DART-05: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Modified One Generation Dose Range Finding Study, Modified One Generation Main Study Studies
DOI:
https://doi.org/10.22427/NTP-DATA-DART-05
Tables were updated on January 15, 2019 because of a change in format to increase clarity of data displayed
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Tables were updated on February 12, 2020 to increase the clarity of footnotes describing statistical analyses. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I08, R19, R19C and R19G.
Tables were updated on January 15, 2019 because of a change in format to increase clarity of data displayed
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Tables were updated on February 12, 2020 to increase the clarity of footnotes describing statistical analyses. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I08, R19, R19C and R19G.
DART-05: 2-Hydroxy-4-methoxybenzophenone
Modified One Generation Dose Range Finding Study
Modified One Generation Toxicity Dose Range Finding Study Tables
- I01 - Animal Removal Summary (40 KB)
- I02 - Animal Removals (201 KB)
- I03 - Growth Curve (598 KB)
- I03C - Growth Curve (606 KB)
- I04 - Mean Body Weights and Survival (160 KB)
- I04G - Mean Body Weight Gain (95 KB)
- I05 - Clinical Observations Summary (35 KB)
- I05P - Pup Clinical Observations Summary (157 KB)
- I06 - Mean Feed Consumption (102 KB)
- I08 - Mean Test Compound Consumption (78 KB)
- R01 - Multigeneration Cross Reference (783 KB)
- R02 - Reproductive Performance Summary (39 KB)
- R03 - Litter Data Summary (90 KB)
- R19 - Pup Bodyweight Summary (183 KB)
- R19C - Pup Growth Curves (860 KB)
- R19G - Pup Bodyweight Gain Summary (152 KB)
- R20 - Pup Necropsy Summary (134 KB)
Modified One Generation Toxicity Dose Range Finding Individual Animal Data
- Individual Animal Body Weight Data (32 KB)
- Individual Animal Clinical Observations Data (59 KB)
- Individual Animal Consumption Data (33 KB)
- Individual Animal Gross Pathology Data (5 KB)
- Individual Animal Litter Data (43 KB)
- Individual Animal Pup Body Weight Data (76 KB)
- Individual Animal Pup Clinical Observations Data (339 KB)
- Individual Animal Pup Necropsy Data (7 KB)
- Individual Animal Removal Reasons Data (6 KB)
- Individual Animal Reproductive Performance Data (7 KB)
Modified One Generation Main Study
Modified One Generation Toxicity Study Tables
- F1 All Cohorts Vaginal Cytology Plots (126 KB)
- F1 All Cohorts Vaginal Cytology Summary 2020-08-19 (27 KB)
- I01 - Animal Removal Summary (187 KB)
- I02 - Animal Removals (6 MB)
- I03 - Growth Curve (2 MB)
- I03C - Growth Curve (2 MB)
- I04 - Mean Body Weights (653 KB)
- I04G - Mean Body Weight Gain (389 KB)
- I05 - Clinical Observations Summary (282 KB)
- I05P - Pup Clinical Observations Summary (633 KB)
- I06 - Mean Feed Consumption (469 KB)
- I08 - Mean Test Compound Consumption (332 KB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (775 KB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (868 KB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (771 KB)
- PA06R - Organ Weights Summary (210 KB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (639 KB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions and Litter Incidence (720 KB)
- PA14 - Redline Individual Histopathology Data (6 MB)
- PA18R - Non-Neoplastic Lesion Summary with Severity Grade and Litter Incidence (868 KB)
- PA46R - Gross Pathology Summary with Litter Incidence (929 KB)
- R01 - Multigeneration Cross Reference (7 MB)
- R02 - Reproductive Performance Summary (80 KB)
- R03 - Litter Data Summary (168 KB)
- R04 - Anogenital Distance Summary (64 KB)
- R06 - Andrology Summary (61 KB)
- R09 - Uterine Content Summary (90 KB)
- R10 - Fetal Defects (260 KB)
- R11 - Fetal Defect Summary (110 KB)
- R13 - Fetal Defect Cross Reference Summary (137 KB)
- R14 - Developmental Markers Summary (87 KB)
- R14C - Time to Attainment Curves for Testicular Descent (608 KB)
- R16 - Pubertal Markers Summary (74 KB)
- R16C - Time to Attainment Curves for Pubertal Markers (2 MB)
- R19 - Pup Bodyweight Summary (530 KB)
- R19C - Pup Growth Curves (2 MB)
- R19G - Pup Bodyweight Gain Summary (382 KB)
- R20 - Pup Necropsy Summary (257 KB)
- Vaginal Cytology Markov Model (268 KB)
Modified One Generation Toxicity Individual Animal Data
- F1 Fertility Cohort Vaginal Cytology Plots (88 KB)
- F1 Prenatal Cohort Vaginal Cytology Plots (66 KB)
- Individual Animal Andrology Data (20 KB)
- Individual Animal Body Weight Data (750 KB)
- Individual Animal Clinical Observations Data (3 MB)
- Individual Animal Consumption Data (767 KB)
- Individual Animal Developmental Markers Data (300 KB)
- Individual Animal Gross Pathology Data (287 KB)
- Individual Animal Histo Pathology Data (146 KB)
- Individual Animal Litter Data (408 KB)
- Individual Animal Organ Weight Data (76 KB)
- Individual Animal Pup Body Weight Data (752 KB)
- Individual Animal Pup Clinical Observations Data (3 MB)
- Individual Animal Pup Necropsy Data (30 KB)
- Individual Animal Removal Reasons Data (67 KB)
- Individual Animal Reproductive Performance Data (25 KB)
- Individual Animal Teratology Dam Data (12 KB)
- Individual Animal Teratology Fetal Weight Data (49 KB)
- Individual Animal Teratology Implant Findings Data (239 KB)