine (3TC; CASRN 134678-17-4) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 16

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A40581 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A62246 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A62527 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A75317 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A78223 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Micronucleus Study A83804 in CD-1 Mice
Summary and Individual Animal Data

Other NTP Studies

Prenatal Developmental Toxicity Pilot Study (TRP20202) of AZT+3TC+NVP Combination (AZT3TCCOMBO) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
Prenatal Developmental Toxicity Study (TER20203) of AZT+3TC+NVP combination (AZT3TCCOMBO) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data

DTT Data Collections