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1020 Long Multiwalled Carbon Nanotube (L-MWNT-1020)

Citation Information

NTP. 1020 Long Multiwalled Carbon Nanotube (L-MWNT-1020). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-94 Toxicity Studies of 1020 Long Multiwalled Carbon Nanotubes Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

Immunotoxicity Assessment of Multiwalled Carbon Nanotubes Following Whole-Body Inhalation Exposure for 30 and 90 Days in B6C3F1/N Mice and 30 Days in HSD:Harlan Sprague Dawley SD® Rats Victor J. Johnson¹, Nigel J. Walker², Michael I. Luster¹, Gary R. Burleson¹, Michelle Cora², Gregory L. Baker³, Barney Sparrow⁴, Dori R. Germolec²,

¹Burleson Research Technologies, Inc., Morrisville, NC, USA
²Division of Translational Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
³Sarepta Therapeutics, Columbus, OH, USA
⁴Battelle Memorial Institute, Columbus, OH, USA

DOI: https://doi.org/10.22427/NTP-DATA-500-005-001-000-1

Study Data

Protocol

Toxicity and Carcinogenicity Studies

30-Day Evaluation of the Toxicity (C07062) of 1020 Long Multiwalled Carbon Nanotube (L-MWNT-1020) in Harlan Sprague-Dawley Rats via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (348 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (14 kB)
E12 - Animal History (799 kB)
Female Tissue Burden Analysis (50 kB)
Male Tissue Burden Analysis (51 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28 kB)
P04 - Neoplasms by Individual Animal (314 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (30 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (371 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (82 kB)
P14 - Individual Animal Pathology Data (265 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29 kB)
P40 - Survival Curves (427 kB)
PA06 - Organ Weights Summary (88 kB)
PA47 - Lung Burden Summary (172 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (80 kB)
Female Individual Animal Non Neoplastic Pathology Data (77 kB)
Female Individual Animal Organ Weight Data (60 kB)
Female Individual Animal Survival Data (34 kB)
Individual Animal Organ Weight Data (13 kB)
Individual Lung Burden Data (26 kB)
Male Individual Animal Body Weight Data (80 kB)
Male Individual Animal Clinical Observations (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (68 kB)
Male Individual Animal Organ Weight Data (60 kB)
Male Individual Animal Survival Data (34 kB)

30-Day Evaluation of the Toxicity (C07062) of 1020 Long Multiwalled Carbon Nanotube (L-MWNT-1020) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables - Mice

E03 - Growth Curves (347 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (11 kB)
E12 - Animal History (799 kB)
Female Tissue Burden Analysis (132 kB)
Male Tissue Burden Analysis (134 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28 kB)
P04 - Neoplasms by Individual Animal (317 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (29 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (372 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (93 kB)
P14 - Individual Animal Pathology Data (267 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29 kB)
P40 - Survival Curves (432 kB)
PA06 - Organ Weights Summary (88 kB)
PA47 - Lung Burden Summary (160 kB)

Individual Animal Data - Mice

Female Individual Animal Body Weight Data (73 kB)
Female Individual Animal Non Neoplastic Pathology Data (75 kB)
Female Individual Animal Organ Weight Data (60 kB)
Female Individual Animal Survival Data (34 kB)
Individual Animal Organ Weight Data (12 kB)
Individual Lung Burden Data (25 kB)
Male Individual Animal Body Weight Data (73 kB)
Male Individual Animal Non Neoplastic Pathology Data (70 kB)
Male Individual Animal Organ Weight Data (59 kB)
Male Individual Animal Survival Data (34 kB)