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3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2030277

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB).
Micronucleus - Mice
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  • Female: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Negative
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  • Male: Positive
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  • Female: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive

Citation Information

NTP. 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Bishop JB, Witt KL, Tice RR, Wolfe G. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen. 2004;43(1):3-9.
Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A03310 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A07834 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A10804 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A24399 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A28891 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A29422 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A31999 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A38558 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A43440 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A53298 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A54094 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A60084 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A64786 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A68101 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A70649 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS Initiative) (AZTDDICOMB) in Micronucleus Study A76722 in CD-1 Mice
Summary and Individual Animal Data

Other NTP Studies

Toxicokinetic Evaluation (S0408) of 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine (DTXSID2030277) in Mouse
Data

DTT Data Collections