DART-06: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Modified One Generation Dose Range Finding Study, Modified One Generation Main Study Studies
DOI:
https://doi.org/10.22427/NTP-DATA-DART-06
Tables were updated on January 16, 2019 because of a change in format to increase clarity of data displayed. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I08, R19, R19C and R19G.
The I06 and I08 reports for the Dose Range Finding Study were replaced on December 4, 2020.
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Tables were updated on January 16, 2019 because of a change in format to increase clarity of data displayed. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I08, R19, R19C and R19G.
The I06 and I08 reports for the Dose Range Finding Study were replaced on December 4, 2020.
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
DART-06: 2-Ethylhexyl p-methoxycinnamate
Modified One Generation Dose Range Finding Study
Modified One Generation Toxicity Dose Range Finding Study Tables
- I01 - Animal Removal Summary (35 KB)
- I02 - Animal Removals (204 KB)
- I03 - Growth Curve (554 KB)
- I03C - Growth Curve (551 KB)
- I04 - Mean Body Weight Summary (161 KB)
- I04G - Mean Body Weight Gain (92 KB)
- I05 - Clinical Observations Summary (54 KB)
- I05P - Pup Clinical Observations Summary (201 KB)
- I06 - Mean Feed Consumption (105 KB)
- I08 - Mean Test Compound Consumption (76 KB)
- R01 - Multigeneration Cross Reference (914 KB)
- R02 - Reproductive Performance Summary (39 KB)
- R03 - Summary of Litter Data (90 KB)
- R19 - Pup Mean Body Weight Summary (182 KB)
- R19C - Pup Growth Curves (795 KB)
- R19G - Pup Mean Body Weight Gain (141 KB)
- R20 - Pup Necropsy Summary (132 KB)
Modified One Generation Toxicity Dose Range Finding Individual Animal Data
- Individual Animal Body Weight Data (36 KB)
- Individual Animal Clinical Observations Data (57 KB)
- Individual Animal Consumption Data (32 KB)
- Individual Animal Gross Pathology Data (5 KB)
- Individual Animal Litter Data (42 KB)
- Individual Animal Pup Body Weight Data (78 KB)
- Individual Animal Pup Clinical Observations Data (358 KB)
- Individual Animal Pup Necropsy Data (8 KB)
- Individual Animal Removal Reasons Data (6 KB)
- Individual Animal Reproductive Performance Data (7 KB)
Modified One Generation Main Study
Modified One Generation Toxicity Study Tables
- F1 All Cohorts Vaginal Cytology Plots (125 KB)
- F1 All Cohorts Vaginal Cytology Summary 2020-07-21 (26 KB)
- I01 - Animal Removal Summary (196 KB)
- I02 - Animal Removals (6 MB)
- I03 - Growth Curve (2 MB)
- I03C - Growth Curve (2 MB)
- I04 - Mean Body Weight Summary (508 KB)
- I04G - Mean Body Weight Gain (337 KB)
- I05 - Clinical Observations Summary (540 KB)
- I05P - Pup Clinical Observations Summary (394 KB)
- I06 - Mean Feed Consumption (464 KB)
- I08 - Mean Test Compound Consumption (326 KB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (914 KB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (942 KB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (914 KB)
- PA06R - Organ Weights Summary (228 KB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (748 KB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (953 KB)
- PA11 - Statistical Analysis of Survival Data (487 KB)
- PA14 - Individual Animal Pathology Data (4 MB)
- PA18R - Non-Neoplastic Lesion Summary with Mean Severity Grade and Litter Incidence (942 KB)
- PA40 - Survival Curve (1 MB)
- PA41 - Clinical Chemistry Summary (142 KB)
- PA43 - Hematology Summary (238 KB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1 MB)
- R01 - Multigeneration Cross Reference (5 MB)
- R02 - Reproductive Performance Summary (73 KB)
- R03 - Summary of Litter Data (149 KB)
- R04 - Anogenital Distance Summary (59 KB)
- R06 - Andrology Summary (48 KB)
- R09 - Uterine Content Summary (80 KB)
- R10 - Fetal Defects (171 KB)
- R11 - Fetal Defect Summary (90 KB)
- R13 - Fetal Defect Cross Reference Summary (123 KB)
- R14 - Developmental Markers Summary (76 KB)
- R14C - Time to Attainment Curves for Testicular Descent (471 KB)
- R16 - Pubertal Markers Summary (66 KB)
- R16C - Time to Attainment Curves for Pubertal Markers (2 MB)
- R19 - Pup Mean Body Weight Summary (408 KB)
- R19C - Pup Growth Curve (1 MB)
- R19G - Pup Mean Body Weight Gain (293 KB)
- R20 - Pup Necropsy Summary (251 KB)
- Vaginal Cytology Markov Model (191 KB)
Modified One Generation Toxicity Individual Animal Data
- F1 Fertility Cohort Vaginal Cytology Plots (76 KB)
- F1 Prechronic Cohort Vaginal Cytology Plots (58 KB)
- F1 Prenatal Cohort Vaginal Cytology Plots (69 KB)
- Individual Animal Andrology Data (17 KB)
- Individual Animal Body Weight Data (623 KB)
- Individual Animal Clinical Chemistry Data (12 KB)
- Individual Animal Clinical Observations Data (2 MB)
- Individual Animal Consumption Data (642 KB)
- Individual Animal Developmental Markers Data (225 KB)
- Individual Animal Gross Pathology Data (338 KB)
- Individual Animal Hematology Data (18 KB)
- Individual Animal Histopathology Data (175 KB)
- Individual Animal Litter Data (291 KB)
- Individual Animal Organ Weight Data (68 KB)
- Individual Animal Pup Body Weight Data (625 KB)
- Individual Animal Pup Clinical Observations Data (2 MB)
- Individual Animal Pup Necropsy Data (23 KB)
- Individual Animal Removal Reasons Data (59 KB)
- Individual Animal Reproductive Performance Data (21 KB)
- Individual Animal Teratology Dam Data (10 KB)
- Individual Animal Teratology Fetal Weight Data (38 KB)
- Individual Animal Teratology Implant Findings Data (182 KB)